JPS5495721A - Nifedipine preparation - Google Patents
Nifedipine preparationInfo
- Publication number
- JPS5495721A JPS5495721A JP111778A JP111778A JPS5495721A JP S5495721 A JPS5495721 A JP S5495721A JP 111778 A JP111778 A JP 111778A JP 111778 A JP111778 A JP 111778A JP S5495721 A JPS5495721 A JP S5495721A
- Authority
- JP
- Japan
- Prior art keywords
- nifedipine
- glycerine
- mixture
- dimethyl
- propylene glycol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To provide a rapid-acting nifedipine preparation which produces precipitate in water, by dissolving nifedipine which is a coronary vessel dilator, in a mixture of polyoxyethylene derivative, glycerine, and propylene glycol.
CONSTITUTION: One part of dimethyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)- 3,5-pyridine dicarboxylate (nifedipine) is added to 20-40 parts of a mixture composed of 10-90% of a polyoxyethylene derivative, pref. having an HLB of 10-20, e.g. polyoxyethylene hardened castor oil derivative, and 90-10% of glycerine or a mixture of glycerine and propylene glycol, and slowly heated to 60-70°C to obtain a clear liquid. The liquid thus obtained is used as it is, or, if necessary, encapsulated with soft carsule or hard capsule, or absorbed to hydrous or anhydrous silicic acid.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP111778A JPS5495721A (en) | 1978-01-11 | 1978-01-11 | Nifedipine preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP111778A JPS5495721A (en) | 1978-01-11 | 1978-01-11 | Nifedipine preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5495721A true JPS5495721A (en) | 1979-07-28 |
JPS612046B2 JPS612046B2 (en) | 1986-01-22 |
Family
ID=11492506
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP111778A Granted JPS5495721A (en) | 1978-01-11 | 1978-01-11 | Nifedipine preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5495721A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5777626A (en) * | 1980-06-25 | 1982-05-15 | Procter & Gamble | Palatable composition containing oil or oily substance |
JPS62242613A (en) * | 1986-04-11 | 1987-10-23 | アクチエボラゲツト・ヘツスレ | Slow release novel medicine |
EP0277459A2 (en) * | 1987-02-02 | 1988-08-10 | Mepha AG | Sustained release drug |
WO2003094897A1 (en) | 2002-05-09 | 2003-11-20 | Chugai Seiyaku Kabushiki Kaisha | Photostabilized soft capsule |
-
1978
- 1978-01-11 JP JP111778A patent/JPS5495721A/en active Granted
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5777626A (en) * | 1980-06-25 | 1982-05-15 | Procter & Gamble | Palatable composition containing oil or oily substance |
JPH049768B2 (en) * | 1980-06-25 | 1992-02-21 | ||
JPS62242613A (en) * | 1986-04-11 | 1987-10-23 | アクチエボラゲツト・ヘツスレ | Slow release novel medicine |
EP0277459A2 (en) * | 1987-02-02 | 1988-08-10 | Mepha AG | Sustained release drug |
WO2003094897A1 (en) | 2002-05-09 | 2003-11-20 | Chugai Seiyaku Kabushiki Kaisha | Photostabilized soft capsule |
Also Published As
Publication number | Publication date |
---|---|
JPS612046B2 (en) | 1986-01-22 |
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