NO20091242L - Fremgangsmate for fremstilling av biarylsubstituerte 4-aminosmorsyre eller derivater derav og deres anvendelse ved fremstilling av NEP-inhibitorer - Google Patents

Fremgangsmate for fremstilling av biarylsubstituerte 4-aminosmorsyre eller derivater derav og deres anvendelse ved fremstilling av NEP-inhibitorer

Info

Publication number
NO20091242L
NO20091242L NO20091242A NO20091242A NO20091242L NO 20091242 L NO20091242 L NO 20091242L NO 20091242 A NO20091242 A NO 20091242A NO 20091242 A NO20091242 A NO 20091242A NO 20091242 L NO20091242 L NO 20091242L
Authority
NO
Norway
Prior art keywords
preparation
nep inhibitors
biaryl
derivatives
amino
Prior art date
Application number
NO20091242A
Other languages
English (en)
Other versions
NO341967B1 (no
Inventor
Bernhard Wietfeld
David Hook
Matthias Lotz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37814152&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20091242(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20091242L publication Critical patent/NO20091242L/no
Publication of NO341967B1 publication Critical patent/NO341967B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Oppfinnelsen angår en fremgangsmåte for fremstilling av en forbindelse med formel (i) (i) eller salt derav, hvori R1 og R1' er uavhengig hydrogen eller en aminbeskyttende gruppe og R2 er en karboksylgruppe eller en estergruppe, som innbefatter omsetning av en forbindelse med formel (ii) (ii) eller salt derav, hvori R1, R1'og R2 er som definert ovenfor, med hydrogen under nærvær av en overgangsmetallkatalysator og en kiral ligand, hvori overgangsmetallet er valgt fra gruppe 7, 8 eller 9 i det periodiske system. Videre angår oppfinnelsen produkter oppnådd ved nevnte fremgangsmåte og deres anvendelse ved fremstilling av NEP-inhibitorer. Videre angår oppfinnelsen anvendelse av overgangsmetallkatalysator ved fremstilling av NEP-inhibitorer eller prodrug derav.
NO20091242A 2006-09-13 2009-03-25 Fremgangsmåte for fremstilling av biarylsubstituerte 4-aminosmørsyre eller derivater derav og deres anvendelse ved fremstilling av NEP-inhibitorer NO341967B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06120576A EP1903027A1 (en) 2006-09-13 2006-09-13 Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors
PCT/EP2007/007913 WO2008031567A1 (en) 2006-09-13 2007-09-11 Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of nep inhibitors

Publications (2)

Publication Number Publication Date
NO20091242L true NO20091242L (no) 2009-03-25
NO341967B1 NO341967B1 (no) 2018-03-05

Family

ID=37814152

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20091242A NO341967B1 (no) 2006-09-13 2009-03-25 Fremgangsmåte for fremstilling av biarylsubstituerte 4-aminosmørsyre eller derivater derav og deres anvendelse ved fremstilling av NEP-inhibitorer

Country Status (29)

Country Link
US (2) US20090326066A1 (no)
EP (2) EP1903027A1 (no)
JP (1) JP5455627B2 (no)
KR (1) KR101401118B1 (no)
CN (1) CN101516831B (no)
AU (1) AU2007296889B2 (no)
BR (1) BRPI0716990A2 (no)
CA (1) CA2662393C (no)
CO (1) CO6190550A2 (no)
CY (1) CY1115696T1 (no)
DK (1) DK2066618T3 (no)
ES (1) ES2519446T3 (no)
GT (1) GT200900058A (no)
HK (1) HK1131381A1 (no)
HR (1) HRP20140984T1 (no)
IL (1) IL196925A (no)
MA (1) MA30724B1 (no)
MX (1) MX2009002746A (no)
MY (1) MY146660A (no)
NO (1) NO341967B1 (no)
NZ (1) NZ574665A (no)
PL (1) PL2066618T3 (no)
PT (1) PT2066618E (no)
RU (1) RU2469019C2 (no)
SG (1) SG177205A1 (no)
SI (1) SI2066618T1 (no)
TN (1) TN2009000077A1 (no)
WO (1) WO2008031567A1 (no)
ZA (1) ZA200900779B (no)

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SG176010A1 (en) 2009-05-28 2011-12-29 Novartis Ag Substituted aminobutyric derivatives as neprilysin inhibitors
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JP5705984B2 (ja) * 2010-08-23 2015-04-22 ノバルティス アーゲー Ｎｅｐ阻害剤を製造するための中間体の調製方法
CN103080077B (zh) * 2010-08-23 2015-06-10 诺华股份有限公司 用于制造nep抑制剂的中间体的制备工艺
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JP6945619B2 (ja) 2016-08-17 2021-10-06 ノバルティス アーゲー Ｎｅｐ阻害剤合成のための新規な方法および中間体
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CN109400504A (zh) * 2018-12-11 2019-03-01 重庆三圣实业股份有限公司 Lcz696中间体非对映异构体的分离纯化方法
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CN110128298B (zh) * 2019-06-13 2021-08-03 南京一心和医药科技有限公司 一种沙库巴曲中间体的合成方法
CN112574132B (zh) * 2019-09-30 2024-02-27 广东东阳光药业股份有限公司 一种沙库必曲缬沙坦钠的制备方法
CN113135836A (zh) * 2020-01-20 2021-07-20 鲁南制药集团股份有限公司 一种沙库巴曲钙盐的制备方法
CN113321600B (zh) * 2020-02-28 2024-06-14 四川科伦药物研究院有限公司 制备手性联芳基取代的4-氨基-丁酸及其衍生物的方法
CN113387841A (zh) * 2020-03-13 2021-09-14 凯特立斯（深圳）科技有限公司 一种沙库必曲中间体的合成方法
CN111269148B (zh) * 2020-04-08 2022-02-08 台州职业技术学院 一种沙库比曲中间体的制备方法
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Also Published As

Publication number Publication date
WO2008031567B1 (en) 2008-05-08
EP2066618B1 (en) 2014-07-23
KR20090076910A (ko) 2009-07-13
BRPI0716990A2 (pt) 2014-02-04
GT200900058A (es) 2010-03-11
IL196925A (en) 2013-10-31
CN101516831B (zh) 2013-12-25
CN101516831A (zh) 2009-08-26
ZA200900779B (en) 2009-12-30
RU2009113666A (ru) 2010-10-20
TN2009000077A1 (en) 2010-08-19
CA2662393C (en) 2015-11-03
HRP20140984T1 (hr) 2014-12-05
JP2010503628A (ja) 2010-02-04
US20130066101A1 (en) 2013-03-14
EP2066618A1 (en) 2009-06-10
US8946481B2 (en) 2015-02-03
NZ574665A (en) 2012-03-30
RU2469019C2 (ru) 2012-12-10
HK1131381A1 (en) 2010-01-22
NO341967B1 (no) 2018-03-05
JP5455627B2 (ja) 2014-03-26
SG177205A1 (en) 2012-01-30
CO6190550A2 (es) 2010-08-19
CA2662393A1 (en) 2008-03-20
WO2008031567A1 (en) 2008-03-20
DK2066618T3 (da) 2014-09-22
EP1903027A1 (en) 2008-03-26
PL2066618T3 (pl) 2015-01-30
KR101401118B1 (ko) 2014-05-29
MX2009002746A (es) 2009-03-26
MA30724B1 (fr) 2009-09-01
AU2007296889A1 (en) 2008-03-20
SI2066618T1 (sl) 2014-11-28
IL196925A0 (en) 2009-11-18
AU2007296889B2 (en) 2012-03-01
ES2519446T3 (es) 2014-11-07
PT2066618E (pt) 2014-09-10
MY146660A (en) 2012-09-14
CY1115696T1 (el) 2017-01-25
US20090326066A1 (en) 2009-12-31

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