AU3931400A - N-benzimidazolylmethyl- and n-indolylmethyl-benzamides and their use as crf modulators - Google Patents

N-benzimidazolylmethyl- and n-indolylmethyl-benzamides and their use as crf modulators

Info

Publication number
AU3931400A
AU3931400A AU39314/00A AU3931400A AU3931400A AU 3931400 A AU3931400 A AU 3931400A AU 39314/00 A AU39314/00 A AU 39314/00A AU 3931400 A AU3931400 A AU 3931400A AU 3931400 A AU3931400 A AU 3931400A
Authority
AU
Australia
Prior art keywords
benzimidazolylmethyl
indolylmethyl
benzamides
crf
modulators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU39314/00A
Inventor
Ping Ge
Raymond F Horvath
Alan Hutchison
Taeyoung Yoon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neurogen Corp
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of AU3931400A publication Critical patent/AU3931400A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
AU39314/00A 1999-04-02 2000-03-31 N-benzimidazolylmethyl- and n-indolylmethyl-benzamides and their use as crf modulators Abandoned AU3931400A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12762499P 1999-04-02 1999-04-02
US28542099A 1999-04-02 1999-04-02
US60127624 1999-04-02
US09285420 1999-04-02
PCT/US2000/008570 WO2000059888A1 (en) 1999-04-02 2000-03-31 N-benzimidazolylmethyl- and n-indolylmethyl-benzamides and their use as crf modulators

Publications (1)

Publication Number Publication Date
AU3931400A true AU3931400A (en) 2000-10-23

Family

ID=26825805

Family Applications (1)

Application Number Title Priority Date Filing Date
AU39314/00A Abandoned AU3931400A (en) 1999-04-02 2000-03-31 N-benzimidazolylmethyl- and n-indolylmethyl-benzamides and their use as crf modulators

Country Status (5)

Country Link
EP (1) EP1165517A1 (en)
JP (1) JP2003528802A (en)
AU (1) AU3931400A (en)
CA (1) CA2369553A1 (en)
WO (1) WO2000059888A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030060904A (en) * 2000-10-06 2003-07-16 뉴로젠 코포레이션 Benzimidazole and indole derivatives as CRF receptor modulators
PA8535601A1 (en) 2000-12-21 2002-11-28 Pfizer BENZIMIDAZOL AND PIRIDILIMIDAZOL DERIVATIVES AS LIGANDOS FOR GABAA
KR101036391B1 (en) * 2003-03-13 2011-05-23 이데미쓰 고산 가부시키가이샤 Nitrogen-containing heterocycle derivative and organic electroluminescent element using the same
US7030145B2 (en) 2003-04-18 2006-04-18 Bristol-Myers Squibb Company Pyridinyl derivatives for the treatment of depression
US7112585B2 (en) 2003-04-18 2006-09-26 Bristol-Myers Squibb Company Pyrimidine derivatives as corticotropin releasing factor inhibitors
US7442709B2 (en) 2003-08-21 2008-10-28 Osi Pharmaceuticals, Inc. N3-substituted imidazopyridine c-Kit inhibitors
ATE413395T1 (en) 2003-08-21 2008-11-15 Osi Pharm Inc N-SUBSTITUTED PYRAZOLYL-AMIDYL-BENZIMIDAZOLYL-C KIT INHIBITOR N
JP4842829B2 (en) * 2003-10-31 2011-12-21 武田薬品工業株式会社 Nitrogen-containing fused heterocyclic compounds
AU2005214167B2 (en) 2004-02-13 2008-08-07 Warner-Lambert Company Llc Androgen receptor modulators
EP1737813A1 (en) 2004-04-13 2007-01-03 Warner-Lambert Company LLC Androgen modulators
US7271271B2 (en) * 2004-06-28 2007-09-18 Amgen Sf, Llc Imidazolo-related compounds, compositions and methods for their use
TW200724139A (en) 2005-05-05 2007-07-01 Warner Lambert Co Androgen modulators
CN103194212B (en) * 2013-03-30 2014-09-17 渤海大学 Ratio-dependent florescent probe for identifying Zn<2+> and S<2-> in relayed manner as well as synthesis method and application of ratio-dependent florescent probe
CA3155599A1 (en) 2014-01-21 2015-07-30 Neurocrine Biosciences, Inc. Crf1 receptor antagonists for the treatment of congenital adrenal hyperplasia
JP2023512038A (en) * 2020-01-29 2023-03-23 フォグホーン セラピューティクス インコーポレイテッド Compounds and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955613A (en) * 1995-10-13 1999-09-21 Neurogen Corporation Certain pyrrolopyridine derivatives; novel CRF1 specific ligands

Also Published As

Publication number Publication date
JP2003528802A (en) 2003-09-30
CA2369553A1 (en) 2000-10-12
WO2000059888A1 (en) 2000-10-12
EP1165517A1 (en) 2002-01-02

Similar Documents

Publication Publication Date Title
AU3620600A (en) Skin-marking devices and their use
AUPQ419099A0 (en) Novel compositions and methods
AU4520801A (en) Novel substituted phenanthridinones and methods of use thereof
AU7989400A (en) Compounds and methods
AU7651400A (en) Fluorescent maleimides and uses thereof
AU4943200A (en) Modified cytokine
AU3215500A (en) Compounds and methods
AU4431000A (en) Novel use
AU1890599A (en) Novel microorganism and use thereof
AU2678800A (en) Modified calycins
AU4923200A (en) Isothiazolecarboxamides and their use as microbicides
AU1403501A (en) Novel composition and use
AU3931400A (en) N-benzimidazolylmethyl- and n-indolylmethyl-benzamides and their use as crf modulators
AU6635800A (en) Pyridomorphinans, thienomoprhinans and use thereof
AU3175900A (en) Tampon
AU2841801A (en) Triazolotriazinones and the use thereof
AU1152601A (en) Compositions and their use
AU1083501A (en) Antibiotic-metal complex and methods
AU4755600A (en) Benzohetero cyclylcyclo hexenones and their use as herbicides
AU7410900A (en) Alginate preparation and use of the same
AU2669201A (en) Taccalonolides and their use
AU1894601A (en) Novel gene and use thereof
AU5979300A (en) Angiopoietin-6 and uses thereof
AU6270300A (en) Substituted heteroaryloxyacetanilides and their use as herbicides
AUPQ078799A0 (en) New use

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase