SI1367055T1 - Izokinolinil-karboksamidi in njihova uporaba kot antikonvulzivi - Google Patents

Izokinolinil-karboksamidi in njihova uporaba kot antikonvulzivi

Info

Publication number
SI1367055T1
SI1367055T1 SI200030777T SI200030777T SI1367055T1 SI 1367055 T1 SI1367055 T1 SI 1367055T1 SI 200030777 T SI200030777 T SI 200030777T SI 200030777 T SI200030777 T SI 200030777T SI 1367055 T1 SI1367055 T1 SI 1367055T1
Authority
SI
Slovenia
Prior art keywords
anticonvulsants
carboxamides
isoquinolinyl
isoquinolinyl carboxamides
Prior art date
Application number
SI200030777T
Other languages
English (en)
Inventor
John David Harling
Mervyn Thompson
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of SI1367055T1 publication Critical patent/SI1367055T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SI200030777T 1999-07-02 2000-06-29 Izokinolinil-karboksamidi in njihova uporaba kot antikonvulzivi SI1367055T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9915589.7A GB9915589D0 (en) 1999-07-02 1999-07-02 Novel compounds
EP03076336A EP1367055B1 (en) 1999-07-02 2000-06-29 Isoquinolinyl carboxamides and their use as anticonvulsants

Publications (1)

Publication Number Publication Date
SI1367055T1 true SI1367055T1 (sl) 2006-02-28

Family

ID=10856577

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200030777T SI1367055T1 (sl) 1999-07-02 2000-06-29 Izokinolinil-karboksamidi in njihova uporaba kot antikonvulzivi
SI200030374T SI1200409T1 (sl) 1999-07-02 2000-06-29 Substituirani derivati izokvinolina in njihova uporaba pri preprečevanju bolezenskih napadov krčev

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200030374T SI1200409T1 (sl) 1999-07-02 2000-06-29 Substituirani derivati izokvinolina in njihova uporaba pri preprečevanju bolezenskih napadov krčev

Country Status (30)

Country Link
US (3) US6492388B1 (sl)
EP (2) EP1200409B1 (sl)
JP (2) JP4108977B2 (sl)
KR (1) KR20020016879A (sl)
CN (1) CN1192022C (sl)
AR (1) AR029375A1 (sl)
AT (2) ATE307115T1 (sl)
AU (1) AU762716B2 (sl)
BR (1) BR0011862A (sl)
CA (2) CA2376495A1 (sl)
CO (1) CO5200763A1 (sl)
CY (1) CY1105373T1 (sl)
CZ (1) CZ20014721A3 (sl)
DE (2) DE60008539T2 (sl)
DK (2) DK1367055T3 (sl)
ES (2) ES2214287T3 (sl)
GB (1) GB9915589D0 (sl)
GC (1) GC0000195A (sl)
HK (2) HK1047090B (sl)
HU (1) HUP0203210A3 (sl)
IL (1) IL147103A0 (sl)
MX (1) MXPA02000064A (sl)
MY (1) MY123639A (sl)
NO (2) NO20016273D0 (sl)
NZ (2) NZ534600A (sl)
PL (1) PL355845A1 (sl)
PT (1) PT1200409E (sl)
SI (2) SI1367055T1 (sl)
WO (1) WO2001002366A2 (sl)
ZA (1) ZA200200341B (sl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010016657A1 (en) * 1997-03-18 2001-08-23 Smithkline Beecham P.L.C. Substituted isoquinoline derivatives and their use as anticonvulsants
GB9915589D0 (en) * 1999-07-02 1999-09-01 Smithkline Beecham Plc Novel compounds
CN100341163C (zh) * 2004-03-29 2007-10-03 宏齐科技股份有限公司 白光发光二极管单元
GB0518237D0 (en) * 2005-09-07 2005-10-19 Angeletti P Ist Richerche Bio Therapeutic compounds
EP2927215A1 (en) 2014-04-03 2015-10-07 Farma-Derma S.R.L. Copper chelators

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Also Published As

Publication number Publication date
AU5692800A (en) 2001-01-22
NZ516130A (en) 2004-11-26
US20030036551A1 (en) 2003-02-20
ATE307115T1 (de) 2005-11-15
CY1105373T1 (el) 2010-04-28
EP1200409A2 (en) 2002-05-02
HUP0203210A2 (hu) 2003-01-28
EP1367055B1 (en) 2005-10-19
AU762716B2 (en) 2003-07-03
GC0000195A (en) 2006-03-29
WO2001002366A2 (en) 2001-01-11
IL147103A0 (en) 2002-08-14
CZ20014721A3 (cs) 2002-05-15
US20040142964A1 (en) 2004-07-22
ATE260259T1 (de) 2004-03-15
CA2376495A1 (en) 2001-01-11
ES2214287T3 (es) 2004-09-16
PL355845A1 (en) 2004-05-31
KR20020016879A (ko) 2002-03-06
DE60008539T2 (de) 2004-12-23
EP1367055A1 (en) 2003-12-03
PT1200409E (pt) 2004-06-30
DE60023362D1 (de) 2006-03-02
JP4108977B2 (ja) 2008-06-25
NO20016273L (no) 2001-12-20
HK1047090B (zh) 2004-12-24
ES2251665T3 (es) 2006-05-01
MXPA02000064A (es) 2002-07-02
CA2527931A1 (en) 2001-01-11
NZ534600A (en) 2006-03-31
ZA200200341B (en) 2004-01-28
US6492388B1 (en) 2002-12-10
NO20061099L (no) 2001-01-03
DE60008539D1 (de) 2004-04-01
DK1200409T3 (da) 2004-06-28
DK1367055T3 (da) 2006-02-27
JP2007145862A (ja) 2007-06-14
WO2001002366A3 (en) 2001-04-19
CN1390205A (zh) 2003-01-08
DE60023362T2 (de) 2006-07-06
CO5200763A1 (es) 2002-09-27
US6770657B2 (en) 2004-08-03
HK1047090A1 (en) 2003-02-07
BR0011862A (pt) 2002-04-09
HUP0203210A3 (en) 2003-02-28
NO20016273D0 (no) 2001-12-20
EP1200409B1 (en) 2004-02-25
US7105536B2 (en) 2006-09-12
HK1062436A1 (en) 2004-11-05
MY123639A (en) 2006-05-31
AR029375A1 (es) 2003-06-25
CN1192022C (zh) 2005-03-09
JP2003527316A (ja) 2003-09-16
SI1200409T1 (sl) 2004-08-31
GB9915589D0 (en) 1999-09-01

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