RS51186B - Derivati oksadiazolona kao ppar delta agonisti - Google Patents
Derivati oksadiazolona kao ppar delta agonistiInfo
- Publication number
- RS51186B RS51186B RSP-2009/0391A RSP20090391A RS51186B RS 51186 B RS51186 B RS 51186B RS P20090391 A RSP20090391 A RS P20090391A RS 51186 B RS51186 B RS 51186B
- Authority
- RS
- Serbia
- Prior art keywords
- alkylene
- alkyl
- oxadiayolone
- derivatives
- phenyl
- Prior art date
Links
- 101150014691 PPARA gene Proteins 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 2
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 abstract 2
- 125000004785 fluoromethoxy group Chemical group [H]C([H])(F)O* 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- -1 O-phenyl Chemical group 0.000 abstract 1
- 101100054666 Streptomyces halstedii sch3 gene Proteins 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Jedinjenja formule I:gdeX je CH2 ili veza;Rl, R2, R3, R4 nezavisno su H, F, Cl, Br, CF3, (C1-C4) alkil, (CO-C4) alkilen-O-(CO-C4) alkilen-H, SCH3, S(O)CH3, S(O)2CH3, CN, OCF3, OCHF2, OCH2F; Z je veza ili CH2; Y je O, S, S(O) ili S(O)2; W je CH2 ili CH2CH2; jedan od U i V je N, a dragi je S ili O;R5 je izabran iz grupe koju čine (C1-C8) alkil, (C1-C6) alkilen-O-(CO-C4) alkilen-H, (CO-C6) alkilenfenil, (C1-C6) alkilen-O-(CO-C4) alkilen-fenil, (C3-C6) cikloalkil, (C2-C8) alkenil, i gde (C1-C8) alkil ili alkilen može biti supstituisan 1 - 2 puta sa OH ili O-(C1-C4) alkil;R6, R7 nezavisno su H, F, Br, CF3, OCF3, (C1-C6) alkil, (CO-C4) alkilen-O-(CO-C4) alkilen-H, SCF3, SF5, OCF2-CHF2, OCHF2, OCH2F, O-fenil, fenil, NO2; ilikao i njihove fiziološki prihvatljive soli i tautomerni oblici.Prijava sadrži još 35 patentnih zahteva.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04007879A EP1586573B1 (en) | 2004-04-01 | 2004-04-01 | Oxadiazolones, processes for their preparation and their use as pharmaceuticals |
| PCT/EP2005/002950 WO2005097786A1 (en) | 2004-04-01 | 2005-03-19 | Oxadiazolone derivatives as ppar delta agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS51186B true RS51186B (sr) | 2010-10-31 |
Family
ID=34924545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RSP-2009/0391A RS51186B (sr) | 2004-04-01 | 2005-03-19 | Derivati oksadiazolona kao ppar delta agonisti |
Country Status (37)
| Country | Link |
|---|---|
| US (3) | US20070179191A1 (sr) |
| EP (3) | EP1586573B1 (sr) |
| JP (1) | JP2007530612A (sr) |
| KR (1) | KR20060135857A (sr) |
| CN (1) | CN100582104C (sr) |
| AR (1) | AR050576A1 (sr) |
| AT (1) | ATE435225T1 (sr) |
| AU (1) | AU2005231916A1 (sr) |
| BR (1) | BRPI0509517A (sr) |
| CA (1) | CA2561627A1 (sr) |
| CR (1) | CR8572A (sr) |
| CY (1) | CY1109370T1 (sr) |
| DE (2) | DE602004004631D1 (sr) |
| DK (1) | DK1740583T3 (sr) |
| DO (1) | DOP2005000051A (sr) |
| EC (1) | ECSP066892A (sr) |
| ES (1) | ES2329484T3 (sr) |
| GT (1) | GT200500028A (sr) |
| HR (1) | HRP20090493T1 (sr) |
| IL (1) | IL178056A0 (sr) |
| MA (1) | MA28495B1 (sr) |
| MY (1) | MY142431A (sr) |
| NO (1) | NO20064981L (sr) |
| PA (1) | PA8628701A1 (sr) |
| PE (1) | PE20060323A1 (sr) |
| PL (1) | PL1740583T3 (sr) |
| PT (1) | PT1740583E (sr) |
| RS (1) | RS51186B (sr) |
| RU (1) | RU2374243C2 (sr) |
| SI (1) | SI1740583T1 (sr) |
| SV (1) | SV2006002071A (sr) |
| TN (1) | TNSN06317A1 (sr) |
| TW (1) | TW200602342A (sr) |
| UA (1) | UA84203C2 (sr) |
| UY (1) | UY28837A1 (sr) |
| WO (1) | WO2005097786A1 (sr) |
| ZA (1) | ZA200606870B (sr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060017929A (ko) * | 2004-08-04 | 2006-02-28 | 동화약품공업주식회사 | 티아졸 유도체가 치환된 신규한 벤즈아미딘 유도체, 그의제조방법 및 이를 유효성분으로 하는 약학 조성물 |
| EP1931337B1 (en) | 2005-09-29 | 2013-10-23 | Sanofi | Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals |
| CN101277953A (zh) | 2005-09-29 | 2008-10-01 | 塞诺菲-安万特股份有限公司 | 2－氨基噻唑类和2－氨基唑类衍生物、它们的制备方法及它们作为药物的用途 |
| CA2624105C (en) * | 2005-09-29 | 2014-02-18 | Sanofi-Aventis | Phenyl-[1,2,4]-oxadiazol-5-one derivatives with phenyl group, processes for their preparation and their use as pharmaceuticals |
| WO2008030595A2 (en) | 2006-09-08 | 2008-03-13 | Rhode Island Hospital | Treatment, prevention, and reversal of alcohol-induced liver disease |
| CA2663121C (en) | 2006-09-08 | 2016-01-19 | Rhode Island Hospital | Treatment, prevention, and reversal of alcohol-induced brain disease |
| EP1932843A1 (en) * | 2006-12-14 | 2008-06-18 | sanofi-aventis | Sulfonyl-phenyl-2H-(1,2,4) oxadiazole-5-one derivatives, processes for their preparation and their use as pharmaceuticals |
| US8946212B2 (en) * | 2008-06-09 | 2015-02-03 | Sanofi-Aventis | Annelated N-heterocyclic sulfonamides with oxadiazolone headgroup, processes for their preparation and their use as pharmaceuticals |
| EP2288607B1 (en) | 2008-06-09 | 2014-09-24 | Sanofi | Sulfonamides with heterocycle and oxadiazolone headgroup, processes for their preparation and their use as pharmaceuticals |
| WO2009149819A1 (en) * | 2008-06-09 | 2009-12-17 | Sanofi-Aventis | Annelated pyrrolidin sulfonamides with oxadiazolone headgroup, processes for their preparation and their use as pharmaceuticals |
| CN102202672A (zh) | 2008-10-10 | 2011-09-28 | 达拉生物科学公司 | 使用穗霉素衍生物治疗或预防疼痛的方法 |
| PT3135672T (pt) * | 2008-10-10 | 2020-04-02 | Vm Discovery Inc | Composições e métodos para o tratamento distúrbios de utilização de álcool, dor e outras doenças |
| CA2770405C (en) * | 2009-08-05 | 2015-03-17 | Daiichi Sankyo Company, Limited | Sulfone derivative |
| JP5546542B2 (ja) * | 2009-08-05 | 2014-07-09 | 第一三共株式会社 | アミド誘導体 |
| WO2015061481A1 (en) | 2013-10-23 | 2015-04-30 | Dara Biosciences, Inc. | Methods of treating liquid tumors using compositions comprising spicamycin derivatives |
| US20220387393A1 (en) * | 2019-11-06 | 2022-12-08 | Board Of Regents, The University Of Texas System | Methods for the treatment of dysmyelinating/demyelinating diseases |
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| FR2663336B1 (fr) | 1990-06-18 | 1992-09-04 | Adir | Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| TW222626B (sr) * | 1991-07-22 | 1994-04-21 | Pfizer | |
| IL108634A0 (en) | 1993-02-15 | 1994-05-30 | Wellcome Found | Hypolipidaemic heterocyclic compounds, their prepatation and pharmaceutical compositions containing them |
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| AU757693B2 (en) | 1997-07-16 | 2003-03-06 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine derivatives, their preparation and use |
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| DE19823831A1 (de) | 1998-05-28 | 1999-12-02 | Probiodrug Ges Fuer Arzneim | Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen |
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| DE19828113A1 (de) | 1998-06-24 | 2000-01-05 | Probiodrug Ges Fuer Arzneim | Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV |
| DE19828114A1 (de) | 1998-06-24 | 2000-01-27 | Probiodrug Ges Fuer Arzneim | Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV |
| DE19845405C2 (de) | 1998-10-02 | 2000-07-13 | Aventis Pharma Gmbh | Arylsubstituierte Propanolaminderivate und deren Verwendung |
| GB9900416D0 (en) | 1999-01-08 | 1999-02-24 | Alizyme Therapeutics Ltd | Inhibitors |
| DE19916108C1 (de) | 1999-04-09 | 2001-01-11 | Aventis Pharma Gmbh | Mit Zuckerresten substituierte 1,4-Benzothiazepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und deren Verwendung |
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-
2004
- 2004-04-01 EP EP04007879A patent/EP1586573B1/en not_active Expired - Lifetime
- 2004-04-01 DE DE602004004631T patent/DE602004004631D1/de not_active Expired - Lifetime
-
2005
- 2005-02-17 GT GT200500028A patent/GT200500028A/es unknown
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2006
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2008
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2009
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