CO5200763A1 - Compuestos de carboxamida con actividad anticonvulsionante y su preparacion - Google Patents

Compuestos de carboxamida con actividad anticonvulsionante y su preparacion

Info

Publication number
CO5200763A1
CO5200763A1 CO00049344A CO00049344A CO5200763A1 CO 5200763 A1 CO5200763 A1 CO 5200763A1 CO 00049344 A CO00049344 A CO 00049344A CO 00049344 A CO00049344 A CO 00049344A CO 5200763 A1 CO5200763 A1 CO 5200763A1
Authority
CO
Colombia
Prior art keywords
alkyl
cycloalkyl
hydrogen
perfluoroalkyl
halogen
Prior art date
Application number
CO00049344A
Other languages
English (en)
Inventor
John David Harling
Mervyn Thompson
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of CO5200763A1 publication Critical patent/CO5200763A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un compuesto de fórmula (I):<EMI FILE="00049344_1" ID="1" IMF=JPEG >en la que:Q es un anillo de arilo o heteroarilo monociclíco o biciclíco;R1 es hidrógeno;R2 es hidrógeno o hasta tres sustituyentes seleccionados entre halógeno, NO2, CN, N3, CF3-O-, CF3-S, CF3-SO2-, CF3CO-, alquilo C1-6, alquenilo C1-6, alquinilo C1-6 perfluoroalquilo C1-6, cicloalquilo C3-6, cicloalquil C3-6-alquilo C1-4, alquil C1-6-O-alquil C1-6-CO-, cicloalquil C3-6-O-, cicloalquil C3-6-CO-, cicloalquilC3-6-alquilC1-4-O-, cicloalquil C3-6-alquil C1-4-CO-, fenilo, fenoxi, benciloxi, benzoílo, fenil-alquilo C1-4, alquil C1-6-S-, alquil C1-6-SO2-, (alquil C1-4)2-NSO2-, (alquil C1-4)-NHSO2-, (alquil C1-4)2-NCO-, (alquil C1-4)-NHCO- ó CONH2, o -NR3R4 en donde R3 es hidrógeno o alquilo C1-4, y R4 es hidrógeno, alquilo C1-4; formilo, -CO2-alquilo C1-4 o -CO-alquilo C1-4, o dos grupos R2 juntos forman un anillo carbocíclico que es saturado o insaturado, no sustituido o sustituido con -OH u =O;X es halógeno; alcoxi C1-6, alquilo C1-6 o perfluoroalquilo C1-6, eY es hidrógeno, halógeno, alcoxi C1-6, alquilo C1-6 o perfluoroalquilo C1-6;pero excluyendo los compuestos N-(5-yodo-1,2,3,4-tetrahidroisoquinolin-7-il)-4-azidobenzamida y N-(5-yodo-1, 2,3,4-tetrahidroisoquinolin-7-il)-5-benzoil-2-metoxibenzamida;o una sal o un solvato farmacéuticamente aceptable del mismo.
CO00049344A 1999-07-02 2000-06-30 Compuestos de carboxamida con actividad anticonvulsionante y su preparacion CO5200763A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9915589.7A GB9915589D0 (en) 1999-07-02 1999-07-02 Novel compounds

Publications (1)

Publication Number Publication Date
CO5200763A1 true CO5200763A1 (es) 2002-09-27

Family

ID=10856577

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00049344A CO5200763A1 (es) 1999-07-02 2000-06-30 Compuestos de carboxamida con actividad anticonvulsionante y su preparacion

Country Status (30)

Country Link
US (3) US6492388B1 (es)
EP (2) EP1200409B1 (es)
JP (2) JP4108977B2 (es)
KR (1) KR20020016879A (es)
CN (1) CN1192022C (es)
AR (1) AR029375A1 (es)
AT (2) ATE307115T1 (es)
AU (1) AU762716B2 (es)
BR (1) BR0011862A (es)
CA (2) CA2376495A1 (es)
CO (1) CO5200763A1 (es)
CY (1) CY1105373T1 (es)
CZ (1) CZ20014721A3 (es)
DE (2) DE60008539T2 (es)
DK (2) DK1367055T3 (es)
ES (2) ES2214287T3 (es)
GB (1) GB9915589D0 (es)
GC (1) GC0000195A (es)
HK (2) HK1047090B (es)
HU (1) HUP0203210A3 (es)
IL (1) IL147103A0 (es)
MX (1) MXPA02000064A (es)
MY (1) MY123639A (es)
NO (2) NO20016273D0 (es)
NZ (2) NZ534600A (es)
PL (1) PL355845A1 (es)
PT (1) PT1200409E (es)
SI (2) SI1367055T1 (es)
WO (1) WO2001002366A2 (es)
ZA (1) ZA200200341B (es)

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GB0518237D0 (en) * 2005-09-07 2005-10-19 Angeletti P Ist Richerche Bio Therapeutic compounds
EP2927215A1 (en) 2014-04-03 2015-10-07 Farma-Derma S.R.L. Copper chelators

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Also Published As

Publication number Publication date
AU5692800A (en) 2001-01-22
NZ516130A (en) 2004-11-26
US20030036551A1 (en) 2003-02-20
ATE307115T1 (de) 2005-11-15
CY1105373T1 (el) 2010-04-28
EP1200409A2 (en) 2002-05-02
HUP0203210A2 (hu) 2003-01-28
EP1367055B1 (en) 2005-10-19
AU762716B2 (en) 2003-07-03
GC0000195A (en) 2006-03-29
WO2001002366A2 (en) 2001-01-11
IL147103A0 (en) 2002-08-14
CZ20014721A3 (cs) 2002-05-15
US20040142964A1 (en) 2004-07-22
ATE260259T1 (de) 2004-03-15
CA2376495A1 (en) 2001-01-11
ES2214287T3 (es) 2004-09-16
PL355845A1 (en) 2004-05-31
KR20020016879A (ko) 2002-03-06
DE60008539T2 (de) 2004-12-23
EP1367055A1 (en) 2003-12-03
PT1200409E (pt) 2004-06-30
DE60023362D1 (de) 2006-03-02
JP4108977B2 (ja) 2008-06-25
NO20016273L (no) 2001-12-20
HK1047090B (zh) 2004-12-24
ES2251665T3 (es) 2006-05-01
MXPA02000064A (es) 2002-07-02
CA2527931A1 (en) 2001-01-11
NZ534600A (en) 2006-03-31
ZA200200341B (en) 2004-01-28
US6492388B1 (en) 2002-12-10
NO20061099L (no) 2001-01-03
DE60008539D1 (de) 2004-04-01
DK1200409T3 (da) 2004-06-28
DK1367055T3 (da) 2006-02-27
JP2007145862A (ja) 2007-06-14
WO2001002366A3 (en) 2001-04-19
CN1390205A (zh) 2003-01-08
DE60023362T2 (de) 2006-07-06
US6770657B2 (en) 2004-08-03
HK1047090A1 (en) 2003-02-07
BR0011862A (pt) 2002-04-09
HUP0203210A3 (en) 2003-02-28
NO20016273D0 (no) 2001-12-20
SI1367055T1 (sl) 2006-02-28
EP1200409B1 (en) 2004-02-25
US7105536B2 (en) 2006-09-12
HK1062436A1 (en) 2004-11-05
MY123639A (en) 2006-05-31
AR029375A1 (es) 2003-06-25
CN1192022C (zh) 2005-03-09
JP2003527316A (ja) 2003-09-16
SI1200409T1 (en) 2004-08-31
GB9915589D0 (en) 1999-09-01

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