RU95106675A - 3-индолилпиперидины, способ их получения, фармацевтическая композиция и способ ее получения - Google Patents

3-индолилпиперидины, способ их получения, фармацевтическая композиция и способ ее получения

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Publication number
RU95106675A
RU95106675A RU95106675/04A RU95106675A RU95106675A RU 95106675 A RU95106675 A RU 95106675A RU 95106675/04 A RU95106675/04 A RU 95106675/04A RU 95106675 A RU95106675 A RU 95106675A RU 95106675 A RU95106675 A RU 95106675A
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RU
Russia
Prior art keywords
preparation
piperidines
indolyl
rand
dopamine
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Application number
RU95106675/04A
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English (en)
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RU2151148C1 (ru
Inventor
Бетхер Хеннинг
De]
Мэрц Йоахим
Зейфрид Кристоф
Грайнер Хартмут
Бартошик Герд
Original Assignee
Мерк Патент ГмбХ (DE)
Мерк Патент Гмбх
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Publication of RU95106675A publication Critical patent/RU95106675A/ru
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Abstract

3-Индолилпиперидины формулы Iгде R, R, Rи Rнезависимо друг от друга H, A, OH, OA, F, Cl, Br, J, CN, CF, COOH, CONH, CONHA, CONAили COOA или Rи R, а также Rи Rвместе - метилендиокси-группа; R- H или OH; R- H; или Rи Rтакже вместе обозначают связь; A - алкил с 1-6 C-атомами; n - 2, 3, 4, 5 или 6, а также их физиологически приемлемые соли, оказывают воздействие на центральную нервную систему, в особенности обладают допамин-агонистическим или допамин-антагонистическим действием.

Claims (1)

  1. 3-Индолилпиперидины формулы I
    Figure 00000001

    где R1, R2, R3 и R4 независимо друг от друга H, A, OH, OA, F, Cl, Br, J, CN, CF3, COOH, CONH2, CONHA, CONA2 или COOA или R1 и R2, а также R3 и R4 вместе - метилендиокси-группа; R5 - H или OH; R6 - H; или R5 и R6 также вместе обозначают связь; A - алкил с 1-6 C-атомами; n - 2, 3, 4, 5 или 6, а также их физиологически приемлемые соли, оказывают воздействие на центральную нервную систему, в особенности обладают допамин-агонистическим или допамин-антагонистическим действием.
RU95106675/04A 1994-04-22 1995-04-21 3-индолилпиперидины, способ их получения, фармацевтическая композиция и способ ее получения RU2151148C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4414113A DE4414113A1 (de) 1994-04-22 1994-04-22 3-Indolylpiperidine
DEP4414113.0 1994-04-22

Publications (2)

Publication Number Publication Date
RU95106675A true RU95106675A (ru) 1997-03-20
RU2151148C1 RU2151148C1 (ru) 2000-06-20

Family

ID=6516183

Family Applications (1)

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RU95106675/04A RU2151148C1 (ru) 1994-04-22 1995-04-21 3-индолилпиперидины, способ их получения, фармацевтическая композиция и способ ее получения

Country Status (20)

Country Link
US (1) US5693655A (ru)
EP (1) EP0683166B1 (ru)
JP (1) JPH07291969A (ru)
KR (1) KR100361950B1 (ru)
CN (1) CN1047385C (ru)
AT (1) ATE172730T1 (ru)
AU (1) AU697749B2 (ru)
CA (1) CA2147451C (ru)
CZ (1) CZ285369B6 (ru)
DE (2) DE4414113A1 (ru)
DK (1) DK0683166T3 (ru)
ES (1) ES2125508T3 (ru)
HU (1) HUT74096A (ru)
NO (1) NO307831B1 (ru)
PL (1) PL180781B1 (ru)
RU (1) RU2151148C1 (ru)
SK (1) SK280881B6 (ru)
TW (1) TW401416B (ru)
UA (1) UA41333C2 (ru)
ZA (1) ZA953260B (ru)

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DE4414113A1 (de) * 1994-04-22 1995-10-26 Merck Patent Gmbh 3-Indolylpiperidine
GB9523462D0 (en) * 1995-11-16 1996-01-17 Merck Sharp & Dohme Therapeutic agents
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
DE19707628A1 (de) * 1997-02-26 1998-08-27 Merck Patent Gmbh Oxazolidinone
WO1999005140A1 (en) * 1997-07-25 1999-02-04 H. Lundbeck A/S Indole and 2,3-dihydroindole derivatives, their preparation and use
WO1999009025A2 (en) * 1997-08-15 1999-02-25 Pfizer Products Inc. 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1h-indole derivatives interacting with the dopamine d4 receptor
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
DK1065205T3 (da) 1998-03-18 2003-06-23 Taisho Pharmaceutical Co Ltd Heteroaromatiske derivater
EP1070715A4 (en) 1998-03-19 2002-10-17 Nihon Nohyaku Co Ltd ARYLPIPERIDINE AND THEIR USE
US6310066B1 (en) 1998-04-29 2001-10-30 American Home Products Corp. Antipsychotic indolyl derivatives
US6204274B1 (en) 1998-04-29 2001-03-20 American Home Products Corporation Indolyl derivatives as serotonergic agents
IL139962A0 (en) 1998-06-19 2002-02-10 Lundbeck & Co As H 4,5,6 and 7-indole and indoline derivatives, their preparation and use
US6066637A (en) * 1998-06-19 2000-05-23 American Home Products Corporation Indolyl derivatives as serotonergic agents
AU765317C (en) * 1998-06-19 2004-05-20 H. Lundbeck A/S 4,5,6 and 7-indole and indoline derivatives, their preparation and use
AR020773A1 (es) 1998-10-16 2002-05-29 Duphar Int Res Compuesto derivados de 3-(tetrahidropiridin-4-il)indol, metodo para prepararlo, una composicion farmaceutica que los contiene, metodo para preparar dicha composicion y uso del compuesto
WO2000069424A2 (en) * 1999-05-12 2000-11-23 Solvay Pharmaceuticals B.V. Method of treating psychotic disorders
SK287018B6 (sk) 1999-08-23 2009-09-07 Solvay Pharmaceuticals B. V. Deriváty fenylpiperazínov, spôsob ich prípravy, farmaceutická kompozícia s ich obsahom a ich použitie
US6806275B2 (en) 2000-09-13 2004-10-19 Nihon Nohyaku Co., Ltd. Arylpiperidine derivatives and use thereof
AR032712A1 (es) 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
WO2003010169A1 (en) * 2001-07-25 2003-02-06 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 7, 8-dihydro-6h-5-oxa-1-aza-phenanthrene
DE10217006A1 (de) * 2002-04-16 2003-11-06 Merck Patent Gmbh Substituierte Indole
US7235569B2 (en) * 2003-05-02 2007-06-26 Wyeth Piperidinyl indole and tetrohydropyridinyl indole derivatives and method of their use
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Also Published As

Publication number Publication date
UA41333C2 (ru) 2001-09-17
US5693655A (en) 1997-12-02
KR950032176A (ko) 1995-12-20
ZA953260B (en) 1996-01-09
CA2147451A1 (en) 1995-10-23
NO951529D0 (no) 1995-04-21
PL180781B1 (pl) 2001-04-30
CZ103595A3 (en) 1995-12-13
HU9501139D0 (en) 1995-06-28
CN1114651A (zh) 1996-01-10
EP0683166B1 (de) 1998-10-28
CN1047385C (zh) 1999-12-15
NO307831B1 (no) 2000-06-05
RU2151148C1 (ru) 2000-06-20
EP0683166A1 (de) 1995-11-22
DE59504032D1 (de) 1998-12-03
NO951529L (no) 1995-10-23
KR100361950B1 (ko) 2003-02-05
ES2125508T3 (es) 1999-03-01
HUT74096A (en) 1996-11-28
ATE172730T1 (de) 1998-11-15
CA2147451C (en) 2006-03-28
PL308287A1 (en) 1995-10-30
CZ285369B6 (cs) 1999-07-14
AU697749B2 (en) 1998-10-15
DK0683166T3 (da) 1999-07-12
DE4414113A1 (de) 1995-10-26
AU1648895A (en) 1995-11-02
SK50895A3 (en) 1995-11-08
SK280881B6 (sk) 2000-08-14
TW401416B (en) 2000-08-11
JPH07291969A (ja) 1995-11-07

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