DE60023362D1 - Isochinolincarboxamide und ihre Verwendung als anticonvulsiva - Google Patents

Isochinolincarboxamide und ihre Verwendung als anticonvulsiva

Info

Publication number
DE60023362D1
DE60023362D1 DE60023362T DE60023362T DE60023362D1 DE 60023362 D1 DE60023362 D1 DE 60023362D1 DE 60023362 T DE60023362 T DE 60023362T DE 60023362 T DE60023362 T DE 60023362T DE 60023362 D1 DE60023362 D1 DE 60023362D1
Authority
DE
Germany
Prior art keywords
anticonvulsants
isoquinoline carboxamides
carboxamides
isoquinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60023362T
Other languages
English (en)
Other versions
DE60023362T2 (de
Inventor
John David Harling
Mervyn Thompson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of DE60023362D1 publication Critical patent/DE60023362D1/de
Application granted granted Critical
Publication of DE60023362T2 publication Critical patent/DE60023362T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60023362T 1999-07-02 2000-06-29 Isochinolincarboxamide und ihre Verwendung als anticonvulsiva Expired - Lifetime DE60023362T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9915589.7A GB9915589D0 (en) 1999-07-02 1999-07-02 Novel compounds
GB9915589 1999-07-02

Publications (2)

Publication Number Publication Date
DE60023362D1 true DE60023362D1 (de) 2006-03-02
DE60023362T2 DE60023362T2 (de) 2006-07-06

Family

ID=10856577

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60008539T Expired - Lifetime DE60008539T2 (de) 1999-07-02 2000-06-29 Substituierte isochinolinderivate und ihre verwendung als anticonvulsiva
DE60023362T Expired - Lifetime DE60023362T2 (de) 1999-07-02 2000-06-29 Isochinolincarboxamide und ihre Verwendung als anticonvulsiva

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60008539T Expired - Lifetime DE60008539T2 (de) 1999-07-02 2000-06-29 Substituierte isochinolinderivate und ihre verwendung als anticonvulsiva

Country Status (30)

Country Link
US (3) US6492388B1 (de)
EP (2) EP1200409B1 (de)
JP (2) JP4108977B2 (de)
KR (1) KR20020016879A (de)
CN (1) CN1192022C (de)
AR (1) AR029375A1 (de)
AT (2) ATE307115T1 (de)
AU (1) AU762716B2 (de)
BR (1) BR0011862A (de)
CA (2) CA2376495A1 (de)
CO (1) CO5200763A1 (de)
CY (1) CY1105373T1 (de)
CZ (1) CZ20014721A3 (de)
DE (2) DE60008539T2 (de)
DK (2) DK1367055T3 (de)
ES (2) ES2214287T3 (de)
GB (1) GB9915589D0 (de)
GC (1) GC0000195A (de)
HK (2) HK1047090B (de)
HU (1) HUP0203210A3 (de)
IL (1) IL147103A0 (de)
MX (1) MXPA02000064A (de)
MY (1) MY123639A (de)
NO (2) NO20016273D0 (de)
NZ (2) NZ534600A (de)
PL (1) PL355845A1 (de)
PT (1) PT1200409E (de)
SI (2) SI1367055T1 (de)
WO (1) WO2001002366A2 (de)
ZA (1) ZA200200341B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010016657A1 (en) * 1997-03-18 2001-08-23 Smithkline Beecham P.L.C. Substituted isoquinoline derivatives and their use as anticonvulsants
GB9915589D0 (en) * 1999-07-02 1999-09-01 Smithkline Beecham Plc Novel compounds
CN100341163C (zh) * 2004-03-29 2007-10-03 宏齐科技股份有限公司 白光发光二极管单元
GB0518237D0 (en) * 2005-09-07 2005-10-19 Angeletti P Ist Richerche Bio Therapeutic compounds
EP2927215A1 (de) 2014-04-03 2015-10-07 Farma-Derma S.R.L. Kupferchelatbildner

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JP3271453B2 (ja) * 1994-12-28 2002-04-02 三菱電機株式会社 半導体装置における素子分離領域の形成方法
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TR199902283T2 (xx) * 1997-03-18 1999-12-21 Smithkline Beecham P.L.C. �kame edilmi� izokuinolin t�revleri ve bunlar�n antikonvulsant olarak kullan�m�.
DZ2446A1 (fr) 1997-03-18 2003-01-11 Smithkline Beecham Plc Nouveaux composés
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Also Published As

Publication number Publication date
AU5692800A (en) 2001-01-22
NZ516130A (en) 2004-11-26
US20030036551A1 (en) 2003-02-20
ATE307115T1 (de) 2005-11-15
CY1105373T1 (el) 2010-04-28
EP1200409A2 (de) 2002-05-02
HUP0203210A2 (hu) 2003-01-28
EP1367055B1 (de) 2005-10-19
AU762716B2 (en) 2003-07-03
GC0000195A (en) 2006-03-29
WO2001002366A2 (en) 2001-01-11
IL147103A0 (en) 2002-08-14
CZ20014721A3 (cs) 2002-05-15
US20040142964A1 (en) 2004-07-22
ATE260259T1 (de) 2004-03-15
CA2376495A1 (en) 2001-01-11
ES2214287T3 (es) 2004-09-16
PL355845A1 (en) 2004-05-31
KR20020016879A (ko) 2002-03-06
DE60008539T2 (de) 2004-12-23
EP1367055A1 (de) 2003-12-03
PT1200409E (pt) 2004-06-30
JP4108977B2 (ja) 2008-06-25
NO20016273L (no) 2001-12-20
HK1047090B (zh) 2004-12-24
ES2251665T3 (es) 2006-05-01
MXPA02000064A (es) 2002-07-02
CA2527931A1 (en) 2001-01-11
NZ534600A (en) 2006-03-31
ZA200200341B (en) 2004-01-28
US6492388B1 (en) 2002-12-10
NO20061099L (no) 2001-01-03
DE60008539D1 (de) 2004-04-01
DK1200409T3 (da) 2004-06-28
DK1367055T3 (da) 2006-02-27
JP2007145862A (ja) 2007-06-14
WO2001002366A3 (en) 2001-04-19
CN1390205A (zh) 2003-01-08
DE60023362T2 (de) 2006-07-06
CO5200763A1 (es) 2002-09-27
US6770657B2 (en) 2004-08-03
HK1047090A1 (en) 2003-02-07
BR0011862A (pt) 2002-04-09
HUP0203210A3 (en) 2003-02-28
NO20016273D0 (no) 2001-12-20
SI1367055T1 (sl) 2006-02-28
EP1200409B1 (de) 2004-02-25
US7105536B2 (en) 2006-09-12
HK1062436A1 (en) 2004-11-05
MY123639A (en) 2006-05-31
AR029375A1 (es) 2003-06-25
CN1192022C (zh) 2005-03-09
JP2003527316A (ja) 2003-09-16
SI1200409T1 (en) 2004-08-31
GB9915589D0 (en) 1999-09-01

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