CO6190550A2 - Procedimiento para preparar acido 4- amino-butirico biaril- substituido o derivados del mismo y su uso en la produccuion de inhibidores de endopeptidasa neutra - Google Patents

Procedimiento para preparar acido 4- amino-butirico biaril- substituido o derivados del mismo y su uso en la produccuion de inhibidores de endopeptidasa neutra

Info

Publication number
CO6190550A2
CO6190550A2 CO09035919A CO09035919A CO6190550A2 CO 6190550 A2 CO6190550 A2 CO 6190550A2 CO 09035919 A CO09035919 A CO 09035919A CO 09035919 A CO09035919 A CO 09035919A CO 6190550 A2 CO6190550 A2 CO 6190550A2
Authority
CO
Colombia
Prior art keywords
transition metal
metal catalyst
butirico
biaril
amino
Prior art date
Application number
CO09035919A
Other languages
English (en)
Inventor
David Hook
Bernhard Wietfeld
Matthias Lotz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37814152&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6190550(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CO6190550A2 publication Critical patent/CO6190550A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

1.- Un procedimiento para producir un compuesto de acuerdo con la fórmula (I),o una sal del mismo, en donde R1 y R1´ son independientemente hidrógeno o un grupo protector amina, y R2 es un grupo carboxilo o un grupo éster, que comprende hacer reaccionar un compuesto de acuerdo con la fórmula (ii),o una sal del mismo, en donde R1 y R1' son como se definieron anteriormente, con hidrógeno en presencia de un catalizador de metal de transición y un ligando quiral, en donde el metal de transición se selecciona del grupo 7, 8 ó 9 de la tabla periódica. 2.- Un procedimiento de acuerdo con a reivindicación 1, en donde la reacción se realiza como una catálisis homogénea. 3.- Un procedimiento de acuerdo con la reivindicación 1 ó 2, en donde el catalizador de metal de transición comprende rodio o rutenio. 4.- Un procedimiento de acuerdo con cualquiera de las reivindicaciones precedentes, en donde el catalizador de metal de transición comprende un complejo de dímero, de preferencia un complejo de dímero de rutenio. 5.- Un procedimiento de acuerdo con cualquiera de las reivindicaciones precedentes, en donde el catalizador de metal de transición comprende [Rul2(p-cimeno)]2. 6.- Un procedimiento de acuerdo con cualquiera de las reivindicaciones 1 a 3, en donde e 1 catalizador de metal de transición comprende Rh(nbd)2BF4. 7.- Un procedimiento de acuerdo con cualquiera de las reivindicaciones precedentes, en donde el ligando quiral es una fosfina quiral. 8.- Un procedimiento de acuerdo con cualquiera de las reivindicaciones precedentes, en donde el ligando quiral es un ferroceno quiral.
CO09035919A 2006-09-13 2009-04-07 Procedimiento para preparar acido 4- amino-butirico biaril- substituido o derivados del mismo y su uso en la produccuion de inhibidores de endopeptidasa neutra CO6190550A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06120576A EP1903027A1 (en) 2006-09-13 2006-09-13 Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors

Publications (1)

Publication Number Publication Date
CO6190550A2 true CO6190550A2 (es) 2010-08-19

Family

ID=37814152

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09035919A CO6190550A2 (es) 2006-09-13 2009-04-07 Procedimiento para preparar acido 4- amino-butirico biaril- substituido o derivados del mismo y su uso en la produccuion de inhibidores de endopeptidasa neutra

Country Status (29)

Country Link
US (2) US20090326066A1 (es)
EP (2) EP1903027A1 (es)
JP (1) JP5455627B2 (es)
KR (1) KR101401118B1 (es)
CN (1) CN101516831B (es)
AU (1) AU2007296889B2 (es)
BR (1) BRPI0716990A2 (es)
CA (1) CA2662393C (es)
CO (1) CO6190550A2 (es)
CY (1) CY1115696T1 (es)
DK (1) DK2066618T3 (es)
ES (1) ES2519446T3 (es)
GT (1) GT200900058A (es)
HK (1) HK1131381A1 (es)
HR (1) HRP20140984T1 (es)
IL (1) IL196925A (es)
MA (1) MA30724B1 (es)
MX (1) MX2009002746A (es)
MY (1) MY146660A (es)
NO (1) NO341967B1 (es)
NZ (1) NZ574665A (es)
PL (1) PL2066618T3 (es)
PT (1) PT2066618E (es)
RU (1) RU2469019C2 (es)
SG (1) SG177205A1 (es)
SI (1) SI2066618T1 (es)
TN (1) TN2009000077A1 (es)
WO (1) WO2008031567A1 (es)
ZA (1) ZA200900779B (es)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2121578T (lt) 2007-01-12 2016-11-25 Novartis Ag 5-bifenil-4-amino-2-metilpentano rūgšties gavimo būdas
PE20091364A1 (es) 2008-01-17 2009-10-13 Novartis Ag Proceso para la preparacion de inhibidores de nep
CN103896796B (zh) 2009-05-28 2016-04-27 诺华股份有限公司 作为脑啡肽酶抑制剂的取代的氨基丙酸衍生物
JP5466759B2 (ja) 2009-05-28 2014-04-09 ノバルティス アーゲー ネプリライシン阻害剤としての置換アミノ酪酸誘導体
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
PT2526088E (pt) * 2010-01-22 2015-11-03 Novartis Ag Intermediários dos inibidores da endopeptidase neutra e método de preparação dos mesmos
KR101476937B1 (ko) * 2010-08-23 2014-12-24 노파르티스 아게 Ｎｅｐ 억제제의 제조를 위한 중간체의 제조 방법
EP2609071B1 (en) * 2010-08-23 2016-09-21 Novartis AG New process for the preparation of intermediates useful for the manufacture of nep inhibitors
CN103080077B (zh) * 2010-08-23 2015-06-10 诺华股份有限公司 用于制造nep抑制剂的中间体的制备工艺
US8993631B2 (en) 2010-11-16 2015-03-31 Novartis Ag Method of treating contrast-induced nephropathy
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
AR092278A1 (es) * 2012-08-31 2015-04-08 Novartis Ag Proceso de obtencion de derivados n-acilicos de bifenil-alanina e intermediarios relacionados
AU2014216417B2 (en) 2013-02-14 2016-05-12 Novartis Ag Substituted bisphenyl butanoic acid derivatives as NEP inhibitors with improved in vivo efficacy
NZ710574A (en) 2013-02-14 2017-11-24 Novartis Ag Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors
CN104230865B (zh) * 2013-06-13 2018-01-09 上海翰森生物医药科技有限公司 联芳基取代的4‑氨基丁酸衍生物及其制备方法和用途
EP3119742A1 (en) * 2013-08-21 2017-01-25 DPX Holdings B.V. Synthesis of biphenylalaninol via novel intermediates
CN105461587A (zh) * 2014-08-27 2016-04-06 上海翰森生物医药科技有限公司 Ahu-377半钙盐晶型及其制备方法和应用
WO2016029828A1 (zh) * 2014-08-27 2016-03-03 上海翰森生物医药科技有限公司 AHU-377结晶型游离酸、半钙盐、α﹣苯乙胺盐及其制备方法和应用
WO2016037098A1 (en) 2014-09-04 2016-03-10 Concert Pharmaceuticals, Inc. Deuterated sacubitril
PL3218351T3 (pl) 2014-11-14 2019-12-31 Zentiva K.S. Sposób wytwarzania, wyodrębniania i oczyszczania farmaceutycznie dopuszczalnych postaci AHU-377
CN104557600B (zh) * 2015-01-26 2016-05-04 苏州明锐医药科技有限公司 沙库比曲的制备方法
TW201632493A (zh) 2015-02-13 2016-09-16 諾華公司 新穎方法
CN105884644B (zh) * 2015-02-15 2020-06-09 深圳信立泰药业股份有限公司 一种中性内肽酶抑制剂盐优势形态及其制备方法
CN106146351B (zh) * 2015-04-03 2020-09-11 博瑞生物医药（苏州）股份有限公司 制备联芳基取代的4-氨基-丁酸或其衍生物的方法
CN106065006B (zh) * 2015-04-22 2020-06-05 深圳信立泰药业股份有限公司 一种中性内肽酶抑制剂盐晶型及其制备方法
CN106187808A (zh) * 2015-05-08 2016-12-07 苏州鹏旭医药科技有限公司 Ahu-377的制备方法、ahu-377中间体及ahu-377中间体的制备方法
CN104860894B (zh) * 2015-06-10 2017-05-17 北京博全健医药科技有限公司 一种抗心衰药lcz696的制备方法
JP6748123B2 (ja) * 2015-07-02 2020-08-26 ノバルティス アーゲー サクビトリルカルシウム塩
WO2017009784A1 (en) 2015-07-14 2017-01-19 Cadila Healthcare Limited Solid state forms of trisodium salt of valsartan/sacubitril complex and sacubitril
CN105061263B (zh) * 2015-08-11 2017-03-15 苏州楚凯药业有限公司 一种nep抑制剂中间体的制备方法
CN105085322B (zh) * 2015-08-15 2017-10-03 浙江永宁药业股份有限公司 Ahu‑377中间体的制备方法及其中间体和中间体的制备方法
CN105168205A (zh) * 2015-08-18 2015-12-23 泰力特医药（湖北）有限公司 一种血管紧张素ii受体和脑啡肽酶受体双重抑制剂lcz696的制备方法
WO2017033128A1 (en) * 2015-08-25 2017-03-02 Novartis Ag Biphenyl-substitued 4-amino-butyric acid derivatives and their use in the synthesis of nep inhibitors
CN105152980B (zh) * 2015-09-11 2017-03-29 浙江永宁药业股份有限公司 N‑叔丁氧羰基‑（4s）‑（对苯基苯基甲基）‑4‑氨基‑（2r）‑甲基丁酸的手性制备方法
WO2017051326A1 (en) 2015-09-23 2017-03-30 Novartis Ag New processes and intermediates useful in synthesis of nep inhibitors
CN105348209B (zh) 2015-12-09 2017-12-26 浙江天宇药业股份有限公司 一种抗心衰药lcz696的制备方法
CN105523964B (zh) * 2015-12-09 2017-05-24 苏州楚凯药业有限公司 一种抗心衰药物中间体的制备方法
JP7001597B2 (ja) * 2015-12-10 2022-01-19 ノバルティス アーゲー 新規なプロセスおよび中間体
WO2017097275A1 (en) 2015-12-11 2017-06-15 Zentiva, K.S. Solid forms of (2r,4s)-5-(biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2- -methylpentanoic acid ethyl ester, its salts and a preparation method
CN106977415B (zh) * 2016-01-15 2021-03-26 广东东阳光药业有限公司 一种沙库必曲的中间体及其制备方法
WO2017141193A1 (en) * 2016-02-16 2017-08-24 Sun Pharmaceutical Industries Limited Process for the preparation of sacubitril or salts thereof
CN105924355B (zh) * 2016-05-11 2018-08-17 浙江宏元药业有限公司 沙库比曲中间体及沙库比曲中间体和沙库比曲的制备方法
WO2018007919A1 (en) 2016-07-05 2018-01-11 Novartis Ag New process for early sacubitril intermediates
JP6945619B2 (ja) 2016-08-17 2021-10-06 ノバルティス アーゲー Ｎｅｐ阻害剤合成のための新規な方法および中間体
CN106380421B (zh) * 2016-08-26 2017-12-08 中国科学院上海有机化学研究所 沙库必曲的合成方法
EP3522886A4 (en) 2016-10-10 2020-02-19 Laurus Labs Limited STABLE AMORPHE FORM OF THE SACUBITRIL VALSARTAN TRINATRIUM COMPLEX AND METHOD FOR THE PRODUCTION THEREOF
CN106631903A (zh) * 2016-12-16 2017-05-10 重庆市碚圣医药科技股份有限公司 一种lcz‑696关键中间体的制备方法
WO2018116203A1 (en) 2016-12-23 2018-06-28 Novartis Ag New process for early sacubitril intermediates
CN107011203B (zh) * 2017-04-28 2019-03-29 江苏阿尔法药业有限公司 一种lcz696中间体ahu-377的制备方法
CN107522628A (zh) * 2017-09-20 2017-12-29 吉尔生化（上海）有限公司 一种l‑3‑（6‑乙酰基‑2‑萘胺基）‑2‑氨基丙酸的合成方法
CN108084058A (zh) * 2017-12-15 2018-05-29 江苏中邦制药有限公司 一种lcz696中间体的制备方法
CN108373423B (zh) * 2018-04-28 2020-10-23 成都苑东生物制药股份有限公司 一种沙库比曲缬沙坦复合物和/或共晶关键中间体沙库比曲钙的制备方法
CN109400504A (zh) * 2018-12-11 2019-03-01 重庆三圣实业股份有限公司 Lcz696中间体非对映异构体的分离纯化方法
CN109503404A (zh) * 2018-12-28 2019-03-22 凯瑞斯德生化(苏州)有限公司 一种lcz-696关键中间体的制备方法
CN111748590A (zh) * 2019-03-29 2020-10-09 台州保灵药业有限公司 转氨酶在制备Sacubitril中间体中的应用
CN110128298B (zh) * 2019-06-13 2021-08-03 南京一心和医药科技有限公司 一种沙库巴曲中间体的合成方法
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CN113135836A (zh) * 2020-01-20 2021-07-20 鲁南制药集团股份有限公司 一种沙库巴曲钙盐的制备方法
CN113321600A (zh) * 2020-02-28 2021-08-31 四川科伦药物研究院有限公司 制备手性联芳基取代的4-氨基-丁酸及其衍生物的方法
CN113387841A (zh) * 2020-03-13 2021-09-14 凯特立斯（深圳）科技有限公司 一种沙库必曲中间体的合成方法
CN111269148B (zh) * 2020-04-08 2022-02-08 台州职业技术学院 一种沙库比曲中间体的制备方法
JP7064527B2 (ja) * 2020-05-01 2022-05-10 ノバルティス アーゲー サクビトリルカルシウム塩
CN112745246A (zh) * 2020-12-30 2021-05-04 重庆市碚圣医药科技股份有限公司 一种沙库必曲中间体的纯化方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250522A (en) * 1992-10-09 1993-10-05 Ciba-Geigy Corporation Phosphono/biaryl substituted amino acid derivatives
US5217996A (en) * 1992-01-22 1993-06-08 Ciba-Geigy Corporation Biaryl substituted 4-amino-butyric acid amides
JP3020128B2 (ja) * 1994-03-08 2000-03-15 高砂香料工業株式会社 光学活性カルボン酸の製造法
US5550119A (en) * 1995-03-02 1996-08-27 Ciba-Geigy Corporation Phosphono substituted tetrazole derivatives as ECE inhibitors
US6214763B1 (en) * 1997-05-20 2001-04-10 Firmenich Sa Ruthenium catalysts and their use in the asymmetric hydrogenation of weakly coordinating substrates
DE60102356T2 (de) 2000-01-27 2005-02-17 Warner-Lambert Co. Asymmetrische synthese von pregabalin
GB0026890D0 (en) * 2000-11-03 2000-12-20 Ici Plc Catalyst
AR043515A1 (es) * 2003-03-19 2005-08-03 Merck & Co Inc Procedimiento para preparar derivados quirales beta aminoacidos mediante hidrogenacion asimetrica
US20050033384A1 (en) 2003-08-04 2005-02-10 Sacha Mike K. Cochlear ear implant
OA13258A (en) * 2003-09-25 2007-01-31 Warner Lambert Co Amino acids with affinity for the alpha2delta-protein.
EP1763532B1 (de) * 2004-07-05 2007-10-10 Solvias AG 1,1'diphosphinoferrocene mit 2,2'-gebundenen achiralen oder chiralen resten
GB0418046D0 (en) * 2004-08-12 2004-09-15 Prosidion Ltd Eantioselective process
WO2006057904A1 (en) * 2004-11-23 2006-06-01 Merck & Co., Inc. Stereoselective preparation of 4-aryl piperidine amides by asymmetric hydrogenation of a prochiral enamide and intermediates of this process
AT501193B1 (de) * 2004-12-27 2007-03-15 Dsm Fine Chem Austria Gmbh Verfahen zur übergangsmetall - katalysierten asymmetrischen hydrierung von acrylsäurederivaten

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SG177205A1 (en) 2012-01-30
TN2009000077A1 (en) 2010-08-19
MA30724B1 (fr) 2009-09-01
SI2066618T1 (sl) 2014-11-28
PL2066618T3 (pl) 2015-01-30
HK1131381A1 (en) 2010-01-22
JP2010503628A (ja) 2010-02-04
MX2009002746A (es) 2009-03-26
GT200900058A (es) 2010-03-11
KR101401118B1 (ko) 2014-05-29
EP1903027A1 (en) 2008-03-26
HRP20140984T1 (hr) 2014-12-05
CN101516831A (zh) 2009-08-26
NZ574665A (en) 2012-03-30
DK2066618T3 (da) 2014-09-22
EP2066618A1 (en) 2009-06-10
MY146660A (en) 2012-09-14
CA2662393A1 (en) 2008-03-20
EP2066618B1 (en) 2014-07-23
US20090326066A1 (en) 2009-12-31
NO20091242L (no) 2009-03-25
CY1115696T1 (el) 2017-01-25
CN101516831B (zh) 2013-12-25
ES2519446T3 (es) 2014-11-07
RU2009113666A (ru) 2010-10-20
NO341967B1 (no) 2018-03-05
KR20090076910A (ko) 2009-07-13
ZA200900779B (en) 2009-12-30
US8946481B2 (en) 2015-02-03
JP5455627B2 (ja) 2014-03-26
AU2007296889B2 (en) 2012-03-01
CA2662393C (en) 2015-11-03
IL196925A0 (en) 2009-11-18
IL196925A (en) 2013-10-31
PT2066618E (pt) 2014-09-10
AU2007296889A1 (en) 2008-03-20
BRPI0716990A2 (pt) 2014-02-04
US20130066101A1 (en) 2013-03-14
WO2008031567B1 (en) 2008-05-08
RU2469019C2 (ru) 2012-12-10
WO2008031567A1 (en) 2008-03-20

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