CO6190550A2 - Procedimiento para preparar acido 4- amino-butirico biaril- substituido o derivados del mismo y su uso en la produccuion de inhibidores de endopeptidasa neutra - Google Patents
Procedimiento para preparar acido 4- amino-butirico biaril- substituido o derivados del mismo y su uso en la produccuion de inhibidores de endopeptidasa neutraInfo
- Publication number
- CO6190550A2 CO6190550A2 CO09035919A CO09035919A CO6190550A2 CO 6190550 A2 CO6190550 A2 CO 6190550A2 CO 09035919 A CO09035919 A CO 09035919A CO 09035919 A CO09035919 A CO 09035919A CO 6190550 A2 CO6190550 A2 CO 6190550A2
- Authority
- CO
- Colombia
- Prior art keywords
- transition metal
- metal catalyst
- butirico
- biaril
- amino
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/22—Organic complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Materials Engineering (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1.- Un procedimiento para producir un compuesto de acuerdo con la fórmula (I),o una sal del mismo, en donde R1 y R1´ son independientemente hidrógeno o un grupo protector amina, y R2 es un grupo carboxilo o un grupo éster, que comprende hacer reaccionar un compuesto de acuerdo con la fórmula (ii),o una sal del mismo, en donde R1 y R1' son como se definieron anteriormente, con hidrógeno en presencia de un catalizador de metal de transición y un ligando quiral, en donde el metal de transición se selecciona del grupo 7, 8 ó 9 de la tabla periódica. 2.- Un procedimiento de acuerdo con a reivindicación 1, en donde la reacción se realiza como una catálisis homogénea. 3.- Un procedimiento de acuerdo con la reivindicación 1 ó 2, en donde el catalizador de metal de transición comprende rodio o rutenio. 4.- Un procedimiento de acuerdo con cualquiera de las reivindicaciones precedentes, en donde el catalizador de metal de transición comprende un complejo de dímero, de preferencia un complejo de dímero de rutenio. 5.- Un procedimiento de acuerdo con cualquiera de las reivindicaciones precedentes, en donde el catalizador de metal de transición comprende [Rul2(p-cimeno)]2. 6.- Un procedimiento de acuerdo con cualquiera de las reivindicaciones 1 a 3, en donde e 1 catalizador de metal de transición comprende Rh(nbd)2BF4. 7.- Un procedimiento de acuerdo con cualquiera de las reivindicaciones precedentes, en donde el ligando quiral es una fosfina quiral. 8.- Un procedimiento de acuerdo con cualquiera de las reivindicaciones precedentes, en donde el ligando quiral es un ferroceno quiral.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06120576A EP1903027A1 (en) | 2006-09-13 | 2006-09-13 | Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6190550A2 true CO6190550A2 (es) | 2010-08-19 |
Family
ID=37814152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09035919A CO6190550A2 (es) | 2006-09-13 | 2009-04-07 | Procedimiento para preparar acido 4- amino-butirico biaril- substituido o derivados del mismo y su uso en la produccuion de inhibidores de endopeptidasa neutra |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US20090326066A1 (es) |
| EP (2) | EP1903027A1 (es) |
| JP (1) | JP5455627B2 (es) |
| KR (1) | KR101401118B1 (es) |
| CN (1) | CN101516831B (es) |
| AU (1) | AU2007296889B2 (es) |
| BR (1) | BRPI0716990A2 (es) |
| CA (1) | CA2662393C (es) |
| CO (1) | CO6190550A2 (es) |
| CY (1) | CY1115696T1 (es) |
| DK (1) | DK2066618T3 (es) |
| ES (1) | ES2519446T3 (es) |
| GT (1) | GT200900058A (es) |
| HK (1) | HK1131381A1 (es) |
| HR (1) | HRP20140984T1 (es) |
| IL (1) | IL196925A (es) |
| MA (1) | MA30724B1 (es) |
| MX (1) | MX2009002746A (es) |
| MY (1) | MY146660A (es) |
| NO (1) | NO341967B1 (es) |
| NZ (1) | NZ574665A (es) |
| PL (1) | PL2066618T3 (es) |
| PT (1) | PT2066618E (es) |
| RU (1) | RU2469019C2 (es) |
| SG (1) | SG177205A1 (es) |
| SI (1) | SI2066618T1 (es) |
| TN (1) | TN2009000077A1 (es) |
| WO (1) | WO2008031567A1 (es) |
| ZA (1) | ZA200900779B (es) |
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| MY151993A (en) | 2007-01-12 | 2014-07-31 | Novartis Ag | Process for preparing 5-biphenyl-4-amino-2-methyl pentanoic acid |
| AR070176A1 (es) | 2008-01-17 | 2010-03-17 | Novartis Ag | Procesos de sintesis de inhibidores de nep, compuestos intermediarios y uso de los mismos en la sintesis |
| EA019511B1 (ru) | 2009-05-28 | 2014-04-30 | Новартис Аг | Замещенные производные аминопропионовой кислоты в качестве ингибиторов неприлизина |
| ES2582395T3 (es) | 2009-05-28 | 2016-09-12 | Novartis Ag | Derivados aminobutíricos sustituidos como inhibidores de neprilisina |
| JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
| MX2012008483A (es) * | 2010-01-22 | 2012-08-15 | Novartis Ag | Intermediarios de inhibidores de la endopeptidasa neutra y metodo de preparacion de los mismos. |
| US9085529B2 (en) | 2010-08-23 | 2015-07-21 | Novartis Ag | Process for the preparation of intermediates useful for the manufacture NEP inhibitors |
| CN103080077B (zh) * | 2010-08-23 | 2015-06-10 | 诺华股份有限公司 | 用于制造nep抑制剂的中间体的制备工艺 |
| MX2013002150A (es) | 2010-08-23 | 2013-04-03 | Novartis Ag | Proceso para la preparacion de intermediarios para la elaboracion de inhibidores de nep. |
| US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
| US8993631B2 (en) | 2010-11-16 | 2015-03-31 | Novartis Ag | Method of treating contrast-induced nephropathy |
| AR092278A1 (es) * | 2012-08-31 | 2015-04-08 | Novartis Ag | Proceso de obtencion de derivados n-acilicos de bifenil-alanina e intermediarios relacionados |
| BR112015019307A8 (pt) | 2013-02-14 | 2018-01-30 | Novartis Ag | derivados de ácido butanóico substituído com bisfenila, seus usos, e composição farmacêutica |
| BR112015019369A2 (pt) | 2013-02-14 | 2017-07-18 | Novartis Ag | derivados de ácido bisfenil butanóico substituídos como inibidores de nep (endopeptidase neutra) |
| CN104230865B (zh) * | 2013-06-13 | 2018-01-09 | 上海翰森生物医药科技有限公司 | 联芳基取代的4‑氨基丁酸衍生物及其制备方法和用途 |
| CN105473546A (zh) * | 2013-08-21 | 2016-04-06 | DPx控股有限公司 | 通过新颖的中间体合成联苯丙氨醇 |
| CN105461587A (zh) * | 2014-08-27 | 2016-04-06 | 上海翰森生物医药科技有限公司 | Ahu-377半钙盐晶型及其制备方法和应用 |
| WO2016029828A1 (zh) * | 2014-08-27 | 2016-03-03 | 上海翰森生物医药科技有限公司 | AHU-377结晶型游离酸、半钙盐、α﹣苯乙胺盐及其制备方法和应用 |
| WO2016037098A1 (en) | 2014-09-04 | 2016-03-10 | Concert Pharmaceuticals, Inc. | Deuterated sacubitril |
| LT3218351T (lt) | 2014-11-14 | 2019-09-25 | Zentiva K.S. | Ahu-377 farmaciniu požiūriu priimtinų formų gavimo, atskyrimo ir gryninimo būdas |
| CN104557600B (zh) * | 2015-01-26 | 2016-05-04 | 苏州明锐医药科技有限公司 | 沙库比曲的制备方法 |
| TW201632493A (zh) | 2015-02-13 | 2016-09-16 | 諾華公司 | 新穎方法 |
| CN105884644B (zh) * | 2015-02-15 | 2020-06-09 | 深圳信立泰药业股份有限公司 | 一种中性内肽酶抑制剂盐优势形态及其制备方法 |
| CN106146351B (zh) * | 2015-04-03 | 2020-09-11 | 博瑞生物医药（苏州）股份有限公司 | 制备联芳基取代的4-氨基-丁酸或其衍生物的方法 |
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| CN105348209B (zh) | 2015-12-09 | 2017-12-26 | 浙江天宇药业股份有限公司 | 一种抗心衰药lcz696的制备方法 |
| CN105523964B (zh) * | 2015-12-09 | 2017-05-24 | 苏州楚凯药业有限公司 | 一种抗心衰药物中间体的制备方法 |
| EP3386955B1 (en) * | 2015-12-10 | 2020-08-05 | Novartis AG | Intermediates for the preparation of sacubitril and their preparation |
| BR112018011788A2 (pt) | 2015-12-11 | 2018-12-04 | Zentiva Ks | formas sólidas de éster etílico de ácido (2r,4s)-5-(bifenil-4-il)-4-[(3-carboxipropionil)amino]-2-metil-pentanoico, seus sais e um método de preparação |
| CN106977415B (zh) * | 2016-01-15 | 2021-03-26 | 广东东阳光药业有限公司 | 一种沙库必曲的中间体及其制备方法 |
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| EP3481799A1 (en) | 2016-07-05 | 2019-05-15 | Novartis AG | New process for early sacubitril intermediates |
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| CN109400504A (zh) * | 2018-12-11 | 2019-03-01 | 重庆三圣实业股份有限公司 | Lcz696中间体非对映异构体的分离纯化方法 |
| CN109503404A (zh) * | 2018-12-28 | 2019-03-22 | 凯瑞斯德生化(苏州)有限公司 | 一种lcz-696关键中间体的制备方法 |
| CN111748590B (zh) * | 2019-03-29 | 2024-05-28 | 弈柯莱(台州)药业有限公司 | 转氨酶在制备Sacubitril中间体中的应用 |
| CN110128298B (zh) * | 2019-06-13 | 2021-08-03 | 南京一心和医药科技有限公司 | 一种沙库巴曲中间体的合成方法 |
| CN112574132B (zh) * | 2019-09-30 | 2024-02-27 | 广东东阳光药业股份有限公司 | 一种沙库必曲缬沙坦钠的制备方法 |
| CN113135836A (zh) * | 2020-01-20 | 2021-07-20 | 鲁南制药集团股份有限公司 | 一种沙库巴曲钙盐的制备方法 |
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2006
- 2006-09-13 EP EP06120576A patent/EP1903027A1/en not_active Ceased
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2007
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