PE20010636A1 - Composiciones de agentes activos poco solubles como ciclosporina, paclitaxel o nifedipina para administracion oral o topica - Google Patents

Composiciones de agentes activos poco solubles como ciclosporina, paclitaxel o nifedipina para administracion oral o topica

Info

Publication number
PE20010636A1
PE20010636A1 PE2000000842A PE0008422000A PE20010636A1 PE 20010636 A1 PE20010636 A1 PE 20010636A1 PE 2000000842 A PE2000000842 A PE 2000000842A PE 0008422000 A PE0008422000 A PE 0008422000A PE 20010636 A1 PE20010636 A1 PE 20010636A1
Authority
PE
Peru
Prior art keywords
chor
ch2o
fatty acids
ch2or
formulation
Prior art date
Application number
PE2000000842A
Other languages
English (en)
Inventor
Tomas Andrysek
Alexandr Jegerov
Ales Vrana
Milan Stuchlik
Josef Stuchlik
Vladimir Matha
Original Assignee
Ivax Cr A S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10859192&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20010636(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ivax Cr A S filed Critical Ivax Cr A S
Publication of PE20010636A1 publication Critical patent/PE20010636A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)

Abstract

SE REFIERE A UN METODO PARA INCREMENTAR LA VISCOSIDAD DE UNA FORMULACION DE ADMINISTRACION ORAL O TOPICA LA CUAL COMPRENDE LOS PASOS DE COMBINAR: a)DE 0,1% A 30% DE UN AGENTE ACTIVO HIDROFOBICO TAL COMO TAXANOS (DOCATAXEL, PACLITAXEL), CICLOSPORINAS; b)DE 5% A 50% DE ESTERES DE POLIGLICEROL DE ACIDOS GRASOS DE FORMULA CH2OR-CHOR-CH2O-[CH2CHOR-CH2O-]nCH2-CHOR-CH2OR; n ES 4-13; R ES H, CO.R; R` ES ALQUILO C8-C22; R NO ES H; c)DE 5% A 50% DE ESTERES DE POLIGLICEROL DE ACIDOS GRASOS Y ACIDOS GRASOS INSATURADOS DE FORMULA CH2OR-CHOR-CH2O-[CH2CHOR-CH2O-]nCH2-CHOR-CH2OR; n ES 0-10; R ES H, CO.R"; R" ES ALQUILO C8-C22, AL MENOS UN R NO ES H; d)DE 5% A 50% DE ESTERES DE GLICEROL MACROGOL TRIGLICERIDO, GLICERIDOS PARCIALES O ACIDOS GRASOS O ESTERES MACROGOL DE ACIDOS GRASOS (ACEITE DE CASTOR HALOGENADO, LA CANTIDAD DE OXIDO DE ETILENO PARA LA SINTESIS DE ESTAS SUSTANCIAS OSCILA ENTRE 50 MOL A 150 MOL, SIENDO LA PROPORCION DE LOS COMPONENTES b Y d DE 0,1:1 A 10:1; DE a:c Y a:e ES DE 0,001:1 A 10:1, SE CARACTERIZA POR LA PREVIA DILUCION EN AGUA 1.1 POR VOLUMEN, LA VISCOSIDAD DE LA FORMULACION SE INCREMENTA EN AL MENOS 5 VECES EN COMPARACION CON LA FORMULACION NO DILUIDA; LA FORMULACION CREA UNA DISPERSION DE PARTICULAS DE GEL POLIMORFO CON UNA DIMENSION DE 0,2µm A 500µm
PE2000000842A 1999-08-17 2000-08-17 Composiciones de agentes activos poco solubles como ciclosporina, paclitaxel o nifedipina para administracion oral o topica PE20010636A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9919288A GB2355656B (en) 1999-08-17 1999-08-17 Pharmaceutical compositions for oral and topical administration

Publications (1)

Publication Number Publication Date
PE20010636A1 true PE20010636A1 (es) 2001-06-02

Family

ID=10859192

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000842A PE20010636A1 (es) 1999-08-17 2000-08-17 Composiciones de agentes activos poco solubles como ciclosporina, paclitaxel o nifedipina para administracion oral o topica

Country Status (40)

Country Link
US (1) US20070190132A1 (es)
EP (2) EP1210119B1 (es)
JP (2) JP2003507343A (es)
KR (2) KR100828747B1 (es)
CN (2) CN101406453A (es)
AR (2) AR025324A1 (es)
AT (2) ATE402691T1 (es)
AU (1) AU777740B2 (es)
BR (1) BR0013385A (es)
CA (2) CA2452118A1 (es)
CO (1) CO5380014A1 (es)
CY (1) CY1105318T1 (es)
CZ (2) CZ296170B6 (es)
DE (2) DE60018081T2 (es)
DK (2) DK1334717T3 (es)
EE (2) EE04955B1 (es)
EG (1) EG23994A (es)
ES (2) ES2311077T3 (es)
GB (1) GB2355656B (es)
HK (1) HK1049629A1 (es)
HR (1) HRP20020154B1 (es)
HU (1) HUP0203236A3 (es)
IL (4) IL158108A0 (es)
JO (1) JO2324B1 (es)
MX (1) MXPA02001631A (es)
NO (2) NO20020760L (es)
NZ (1) NZ517271A (es)
PE (1) PE20010636A1 (es)
PL (1) PL192769B1 (es)
PT (2) PT1210119E (es)
RU (2) RU2279894C2 (es)
SA (1) SA00210487B1 (es)
SG (1) SG143019A1 (es)
SI (1) SI1210119T1 (es)
SK (2) SK286083B6 (es)
TN (1) TNSN00173A1 (es)
UA (2) UA72539C2 (es)
UY (1) UY26303A1 (es)
WO (1) WO2001012229A1 (es)
ZA (2) ZA200308221B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2355656B (en) * 1999-08-17 2004-04-07 Galena As Pharmaceutical compositions for oral and topical administration
FR2826261B1 (fr) * 2001-06-26 2005-03-25 Lmd Composition a usage topique comprenant un produit cytotoxique et son utilisation dans le traitement de l'alopeche
DE10154464B4 (de) * 2001-11-08 2005-10-20 Max Delbrueck Centrum Oral verabreichbare pharmazeutische Zubereitung umfassend liposomal verkapseltes Taxol
KR20030065831A (ko) * 2002-02-01 2003-08-09 주식회사 태평양 사이클로스포린을 함유한 지속 방출형 약학적 조성물
US7101576B2 (en) 2002-04-12 2006-09-05 Elan Pharma International Limited Nanoparticulate megestrol formulations
US9101540B2 (en) 2002-04-12 2015-08-11 Alkermes Pharma Ireland Limited Nanoparticulate megestrol formulations
EP1935407A1 (en) * 2002-12-03 2008-06-25 Elan Pharma International Limited Low viscosity liquid dosage forms
JP4518042B2 (ja) * 2002-12-04 2010-08-04 日油株式会社 コエンザイムｑ１０を含有する水溶性組成物の製造方法
EP1582206A4 (en) * 2002-12-04 2010-09-22 Nisshin Pharma Inc WATER-SOLUBLE COMPOSITION WITH COENZYM Q10
KR20200083657A (ko) * 2002-12-09 2020-07-08 아브락시스 바이오사이언스, 엘엘씨 약리학적 물질의 조성물 및 그 전달방법
US6979672B2 (en) * 2002-12-20 2005-12-27 Polichem, S.A. Cyclosporin-based pharmaceutical compositions
TW200616681A (en) * 2004-10-05 2006-06-01 Recordati Ireland Ltd Lercanidipine capsules
US8236286B2 (en) * 2004-10-20 2012-08-07 Kao Corporation Liquid compositions for the oral cavity
BRPI0608173A2 (pt) * 2005-02-24 2010-11-09 Elan Pharma Int Ltd composição, uso da mesma, e, método de produzir uma composição de docetaxel nanoparticulada ou análogo do mesmo
AU2009319167A1 (en) * 2008-11-28 2010-06-03 Lectio Pharmaentwicklungs-Und Verwertungs Gmbh Pharmaceutical formulation comprising diclofenac and a hydroxy fatty acid polyoxyalkylene ester
SI2405892T1 (sl) * 2009-03-12 2013-06-28 Lectio Pharmaentwicklungs- Und Verwertungs Gmbh Farmacevtska formulacija, ki obsega ketoprofen in polioksialkilenski ester hidroksimaščobne kisline
KR101100933B1 (ko) * 2009-04-23 2012-01-02 한국기술교육대학교 산학협력단 솔더 볼 제거 장치
WO2016160412A1 (en) * 2015-03-27 2016-10-06 Arch Personal Care Products, Lp Viscosity building composition for personal care products
CN112426403B (zh) * 2020-12-09 2021-09-17 南京天纵易康生物科技股份有限公司 一种口腔溃疡凝胶及其制备方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
KR0148748B1 (ko) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
CZ288631B6 (cs) * 1996-01-18 2001-08-15 Galena, A. S. Léčivé přípravky s obsahem cyklosporinu
CZ288739B6 (cs) * 1996-08-01 2001-08-15 Galena, A. S. Cyklosporin obsahující léčivé přípravky
CZ267796A3 (cs) * 1996-09-12 1998-04-15 Galena A.S. Léčivé přípravky, zejména pro vnitřní aplikaci, ve formě samomikroemulgujících terapeutických systémů
WO1998040094A1 (en) * 1997-03-12 1998-09-17 Abbott Laboratories Hydrophilic binary systems for the administration of cyclosporine
JP2001515491A (ja) * 1997-03-12 2001-09-18 アボツト・ラボラトリーズ 親油性化合物の投与のための親油性二成分系
BR9811058A (pt) * 1997-07-29 2000-09-05 Upjohn Co Formulação auto-emulsificante para compostos lipofìlicos
US6063762A (en) * 1997-12-05 2000-05-16 Chong Kun Dang Corp. Cyclosporin-containing microemulsion preconcentrate composition
US20030216303A1 (en) * 1998-03-06 2003-11-20 Michael Ambuhl Emulsion preconcentrates containing cyclosporin or a macrolide
GB2355656B (en) * 1999-08-17 2004-04-07 Galena As Pharmaceutical compositions for oral and topical administration

Also Published As

Publication number Publication date
DE60322454D1 (de) 2008-09-11
EP1210119A1 (en) 2002-06-05
RU2279894C2 (ru) 2006-07-20
JP2003507343A (ja) 2003-02-25
GB2355656B (en) 2004-04-07
JP2004238399A (ja) 2004-08-26
CA2452118A1 (en) 2001-02-22
UY26303A1 (es) 2001-03-16
ES2237443T3 (es) 2005-08-01
GB2355656A (en) 2001-05-02
CO5380014A1 (es) 2004-03-31
SG143019A1 (en) 2008-06-27
UA72539C2 (en) 2005-03-15
CZ296591B6 (cs) 2006-04-12
EE200200075A (et) 2003-04-15
EE04955B1 (et) 2008-02-15
SI1210119T1 (en) 2005-06-30
HK1049629A1 (zh) 2003-05-23
US20070190132A1 (en) 2007-08-16
CA2380951C (en) 2010-03-23
NO20020760L (no) 2002-04-16
NO20020760D0 (no) 2002-02-15
EE200300371A (et) 2003-10-15
HUP0203236A3 (en) 2004-06-28
KR20050095651A (ko) 2005-09-29
MXPA02001631A (es) 2003-07-14
SK2482002A3 (en) 2002-12-03
HUP0203236A2 (hu) 2003-01-28
SK286083B6 (sk) 2008-03-05
BR0013385A (pt) 2002-05-07
RU2279895C2 (ru) 2006-07-20
ATE288766T1 (de) 2005-02-15
CN1382061A (zh) 2002-11-27
PL353445A1 (en) 2003-11-17
DE60018081T2 (de) 2006-01-05
EP1334717A3 (en) 2004-01-02
ZA200308221B (en) 2004-09-29
IL148200A (en) 2007-12-03
KR100828748B1 (ko) 2008-05-09
AU777740B2 (en) 2004-10-28
EP1334717A2 (en) 2003-08-13
DK1210119T3 (da) 2005-06-20
PT1210119E (pt) 2005-05-31
NZ517271A (en) 2004-02-27
HRP20020154B1 (en) 2006-07-31
IL158108A0 (en) 2004-03-28
DE60018081D1 (de) 2005-03-17
AR043106A2 (es) 2005-07-20
KR100828747B1 (ko) 2008-05-09
NO20034778L (no) 2002-04-16
HRP20020154A2 (en) 2003-12-31
EP1210119B1 (en) 2005-02-09
IL148200A0 (en) 2002-09-12
DK1334717T3 (da) 2008-11-24
CZ296170B6 (cs) 2006-01-11
ZA200201315B (en) 2004-06-30
GB9919288D0 (en) 1999-10-20
ES2311077T3 (es) 2009-02-01
RU2003133451A (ru) 2005-04-20
AU6461300A (en) 2001-03-13
SA00210487B1 (ar) 2006-09-10
PT1334717E (pt) 2008-10-09
EP1334717B1 (en) 2008-07-30
WO2001012229A1 (en) 2001-02-22
CA2380951A1 (en) 2001-02-22
IL158108A (en) 2010-04-15
JO2324B1 (en) 2005-09-12
TNSN00173A1 (en) 2005-11-10
CZ2002575A3 (cs) 2003-05-14
CN101406453A (zh) 2009-04-15
UA75926C2 (en) 2006-06-15
EE04954B1 (et) 2008-02-15
ATE402691T1 (de) 2008-08-15
EG23994A (en) 2008-03-10
CY1105318T1 (el) 2010-03-03
PL192769B1 (pl) 2006-12-29
AR025324A1 (es) 2002-11-20
NO20034778D0 (no) 2003-10-24
KR20020059367A (ko) 2002-07-12

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