CO5380014A1 - Formulacion farmaceuticas para la administracion oral o topica de compuestos hidrofobicos que no frma emulsion - Google Patents

Formulacion farmaceuticas para la administracion oral o topica de compuestos hidrofobicos que no frma emulsion

Info

Publication number
CO5380014A1
CO5380014A1 CO00061955A CO00061955A CO5380014A1 CO 5380014 A1 CO5380014 A1 CO 5380014A1 CO 00061955 A CO00061955 A CO 00061955A CO 00061955 A CO00061955 A CO 00061955A CO 5380014 A1 CO5380014 A1 CO 5380014A1
Authority
CO
Colombia
Prior art keywords
ch2or
chor
ch2o
fatty acids
oral
Prior art date
Application number
CO00061955A
Other languages
English (en)
Inventor
Tomas Andrysek
Milan Stuchlik
Ales Vrana
Alexander Jegorov
Josef Stuchlik
Vladimir Matha
Original Assignee
Ivax Pharmaceuticals Sro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10859192&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO5380014(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ivax Pharmaceuticals Sro filed Critical Ivax Pharmaceuticals Sro
Publication of CO5380014A1 publication Critical patent/CO5380014A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)

Abstract

Un método para incrementar la viscosidad de una formulación farmacéutica para administración oral o tópica que comprende los pasos de combinar:a) una cantidad efectiva de uno o más ingredientes activos hidrofobicos; b) de 5 a 50% de uno o más compuestos seleccionados de esteres de poliglicerol o ácidos grasos de fórmula (1) CH2OR-CHOR-CH2O-[CH2CHOR-CH2O-]NCH2-CHOR-CH2OR (1)en donde n es un entero de 4 a 13 y R es H ó CO RAND#39 en donde RAND#39 es un alquilo hidroxilado saturado o insaturado de C8-22 y en donde por lo menos un grupo R no es hidrógeno;c) de 5 a 50% de uno o más compuestos seleccionado de ésteres de poliglicerol o ácidos grasos y/o ácidos grasos insaturado de fórmula (2) CH2OR-CHOR-CH2O-[CH2CHOR-CH2O-]NCH2-CHOR-CH2OR (2)en donde N es un entero de 0 a 10 y R es H ó COR" en donde R" es un alquilo hidroxilado saturado o insaturado de C8-22, y en donde mientras al menos un grupo R no es hidrógeno;d) de 5 a 50% de uno o más compuestos seleccionados de triglicerido de macrogol ésteres de glicerol, gliceridos parciales o ácidos grasos ó esteres de macrogol de ácidos grasos en los cuales la cantidad promedio de oxido de etileno reaccionado en la síntesis de estas sustancias varia desde 50 a 150 moles y constantemente la proporción entre los componentes b) y d) es desde 0,1:1 hasta 10:1;en donde los anteriores porcentajes son seleccionados de un total del 100%;y donde después de la disolución con agua 1:1 en volumen la viscosidad de la disolución se incrementa hasta por lo menos 5 veces en comparación con la composición sin diluir.
CO00061955A 1999-08-17 2000-08-17 Formulacion farmaceuticas para la administracion oral o topica de compuestos hidrofobicos que no frma emulsion CO5380014A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9919288A GB2355656B (en) 1999-08-17 1999-08-17 Pharmaceutical compositions for oral and topical administration

Publications (1)

Publication Number Publication Date
CO5380014A1 true CO5380014A1 (es) 2004-03-31

Family

ID=10859192

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00061955A CO5380014A1 (es) 1999-08-17 2000-08-17 Formulacion farmaceuticas para la administracion oral o topica de compuestos hidrofobicos que no frma emulsion

Country Status (40)

Country Link
US (1) US20070190132A1 (es)
EP (2) EP1334717B1 (es)
JP (2) JP2003507343A (es)
KR (2) KR100828748B1 (es)
CN (2) CN101406453A (es)
AR (2) AR025324A1 (es)
AT (2) ATE288766T1 (es)
AU (1) AU777740B2 (es)
BR (1) BR0013385A (es)
CA (2) CA2452118A1 (es)
CO (1) CO5380014A1 (es)
CY (1) CY1105318T1 (es)
CZ (2) CZ296591B6 (es)
DE (2) DE60018081T2 (es)
DK (2) DK1210119T3 (es)
EE (2) EE04955B1 (es)
EG (1) EG23994A (es)
ES (2) ES2237443T3 (es)
GB (1) GB2355656B (es)
HK (1) HK1049629A1 (es)
HR (1) HRP20020154B1 (es)
HU (1) HUP0203236A3 (es)
IL (4) IL158108A0 (es)
JO (1) JO2324B1 (es)
MX (1) MXPA02001631A (es)
NO (2) NO20020760L (es)
NZ (1) NZ517271A (es)
PE (1) PE20010636A1 (es)
PL (1) PL192769B1 (es)
PT (2) PT1210119E (es)
RU (2) RU2279894C2 (es)
SA (1) SA00210487B1 (es)
SG (1) SG143019A1 (es)
SI (1) SI1210119T1 (es)
SK (2) SK286083B6 (es)
TN (1) TNSN00173A1 (es)
UA (2) UA72539C2 (es)
UY (1) UY26303A1 (es)
WO (1) WO2001012229A1 (es)
ZA (2) ZA200308221B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2355656B (en) * 1999-08-17 2004-04-07 Galena As Pharmaceutical compositions for oral and topical administration
FR2826261B1 (fr) * 2001-06-26 2005-03-25 Lmd Composition a usage topique comprenant un produit cytotoxique et son utilisation dans le traitement de l'alopeche
DE10154464B4 (de) * 2001-11-08 2005-10-20 Max Delbrueck Centrum Oral verabreichbare pharmazeutische Zubereitung umfassend liposomal verkapseltes Taxol
KR20030065831A (ko) * 2002-02-01 2003-08-09 주식회사 태평양 사이클로스포린을 함유한 지속 방출형 약학적 조성물
US7101576B2 (en) * 2002-04-12 2006-09-05 Elan Pharma International Limited Nanoparticulate megestrol formulations
US9101540B2 (en) 2002-04-12 2015-08-11 Alkermes Pharma Ireland Limited Nanoparticulate megestrol formulations
EP1935407A1 (en) * 2002-12-03 2008-06-25 Elan Pharma International Limited Low viscosity liquid dosage forms
CN100337620C (zh) * 2002-12-04 2007-09-19 日清药业股份有限公司 含有辅酶q10的水溶性组合物
JP4518042B2 (ja) * 2002-12-04 2010-08-04 日油株式会社 コエンザイムｑ１０を含有する水溶性組成物の製造方法
AU2003299590B8 (en) * 2002-12-09 2010-04-08 Abraxis Bioscience, Llc Compositions and methods of delivery of pharmacological agents
US6979672B2 (en) * 2002-12-20 2005-12-27 Polichem, S.A. Cyclosporin-based pharmaceutical compositions
TW200616681A (en) * 2004-10-05 2006-06-01 Recordati Ireland Ltd Lercanidipine capsules
EP1806125B1 (en) * 2004-10-20 2011-08-03 Kao Corporation Liquid compositions for oral cavity
BRPI0608173A2 (pt) * 2005-02-24 2010-11-09 Elan Pharma Int Ltd composição, uso da mesma, e, método de produzir uma composição de docetaxel nanoparticulada ou análogo do mesmo
BRPI0921654A2 (pt) * 2008-11-28 2016-02-10 Advance Holdings Ltd formulação farmacêutica
DK2405892T3 (da) * 2009-03-12 2013-04-08 Advance Holdings Ltd Farmaceutisk formulering omfattende ketoprofen og en polyoxyalkylenester af en hydroxy-fedtsyre
KR101100933B1 (ko) * 2009-04-23 2012-01-02 한국기술교육대학교 산학협력단 솔더 볼 제거 장치
JP6763939B2 (ja) 2015-03-27 2020-09-30 アーチ・パーソナル・ケア・プロダクツ・エルピー パーソナルケア製品のための粘度増強組成物
CN112426403B (zh) * 2020-12-09 2021-09-17 南京天纵易康生物科技股份有限公司 一种口腔溃疡凝胶及其制备方法和应用

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Publication number Priority date Publication date Assignee Title
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
CZ288631B6 (cs) * 1996-01-18 2001-08-15 Galena, A. S. Léčivé přípravky s obsahem cyklosporinu
CZ288739B6 (cs) * 1996-08-01 2001-08-15 Galena, A. S. Cyklosporin obsahující léčivé přípravky
CZ283516B6 (cs) * 1996-09-12 1998-04-15 Galena A.S. Léčivé přípravky, zejména pro vnitřní aplikaci, ve formě samomikroemulgujících terapeutických systémů
TR199902199T2 (xx) * 1997-03-12 2002-06-21 Abbott Laboratories Siklosporin tatbiki i�in hidrofilik ikili sistemler.
JP2001515491A (ja) * 1997-03-12 2001-09-18 アボツト・ラボラトリーズ 親油性化合物の投与のための親油性二成分系
PL191780B1 (pl) * 1997-07-29 2006-07-31 Upjohn Co Kompozycja farmaceutyczna w postaci samoemulgującej formulacji związków lipofilowych i samoemulgujące podłoże formulacji
US6063762A (en) * 1997-12-05 2000-05-16 Chong Kun Dang Corp. Cyclosporin-containing microemulsion preconcentrate composition
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GB2355656B (en) * 1999-08-17 2004-04-07 Galena As Pharmaceutical compositions for oral and topical administration

Also Published As

Publication number Publication date
GB9919288D0 (en) 1999-10-20
DK1334717T3 (da) 2008-11-24
HRP20020154A2 (en) 2003-12-31
IL148200A (en) 2007-12-03
EE04954B1 (et) 2008-02-15
ES2311077T3 (es) 2009-02-01
ZA200201315B (en) 2004-06-30
MXPA02001631A (es) 2003-07-14
HUP0203236A2 (hu) 2003-01-28
IL148200A0 (en) 2002-09-12
EP1210119A1 (en) 2002-06-05
KR20050095651A (ko) 2005-09-29
WO2001012229A1 (en) 2001-02-22
CA2452118A1 (en) 2001-02-22
IL158108A (en) 2010-04-15
PT1210119E (pt) 2005-05-31
SK2482002A3 (en) 2002-12-03
ZA200308221B (en) 2004-09-29
CZ296591B6 (cs) 2006-04-12
EE200200075A (et) 2003-04-15
ES2237443T3 (es) 2005-08-01
RU2279895C2 (ru) 2006-07-20
PL353445A1 (en) 2003-11-17
AR025324A1 (es) 2002-11-20
TNSN00173A1 (en) 2005-11-10
GB2355656A (en) 2001-05-02
SI1210119T1 (en) 2005-06-30
CN1382061A (zh) 2002-11-27
DE60322454D1 (de) 2008-09-11
EE200300371A (et) 2003-10-15
AR043106A2 (es) 2005-07-20
HUP0203236A3 (en) 2004-06-28
PE20010636A1 (es) 2001-06-02
NO20020760L (no) 2002-04-16
PT1334717E (pt) 2008-10-09
CN101406453A (zh) 2009-04-15
JP2004238399A (ja) 2004-08-26
JO2324B1 (en) 2005-09-12
NO20034778D0 (no) 2003-10-24
SK286083B6 (sk) 2008-03-05
US20070190132A1 (en) 2007-08-16
EG23994A (en) 2008-03-10
JP2003507343A (ja) 2003-02-25
EP1334717A2 (en) 2003-08-13
CZ296170B6 (cs) 2006-01-11
GB2355656B (en) 2004-04-07
DK1210119T3 (da) 2005-06-20
HRP20020154B1 (en) 2006-07-31
HK1049629A1 (zh) 2003-05-23
KR100828747B1 (ko) 2008-05-09
NO20034778L (no) 2002-04-16
EP1334717A3 (en) 2004-01-02
RU2003133451A (ru) 2005-04-20
SG143019A1 (en) 2008-06-27
AU777740B2 (en) 2004-10-28
NZ517271A (en) 2004-02-27
CZ2002575A3 (cs) 2003-05-14
BR0013385A (pt) 2002-05-07
ATE402691T1 (de) 2008-08-15
NO20020760D0 (no) 2002-02-15
UA75926C2 (en) 2006-06-15
PL192769B1 (pl) 2006-12-29
EP1334717B1 (en) 2008-07-30
AU6461300A (en) 2001-03-13
ATE288766T1 (de) 2005-02-15
IL158108A0 (en) 2004-03-28
CY1105318T1 (el) 2010-03-03
SA00210487B1 (ar) 2006-09-10
DE60018081D1 (de) 2005-03-17
EE04955B1 (et) 2008-02-15
UY26303A1 (es) 2001-03-16
KR100828748B1 (ko) 2008-05-09
CA2380951A1 (en) 2001-02-22
DE60018081T2 (de) 2006-01-05
RU2279894C2 (ru) 2006-07-20
EP1210119B1 (en) 2005-02-09
CA2380951C (en) 2010-03-23
KR20020059367A (ko) 2002-07-12
UA72539C2 (en) 2005-03-15

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