CY1110167T1 - Κυκλοπροπυλ αμινες ως ρυθμισεις του η3 υποδοχεα της ισταμινης - Google Patents

Κυκλοπροπυλ αμινες ως ρυθμισεις του η3 υποδοχεα της ισταμινης

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Publication number
CY1110167T1
CY1110167T1 CY20101100593T CY101100593T CY1110167T1 CY 1110167 T1 CY1110167 T1 CY 1110167T1 CY 20101100593 T CY20101100593 T CY 20101100593T CY 101100593 T CY101100593 T CY 101100593T CY 1110167 T1 CY1110167 T1 CY 1110167T1
Authority
CY
Cyprus
Prior art keywords
cyclopropyl
amins
hypothesis
regulations
receptor
Prior art date
Application number
CY20101100593T
Other languages
English (en)
Inventor
Brett D Allison
Nicholas I Carruthers
Cheryl A Grice
Michael A Letavic
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of CY1110167T1 publication Critical patent/CY1110167T1/el

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61P25/20—Hypnotics; Sedatives
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

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  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
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  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Psychology (AREA)
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  • Obesity (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Ορισμένες κυκλοπροπυλ αμίνες είναι ρυθμιστές του υποδοχέα Η3 της ισταμίνης χρήσιμες στη θεραπεία ασθενειών που διαμεσολαβούνται από τον υποδοχέα Η3 της ισταμίνης.
CY20101100593T 2005-09-16 2010-06-28 Κυκλοπροπυλ αμινες ως ρυθμισεις του η3 υποδοχεα της ισταμινης CY1110167T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71765905P 2005-09-16 2005-09-16
EP06824964A EP1948607B1 (en) 2005-09-16 2006-09-14 Cyclopropyl amines as modulators of the histamine h3 receptor

Publications (1)

Publication Number Publication Date
CY1110167T1 true CY1110167T1 (el) 2015-01-14

Family

ID=37889336

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100593T CY1110167T1 (el) 2005-09-16 2010-06-28 Κυκλοπροπυλ αμινες ως ρυθμισεις του η3 υποδοχεα της ισταμινης

Country Status (33)

Country Link
US (3) US7687499B2 (el)
EP (1) EP1948607B1 (el)
JP (1) JP5185120B2 (el)
KR (1) KR101336106B1 (el)
CN (1) CN101321730B (el)
AR (1) AR058670A1 (el)
AT (1) ATE463481T1 (el)
AU (1) AU2006292598B2 (el)
BR (1) BRPI0622428A2 (el)
CA (1) CA2622760C (el)
CR (1) CR9891A (el)
CY (1) CY1110167T1 (el)
DE (1) DE602006013501D1 (el)
DK (1) DK1948607T3 (el)
EA (1) EA014370B1 (el)
EC (1) ECSP088279A (el)
ES (1) ES2342323T3 (el)
HK (1) HK1123291A1 (el)
HR (1) HRP20100263T1 (el)
IL (1) IL190110A (el)
ME (1) ME01181B (el)
MX (1) MX2008003691A (el)
MY (1) MY145305A (el)
NO (1) NO340949B1 (el)
NZ (1) NZ566533A (el)
PL (1) PL1948607T3 (el)
PT (1) PT1948607E (el)
RS (1) RS51311B (el)
SI (1) SI1948607T1 (el)
TW (1) TWI418552B (el)
UA (1) UA96424C2 (el)
WO (1) WO2007035425A2 (el)
ZA (1) ZA200803337B (el)

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TW200823204A (en) * 2006-10-17 2008-06-01 Arena Pharm Inc Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto
ES2620818T3 (es) * 2006-12-14 2017-06-29 Janssen Pharmaceutica N.V. Procedimiento para la preparación de derivados de piperazinil y diazepanil benzamida
JP4691669B2 (ja) 2007-08-22 2011-06-01 アストラゼネカ・アクチエボラーグ シクロプロピルアミド誘導体
EP2222664B1 (en) 2007-11-20 2014-10-29 Janssen Pharmaceutica, N.V. Cycloalkyloxy- and heterocycloalkyloxypyridine compounds as modulators of the histamine h3 receptor
TW201039825A (en) * 2009-02-20 2010-11-16 Astrazeneca Ab Cyclopropyl amide derivatives 983
US9186353B2 (en) * 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
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TWI520945B (zh) * 2010-02-18 2016-02-11 阿斯特捷利康公司 環丙基苯甲醯胺衍生物之新穎結晶形式
PL3789038T3 (pl) 2010-05-14 2023-01-23 The Board Of Trustees Of The Leland Stanford Junior University Humanizowane i chimeryczne przeciwciała monoklonalne wobec cd47
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ATE463481T1 (de) 2010-04-15
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