NO20061099L - Nye forbindelser - Google Patents

Nye forbindelser

Info

Publication number
NO20061099L
NO20061099L NO20061099A NO20061099A NO20061099L NO 20061099 L NO20061099 L NO 20061099L NO 20061099 A NO20061099 A NO 20061099A NO 20061099 A NO20061099 A NO 20061099A NO 20061099 L NO20061099 L NO 20061099L
Authority
NO
Norway
Prior art keywords
alkyl
hydrogen
4alkyl
halogen
tetrahydroisoquinolin
Prior art date
Application number
NO20061099A
Other languages
English (en)
Inventor
John David Harling
Mervyn Thompson
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO20061099L publication Critical patent/NO20061099L/no
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Forbindelser med formel (I) hvori Q er en monocyklisk eller bicyklisk aryl- eller heteroarylring; R1 er hydrogen; R2 er hydrogen eller opptil tre substituenter valgt fra halogen, NO2, CN, N3, CF3O-, CF3S-, CF3SO2-, CF3CO-, Cj^alkyl, Cj.galkenyl, Cj. galkynyl, Cj.gperfluoralkyl, C3_6cykloalkyl, C3_6cykloalkyl-C^_4alkyl-, Cj.galkylO-, C^galkylCO-, C3_6cykloalkylO-, C3_6cykloalkylCO-,C3_6cykloalkyl-C1_4alkylO-, C3. gcykloalkyl-C^alkylCO-, fen yl, fenoksy, benzyloksy, benzoyl, fenyl-C^alkyl-, Cj. 6alkylS-, C1.6alkylSO2-, (C1.4alkyl)2NSO2-, (C1.4alkyl)NHSO2-, (C1.4alkyl)2NCO-, (Ci^alkyl)NHCO- eller CONH2 eller -NR3R4 hvori R3 er hydrogen eller C^ alkyl og R4 er hydrogen, C^alkyl, formyl, -CO2Cj.4alkyl eller -COCi_4alkyl eller to R2 grupper sammen danner en karbocyklisk ring som er mettet eller umettet og usubstituert eller substituert med -OH eller =0; X er halogen, C^.g alkoksy, C^.g alkyl eller C^.6 perfluoralkyl og; Y er hydrogen, halogen, C^.g alkoksy, Ci_6 alkyl eller C j.g perfluoralkyl; men med unntak av forbindelsene N-(5-Jod-1,2,3,4-tetrahydroisokinolin-7-yl)-4-azidobenzamid, N-(5-jod-l,2,3,4-tetrahydroisokinolin-7-yl)-5-benzoyl-2-metoksybenzamid og N-(5,8-diklor-1,2,3,4-tetrahydroisokinolin-7-yl)-3-acetyl-4-isø-propoksybenzamid; og farmasøytisk akseptable salter eller solvater derav har antikonvulsiv aktivitet og er anvendelige ved behandling av en rekke forstyrrelser.
NO20061099A 1999-07-02 2006-03-07 Nye forbindelser NO20061099L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9915589.7A GB9915589D0 (en) 1999-07-02 1999-07-02 Novel compounds

Publications (1)

Publication Number Publication Date
NO20061099L true NO20061099L (no) 2001-01-03

Family

ID=10856577

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20016273A NO20016273D0 (no) 1999-07-02 2001-12-20 Nye forbindelser
NO20061099A NO20061099L (no) 1999-07-02 2006-03-07 Nye forbindelser

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20016273A NO20016273D0 (no) 1999-07-02 2001-12-20 Nye forbindelser

Country Status (30)

Country Link
US (3) US6492388B1 (no)
EP (2) EP1200409B1 (no)
JP (2) JP4108977B2 (no)
KR (1) KR20020016879A (no)
CN (1) CN1192022C (no)
AR (1) AR029375A1 (no)
AT (2) ATE307115T1 (no)
AU (1) AU762716B2 (no)
BR (1) BR0011862A (no)
CA (2) CA2376495A1 (no)
CO (1) CO5200763A1 (no)
CY (1) CY1105373T1 (no)
CZ (1) CZ20014721A3 (no)
DE (2) DE60023362T2 (no)
DK (2) DK1200409T3 (no)
ES (2) ES2214287T3 (no)
GB (1) GB9915589D0 (no)
GC (1) GC0000195A (no)
HK (2) HK1047090B (no)
HU (1) HUP0203210A3 (no)
IL (1) IL147103A0 (no)
MX (1) MXPA02000064A (no)
MY (1) MY123639A (no)
NO (2) NO20016273D0 (no)
NZ (2) NZ534600A (no)
PL (1) PL355845A1 (no)
PT (1) PT1200409E (no)
SI (2) SI1200409T1 (no)
WO (1) WO2001002366A2 (no)
ZA (1) ZA200200341B (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010016657A1 (en) * 1997-03-18 2001-08-23 Smithkline Beecham P.L.C. Substituted isoquinoline derivatives and their use as anticonvulsants
GB9915589D0 (en) * 1999-07-02 1999-09-01 Smithkline Beecham Plc Novel compounds
CN100341163C (zh) * 2004-03-29 2007-10-03 宏齐科技股份有限公司 白光发光二极管单元
GB0518237D0 (en) * 2005-09-07 2005-10-19 Angeletti P Ist Richerche Bio Therapeutic compounds
EP2927215A1 (en) 2014-04-03 2015-10-07 Farma-Derma S.R.L. Copper chelators

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Also Published As

Publication number Publication date
DE60023362D1 (de) 2006-03-02
NO20016273L (no) 2001-12-20
US7105536B2 (en) 2006-09-12
NZ534600A (en) 2006-03-31
EP1200409B1 (en) 2004-02-25
JP4108977B2 (ja) 2008-06-25
DE60023362T2 (de) 2006-07-06
JP2003527316A (ja) 2003-09-16
US6770657B2 (en) 2004-08-03
US6492388B1 (en) 2002-12-10
MXPA02000064A (es) 2002-07-02
MY123639A (en) 2006-05-31
KR20020016879A (ko) 2002-03-06
HK1062436A1 (en) 2004-11-05
US20030036551A1 (en) 2003-02-20
DK1200409T3 (da) 2004-06-28
IL147103A0 (en) 2002-08-14
PT1200409E (pt) 2004-06-30
CN1390205A (zh) 2003-01-08
DE60008539T2 (de) 2004-12-23
HUP0203210A3 (en) 2003-02-28
CZ20014721A3 (cs) 2002-05-15
SI1367055T1 (sl) 2006-02-28
GC0000195A (en) 2006-03-29
AU762716B2 (en) 2003-07-03
CN1192022C (zh) 2005-03-09
HK1047090A1 (en) 2003-02-07
ES2251665T3 (es) 2006-05-01
WO2001002366A3 (en) 2001-04-19
ES2214287T3 (es) 2004-09-16
CY1105373T1 (el) 2010-04-28
PL355845A1 (en) 2004-05-31
GB9915589D0 (en) 1999-09-01
NZ516130A (en) 2004-11-26
ATE260259T1 (de) 2004-03-15
HK1047090B (zh) 2004-12-24
HUP0203210A2 (hu) 2003-01-28
AR029375A1 (es) 2003-06-25
EP1367055B1 (en) 2005-10-19
DK1367055T3 (da) 2006-02-27
ATE307115T1 (de) 2005-11-15
BR0011862A (pt) 2002-04-09
DE60008539D1 (de) 2004-04-01
CO5200763A1 (es) 2002-09-27
WO2001002366A2 (en) 2001-01-11
EP1367055A1 (en) 2003-12-03
EP1200409A2 (en) 2002-05-02
JP2007145862A (ja) 2007-06-14
SI1200409T1 (en) 2004-08-31
CA2527931A1 (en) 2001-01-11
NO20016273D0 (no) 2001-12-20
US20040142964A1 (en) 2004-07-22
ZA200200341B (en) 2004-01-28
CA2376495A1 (en) 2001-01-11
AU5692800A (en) 2001-01-22

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