CO6630192A2 - Control de retroalimentación en sistemas microfluidicos - Google Patents

Control de retroalimentación en sistemas microfluidicos

Info

Publication number
CO6630192A2
CO6630192A2 CO12207302A CO12207302A CO6630192A2 CO 6630192 A2 CO6630192 A2 CO 6630192A2 CO 12207302 A CO12207302 A CO 12207302A CO 12207302 A CO12207302 A CO 12207302A CO 6630192 A2 CO6630192 A2 CO 6630192A2
Authority
CO
Colombia
Prior art keywords
microfluidic system
time
microfluidic
systems
feedback control
Prior art date
Application number
CO12207302A
Other languages
English (en)
Inventor
Vincent Linder
David Steinmiller
Original Assignee
Opko Diagnostics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Opko Diagnostics Llc filed Critical Opko Diagnostics Llc
Publication of CO6630192A2 publication Critical patent/CO6630192A2/es

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    • G01N2333/96425Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
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    • Y10T137/0324With control of flow by a condition or characteristic of a fluid
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Abstract

Sistemas y métodos para controlar fluidos en sistemas microfluidicos son generalmente descritos. En algunas realizaciones, el control de fluidos implica el uso de retroalimentación de uno o más procesos o eventos ocurriendo en el sistema microfluídico. Por ejemplo, un detector puede detectar uno o más fluidos en una zona de medición de un sistema microfluídico y una o más señales, o un patrón de señales, puede ser generada correspondiente al fluido(s). En algunos casos, la señal o patrón de señales puede corresponder a una intensidad, una duración, una posición en tiempo con respecto a una segunda posición en tiempo o con respecto a otro proceso, y/o un período de tiempo promedio entre eventos. Utilizando estos datos, un sistema de control puede determinar si modular flujo de fluido posterior en el sistema microfluídico. En algunas realizaciones, estos y otros métodos pueden ser utilizados para conducir control de calidad para determinar anormalidades en operación del sistema microfluídico.
CO12207302A 2010-04-16 2012-11-15 Control de retroalimentación en sistemas microfluidicos CO6630192A2 (es)

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Families Citing this family (141)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4773348B2 (ja) 2003-07-12 2011-09-14 アクセラー8 テクノロジー コーポレイション 高感度かつ迅速なバイオ検出法
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
PL1776181T3 (pl) 2004-01-26 2014-03-31 Harvard College Układ i sposób doprowadzania płynów
CN103495439B (zh) 2007-05-04 2015-09-16 欧普科诊断有限责任公司 流体连接器和微流体系统
US8600932B2 (en) 2007-05-07 2013-12-03 Trimble Navigation Limited Telematic asset microfluidic analysis
US8448499B2 (en) 2008-12-23 2013-05-28 C A Casyso Ag Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method
WO2010087999A1 (en) 2009-02-02 2010-08-05 Claros Diagnostics, Inc. Structures for controlling light interaction with microfluidic devices
WO2011062738A1 (en) 2009-11-23 2011-05-26 Mikhail Briman Controlled electrochemical activation of carbon-based electrodes
DK2504105T3 (da) 2009-11-24 2021-03-15 Opko Diagnostics Llc Fluidblanding og -afgivelse i mikrofluidsystemer
CN105381825A (zh) 2010-04-16 2016-03-09 欧普科诊断有限责任公司 微流体系统中的反馈控制
JP5830230B2 (ja) * 2010-07-20 2015-12-09 アークレイ株式会社 分析装置および分析方法
WO2012094325A2 (en) * 2011-01-03 2012-07-12 Cytonome/St. Llc Method and apparatus for monitoring and optimizing particle sorting
EP2683831B1 (en) 2011-03-07 2015-09-23 Accelerate Diagnostics, Inc. Rapid cell purification systems
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
US9760685B2 (en) * 2011-05-16 2017-09-12 Trimble Inc. Telematic microfluidic analysis using handheld device
US9739763B2 (en) * 2011-05-16 2017-08-22 Trimble Inc. Telematic locomotive microfluidic analysis
EP2737315B1 (en) 2011-07-25 2022-03-16 Proxim Diagnostics Corporation Cartridge for diagnostic testing
US20130053994A1 (en) * 2011-08-31 2013-02-28 General Electric Company Method and apparatus for monitoring radiopharmaceutical processing
CN104303212B (zh) 2011-11-20 2016-08-24 Fio公司 用于生物/环境快速诊断测试设备的质量控制传感器方法、系统及设备
EP3447499A1 (en) 2011-12-23 2019-02-27 Abbott Point of Care Inc. Optical assay device with pneumatic sample actuation
US8984957B2 (en) * 2012-01-30 2015-03-24 The United States Of America, As Represented By The Secretary Of The Navy System and method for testing of micro-sized materials
JP6197263B2 (ja) * 2012-02-06 2017-09-20 ソニー株式会社 マイクロチップ
PT2823427T (pt) * 2012-03-05 2021-03-22 Oy Arctic Partners Ab Métodos e aparelhos para prever o risco de cancro da próstata e o volume da glândula da próstata
DK3312749T3 (da) 2012-03-05 2024-06-03 Oy Arctic Partners Ab Fremgangsmåder og anordninger til forudsigelse af risiko for prostatacancer og prostatakirtelvolumen
US9658629B2 (en) 2012-03-22 2017-05-23 Seagate Technology Llc Method and apparatus for controlling the temperature of components
CN103424550B (zh) * 2012-05-18 2016-04-20 北京勤邦生物技术有限公司 一种检测氯霉素的试剂盒及方法
US9222874B2 (en) * 2012-06-27 2015-12-29 The United States Of America As Represented By The Secretary Of The Army Systems and methods for individually trapping particles from air and measuring the optical spectra or other properties of individual trapped particles
JP2015524568A (ja) * 2012-08-08 2015-08-24 コーニンクレッカ フィリップス エヌ ヴェ 遠心マイクロ流体デバイス及び使用方法
EP2893356B1 (en) * 2012-09-05 2022-04-27 Cepheid Universal docking bay and data door in a fluidic analysis system
EP2895852A4 (en) * 2012-09-11 2016-05-25 Univ Cornell APPARATUS AND METHOD FOR MEASURING ON THE COLLECTION POINT OF A BIOMOLECULAR REACTION
WO2014040185A1 (en) * 2012-09-14 2014-03-20 University Of Manitoba Low-cost portable microfluidic system for cell migration studies
CA2833532C (en) * 2012-11-15 2021-10-26 Ortho-Clinical Diagnostics, Inc. Quality/process control of a lateral flow assay device based on flow monitoring
US9579655B2 (en) 2013-01-18 2017-02-28 Biomeme Incorporated Analytic device
WO2014118549A1 (en) * 2013-01-30 2014-08-07 Vantix Holdings Limited A multi-functional sensor for an electrochemical detection system
CN104769440B (zh) * 2013-03-11 2017-12-12 克忧公司 用于检测和量化分析物的系统和方法
WO2014158367A1 (en) 2013-03-13 2014-10-02 Opko Diagnostics, Llc Mixing of fluids in fluidic systems
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
KR102180837B1 (ko) * 2013-03-27 2020-11-19 주식회사 케이씨씨 방오도료용 공중합체 바인더, 그 제조방법 및 이를 포함한 방오도료 조성물
WO2014171139A1 (ja) * 2013-04-16 2014-10-23 コニカミノルタ株式会社 測定異常の検出方法および表面プラズモン励起増強蛍光測定装置
KR102205650B1 (ko) * 2013-06-05 2021-01-21 넥서스 디엑스, 아이엔씨. 미세유동장치, 검사장치, 이들을 포함하는 검사 시스템 및 검사장치의 제어방법
CN118287167A (zh) * 2013-11-18 2024-07-05 尹特根埃克斯有限公司 用于样本分析的卡盒和仪器
US20150268668A1 (en) 2014-03-20 2015-09-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Apparatus for controlling microfluidic components
SG11201608035UA (en) 2014-03-28 2016-10-28 Opko Diagnostics Llc Compositions and methods related to diagnosis of prostate cancer
WO2015153449A1 (en) * 2014-03-31 2015-10-08 Redshift Systems Corporation Fluid analyzer with modulation for liquids and gases
US9377400B2 (en) 2014-03-31 2016-06-28 Redshift Systems Corporation Motion modulation fluidic analyzer system
JP6603675B2 (ja) * 2014-06-18 2019-11-06 スカンジナビアン マイクロ バイオデバイシズ エイピーエス マイクロ流体検出システム及びマイクロ流体カートリッジ
US10539579B2 (en) 2014-09-29 2020-01-21 C A Casyso Gmbh Blood testing system and method
US10690627B2 (en) * 2014-10-22 2020-06-23 IntegenX, Inc. Systems and methods for sample preparation, processing and analysis
EA038479B1 (ru) 2014-12-12 2021-09-03 Опкоу Дайагностикс, Ллк Устройство для проведения анализа пробы и способ эксплуатации указанного устройства
WO2016121886A1 (ja) * 2015-01-28 2016-08-04 株式会社ダナフォーム 分析用デバイス、分析用チップ、分析キット、および、これらを用いた分析方法
CA2979559A1 (en) 2015-03-27 2016-10-06 Opko Diagnostics, Llc Prostate antigen standards and uses thereof
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
KR20170132856A (ko) 2015-03-30 2017-12-04 액셀러레이트 다이어그노스틱스, 아이엔씨. 신속한 미생물 동정 및 항균제 감수성 시험을 위한 기기 및 시스템
JP6475069B2 (ja) * 2015-04-23 2019-02-27 アズビル株式会社 粒子検出装置及び粒子の検出方法
DE202016008673U1 (de) 2015-04-29 2019-01-22 Opko Diagnostics, Llc Zusammensetzungen zur aktiven Überwachung von Prostatakrebs
GB2539192A (en) * 2015-06-05 2016-12-14 Stratec Biomedical Ag Device, system and method for cooling a reagent compartment
KR20180091805A (ko) * 2015-06-19 2018-08-16 앤드류 알리안스 에스. 에이. 액체의 부피 측정 장치 및 방법
RU2592687C1 (ru) * 2015-06-30 2016-07-27 Евгений Александрович Тоневицкий Устройство пневматического управления клапанами микрофлюидной системы
US10125342B2 (en) * 2015-08-26 2018-11-13 EMULATE, Inc. Droplet fluid connections
CN108474724A (zh) * 2015-09-30 2018-08-31 Koc 大学 使用嵌入套筒的基于纤维的悬臂的感测设备
US11013576B2 (en) 2015-10-16 2021-05-25 Opko Diagnostics, Llc Articles and methods for preparing a surface for obtaining a patent sample
WO2017100457A1 (en) 2015-12-11 2017-06-15 Opko Diagnostics, Llc Fluidic systems involving incubation samples and/or reagents
US10344592B2 (en) * 2015-12-21 2019-07-09 Schlumberger Technology Corporation Flushing microfluidic sensor systems
CN108430639B (zh) 2015-12-29 2021-03-23 欧普科诊断有限责任公司 流体收集装置及相关方法
USD810084S1 (en) * 2016-03-23 2018-02-13 Formfox, Inc. Mobile scanner
WO2017185067A1 (en) 2016-04-22 2017-10-26 Click Diagnostics, Inc. Printed circuit board heater for an amplification module
WO2017197040A1 (en) 2016-05-11 2017-11-16 Click Diagnostics, Inc. Devices and methods for nucleic acid extraction
US10269548B1 (en) 2016-05-16 2019-04-23 Elemental Scientific, Inc. Automatic control of flow rate for sample introduction system responsive to sample intensity
US11519845B2 (en) 2016-05-23 2022-12-06 Siemens Healthineers Nederland B.V. Device for use in fluid sample analysis
US10345244B2 (en) 2016-06-03 2019-07-09 International Business Machines Corporation Diagnostic test device with patterned material spots
US10352578B2 (en) * 2016-06-09 2019-07-16 Board Of Regents, The University Of Texas System Adaptive optimization for dynamic room pressurization control
GB201611502D0 (en) * 2016-06-30 2016-08-17 Ciga Healthcare Ltd A reader for an assay device
AU2017292906B2 (en) * 2016-07-06 2021-08-26 Global Life Sciences Solutions Canada Ulc Smart microfluidic mixing instrument and cartridges
USD800335S1 (en) * 2016-07-13 2017-10-17 Precision Nanosystems Inc. Microfluidic chip
WO2018022025A1 (en) 2016-07-26 2018-02-01 Hewlett-Packard Development Company, L.P. Microfluidic apparatuses
JPWO2018025705A1 (ja) * 2016-08-03 2019-06-27 国立研究開発法人理化学研究所 分析セル、分析デバイス、分析装置および分析システム
US10976329B2 (en) 2016-10-07 2021-04-13 Boehringer Ingelheim Vetmedica Gmbh Method and system for testing a sample
BR112019006879A2 (pt) * 2016-10-07 2019-06-25 Boehringer Ingelheim Vetmedica Gmbh sistema de análise e método para testagem de uma amostra
US20190266384A1 (en) * 2016-10-28 2019-08-29 Manigene Co., Ltd. Image processing system for ovulation prediction analysis
WO2018079916A1 (ko) * 2016-10-28 2018-05-03 주식회사 바이탈스미스 배란일 측정을 위한 영상처리 및 분석 시스템, 이의 제어 방법
EP3535056A4 (en) * 2016-11-07 2020-07-01 Cytochip Inc. FLUID CARTRIDGE FOR ADDITIONAL CYTOMETRY AND ANALYSIS
US11635379B2 (en) * 2017-01-20 2023-04-25 The General Hospital Corporation Portable wide field fluorimeter systems
JP7113486B2 (ja) 2017-02-08 2022-08-05 アヴラン インダストリアル,インコーポレーテッド 動物用噴霧装置および方法
JP7069125B2 (ja) 2017-03-28 2022-05-17 デンカ株式会社 膜担体及びそれを用いた液体試料検査キット
USD849265S1 (en) * 2017-04-21 2019-05-21 Precision Nanosystems Inc Microfluidic chip
JP7203392B2 (ja) * 2017-05-04 2023-01-13 ユニベアズィテート チューリッヒ 細胞培養装置
US11154855B2 (en) * 2017-05-08 2021-10-26 Custom Sensors And Technology Automated liquid handling and testing systems and methods
USD854188S1 (en) * 2017-05-25 2019-07-16 Koninklijke Philips N.V. Apparatus for clinical analysis
US11460869B2 (en) * 2017-07-31 2022-10-04 Fujikin Incorporated Fluid control system and flow rate measurement method
JP7207308B2 (ja) * 2017-08-03 2023-01-18 ソニーグループ株式会社 コンタクトレンズおよび検出方法
DE202017006951U1 (de) 2017-08-14 2019-02-07 Opko Diagnostics, Llc Multiplex-Assays zur Beurteilung des Prostatakrebsstatus
US11215562B2 (en) * 2017-08-28 2022-01-04 Hewlett-Packard Development Company, L.P. Deformable covers on sensors and reservoirs
WO2019055875A2 (en) * 2017-09-15 2019-03-21 Biomeme, Inc. METHODS AND SYSTEMS FOR AUTOMATIC SAMPLE PROCESSING
CN109765218B (zh) * 2017-11-09 2022-04-12 深圳市新产业生物医学工程股份有限公司 耗材盒存储装置的控制方法、系统及耗材盒存储装置
RU177970U1 (ru) * 2017-11-10 2018-03-16 Общество с ограниченной ответственностью "Видящие машины" Устройство для оптического распознавания графических элементов с функцией сканера штрих-кодов и детектора валют
US20210101143A1 (en) * 2017-11-13 2021-04-08 Indian Institute Of Science Clinical sample storage cassettes
WO2019118989A1 (en) 2017-12-15 2019-06-20 Evanostics Llc Optical reader for analyte testing
CN111373262A (zh) * 2017-12-30 2020-07-03 深圳迈瑞生物医疗电子股份有限公司 样本分析仪及其试剂供应方法
USD878622S1 (en) * 2018-04-07 2020-03-17 Precision Nanosystems Inc. Microfluidic chip
EP3569716A1 (en) * 2018-05-14 2019-11-20 Consejo Superior De Investigaciones Científicas (CSIC) A method for controlling timing of events in a microfluidic device and a timer microfluidic device
WO2020018592A1 (en) 2018-07-17 2020-01-23 Methodical Mind, Llc. Graphical user interface system
US11959836B2 (en) * 2018-08-15 2024-04-16 Georgia Tech Research Corporation Analysis system and methods of use thereof
NL2021686B1 (en) * 2018-09-24 2020-05-07 Lely Patent Nv Milking system with detection system
MX2021003484A (es) * 2018-09-28 2021-06-18 Siemens Healthcare Diagnostics Inc Metodos para detectar efecto(s) hook asociado(s) con analito(s) de interes durante o que resulta(n) de la realizacion de ensayo(s) de diagnostico.
US11314375B2 (en) * 2018-10-01 2022-04-26 Precigenome, LLC Multichannel pressure control system with user friendly interface
TWI666403B (zh) * 2018-11-14 2019-07-21 宇辰系統科技股份有限公司 流體填充與抽取系統與方法
CN109374908B (zh) * 2018-11-23 2024-01-26 中国科学院上海高等研究院 一种适用于溶液高通量筛选的真空自动样品装置及真空样品室
US11548000B2 (en) * 2018-11-28 2023-01-10 International Business Machines Corporation Structures for automated, multi-stage processing of nanofluidic chips
AU2019386853A1 (en) * 2018-11-30 2021-07-08 Illumina, Inc. Systems and methods for active warming of a cartridge
WO2020132146A1 (en) 2018-12-18 2020-06-25 Evanostics Llc Optical analyte detection
USD927727S1 (en) * 2018-12-20 2021-08-10 Alveo Technologies, Inc. Reader device for a diagnostic system
WO2020176816A1 (en) * 2019-02-28 2020-09-03 Miroculus Inc. Digital microfluidics devices and methods of using them
WO2020185200A1 (en) * 2019-03-08 2020-09-17 Hewlett-Packard Development Company, L.P. Disposable microfluidic cassettes
CN113874708A (zh) 2019-03-21 2021-12-31 生米公司 多功能分析装置
WO2020205204A1 (en) 2019-04-03 2020-10-08 Opko Diagnostics, Llc Methods for the detection of prostate cancer
WO2020210292A1 (en) * 2019-04-08 2020-10-15 Miroculus Inc. Multi-cartridge digital microfluidics apparatuses and methods of use
WO2020226623A1 (en) * 2019-05-07 2020-11-12 Hewlett-Packard Development Company, L.P. Fluid analysis with channels formed in lids
USD908911S1 (en) * 2019-05-22 2021-01-26 Siemens Healthcare Diagnostics Inc. Analyzing instrument and display monitor in combination
WO2020245964A1 (ja) * 2019-06-06 2020-12-10 株式会社島津製作所 質量分析装置及び質量分析方法
CN113905824B (zh) * 2019-06-27 2023-09-08 阿克斯比尔公司 生物分子诊断系统
US20220214199A1 (en) * 2019-07-18 2022-07-07 Board Of Regents, The University Of Texas System Nano flow sensors
CN110376130B (zh) * 2019-07-31 2022-03-15 中国计量大学 基于负反馈调节的荧光光谱检测系统
CA3159566A1 (en) 2019-10-29 2021-05-06 Quantum-Si Incorporated Peristaltic pumping of fluids and associated methods, systems, and devices
CA3165578A1 (en) 2019-12-27 2021-07-01 Methodical Mind, Llc. Graphical user interface system
WO2021138544A1 (en) 2020-01-03 2021-07-08 Visby Medical, Inc. Devices and methods for antibiotic susceptibility testing
US20230051263A1 (en) * 2020-01-09 2023-02-16 The Regents Of The University Of Michigan Device for rapid and quantitative detection of drugs of abuse in sweat
AU2021211470A1 (en) * 2020-01-22 2022-09-15 Methodical Mind, Llc. Graphical user interface system
DE102020107645B4 (de) * 2020-03-19 2024-07-18 Bruker Daltonics GmbH & Co. KG Betrieb einer Mikrofluidik-Vorrichtung bei der Analyse von Probesubstanzen
US10953404B1 (en) * 2020-04-24 2021-03-23 Pattern Bioscience, Inc. Apparatuses for contactless loading and imaging of microfluidic chips and related methods
FR3111428B1 (fr) * 2020-06-12 2024-07-05 Aryballe Tech Dispositif électronique d’analyse d’un analyte présent dans un fluide et capteur consommable et interchangeable, procédé de fabrication de ce dispositif et de ce capteur consommable et interchangeable
CN116157500A (zh) * 2020-07-08 2023-05-23 卢马克特公司 采样设备和系统
US20220020455A1 (en) * 2020-07-14 2022-01-20 Talis Biomedical Corporation Point-of-care diagnostic instrument workflow
WO2022044034A1 (en) * 2020-08-24 2022-03-03 Resolve Diagnostics Pvt. Ltd. Apparatus, device and method for photodetection of pathogens
JP2023545631A (ja) 2020-09-18 2023-10-31 バイオミーム,インコーポレイテッド 試料を分析するための運搬可能デバイスおよび方法
US20220091031A1 (en) * 2020-09-18 2022-03-24 Salvus, Llc Interferometric Detection and Quantification System and Methods of Use in Chemical Processing
KR20230110308A (ko) * 2020-11-18 2023-07-21 셀에프이, 인크. 생물학적 세포로 기계적 천공 기반 페이로드 전달을 위한 방법 및 시스템
WO2022182767A1 (en) * 2021-02-23 2022-09-01 Nature's Toolbox, Inc. Lipid nanoparticle (lnp) encapsulation of mrna products
FR3122921A1 (fr) * 2021-05-11 2022-11-18 Aryballe Dispositif électronique d’analyse d’un analyte présent dans un fluide comportant un capteur et procédé de remplacement du capteur
KR102497632B1 (ko) * 2021-05-31 2023-02-08 호산테크 주식회사 나노버블 소멸장치
EP4392747A1 (en) * 2021-08-27 2024-07-03 Aspect Biosystems Ltd. Microfluidic-based fiber formation methods and systems
CN114200151A (zh) * 2022-02-17 2022-03-18 宁波海壹生物科技有限公司 一种全自动化学发光免疫分析仪管理系统

Family Cites Families (202)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3735640A (en) 1972-03-10 1973-05-29 L Chizhov Apparatus for injecting a sample into a gas chromatograph
US4318994A (en) 1979-08-30 1982-03-09 Mcdonnell Douglas Corporation Enterobacteriaceae species biochemical test card
US4517302A (en) 1982-11-15 1985-05-14 Technicon Instruments Corporation Continuous flow metering apparatus
CA1211157A (en) 1982-11-22 1986-09-09 Richard L. Columbus Capillary transport device having means for increasing the viscosity of the transported liquid
US4534465A (en) 1983-10-13 1985-08-13 Coulter Electronics, Inc. Cassette for supporting test tubes of different diameters and/or lengths
US4963498A (en) 1985-08-05 1990-10-16 Biotrack Capillary flow device
EP0282601B1 (en) 1986-09-16 1993-02-10 Mitsubishi Corporation Automatic analyzer
US5051237A (en) 1988-06-23 1991-09-24 P B Diagnostic Systems, Inc. Liquid transport system
JPH02176466A (ja) 1988-12-27 1990-07-09 Mochida Pharmaceut Co Ltd 液性試料中の特定物質の測定方法および測定器具
US5286454A (en) 1989-04-26 1994-02-15 Nilsson Sven Erik Cuvette
GB8915512D0 (en) 1989-07-06 1989-08-23 Sec Dep For Health Silver enhanced gold-labelled immuno assay method
US6176962B1 (en) 1990-02-28 2001-01-23 Aclara Biosciences, Inc. Methods for fabricating enclosed microchannel structures
SE470347B (sv) 1990-05-10 1994-01-31 Pharmacia Lkb Biotech Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system
CA2062027C (en) 1991-03-04 1998-05-19 William Aldrich Liquid control system for diagnostic cartridges used in analytical instruments
US5268147A (en) 1992-02-26 1993-12-07 Miles, Inc. Reversible direction capsule chemistry sample liquid analysis system and method
US5726026A (en) 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5486335A (en) 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5885527A (en) 1992-05-21 1999-03-23 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membrances
AU4982093A (en) * 1993-08-31 1995-03-22 Abbott Laboratories Pipetting apparatus equipped with closure detection function
CA2105515A1 (en) 1993-09-03 1995-03-04 Carlos A. Santizo Lescaille Visual immunoassay method for the detection of ligands, based on the use of opaque plastic supports
JP3585236B2 (ja) 1993-10-28 2004-11-04 アイ−スタット コーポレーション 液体サンプル採取及び導入装置
US20040077074A1 (en) 1993-11-01 2004-04-22 Nanogen, Inc. Multi-chambered analysis device
US6638482B1 (en) 1993-11-01 2003-10-28 Nanogen, Inc. Reconfigurable detection and analysis apparatus and method
US5478751A (en) 1993-12-29 1995-12-26 Abbott Laboratories Self-venting immunodiagnositic devices and methods of performing assays
US5580523A (en) 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
US5571410A (en) 1994-10-19 1996-11-05 Hewlett Packard Company Fully integrated miniaturized planar liquid sample handling and analysis device
US5603351A (en) 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
CA2181190C (en) * 1994-11-14 2001-02-06 Peter Wilding Mesoscale sample preparation device and systems for determination and processing of analytes
US5731212A (en) 1994-12-20 1998-03-24 International Technidyne Corporation Test apparatus and method for testing cuvette accommodated samples
GB9502112D0 (en) 1995-02-03 1995-03-22 British Biocell Int Assay device and method
US6207369B1 (en) 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
US6673533B1 (en) 1995-03-10 2004-01-06 Meso Scale Technologies, Llc. Multi-array multi-specific electrochemiluminescence testing
US6168948B1 (en) 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
CA2228485A1 (en) 1995-08-03 1997-02-20 Akzo Nobel Nv Diagnostic device
US20020068357A1 (en) * 1995-09-28 2002-06-06 Mathies Richard A. Miniaturized integrated nucleic acid processing and analysis device and method
US6709869B2 (en) 1995-12-18 2004-03-23 Tecan Trading Ag Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
US6114122A (en) 1996-03-26 2000-09-05 Affymetrix, Inc. Fluidics station with a mounting system and method of using
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US5885470A (en) 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
US6399023B1 (en) 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
ATE357663T1 (de) 1996-04-25 2007-04-15 Genicon Sciences Corp Teilchenförmiges markierungsmittel verwendendes analytassay
US6586193B2 (en) 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
NZ333346A (en) 1996-06-28 2000-03-27 Caliper Techn Corp High-throughput screening assay systems in microscale fluidic devices
BR9710052A (pt) 1996-06-28 2000-01-11 Caliper Techn Corp Sistema microfluido com compensação para polarização eletroforética, eletropipetador, processos para introduzir materiais a partir de uma série de fontes em um sistema microfluido, para distribuir de maneira controlável uma corrente de fluido e para transportar amostras de fluido, sistema de amostragem, emprego de um substrato, emprego de um sistema microfluido, e, substrato.
US5916524A (en) 1997-07-23 1999-06-29 Bio-Dot, Inc. Dispensing apparatus having improved dynamic range
US6074827A (en) 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
AU5895898A (en) 1996-12-20 1998-07-17 Gamera Bioscience Corporation An affinity binding-based system for detecting particulates in a fluid
US6632619B1 (en) 1997-05-16 2003-10-14 The Governors Of The University Of Alberta Microfluidic system and methods of use
US6613512B1 (en) 1997-06-09 2003-09-02 Caliper Technologies Corp. Apparatus and method for correcting for variable velocity in microfluidic systems
US6001231A (en) * 1997-07-15 1999-12-14 Caliper Technologies Corp. Methods and systems for monitoring and controlling fluid flow rates in microfluidic systems
US5932799A (en) 1997-07-21 1999-08-03 Ysi Incorporated Microfluidic analyzer module
US6293012B1 (en) 1997-07-21 2001-09-25 Ysi Incorporated Method of making a fluid flow module
US6073482A (en) 1997-07-21 2000-06-13 Ysi Incorporated Fluid flow module
US6375871B1 (en) 1998-06-18 2002-04-23 3M Innovative Properties Company Methods of manufacturing microfluidic articles
US5876675A (en) 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
US6190616B1 (en) 1997-09-11 2001-02-20 Molecular Dynamics, Inc. Capillary valve, connector, and router
US20020092767A1 (en) 1997-09-19 2002-07-18 Aclara Biosciences, Inc. Multiple array microfluidic device units
US6136272A (en) 1997-09-26 2000-10-24 University Of Washington Device for rapidly joining and splitting fluid layers
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
US6488894B1 (en) 1997-11-19 2002-12-03 Biognosis Gmbh Device for sequential discharge of flowable reagents
US6251343B1 (en) 1998-02-24 2001-06-26 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
EP1046032A4 (en) 1998-05-18 2002-05-29 Univ Washington LIQUID ANALYSIS CARTRIDGE
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US6375901B1 (en) 1998-06-29 2002-04-23 Agilent Technologies, Inc. Chemico-mechanical microvalve and devices comprising the same
US6794197B1 (en) 1998-07-14 2004-09-21 Zyomyx, Inc. Microdevice and method for detecting a characteristic of a fluid
US6333200B1 (en) 1998-07-27 2001-12-25 University Of Delaware Miniaturized immunosensor assembled from colloidal particles between micropatterned electrodes
US6103199A (en) 1998-09-15 2000-08-15 Aclara Biosciences, Inc. Capillary electroflow apparatus and method
EP1125129A1 (en) 1998-10-13 2001-08-22 Biomicro Systems, Inc. Fluid circuit components based upon passive fluid dynamics
US6146489A (en) 1998-11-19 2000-11-14 General Electric Company Method and apparatus for depositing scintillator material on radiation imager
US6416642B1 (en) 1999-01-21 2002-07-09 Caliper Technologies Corp. Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection
US20020019059A1 (en) 1999-01-28 2002-02-14 Calvin Y.H. Chow Devices, systems and methods for time domain multiplexing of reagents
US6297020B1 (en) 1999-03-01 2001-10-02 Bayer Corporation Device for carrying out lateral-flow assays involving more than one analyte
JP2000323241A (ja) 1999-05-12 2000-11-24 Honda Tsushin Kogyo Co Ltd コネクタ
EP1054259A1 (en) 1999-05-19 2000-11-22 Remacle, José Method for the identification of a target compound
JP4495866B2 (ja) 1999-05-28 2010-07-07 セフィード 化学反応を制御するためのカートリッジ
DE19928412C2 (de) 1999-06-22 2002-03-21 Agilent Technologies Inc Versorgungselement für einen Labor-Mikrochip
US6353475B1 (en) 1999-07-12 2002-03-05 Caliper Technologies Corp. Light source power modulation for use with chemical and biochemical analysis
KR100677860B1 (ko) 1999-07-23 2007-02-05 보드 오브 트러스티스 오브 유니버스티 오브 일리노이즈 미세하게 제조되는 장치 및 그의 제조방법
US6495104B1 (en) 1999-08-19 2002-12-17 Caliper Technologies Corp. Indicator components for microfluidic systems
US6858185B1 (en) 1999-08-25 2005-02-22 Caliper Life Sciences, Inc. Dilutions in high throughput systems with a single vacuum source
US6906797B1 (en) 1999-09-13 2005-06-14 Aclara Biosciences, Inc. Side light activated microfluid channels
US6361958B1 (en) 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
DE60030882T2 (de) 2000-01-06 2007-04-05 Caliper Life Sciences, Inc., Mountain View Vorrichtungen und verfahren für hochdurchsatz-probenentnahme und analyse
US7037416B2 (en) * 2000-01-14 2006-05-02 Caliper Life Sciences, Inc. Method for monitoring flow rate using fluorescent markers
EP1898210A3 (en) * 2000-02-23 2008-06-25 Caliper Life Sciences, Inc. Multi-reservoir pressure control system
AU4907101A (en) * 2000-02-23 2001-09-03 Caliper Technologies Inc Multi-reservoir pressure control system
US6488896B2 (en) 2000-03-14 2002-12-03 Micronics, Inc. Microfluidic analysis cartridge
US20050118073A1 (en) 2003-11-26 2005-06-02 Fluidigm Corporation Devices and methods for holding microfluidic devices
US6561208B1 (en) 2000-04-14 2003-05-13 Nanostream, Inc. Fluidic impedances in microfluidic system
US6716620B2 (en) 2000-04-17 2004-04-06 Purdue Research Foundation Biosensor and related method
WO2001086249A2 (en) 2000-05-11 2001-11-15 Caliper Technologies Corp. Microfluidic devices and methods to regulate hydrodynamic and electrical resistance utilizing bulk viscosity enhancers
US20010048637A1 (en) 2000-05-24 2001-12-06 Weigl Bernhard H. Microfluidic system and method
US6549275B1 (en) * 2000-08-02 2003-04-15 Honeywell International Inc. Optical detection system for flow cytometry
US20060263888A1 (en) * 2000-06-02 2006-11-23 Honeywell International Inc. Differential white blood count on a disposable card
US8518328B2 (en) 2005-12-27 2013-08-27 Honeywell International Inc. Fluid sensing and control in a fluidic analyzer
US8329118B2 (en) 2004-09-02 2012-12-11 Honeywell International Inc. Method and apparatus for determining one or more operating parameters for a microfluidic circuit
US20030118486A1 (en) 2000-07-03 2003-06-26 Xeotron Corporation Fluidic methods and devices for parallel chemical reactions
US7061595B2 (en) * 2000-08-02 2006-06-13 Honeywell International Inc. Miniaturized flow controller with closed loop regulation
US7277166B2 (en) * 2000-08-02 2007-10-02 Honeywell International Inc. Cytometer analysis cartridge optical configuration
US20020142618A1 (en) 2000-08-04 2002-10-03 Caliper Technologies Corp. Control of operation conditions within fluidic systems
US6610499B1 (en) 2000-08-31 2003-08-26 The Regents Of The University Of California Capillary array and related methods
GB2366529A (en) 2000-09-11 2002-03-13 Univ Sheffield Fluidic control valve for an assembly containing a plurality of microreactors
EP1331996A2 (en) 2000-09-18 2003-08-06 Harvard College METHOD AND DEVICE FOR GRADIENT GENERATION
US6780584B1 (en) 2000-09-27 2004-08-24 Nanogen, Inc. Electronic systems and component devices for macroscopic and microscopic molecular biological reactions, analyses and diagnostics
US6934836B2 (en) 2000-10-06 2005-08-23 Protasis Corporation Fluid separation conduit cartridge with encryption capability
US6827095B2 (en) 2000-10-12 2004-12-07 Nanostream, Inc. Modular microfluidic systems
JP2002236131A (ja) 2000-12-08 2002-08-23 Minolta Co Ltd マイクロチップ
US6878755B2 (en) 2001-01-22 2005-04-12 Microgen Systems, Inc. Automated microfabrication-based biodetector
US6875403B2 (en) 2001-02-09 2005-04-05 Microchem Solutions Method and apparatus for reproducible sample injection on microfabricated devices
US6949377B2 (en) 2001-03-05 2005-09-27 Ho Winston Z Chemiluminescence-based microfluidic biochip
DE10111457B4 (de) 2001-03-09 2006-12-14 Siemens Ag Diagnoseeinrichtung
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
DE10115474A1 (de) 2001-03-29 2002-10-10 Infineon Technologies Ag Mikrofluidkanalstruktur und Verfahren zur Herstellung einer derartigen Mikrofluidkanalstruktur
US6742661B1 (en) 2001-04-03 2004-06-01 Micronics, Inc. Well-plate microfluidics
KR100425536B1 (ko) 2001-07-16 2004-03-30 학교법인 포항공과대학교 유체 마이크로칩용 브레드보드
FR2828281B1 (fr) 2001-08-02 2004-12-31 Biocytex Dispositif pour l'analyse d'un echantillon notamment par cytometrie de flux
US7094379B2 (en) 2001-10-24 2006-08-22 Commissariat A L'energie Atomique Device for parallel and synchronous injection for sequential injection of different reagents
US20030138969A1 (en) 2002-01-24 2003-07-24 Jakobsen Mogens Havsteen Closed substrate platforms suitable for analysis of biomolecules
WO2003055660A2 (en) 2001-10-26 2003-07-10 Aclara Biosciences Inc. System and method for injection molded micro-replication of micro-fluidic substrates
AU2002360499A1 (en) 2001-12-05 2003-06-17 University Of Washington Microfluidic device and surface decoration process for solid phase affinity binding assays
WO2003054513A2 (en) 2001-12-20 2003-07-03 Radius Biosciences Centrifugal array processing device
US6982787B1 (en) 2002-01-02 2006-01-03 The United States Of America As Represented By The Secretary Of The Air Force Modification of the degree of liquid contact with a solid by control of surface and micro-channel capillary geometry
US7611616B2 (en) 2002-05-07 2009-11-03 Microfabrica Inc. Mesoscale and microscale device fabrication methods using split structures and alignment elements
JP4057967B2 (ja) * 2002-07-31 2008-03-05 株式会社東芝 塩基配列自動解析装置
US7244961B2 (en) 2002-08-02 2007-07-17 Silicon Valley Scientific Integrated system with modular microfluidic components
BR0313618A (pt) 2002-08-21 2005-06-21 Shell Int Research Método para análise quìmica de fluidos de poço
US6867114B2 (en) 2002-08-29 2005-03-15 Micron Technology Inc. Methods to form a memory cell with metal-rich metal chalcogenide
WO2004022233A1 (en) 2002-09-06 2004-03-18 Epigem Limited Modular microfluidic system
US6878271B2 (en) 2002-09-09 2005-04-12 Cytonome, Inc. Implementation of microfluidic components in a microfluidic system
US7094345B2 (en) 2002-09-09 2006-08-22 Cytonome, Inc. Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system
SE524730C2 (sv) 2002-11-20 2004-09-21 Boule Medical Ab Blodprovsapparat
US6987263B2 (en) 2002-12-13 2006-01-17 Nanostream, Inc. High throughput systems and methods for parallel sample analysis
US20060076482A1 (en) 2002-12-13 2006-04-13 Hobbs Steven E High throughput systems and methods for parallel sample analysis
CA3122193A1 (en) * 2002-12-26 2004-07-22 Meso Scale Technologies, Llc. Assay cartridges and methods of using the same
US20050221281A1 (en) 2003-01-08 2005-10-06 Ho Winston Z Self-contained microfluidic biochip and apparatus
DE10315074A1 (de) 2003-04-02 2004-10-14 Clondiag Chip Technologies Gmbh Vorrichtung zur Vervielfältigung und zum Nachweis von Nukleinsäuren
GB0307999D0 (en) 2003-04-07 2003-05-14 Glaxo Group Ltd A system
US7011793B2 (en) 2003-05-15 2006-03-14 Kionix, Inc. Reconfigurable modular microfluidic system and method of fabrication
US7435381B2 (en) 2003-05-29 2008-10-14 Siemens Healthcare Diagnostics Inc. Packaging of microfluidic devices
US7357898B2 (en) 2003-07-31 2008-04-15 Agency For Science, Technology And Research Microfluidics packages and methods of using same
JP2005106669A (ja) 2003-09-30 2005-04-21 Olympus Corp 生体関連物質の反応・測定システム
EP1535667A1 (en) 2003-11-28 2005-06-01 Sysmex Corporation Analyzer, assay cartridge and analyzing method
AU2003292497A1 (en) 2003-12-10 2005-06-29 The Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin A modular biochip assembly
WO2005066613A1 (en) 2003-12-31 2005-07-21 President And Fellows Of Harvard College Assay device and method
US8030057B2 (en) 2004-01-26 2011-10-04 President And Fellows Of Harvard College Fluid delivery system and method
PL1776181T3 (pl) 2004-01-26 2014-03-31 Harvard College Układ i sposób doprowadzania płynów
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US20060257941A1 (en) 2004-02-27 2006-11-16 Mcdevitt John T Integration of fluids and reagents into self-contained cartridges containing particle and membrane sensor elements
US7655470B2 (en) 2004-10-29 2010-02-02 University Of Chicago Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
EP1611954A1 (en) 2004-07-03 2006-01-04 Roche Diagnostics GmbH Liquid reservoir connector
JP4370214B2 (ja) 2004-07-29 2009-11-25 アルプス電気株式会社 検査用プレートと、前記検査用プレートを用いた検査方法
WO2006018044A1 (en) 2004-08-18 2006-02-23 Agilent Technologies, Inc. Microfluidic assembly with coupled microfluidic devices
US8134707B2 (en) 2004-10-22 2012-03-13 Vanderbilt University On-chip polarimetry for high-throughput screening of nanoliter and smaller sample volumes
GB0426082D0 (en) 2004-11-26 2004-12-29 Norchip As A device for carrying out biological assays
US20060172425A1 (en) * 2005-02-01 2006-08-03 Bayer Healthcare, Llc Colored buffer solution for automated clinical analyzer
KR100647317B1 (ko) 2005-02-03 2006-11-23 삼성전자주식회사 다채널 형광 측정용 광학계 및 이를 채용한 다채널 형광시료 분석 장치
JP2008532048A (ja) 2005-03-07 2008-08-14 ノブックス システムズ インコーポレーテッド 自動分析器
US7275682B2 (en) * 2005-03-24 2007-10-02 Varian, Inc. Sample identification utilizing RFID tags
EP1864120B1 (en) 2005-04-01 2011-11-30 Alere Switzerland GmbH Docking station for a sensor cartridge
US20060257290A1 (en) * 2005-04-13 2006-11-16 Fuji Photo Film Co., Ltd. Fluid dispenser, fluid dispensing method and assay apparatus for assay in utilizing attenuated total reflection
JP2008537146A (ja) 2005-04-19 2008-09-11 プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ 蛇行する幅の広いチャネルを備える流体構造
JP2006308428A (ja) 2005-04-28 2006-11-09 Hitachi High-Technologies Corp 核酸分析方法、核酸分析装置および核酸分析用カートリッジ
CN101262948B (zh) 2005-06-06 2011-07-06 决策生物标志股份有限公司 基于流过阵列的液体流的测定
ATE534465T1 (de) * 2005-06-23 2011-12-15 Biocartis Sa Kartusche, system und verfahren für automatisierte medizinische diagnosen
US8273294B2 (en) 2005-07-01 2012-09-25 Honeywell International Inc. Molded cartridge with 3-D hydrodynamic focusing
US8361410B2 (en) 2005-07-01 2013-01-29 Honeywell International Inc. Flow metered analyzer
WO2007005973A2 (en) 2005-07-01 2007-01-11 Honeywell International, Inc. A microfluidic card for rbc analysis
JP2007017354A (ja) 2005-07-08 2007-01-25 Sumitomo Bakelite Co Ltd 化学反応検出システム
DE102005034642B3 (de) * 2005-07-25 2006-08-03 Siemens Ag Mikrofluidiksystem
US20070048189A1 (en) 2005-08-26 2007-03-01 Applera Corporation Fluid processing device, system, kit, and method
DE102005048236A1 (de) 2005-10-07 2007-04-12 Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg Vorrichtung und Verfahren zur Bestimmung der Volumenanteile der Phasen in einer Suspension
US8133456B2 (en) 2005-11-07 2012-03-13 Konica Minolta Medical & Graphic, Inc. Microreactor and method of liquid feeding making use of the same
JP2007147456A (ja) 2005-11-28 2007-06-14 Seiko Epson Corp マイクロ流体システム、試料分析装置、及び標的物質の検出または測定方法
WO2007075919A2 (en) 2005-12-22 2007-07-05 Honeywell International Inc. Portable sample analyzer system
CN101379385A (zh) * 2005-12-22 2009-03-04 霍尼韦尔国际公司 便携式样品分析盒
EP3121601A1 (en) * 2005-12-22 2017-01-25 Honeywell International Inc. Portable sample analyzer system
CN101004423B (zh) 2006-01-19 2011-12-28 博奥生物有限公司 流体样品分析用卡盒系统
WO2007097257A1 (ja) * 2006-02-23 2007-08-30 Konica Minolta Medical & Graphic, Inc. マイクロチップを用いる検査装置
US7629124B2 (en) * 2006-06-30 2009-12-08 Canon U.S. Life Sciences, Inc. Real-time PCR in micro-channels
WO2008005248A2 (en) * 2006-06-30 2008-01-10 Canon U.S. Life Sciences, Inc. Real-time pcr in micro-channels
WO2008028124A1 (en) 2006-09-01 2008-03-06 The Board Of Trustees Of The University Of Arkansas Methods and systems for detection of contaminants
US20080085219A1 (en) 2006-10-05 2008-04-10 Beebe David J Microfluidic platform and method
EP2071026A1 (en) 2007-03-23 2009-06-17 Kabushiki Kaisha Toshiba Nucleic acid detection cassette and nucleic acid detection apparatus
WO2008118098A1 (en) 2007-03-26 2008-10-02 Agency For Science, Technology And Research Fluid cartridge, pump and fluid valve arrangement
CN103495439B (zh) 2007-05-04 2015-09-16 欧普科诊断有限责任公司 流体连接器和微流体系统
JP5282088B2 (ja) * 2007-06-21 2013-09-04 ジェン−プロウブ インコーポレイテッド 処理実行に使用する機器および容器
KR101307859B1 (ko) 2007-07-19 2013-09-12 삼성전자주식회사 생화학 분석기 및 그 내부 온도 제어 방법
WO2009038628A2 (en) * 2007-09-19 2009-03-26 Claros Diagnostics, Inc. Liquid containment for integrated assays
JP2009115729A (ja) 2007-11-09 2009-05-28 Konica Minolta Medical & Graphic Inc マイクロチップ検査装置
ES2654087T3 (es) 2007-11-13 2018-02-12 F. Hoffmann-La Roche Ag Cartucho de sensor modular
JP2009229263A (ja) * 2008-03-24 2009-10-08 Konica Minolta Medical & Graphic Inc 検査システム
JP2009257988A (ja) * 2008-04-18 2009-11-05 Konica Minolta Medical & Graphic Inc 検査装置
US8222049B2 (en) 2008-04-25 2012-07-17 Opko Diagnostics, Llc Flow control in microfluidic systems
KR101099495B1 (ko) * 2008-10-14 2011-12-28 삼성전자주식회사 원심력 기반의 미세유동장치, 이의 제조 방법 및 이를 이용한 시료분석방법
EP2376226B1 (en) 2008-12-18 2018-09-12 Opko Diagnostics, LLC Improved reagent storage in microfluidic systems and related articles and methods
WO2010087999A1 (en) 2009-02-02 2010-08-05 Claros Diagnostics, Inc. Structures for controlling light interaction with microfluidic devices
DK2504105T3 (da) 2009-11-24 2021-03-15 Opko Diagnostics Llc Fluidblanding og -afgivelse i mikrofluidsystemer
CN105381825A (zh) 2010-04-16 2016-03-09 欧普科诊断有限责任公司 微流体系统中的反馈控制

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