KR890001521A - 서방형 신규 제약 제제물 - Google Patents

서방형 신규 제약 제제물 Download PDF

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Publication number
KR890001521A
KR890001521A KR870007169A KR870007169A KR890001521A KR 890001521 A KR890001521 A KR 890001521A KR 870007169 A KR870007169 A KR 870007169A KR 870007169 A KR870007169 A KR 870007169A KR 890001521 A KR890001521 A KR 890001521A
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South Korea
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formulation
active compound
solubilizer
weight
nonionic
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KR870007169A
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English (en)
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KR950002147B1 (ko
Inventor
칼-에릭 레나르트 팔크
스벤 모르간 후고손
아담 로신스키
존 알베르트 스죄그렌
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원본미기재
악티에볼라게트 헤슬레
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

서방형 신규 제약 제제물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 실시예 1,4 및 참조예 A에 의한 조성물이 평균 플라스마 값을 나타내는 그래프임
제2도는 실시예 3 및 참조에 B에 의한 조성물의 평균 플라스마 갑을 나타내는 그래프임,
제3도는 실시예 5에 의한 조성물 및 니페디핀을 함유하는 참조 제제물, 즉 AdalatR10mg(참조예 C)의 평균 플라스마 값을 나타내는 그래프임.

Claims (17)

  1. 반고상 또는 액상 비이온성 가용화제 중에 용해시키거나 분산시킨 유효 화합물을 함유시키되, 가용화제의 양(중량)을 유효 화합물의 양(중량과 적어도 동일하게 함을 특징으로 하는, 매우 낮은 용해도를 갖는 유효 화합물의 서방형 고상 제제물.
  2. 제1항에 있어서, 비이온성 가용화제를 폴리에틸렌글리콜의 에스테르 및 (또는) 에테르 중에서 선택한 제제물.
  3. 제1항 또는 제2항에 있어서, 비이온성 가용화제를 폴리에톡실화 지방산, 히드록실화 지방산 또는 지방 알코올 중에서 선택한 제제물.
  4. 제1항 내지 제3항 중 어느 하나의 항에 있어서, 비이온성 가용화제를 폴리에톡실화 피마자유, 폴리에톡실화 수소첨가 피마자유,피마자유로부터 채취한 폴리에톡실화 지방산 수소첨가 피마자유로부터 채취한 폴리에톡실화 지방산 중에서 선택한 제제물.
  5. 제4항에 있어서, 비이온성 가용화제가 수소첨가 피마자유 지방산과 옥시에틸화 글리세린과의 에스테르, 특히 CremophorRRH 40(바스프 제품)인 제제물.
  6. 제1항에 있어서, 유효 화합물과 가용화제의 비율이 1:1 내지 1:10 적합하기로는 1:2 내지 1:6인 제제물.
  7. 제1항 내지 제6항 중 어느 한 항에 있어서, 유효 화합물이 물 중에서 1:1000(중량) 이하의 용해도를 갖고, 비이온성 가용화제 또는 물과 비이온성 가용화제의 복합물 중에서 가용화될 수 있는 제제물.
  8. 제1항 내지 제7항 중 어느 하나의 항에 있어서, 유효 화합물이 1개 이상의 치환 디히드로피리딘류로 되는 제제물.
  9. 제8항에 있어서, 치환 디히드로피리딘이 니페디핀인 제제물.
  10. 재8항에 있어서, 치환 디히드로피리딘이 펠로디핀인 제제물.
  11. 제1항 내지 제10항중 어느 한 항에 있어서, 방출을 불활성이고 다공성인 기질, 확산 지연 코우팅 또는 붕해 코우팅에 의해 조절시킨 제제물.
  12. 제1항 내지 제10항 중 어느 하나의 항에 있어서, 방출을 친수성 겔 시스템에 의해 조절시킨 제제물.
  13. 제12항에 있어서, 친수성 겔 형성 성분이 제제물의 20%-80% 중량%로 되는 제제물.
  14. 제12항 또는 제13항에 있어서, 친수성 겔 시스템이 히드록시프로필 메틸셀룰로오스로 되는 제제물.
  15. 제14항에 있어서, 히드록시프로필 메틸세룰로오스가 4%-12중량%의 히드록시프로필 함량을 갖는 제제물.
  16. 제12항 내지 제14항 중 어느 하나의 항에 있어서, 친수성 겔 시스템에 카르복시폴리에틸렌을 함유시킨 제제물.
  17. 유효 화합물을 적어도 유효 화합물과 등량(중량)의 반고상 또는 액상 비이온성 가용화제 중에 용해 또는 분산시킨 후, 혼합물을 공지된 방법으로 적합한 서방형 시스템 중에 혼입시킨 다음, 제약 투여 단위로 제제하는 것을 특징으로 하는, 매우 낮은 용해도를 갖는 유효 화합물의 서방형 고상 제제물의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임
KR1019870007169A 1986-04-11 1987-07-06 서방형 신규 제약 제제 KR950002147B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8601624A SE8601624D0 (sv) 1986-04-11 1986-04-11 New pharmaceutical preparations
SE8601624-3 1986-04-11

Publications (2)

Publication Number Publication Date
KR890001521A true KR890001521A (ko) 1989-03-27
KR950002147B1 KR950002147B1 (ko) 1995-03-14

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ID=20364135

Family Applications (2)

Application Number Title Priority Date Filing Date
KR870003416A KR870009720A (ko) 1986-04-11 1987-04-10 서방형 신규 제약 제제물
KR1019870007169A KR950002147B1 (ko) 1986-04-11 1987-07-06 서방형 신규 제약 제제

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KR870003416A KR870009720A (ko) 1986-04-11 1987-04-10 서방형 신규 제약 제제물

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US (1) US4803081A (ko)
EP (1) EP0249587B1 (ko)
JP (1) JPH0778016B2 (ko)
KR (2) KR870009720A (ko)
CN (1) CN1025150C (ko)
AT (1) ATE76288T1 (ko)
AU (1) AU602677B2 (ko)
CA (1) CA1304294C (ko)
CS (1) CS270560B2 (ko)
CY (1) CY1826A (ko)
DD (1) DD263231A5 (ko)
DE (1) DE3779183D1 (ko)
DK (1) DK173033B1 (ko)
DZ (1) DZ1067A1 (ko)
EG (1) EG18265A (ko)
ES (1) ES2031929T3 (ko)
FI (1) FI91826C (ko)
GR (1) GR3005286T3 (ko)
HK (1) HK26795A (ko)
HU (1) HU204699B (ko)
IE (1) IE59419B1 (ko)
IS (1) IS1553B (ko)
MY (1) MY101553A (ko)
NO (1) NO174795B (ko)
NZ (1) NZ219633A (ko)
PH (1) PH22494A (ko)
PL (1) PL265078A1 (ko)
PT (1) PT84663B (ko)
SE (1) SE8601624D0 (ko)
SG (1) SG4295G (ko)
SU (1) SU1743332A3 (ko)
UA (1) UA12336A (ko)
YU (1) YU47258B (ko)
ZA (1) ZA871911B (ko)

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FI871585A0 (fi) 1987-04-10
PH22494A (en) 1988-09-12
NO174795C (ko) 1994-07-13
ATE76288T1 (de) 1992-06-15
ES2031929T3 (es) 1993-01-01
NO871199L (no) 1987-10-12
EP0249587A1 (en) 1987-12-16
DK173033B1 (da) 1999-11-29
IS3214A7 (is) 1987-10-12
HK26795A (en) 1995-03-10
FI91826B (fi) 1994-05-13
IS1553B (is) 1994-08-10
IE870925L (en) 1987-10-11
YU40787A (sh) 1992-09-07
CN87102758A (zh) 1987-10-21
PT84663B (pt) 1989-11-30
CS270560B2 (en) 1990-07-12
SE8601624D0 (sv) 1986-04-11
EG18265A (en) 1992-12-30
DK154987D0 (da) 1987-03-26
KR870009720A (ko) 1987-11-30
IE59419B1 (en) 1994-02-23
SU1743332A3 (ru) 1992-06-23
GR3005286T3 (ko) 1993-05-24
PL265078A1 (en) 1988-07-21
PT84663A (en) 1987-05-01
KR950002147B1 (ko) 1995-03-14
DK154987A (da) 1987-10-12
DD263231A5 (de) 1988-12-28
SG4295G (en) 1995-06-16
DZ1067A1 (fr) 2004-09-13
MY101553A (en) 1991-12-17
JPH0778016B2 (ja) 1995-08-23
CA1304294C (en) 1992-06-30
NO174795B (no) 1994-04-05
NZ219633A (en) 1989-11-28
CN1025150C (zh) 1994-06-29
FI91826C (fi) 1994-08-25
HUT43786A (en) 1987-12-28
YU47258B (sh) 1995-01-31
US4803081A (en) 1989-02-07
ZA871911B (en) 1987-12-30
HU204699B (en) 1992-02-28
EP0249587B1 (en) 1992-05-20
FI871585A (fi) 1987-10-12
CS258787A2 (en) 1989-11-14
AU7004387A (en) 1987-10-15
DE3779183D1 (de) 1992-06-25
UA12336A (uk) 1996-12-25
JPS62242613A (ja) 1987-10-23
NO871199D0 (no) 1987-03-23
CY1826A (en) 1995-12-01
AU602677B2 (en) 1990-10-25

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