ES2125508T3 - 3-indolilpiperidinas. - Google Patents

3-indolilpiperidinas.

Info

Publication number
ES2125508T3
ES2125508T3 ES95105227T ES95105227T ES2125508T3 ES 2125508 T3 ES2125508 T3 ES 2125508T3 ES 95105227 T ES95105227 T ES 95105227T ES 95105227 T ES95105227 T ES 95105227T ES 2125508 T3 ES2125508 T3 ES 2125508T3
Authority
ES
Spain
Prior art keywords
sup
sub
piperidines
indolyl
well
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95105227T
Other languages
English (en)
Inventor
Henning Dr Bottcher
Joachim Dr Marz
Christoph Dr Seyfreid
Harmut Dr Greiner
Gerd Bartoszyk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Application granted granted Critical
Publication of ES2125508T3 publication Critical patent/ES2125508T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Hydrogenated Pyridines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Treatment Of Water By Ion Exchange (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

3 - INDOLIL PIPERIDINA DE LA FORMULA I DONDE R SUP.1 , R SUP.2}, R{SUP.3} Y R{SUP.4} DE FORMA INDEPENDIENTE UNO DE OTRO SIGNIFICAN H, A, OH, OA, F, CL, BR, I, CN, CF{SUB.3}, COOH, CONH{SUB.2}, CONHA, CONA{SUB.2} O COOA, O R{SUP.1} Y R{SUP.3} ASI COMO R{SUP.3} Y R{SUP.4} SIGNIFICAN TAMBIEN CONJUNTAMENTE METILENO DIOXI, R{SUP.5} ES H O OH R{SUP.6} ES H, R{SUP.5} Y R{SUP.6} DE FORMA CONJUNTA SON TAMBIEN UN ENLACE, A ES ALQUIL CON 1 HASTA 6 ATOMOS DE C N ES 2,3,4,5 O 6 ASI COMO SUS SALES INOFENSIVAS FISIOLOGICAMENTE QUE MUESTRAN EFECTO SOBRE EL SISTEMA NERVIOSO CENTRAL, EN PARTICULAR EFECTO AGONISTICO DOPAMINA O EFECTO ANTAGONISTICO DOPAMINA.
ES95105227T 1994-04-22 1995-04-07 3-indolilpiperidinas. Expired - Lifetime ES2125508T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4414113A DE4414113A1 (de) 1994-04-22 1994-04-22 3-Indolylpiperidine

Publications (1)

Publication Number Publication Date
ES2125508T3 true ES2125508T3 (es) 1999-03-01

Family

ID=6516183

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95105227T Expired - Lifetime ES2125508T3 (es) 1994-04-22 1995-04-07 3-indolilpiperidinas.

Country Status (20)

Country Link
US (1) US5693655A (es)
EP (1) EP0683166B1 (es)
JP (1) JPH07291969A (es)
KR (1) KR100361950B1 (es)
CN (1) CN1047385C (es)
AT (1) ATE172730T1 (es)
AU (1) AU697749B2 (es)
CA (1) CA2147451C (es)
CZ (1) CZ285369B6 (es)
DE (2) DE4414113A1 (es)
DK (1) DK0683166T3 (es)
ES (1) ES2125508T3 (es)
HU (1) HUT74096A (es)
NO (1) NO307831B1 (es)
PL (1) PL180781B1 (es)
RU (1) RU2151148C1 (es)
SK (1) SK280881B6 (es)
TW (1) TW401416B (es)
UA (1) UA41333C2 (es)
ZA (1) ZA953260B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4414113A1 (de) * 1994-04-22 1995-10-26 Merck Patent Gmbh 3-Indolylpiperidine
GB9523462D0 (en) * 1995-11-16 1996-01-17 Merck Sharp & Dohme Therapeutic agents
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
DE19707628A1 (de) * 1997-02-26 1998-08-27 Merck Patent Gmbh Oxazolidinone
WO1999005140A1 (en) * 1997-07-25 1999-02-04 H. Lundbeck A/S Indole and 2,3-dihydroindole derivatives, their preparation and use
WO1999009025A2 (en) * 1997-08-15 1999-02-25 Pfizer Products Inc. 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1h-indole derivatives interacting with the dopamine d4 receptor
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
DK1065205T3 (da) 1998-03-18 2003-06-23 Taisho Pharmaceutical Co Ltd Heteroaromatiske derivater
EP1070715A4 (en) 1998-03-19 2002-10-17 Nihon Nohyaku Co Ltd ARYLPIPERIDINE AND THEIR USE
US6310066B1 (en) 1998-04-29 2001-10-30 American Home Products Corp. Antipsychotic indolyl derivatives
US6204274B1 (en) 1998-04-29 2001-03-20 American Home Products Corporation Indolyl derivatives as serotonergic agents
IL139962A0 (en) 1998-06-19 2002-02-10 Lundbeck & Co As H 4,5,6 and 7-indole and indoline derivatives, their preparation and use
US6066637A (en) * 1998-06-19 2000-05-23 American Home Products Corporation Indolyl derivatives as serotonergic agents
AU765317C (en) * 1998-06-19 2004-05-20 H. Lundbeck A/S 4,5,6 and 7-indole and indoline derivatives, their preparation and use
AR020773A1 (es) 1998-10-16 2002-05-29 Duphar Int Res Compuesto derivados de 3-(tetrahidropiridin-4-il)indol, metodo para prepararlo, una composicion farmaceutica que los contiene, metodo para preparar dicha composicion y uso del compuesto
WO2000069424A2 (en) * 1999-05-12 2000-11-23 Solvay Pharmaceuticals B.V. Method of treating psychotic disorders
SK287018B6 (sk) 1999-08-23 2009-09-07 Solvay Pharmaceuticals B. V. Deriváty fenylpiperazínov, spôsob ich prípravy, farmaceutická kompozícia s ich obsahom a ich použitie
US6806275B2 (en) 2000-09-13 2004-10-19 Nihon Nohyaku Co., Ltd. Arylpiperidine derivatives and use thereof
AR032712A1 (es) 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
WO2003010169A1 (en) * 2001-07-25 2003-02-06 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 7, 8-dihydro-6h-5-oxa-1-aza-phenanthrene
DE10217006A1 (de) * 2002-04-16 2003-11-06 Merck Patent Gmbh Substituierte Indole
US7235569B2 (en) * 2003-05-02 2007-06-26 Wyeth Piperidinyl indole and tetrohydropyridinyl indole derivatives and method of their use
WO2016192657A1 (en) 2015-06-03 2016-12-08 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2675801A (en) * 1954-04-20 Intramedbllary nail
FR2349331A1 (fr) * 1976-04-30 1977-11-25 Roussel Uclaf Nouveaux derives de 2,3 dihydro a/4-(3-indolyl) 1-piperidinyl/methyl 1,4-benzodioxin-2-methanol, un procede pour leur preparation et leur application comme medicaments
GB2044254B (en) 1979-01-26 1983-01-26 Wyeth John & Brother Ltd Piperidine derivatives
US4359468A (en) * 1981-02-25 1982-11-16 Boehringer Ingelheim Ltd. Antiallergic N-[4-(indolyl)-piperidino-alkyl]-benzimidazolones
HU198036B (en) * 1983-08-22 1989-07-28 Hoechst Roussel Pharma Process for production of derivatives of 3-piperidil-/1h/-indasole and medical preparatives containing them
US5256673A (en) * 1983-11-25 1993-10-26 Merck Patent Gesellschaft Mit Beschrankter Haftung Indole-3-yl-A-tetrahydropyridyl or piperidyl compounds
US4548939A (en) * 1984-10-01 1985-10-22 Janssen Pharmaceutica N. V. 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
GB8531665D0 (en) * 1985-12-23 1986-02-05 Wyeth John & Brother Ltd Indole derivatives
JP2860688B2 (ja) * 1990-03-14 1999-02-24 第一製薬株式会社 インドール誘導体
FR2675801A1 (fr) 1991-04-24 1992-10-30 Rhone Poulenc Rorer Sa Piperidines, leur preparation et les medicaments les contenant.
DE4414113A1 (de) * 1994-04-22 1995-10-26 Merck Patent Gmbh 3-Indolylpiperidine
KR102044254B1 (ko) * 2018-01-18 2019-11-13 (주)우신에이펙 배광제어가 가능한 led 탐조등

Also Published As

Publication number Publication date
UA41333C2 (uk) 2001-09-17
RU95106675A (ru) 1997-03-20
US5693655A (en) 1997-12-02
KR950032176A (ko) 1995-12-20
ZA953260B (en) 1996-01-09
CA2147451A1 (en) 1995-10-23
NO951529D0 (no) 1995-04-21
PL180781B1 (pl) 2001-04-30
CZ103595A3 (en) 1995-12-13
HU9501139D0 (en) 1995-06-28
CN1114651A (zh) 1996-01-10
EP0683166B1 (de) 1998-10-28
CN1047385C (zh) 1999-12-15
NO307831B1 (no) 2000-06-05
RU2151148C1 (ru) 2000-06-20
EP0683166A1 (de) 1995-11-22
DE59504032D1 (de) 1998-12-03
NO951529L (no) 1995-10-23
KR100361950B1 (ko) 2003-02-05
HUT74096A (en) 1996-11-28
ATE172730T1 (de) 1998-11-15
CA2147451C (en) 2006-03-28
PL308287A1 (en) 1995-10-30
CZ285369B6 (cs) 1999-07-14
AU697749B2 (en) 1998-10-15
DK0683166T3 (da) 1999-07-12
DE4414113A1 (de) 1995-10-26
AU1648895A (en) 1995-11-02
SK50895A3 (en) 1995-11-08
SK280881B6 (sk) 2000-08-14
TW401416B (en) 2000-08-11
JPH07291969A (ja) 1995-11-07

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