ME00040B - Biciklično cinamidno jedinjenje - Google Patents

Biciklično cinamidno jedinjenje

Info

Publication number
ME00040B
ME00040B MEP-2008-49A MEP4908A ME00040B ME 00040 B ME00040 B ME 00040B ME P4908 A MEP4908 A ME P4908A ME 00040 B ME00040 B ME 00040B
Authority
ME
Montenegro
Prior art keywords
group
substituted
alkyl group
cinnamide compound
bicyclic
Prior art date
Application number
MEP-2008-49A
Other languages
English (en)
French (fr)
Inventor
Takehiko Miyagawa
Hiroaki Hagiwara
Yu Yoshida
Teiji Kimura
Koki Kawano
Eriko Doi
Noritaka Kitazawa
Mamoru Takaishi
Koichi Ito
Toshihiko Kaneko
Takeo Sasaki
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of ME00040B publication Critical patent/ME00040B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

    Biciklično cinamidno jedinjenje predstavljeno opštomformulom (I):      Biciklično cinamidno jedinjenje predstavljeno opštomformulom (I): gde ---- predstavlja jednogubu vezu ilidvogubu vezu; Ar1 predstavlja fenil grupu ili piridinil grupu kojamože biti supstituisana jednim do tri supstituenta; gde ---- predstavlja jednogubu vezu ilidvogubu vezu; Ar 1 predstavlja fenil grupu ili piridinil grupu kojamože biti supstituisana jednim do tri supstituenta; R1 i R2 svaki predstavljaC1-6  alkil grupu, hidroksilnu grupau,itd.; Z1 predstavlja metilensku grupu koja može biti supstituisanaili vinilen grupu, atom kiseonika, ili imino grupu koja može biti supstituisanasa C1-6  alkil grupom ili C1-6 acilgrupom; i svaki p, q, i r R 1 i R 2 svaki predstavljaC1-6  alkil grupu, hidroksilnu grupau,itd.; Z 1 predstavlja metilensku grupu koja može biti supstituisanaili vinilen grupu, atom kiseonika, ili imino grupu koja može biti supstituisanasa C1-6  alkil grupom ili C1-6 acilgrupom; i svaki p, q, i r je ceo broj od 0 do 2. Deluje tako što snižava Ab40 i Ab42.  Zbog toga je naročito korisno za prevencijuili lečenje kod neurodegenerativnih bolesti prouzrokovanih Ab-om, kao što jeAlchajmerova bolest i Daunov je ceo broj od 0 do 2. Deluje tako što snižava A b 40 i A b 42.  Zbog toga je naročito korisno za prevencijuili lečenje kod neurodegenerativnih bolesti prouzrokovanih A b -om, kao što jeAlchajmerova bolest i Daunov sindrom. sindrom.
MEP-2008-49A 2005-11-24 2006-11-01 Biciklično cinamidno jedinjenje ME00040B (me)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2005337963 2005-11-24
JP2006205538 2006-07-28
PCT/JP2006/321877 WO2007060821A1 (ja) 2005-11-24 2006-11-01 ２環式シンナミド化合物
EP06822806A EP1953158B1 (en) 2005-11-24 2006-11-01 Bicyclic cinnamide compound

Publications (1)

Publication Number Publication Date
ME00040B true ME00040B (me) 2010-06-10

Family

ID=38067057

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2008-49A ME00040B (me) 2005-11-24 2006-11-01 Biciklično cinamidno jedinjenje

Country Status (26)

Country Link
US (1) US8048878B2 (me)
EP (1) EP1953158B1 (me)
JP (1) JP5178203B2 (me)
KR (1) KR101296239B1 (me)
AR (1) AR057915A1 (me)
AU (1) AU2006317468B2 (me)
BR (1) BRPI0618890A2 (me)
CA (1) CA2629512C (me)
CR (1) CR9983A (me)
EA (1) EA014427B1 (me)
EC (1) ECSP088466A (me)
ES (1) ES2394364T3 (me)
GE (1) GEP20115172B (me)
HK (1) HK1122806A1 (me)
HN (1) HN2008000792A (me)
MA (1) MA29968B1 (me)
ME (1) ME00040B (me)
MY (1) MY144596A (me)
NO (1) NO20082805L (me)
NZ (1) NZ568422A (me)
PE (1) PE20071029A1 (me)
PL (1) PL1953158T3 (me)
RS (1) RS20080242A (me)
SA (1) SA06270432B1 (me)
TW (1) TWI370130B (me)
WO (1) WO2007060821A1 (me)

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Also Published As

Publication number Publication date
KR101296239B1 (ko) 2013-08-13
JPWO2007060821A1 (ja) 2009-05-07
AR057915A1 (es) 2007-12-26
AU2006317468B2 (en) 2011-10-13
EA014427B1 (ru) 2010-12-30
MA29968B1 (fr) 2008-11-03
EP1953158B1 (en) 2012-09-12
ECSP088466A (es) 2008-08-29
SA06270432B1 (ar) 2011-06-22
WO2007060821A1 (ja) 2007-05-31
ES2394364T3 (es) 2013-01-31
MY144596A (en) 2011-10-14
JP5178203B2 (ja) 2013-04-10
NO20082805L (no) 2008-08-20
HK1122806A1 (en) 2009-05-29
US20090181945A1 (en) 2009-07-16
EP1953158A1 (en) 2008-08-06
EP1953158A4 (en) 2010-09-01
TW200804372A (en) 2008-01-16
TWI370130B (en) 2012-08-11
GEP20115172B (en) 2011-03-10
RS20080242A (xx) 2009-09-08
PL1953158T3 (pl) 2013-02-28
KR20080072057A (ko) 2008-08-05
US8048878B2 (en) 2011-11-01
CA2629512C (en) 2014-04-22
HN2008000792A (es) 2010-09-17
CR9983A (es) 2008-08-21
BRPI0618890A2 (pt) 2013-01-08
AU2006317468A1 (en) 2007-05-31
EA200801417A1 (ru) 2009-02-27
CA2629512A1 (en) 2007-05-31
NZ568422A (en) 2010-09-30
PE20071029A1 (es) 2007-11-17

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