BR0011862A - Derivados substituìdos de isoquinolina e seu uso como anticonvulsivantes - Google Patents

Derivados substituìdos de isoquinolina e seu uso como anticonvulsivantes

Info

Publication number
BR0011862A
BR0011862A BR0011862-1A BR0011862A BR0011862A BR 0011862 A BR0011862 A BR 0011862A BR 0011862 A BR0011862 A BR 0011862A BR 0011862 A BR0011862 A BR 0011862A
Authority
BR
Brazil
Prior art keywords
alkyl
cycloalkyl
hydrogen
perfluoro
halogen
Prior art date
Application number
BR0011862-1A
Other languages
English (en)
Inventor
John David Harling
Mervyn Thompson
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of BR0011862A publication Critical patent/BR0011862A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"DERIVADOS SUBSTITUìDOS DE ISOQUINOLINA E SEU USO COMO ANTICONVULSIVANTES". Descreve-se compostos da fórmula (I) nos quais Q é um anel arila ou heteroarila monocíclico ou bicíclico; R^ 1^ é hidrogênio; R^ 2^ é hidrogênio ou até três substituintes selecionados entre halogênio, NO~ 2~, CN, N~ 3~, CF~ 3~O-, CF~ 3~S-, CF~ 3~SO~ 2~-, CF~ 3~CO-, alquila de C~ 1-6~, alquenila de C~ 1-6~, alquinila de C~ 1-6~, perflúor-alquila de C~ 1-6~, ciclo-alquila de C~ 3-6~, ciclo-alquil(C~ 3-6~)-alquila(C~ 1-4~), alquil(C~ 1-6~)O-, alquil(C~ 1-6~) CO-, ciclo-alquil(C~ 3-6~)O-, ciclo-alquil(C~ 3-6~)CO-, ciclo-alquil(C~ 3-6~)alquil(C~ 1-4~)O-, ciclo-alquil(C~ 3-6~)-alquil(C~ 1-4~)CO-, fenila, fenóxi, benzilóxi, benzoíla, fenil-alquila(C~ 1-4~), alquil(C~ 1-6~)Salquil(C~ 1-6~)SO~ 2~-, [alquil (C~ 1-4~)]~ 2~NSO~ 2~- [alquil (C~ 1-4~)]~ 2~NHSO~ 2~-, [alquil(C~ 1-4~)]~ 2~NCO-, alquil(C~ 1-4~)NHCO-, ou CONH~ 2~, ou -NR^ 3^R^ 4^, onde R^ 3^ é hidrogênio ou alquila de C1-4, e R^ 4^ é hidrogênio, alquila de C1-4 formila, -CO~ 2~-alquila (C~ 1-4~) ou -CO-alquila(C~ 1-4~), ou dois grupos R^ 2^ juntos formam um anel carbocíclico que é saturado ou insaturado e não-substituído ou substituído com -OH ou =O; X e halogênio, alcóxi de C~ 1-6~, alquila de C~ 1-6~, ou perflúor-alquila de C~ 1-6~, e Y é hidrogênio, halogênio, alcóxi de C~ 1-6~, alquila de C~ 1-6~, ou perflúor-alquila de C~ 1-6~; porém excluindo os compostos N-(5-iodo-1,2,3,4-tetraidroísoquinolin-7-il)-4-azidobenzamida e N-(5-iodo-1,2,3,4-tetraidroisoquinolin-7-il)-5benzoil-2-metóxi-benzami da; e seus sais ou solvatos de uso farmacêutico; que possuem atividade anticonvulsivante e são úteis no tratamento de uma série de distúrbios.
BR0011862-1A 1999-07-02 2000-06-29 Derivados substituìdos de isoquinolina e seu uso como anticonvulsivantes BR0011862A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9915589.7A GB9915589D0 (en) 1999-07-02 1999-07-02 Novel compounds
PCT/GB2000/002500 WO2001002366A2 (en) 1999-07-02 2000-06-29 Substituted isoquinoline derivatives and their use as inticonvulsants

Publications (1)

Publication Number Publication Date
BR0011862A true BR0011862A (pt) 2002-04-09

Family

ID=10856577

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0011862-1A BR0011862A (pt) 1999-07-02 2000-06-29 Derivados substituìdos de isoquinolina e seu uso como anticonvulsivantes

Country Status (30)

Country Link
US (3) US6492388B1 (pt)
EP (2) EP1200409B1 (pt)
JP (2) JP4108977B2 (pt)
KR (1) KR20020016879A (pt)
CN (1) CN1192022C (pt)
AR (1) AR029375A1 (pt)
AT (2) ATE307115T1 (pt)
AU (1) AU762716B2 (pt)
BR (1) BR0011862A (pt)
CA (2) CA2376495A1 (pt)
CO (1) CO5200763A1 (pt)
CY (1) CY1105373T1 (pt)
CZ (1) CZ20014721A3 (pt)
DE (2) DE60008539T2 (pt)
DK (2) DK1367055T3 (pt)
ES (2) ES2214287T3 (pt)
GB (1) GB9915589D0 (pt)
GC (1) GC0000195A (pt)
HK (2) HK1047090B (pt)
HU (1) HUP0203210A3 (pt)
IL (1) IL147103A0 (pt)
MX (1) MXPA02000064A (pt)
MY (1) MY123639A (pt)
NO (2) NO20016273D0 (pt)
NZ (2) NZ534600A (pt)
PL (1) PL355845A1 (pt)
PT (1) PT1200409E (pt)
SI (2) SI1367055T1 (pt)
WO (1) WO2001002366A2 (pt)
ZA (1) ZA200200341B (pt)

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EP2927215A1 (en) 2014-04-03 2015-10-07 Farma-Derma S.R.L. Copper chelators

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Also Published As

Publication number Publication date
AU5692800A (en) 2001-01-22
NZ516130A (en) 2004-11-26
US20030036551A1 (en) 2003-02-20
ATE307115T1 (de) 2005-11-15
CY1105373T1 (el) 2010-04-28
EP1200409A2 (en) 2002-05-02
HUP0203210A2 (hu) 2003-01-28
EP1367055B1 (en) 2005-10-19
AU762716B2 (en) 2003-07-03
GC0000195A (en) 2006-03-29
WO2001002366A2 (en) 2001-01-11
IL147103A0 (en) 2002-08-14
CZ20014721A3 (cs) 2002-05-15
US20040142964A1 (en) 2004-07-22
ATE260259T1 (de) 2004-03-15
CA2376495A1 (en) 2001-01-11
ES2214287T3 (es) 2004-09-16
PL355845A1 (en) 2004-05-31
KR20020016879A (ko) 2002-03-06
DE60008539T2 (de) 2004-12-23
EP1367055A1 (en) 2003-12-03
PT1200409E (pt) 2004-06-30
DE60023362D1 (de) 2006-03-02
JP4108977B2 (ja) 2008-06-25
NO20016273L (no) 2001-12-20
HK1047090B (zh) 2004-12-24
ES2251665T3 (es) 2006-05-01
MXPA02000064A (es) 2002-07-02
CA2527931A1 (en) 2001-01-11
NZ534600A (en) 2006-03-31
ZA200200341B (en) 2004-01-28
US6492388B1 (en) 2002-12-10
NO20061099L (no) 2001-01-03
DE60008539D1 (de) 2004-04-01
DK1200409T3 (da) 2004-06-28
DK1367055T3 (da) 2006-02-27
JP2007145862A (ja) 2007-06-14
WO2001002366A3 (en) 2001-04-19
CN1390205A (zh) 2003-01-08
DE60023362T2 (de) 2006-07-06
CO5200763A1 (es) 2002-09-27
US6770657B2 (en) 2004-08-03
HK1047090A1 (en) 2003-02-07
HUP0203210A3 (en) 2003-02-28
NO20016273D0 (no) 2001-12-20
SI1367055T1 (sl) 2006-02-28
EP1200409B1 (en) 2004-02-25
US7105536B2 (en) 2006-09-12
HK1062436A1 (en) 2004-11-05
MY123639A (en) 2006-05-31
AR029375A1 (es) 2003-06-25
CN1192022C (zh) 2005-03-09
JP2003527316A (ja) 2003-09-16
SI1200409T1 (en) 2004-08-31
GB9915589D0 (en) 1999-09-01

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