RS51186B - Derivati oksadiazolona kao ppar delta agonisti - Google Patents
Derivati oksadiazolona kao ppar delta agonistiInfo
- Publication number
- RS51186B RS51186B RSP-2009/0391A RSP20090391A RS51186B RS 51186 B RS51186 B RS 51186B RS P20090391 A RSP20090391 A RS P20090391A RS 51186 B RS51186 B RS 51186B
- Authority
- RS
- Serbia
- Prior art keywords
- alkylene
- alkyl
- oxadiayolone
- derivatives
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Jedinjenja formule I:gdeX je CH2 ili veza;Rl, R2, R3, R4 nezavisno su H, F, Cl, Br, CF3, (C1-C4) alkil, (CO-C4) alkilen-O-(CO-C4) alkilen-H, SCH3, S(O)CH3, S(O)2CH3, CN, OCF3, OCHF2, OCH2F; Z je veza ili CH2; Y je O, S, S(O) ili S(O)2; W je CH2 ili CH2CH2; jedan od U i V je N, a dragi je S ili O;R5 je izabran iz grupe koju čine (C1-C8) alkil, (C1-C6) alkilen-O-(CO-C4) alkilen-H, (CO-C6) alkilenfenil, (C1-C6) alkilen-O-(CO-C4) alkilen-fenil, (C3-C6) cikloalkil, (C2-C8) alkenil, i gde (C1-C8) alkil ili alkilen može biti supstituisan 1 - 2 puta sa OH ili O-(C1-C4) alkil;R6, R7 nezavisno su H, F, Br, CF3, OCF3, (C1-C6) alkil, (CO-C4) alkilen-O-(CO-C4) alkilen-H, SCF3, SF5, OCF2-CHF2, OCHF2, OCH2F, O-fenil, fenil, NO2; ilikao i njihove fiziološki prihvatljive soli i tautomerni oblici.Prijava sadrži još 35 patentnih zahteva.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04007879A EP1586573B1 (en) | 2004-04-01 | 2004-04-01 | Oxadiazolones, processes for their preparation and their use as pharmaceuticals |
| PCT/EP2005/002950 WO2005097786A1 (en) | 2004-04-01 | 2005-03-19 | Oxadiazolone derivatives as ppar delta agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS51186B true RS51186B (sr) | 2010-10-31 |
Family
ID=34924545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RSP-2009/0391A RS51186B (sr) | 2004-04-01 | 2005-03-19 | Derivati oksadiazolona kao ppar delta agonisti |
Country Status (38)
| Country | Link |
|---|---|
| US (3) | US20070179191A1 (sr) |
| EP (3) | EP1586573B1 (sr) |
| JP (1) | JP2007530612A (sr) |
| KR (1) | KR20060135857A (sr) |
| CN (1) | CN100582104C (sr) |
| AR (1) | AR050576A1 (sr) |
| AT (1) | ATE435225T1 (sr) |
| AU (1) | AU2005231916A1 (sr) |
| BR (1) | BRPI0509517A (sr) |
| CA (1) | CA2561627A1 (sr) |
| CR (1) | CR8572A (sr) |
| CY (1) | CY1109370T1 (sr) |
| DE (2) | DE602004004631D1 (sr) |
| DK (1) | DK1740583T3 (sr) |
| DO (1) | DOP2005000051A (sr) |
| EC (1) | ECSP066892A (sr) |
| ES (1) | ES2329484T3 (sr) |
| GT (1) | GT200500028A (sr) |
| HK (1) | HK1100408A1 (sr) |
| HR (1) | HRP20090493T1 (sr) |
| IL (1) | IL178056A0 (sr) |
| MA (1) | MA28495B1 (sr) |
| MY (1) | MY142431A (sr) |
| NO (1) | NO20064981L (sr) |
| PA (1) | PA8628701A1 (sr) |
| PE (1) | PE20060323A1 (sr) |
| PL (1) | PL1740583T3 (sr) |
| PT (1) | PT1740583E (sr) |
| RS (1) | RS51186B (sr) |
| RU (1) | RU2374243C2 (sr) |
| SI (1) | SI1740583T1 (sr) |
| SV (1) | SV2006002071A (sr) |
| TN (1) | TNSN06317A1 (sr) |
| TW (1) | TW200602342A (sr) |
| UA (1) | UA84203C2 (sr) |
| UY (1) | UY28837A1 (sr) |
| WO (1) | WO2005097786A1 (sr) |
| ZA (1) | ZA200606870B (sr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060017929A (ko) * | 2004-08-04 | 2006-02-28 | 동화약품공업주식회사 | 티아졸 유도체가 치환된 신규한 벤즈아미딘 유도체, 그의제조방법 및 이를 유효성분으로 하는 약학 조성물 |
| JP2009509988A (ja) | 2005-09-29 | 2009-03-12 | サノフィ−アベンティス | フェニル−及びピリジニル−１，２，４−オキサジアゾロン誘導体、その製造方法、及び医薬品としてのその使用 |
| EP1931659B1 (en) | 2005-09-29 | 2010-09-08 | Sanofi-Aventis | Derivatives of 2 -aminthiazoles and 2-aminooxazoles, processes for their preparation and their use as pharmaceuticals |
| EP1931660B1 (en) * | 2005-09-29 | 2012-08-01 | Sanofi | Phenyl-[1,2,4]-oxadiazol-5-one derivatives with phenyl group, processes for their preparation and their use as pharmaceuticals |
| JP2010502719A (ja) | 2006-09-08 | 2010-01-28 | ロード アイランド ホスピタル | アルコール誘発性脳疾患の治療、予防および回復 |
| JP5864077B2 (ja) | 2006-09-08 | 2016-02-17 | ロード アイランド ホスピタル | アルコール誘発性肝疾患の治療、予防および回復 |
| EP1932843A1 (en) * | 2006-12-14 | 2008-06-18 | sanofi-aventis | Sulfonyl-phenyl-2H-(1,2,4) oxadiazole-5-one derivatives, processes for their preparation and their use as pharmaceuticals |
| EP2288605B1 (en) * | 2008-06-09 | 2014-06-25 | Sanofi | Annelated pyrrolidin sulfonamides with oxadiazolone headgroup, processes for their preparation and their use as pharmaceuticals |
| WO2010000353A1 (en) * | 2008-06-09 | 2010-01-07 | Sanofi-Aventis | Sulfonamides with heterocycle and oxadiazolone headgroup, processes for their preparation and their use as pharmaceuticals |
| US8329725B2 (en) | 2008-06-09 | 2012-12-11 | Sanofi | Annelated pyrrolidin sulfonamides with oxadiazolone headgroup, processes for their preparation and their use as pharmaceuticals |
| WO2010042212A2 (en) | 2008-10-10 | 2010-04-15 | Dara Biosciences, Inc. | Methods for treating or preventing pain using spicamycin derivatives |
| LT3135672T (lt) * | 2008-10-10 | 2020-05-25 | Vm Discovery, Inc. | Kompozicijos ir būdai skirti gydyti alkoholio vartojimo sutrikimus, skausmą ir kitas ligas |
| AU2010279964B2 (en) * | 2009-08-05 | 2016-02-11 | Daiichi Sankyo Company, Limited | Amide derivative |
| JP5546543B2 (ja) * | 2009-08-05 | 2014-07-09 | 第一三共株式会社 | スルホン誘導体 |
| WO2015061481A1 (en) | 2013-10-23 | 2015-04-30 | Dara Biosciences, Inc. | Methods of treating liquid tumors using compositions comprising spicamycin derivatives |
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| FR2663336B1 (fr) | 1990-06-18 | 1992-09-04 | Adir | Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| IL108634A0 (en) | 1993-02-15 | 1994-05-30 | Wellcome Found | Hypolipidaemic heterocyclic compounds, their prepatation and pharmaceutical compositions containing them |
| ZA941003B (en) | 1993-02-15 | 1995-08-14 | Wellcome Found | Hypolipidaemic compounds |
| US5641796A (en) * | 1994-11-01 | 1997-06-24 | Eli Lilly And Company | Oral hypoglycemic agents |
| JP3144624B2 (ja) | 1995-06-02 | 2001-03-12 | 杏林製薬株式会社 | Ｎ−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
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| DE19845405C2 (de) | 1998-10-02 | 2000-07-13 | Aventis Pharma Gmbh | Arylsubstituierte Propanolaminderivate und deren Verwendung |
| GB9900416D0 (en) | 1999-01-08 | 1999-02-24 | Alizyme Therapeutics Ltd | Inhibitors |
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-
2004
- 2004-04-01 EP EP04007879A patent/EP1586573B1/en not_active Expired - Fee Related
- 2004-04-01 DE DE602004004631T patent/DE602004004631D1/de not_active Expired - Lifetime
-
2005
- 2005-02-17 GT GT200500028A patent/GT200500028A/es unknown
- 2005-03-19 SI SI200530778T patent/SI1740583T1/sl unknown
- 2005-03-19 DK DK05716233T patent/DK1740583T3/da active
- 2005-03-19 ES ES05716233T patent/ES2329484T3/es active Active
- 2005-03-19 EP EP05716233A patent/EP1740583B1/en active Active
- 2005-03-19 RU RU2006138498/04A patent/RU2374243C2/ru not_active IP Right Cessation
- 2005-03-19 AT AT05716233T patent/ATE435225T1/de not_active IP Right Cessation
- 2005-03-19 PT PT05716233T patent/PT1740583E/pt unknown
- 2005-03-19 BR BRPI0509517-4A patent/BRPI0509517A/pt not_active IP Right Cessation
- 2005-03-19 EP EP09005458A patent/EP2083006A1/en not_active Withdrawn
- 2005-03-19 CA CA002561627A patent/CA2561627A1/en not_active Abandoned
- 2005-03-19 AU AU2005231916A patent/AU2005231916A1/en not_active Abandoned
- 2005-03-19 DE DE602005015204T patent/DE602005015204D1/de active Active
- 2005-03-19 WO PCT/EP2005/002950 patent/WO2005097786A1/en active Application Filing
- 2005-03-19 RS RSP-2009/0391A patent/RS51186B/sr unknown
- 2005-03-19 CN CN200580010743A patent/CN100582104C/zh not_active Expired - Fee Related
- 2005-03-19 JP JP2007505433A patent/JP2007530612A/ja not_active Abandoned
- 2005-03-19 PL PL05716233T patent/PL1740583T3/pl unknown
- 2005-03-19 UA UAA200611486A patent/UA84203C2/ru unknown
- 2005-03-19 KR KR1020067020503A patent/KR20060135857A/ko not_active Application Discontinuation
- 2005-03-22 PE PE2005000323A patent/PE20060323A1/es not_active Application Discontinuation
- 2005-03-30 DO DO2005000051A patent/DOP2005000051A/es unknown
- 2005-03-30 TW TW094109908A patent/TW200602342A/zh unknown
- 2005-03-30 AR ARP050101221A patent/AR050576A1/es not_active Application Discontinuation
- 2005-03-31 MY MYPI20051461A patent/MY142431A/en unknown
- 2005-04-01 PA PA20058628701A patent/PA8628701A1/es unknown
- 2005-04-01 SV SV2005002071A patent/SV2006002071A/es not_active Application Discontinuation
- 2005-04-01 UY UY28837A patent/UY28837A1/es unknown
-
2006
- 2006-08-15 ZA ZA200606870A patent/ZA200606870B/en unknown
- 2006-08-24 CR CR8572A patent/CR8572A/es not_active Application Discontinuation
- 2006-09-13 IL IL178056A patent/IL178056A0/en unknown
- 2006-09-26 US US11/535,266 patent/US20070179191A1/en not_active Abandoned
- 2006-09-29 MA MA29354A patent/MA28495B1/fr unknown
- 2006-09-29 TN TNP2006000317A patent/TNSN06317A1/en unknown
- 2006-09-29 EC EC2006006892A patent/ECSP066892A/es unknown
- 2006-10-31 NO NO20064981A patent/NO20064981L/no not_active Application Discontinuation
-
2007
- 2007-07-31 HK HK07108322.5A patent/HK1100408A1/xx not_active IP Right Cessation
-
2008
- 2008-06-05 US US12/133,408 patent/US20080262052A1/en not_active Abandoned
- 2008-06-05 US US12/133,405 patent/US7709509B2/en not_active Expired - Fee Related
-
2009
- 2009-09-16 CY CY20091100958T patent/CY1109370T1/el unknown
- 2009-09-16 HR HR20090493T patent/HRP20090493T1/xx unknown
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