GT200900058A - Nuevos procesos - Google Patents

Nuevos procesos

Info

Publication number
GT200900058A
GT200900058A GT200900058A GT200900058A GT200900058A GT 200900058 A GT200900058 A GT 200900058A GT 200900058 A GT200900058 A GT 200900058A GT 200900058 A GT200900058 A GT 200900058A GT 200900058 A GT200900058 A GT 200900058A
Authority
GT
Guatemala
Prior art keywords
new process
unionequential
cardioficial
butirico
biaril
Prior art date
Application number
GT200900058A
Other languages
English (en)
Inventor
Hook David
Wietfeld Bernhard
Lotz Matthias
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37814152&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GT200900058(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of GT200900058A publication Critical patent/GT200900058A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A PROCEDIMIENTOS PARA PREPARAR ACIDO 4-AMINO-BUTIRICO BIARIL-SUBSTITUIDO O DERIVADOS DEL MISMO QUE SON INHIBIDORES DE LA ENDOPEPTIDASA NEUTRA (NEP) POR LO QUE SON DE UTILIDAD EN TRASTORNOS CARDIOVASCULARES TALES COMO HIPERTENSION, INSUFICIENCIA RENAL INCLUYENDO EDEMA.
GT200900058A 2006-09-13 2009-03-12 Nuevos procesos GT200900058A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06120576A EP1903027A1 (en) 2006-09-13 2006-09-13 Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors

Publications (1)

Publication Number Publication Date
GT200900058A true GT200900058A (es) 2010-03-11

Family

ID=37814152

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200900058A GT200900058A (es) 2006-09-13 2009-03-12 Nuevos procesos

Country Status (29)

Country Link
US (2) US20090326066A1 (es)
EP (2) EP1903027A1 (es)
JP (1) JP5455627B2 (es)
KR (1) KR101401118B1 (es)
CN (1) CN101516831B (es)
AU (1) AU2007296889B2 (es)
BR (1) BRPI0716990A2 (es)
CA (1) CA2662393C (es)
CO (1) CO6190550A2 (es)
CY (1) CY1115696T1 (es)
DK (1) DK2066618T3 (es)
ES (1) ES2519446T3 (es)
GT (1) GT200900058A (es)
HK (1) HK1131381A1 (es)
HR (1) HRP20140984T1 (es)
IL (1) IL196925A (es)
MA (1) MA30724B1 (es)
MX (1) MX2009002746A (es)
MY (1) MY146660A (es)
NO (1) NO341967B1 (es)
NZ (1) NZ574665A (es)
PL (1) PL2066618T3 (es)
PT (1) PT2066618E (es)
RU (1) RU2469019C2 (es)
SG (1) SG177205A1 (es)
SI (1) SI2066618T1 (es)
TN (1) TN2009000077A1 (es)
WO (1) WO2008031567A1 (es)
ZA (1) ZA200900779B (es)

Families Citing this family (63)

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JP5715339B2 (ja) 2007-01-12 2015-05-07 ノバルティス アーゲー ５−ビフェニル−４−アミノ−２−メチルペンタン酸の製造方法
AR070176A1 (es) 2008-01-17 2010-03-17 Novartis Ag Procesos de sintesis de inhibidores de nep, compuestos intermediarios y uso de los mismos en la sintesis
EP2594557B1 (en) 2009-05-28 2016-08-10 Novartis AG Substituted aminopropionic derivatives as neprilysin inhibitors
MX2011012627A (es) 2009-05-28 2011-12-14 Novartis Ag Derivados aminobutiricos sustituidos como inhibidores de nepralisina.
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
PT2526088E (pt) * 2010-01-22 2015-11-03 Novartis Ag Intermediários dos inibidores da endopeptidase neutra e método de preparação dos mesmos
CN103080077B (zh) * 2010-08-23 2015-06-10 诺华股份有限公司 用于制造nep抑制剂的中间体的制备工艺
CN103080072B (zh) * 2010-08-23 2016-03-16 诺华有限公司 制备可用于生产nep抑制剂的中间体的新方法
WO2012025501A1 (en) 2010-08-23 2012-03-01 Novartis Ag Process for the preparation of intermediates for the manufacture of nep inhibitors
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
US8993631B2 (en) 2010-11-16 2015-03-31 Novartis Ag Method of treating contrast-induced nephropathy
AR092278A1 (es) * 2012-08-31 2015-04-08 Novartis Ag Proceso de obtencion de derivados n-acilicos de bifenil-alanina e intermediarios relacionados
CN105073762B (zh) 2013-02-14 2017-03-08 诺华股份有限公司 作为nep(中性内肽酶)抑制剂的取代的联苯丁酰膦酸衍生物
EA026989B1 (ru) 2013-02-14 2017-06-30 Новартис Аг Производные замещенной бисфенилбутановой кислоты в качестве ингибиторов nep с улучшенной in vivo эффективностью
CN104230865B (zh) * 2013-06-13 2018-01-09 上海翰森生物医药科技有限公司 联芳基取代的4‑氨基丁酸衍生物及其制备方法和用途
JP2016528271A (ja) * 2013-08-21 2016-09-15 ディーピーエックス ホールディングス ビー．ブイ． □新規な中間体を経由するビフェニルアラニノールの合成
WO2016029828A1 (zh) * 2014-08-27 2016-03-03 上海翰森生物医药科技有限公司 AHU-377结晶型游离酸、半钙盐、α﹣苯乙胺盐及其制备方法和应用
CN105461587A (zh) * 2014-08-27 2016-04-06 上海翰森生物医药科技有限公司 Ahu-377半钙盐晶型及其制备方法和应用
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DK3218351T3 (da) 2014-11-14 2019-09-16 Zentiva Ks Fremgangsmåde til fremstilling, isolering og oprensning af farmaceutisk anvendelige former af ahu-377
CN104557600B (zh) * 2015-01-26 2016-05-04 苏州明锐医药科技有限公司 沙库比曲的制备方法
TW201632493A (zh) 2015-02-13 2016-09-16 諾華公司 新穎方法
CN105884644B (zh) * 2015-02-15 2020-06-09 深圳信立泰药业股份有限公司 一种中性内肽酶抑制剂盐优势形态及其制备方法
CN106146351B (zh) * 2015-04-03 2020-09-11 博瑞生物医药（苏州）股份有限公司 制备联芳基取代的4-氨基-丁酸或其衍生物的方法
CN106065006B (zh) * 2015-04-22 2020-06-05 深圳信立泰药业股份有限公司 一种中性内肽酶抑制剂盐晶型及其制备方法
CN106187808A (zh) * 2015-05-08 2016-12-07 苏州鹏旭医药科技有限公司 Ahu-377的制备方法、ahu-377中间体及ahu-377中间体的制备方法
CN104860894B (zh) * 2015-06-10 2017-05-17 北京博全健医药科技有限公司 一种抗心衰药lcz696的制备方法
US11786498B2 (en) 2015-07-02 2023-10-17 Novartis Ag Sacubitril calcium salts
WO2017009784A1 (en) 2015-07-14 2017-01-19 Cadila Healthcare Limited Solid state forms of trisodium salt of valsartan/sacubitril complex and sacubitril
CN105061263B (zh) * 2015-08-11 2017-03-15 苏州楚凯药业有限公司 一种nep抑制剂中间体的制备方法
CN105085322B (zh) * 2015-08-15 2017-10-03 浙江永宁药业股份有限公司 Ahu‑377中间体的制备方法及其中间体和中间体的制备方法
CN105168205A (zh) * 2015-08-18 2015-12-23 泰力特医药（湖北）有限公司 一种血管紧张素ii受体和脑啡肽酶受体双重抑制剂lcz696的制备方法
WO2017033128A1 (en) * 2015-08-25 2017-03-02 Novartis Ag Biphenyl-substitued 4-amino-butyric acid derivatives and their use in the synthesis of nep inhibitors
CN105152980B (zh) * 2015-09-11 2017-03-29 浙江永宁药业股份有限公司 N‑叔丁氧羰基‑（4s）‑（对苯基苯基甲基）‑4‑氨基‑（2r）‑甲基丁酸的手性制备方法
WO2017051326A1 (en) 2015-09-23 2017-03-30 Novartis Ag New processes and intermediates useful in synthesis of nep inhibitors
CN105348209B (zh) 2015-12-09 2017-12-26 浙江天宇药业股份有限公司 一种抗心衰药lcz696的制备方法
CN105523964B (zh) * 2015-12-09 2017-05-24 苏州楚凯药业有限公司 一种抗心衰药物中间体的制备方法
JP7001597B2 (ja) * 2015-12-10 2022-01-19 ノバルティス アーゲー 新規なプロセスおよび中間体
MX2018007129A (es) 2015-12-11 2018-11-09 Zentiva Ks Formas solidas de ester etilico del acido (2r,4s)-5-(bifenil-4-il) -4-[(3-carboxipropionil)amino]-2-metil-pentanoico, sus sales y un metodo de preparacion.
CN106977415B (zh) * 2016-01-15 2021-03-26 广东东阳光药业有限公司 一种沙库必曲的中间体及其制备方法
WO2017141193A1 (en) * 2016-02-16 2017-08-24 Sun Pharmaceutical Industries Limited Process for the preparation of sacubitril or salts thereof
CN105924355B (zh) * 2016-05-11 2018-08-17 浙江宏元药业有限公司 沙库比曲中间体及沙库比曲中间体和沙库比曲的制备方法
WO2018007919A1 (en) 2016-07-05 2018-01-11 Novartis Ag New process for early sacubitril intermediates
JP6945619B2 (ja) 2016-08-17 2021-10-06 ノバルティス アーゲー Ｎｅｐ阻害剤合成のための新規な方法および中間体
CN106380421B (zh) * 2016-08-26 2017-12-08 中国科学院上海有机化学研究所 沙库必曲的合成方法
US10857132B2 (en) 2016-10-10 2020-12-08 Laurus Labs Limited Stable amorphous form of sacubitril valsartan trisodium complex and processes for preparation thereof
CN106631903A (zh) * 2016-12-16 2017-05-10 重庆市碚圣医药科技股份有限公司 一种lcz‑696关键中间体的制备方法
US10774036B2 (en) 2016-12-23 2020-09-15 Novartis Ag Process for early sacubitril intermediates
CN107011203B (zh) * 2017-04-28 2019-03-29 江苏阿尔法药业有限公司 一种lcz696中间体ahu-377的制备方法
CN107522628A (zh) * 2017-09-20 2017-12-29 吉尔生化（上海）有限公司 一种l‑3‑（6‑乙酰基‑2‑萘胺基）‑2‑氨基丙酸的合成方法
CN108084058A (zh) * 2017-12-15 2018-05-29 江苏中邦制药有限公司 一种lcz696中间体的制备方法
CN108373423B (zh) * 2018-04-28 2020-10-23 成都苑东生物制药股份有限公司 一种沙库比曲缬沙坦复合物和/或共晶关键中间体沙库比曲钙的制备方法
CN109400504A (zh) * 2018-12-11 2019-03-01 重庆三圣实业股份有限公司 Lcz696中间体非对映异构体的分离纯化方法
CN109503404A (zh) * 2018-12-28 2019-03-22 凯瑞斯德生化(苏州)有限公司 一种lcz-696关键中间体的制备方法
CN111748590B (zh) * 2019-03-29 2024-05-28 弈柯莱(台州)药业有限公司 转氨酶在制备Sacubitril中间体中的应用
CN110128298B (zh) * 2019-06-13 2021-08-03 南京一心和医药科技有限公司 一种沙库巴曲中间体的合成方法
CN112574132B (zh) * 2019-09-30 2024-02-27 广东东阳光药业股份有限公司 一种沙库必曲缬沙坦钠的制备方法
CN113135836A (zh) * 2020-01-20 2021-07-20 鲁南制药集团股份有限公司 一种沙库巴曲钙盐的制备方法
CN113321600A (zh) * 2020-02-28 2021-08-31 四川科伦药物研究院有限公司 制备手性联芳基取代的4-氨基-丁酸及其衍生物的方法
CN113387841A (zh) * 2020-03-13 2021-09-14 凯特立斯（深圳）科技有限公司 一种沙库必曲中间体的合成方法
CN111269148B (zh) * 2020-04-08 2022-02-08 台州职业技术学院 一种沙库比曲中间体的制备方法
JP7064527B2 (ja) * 2020-05-01 2022-05-10 ノバルティス アーゲー サクビトリルカルシウム塩
CN112745246A (zh) * 2020-12-30 2021-05-04 重庆市碚圣医药科技股份有限公司 一种沙库必曲中间体的纯化方法

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Also Published As

Publication number Publication date
EP2066618B1 (en) 2014-07-23
DK2066618T3 (da) 2014-09-22
IL196925A0 (en) 2009-11-18
NZ574665A (en) 2012-03-30
CO6190550A2 (es) 2010-08-19
MY146660A (en) 2012-09-14
SG177205A1 (en) 2012-01-30
SI2066618T1 (sl) 2014-11-28
JP5455627B2 (ja) 2014-03-26
ES2519446T3 (es) 2014-11-07
EP1903027A1 (en) 2008-03-26
US8946481B2 (en) 2015-02-03
NO341967B1 (no) 2018-03-05
RU2469019C2 (ru) 2012-12-10
IL196925A (en) 2013-10-31
CN101516831A (zh) 2009-08-26
EP2066618A1 (en) 2009-06-10
HK1131381A1 (en) 2010-01-22
JP2010503628A (ja) 2010-02-04
CA2662393C (en) 2015-11-03
BRPI0716990A2 (pt) 2014-02-04
TN2009000077A1 (en) 2010-08-19
CN101516831B (zh) 2013-12-25
CA2662393A1 (en) 2008-03-20
MX2009002746A (es) 2009-03-26
HRP20140984T1 (hr) 2014-12-05
AU2007296889B2 (en) 2012-03-01
PT2066618E (pt) 2014-09-10
ZA200900779B (en) 2009-12-30
RU2009113666A (ru) 2010-10-20
MA30724B1 (fr) 2009-09-01
PL2066618T3 (pl) 2015-01-30
KR101401118B1 (ko) 2014-05-29
KR20090076910A (ko) 2009-07-13
AU2007296889A1 (en) 2008-03-20
US20090326066A1 (en) 2009-12-31
WO2008031567B1 (en) 2008-05-08
US20130066101A1 (en) 2013-03-14
NO20091242L (no) 2009-03-25
CY1115696T1 (el) 2017-01-25
WO2008031567A1 (en) 2008-03-20

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