CN1874769A - Mek的杂环抑制剂及其使用方法 - Google Patents

Mek的杂环抑制剂及其使用方法 Download PDF

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Publication number
CN1874769A
CN1874769A CNA2004800326551A CN200480032655A CN1874769A CN 1874769 A CN1874769 A CN 1874769A CN A2004800326551 A CNA2004800326551 A CN A2004800326551A CN 200480032655 A CN200480032655 A CN 200480032655A CN 1874769 A CN1874769 A CN 1874769A
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China
Prior art keywords
alkyl
aryl
heteroaryl
heterocyclic radical
chemical compound
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Pending
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CNA2004800326551A
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English (en)
Chinese (zh)
Inventor
伊莱·华莱士
布赖恩·赫尔利
杨鸿云
约瑟夫·莱希凯托斯
阿莉森·L.·马洛
吉姆·布莱克
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Array Biopharma Inc
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Array Biopharma Inc
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Publication of CN1874769A publication Critical patent/CN1874769A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNA2004800326551A 2003-09-03 2004-09-01 Mek的杂环抑制剂及其使用方法 Pending CN1874769A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/654,580 2003-09-03
US10/654,580 US7144907B2 (en) 2003-09-03 2003-09-03 Heterocyclic inhibitors of MEK and methods of use thereof
US10/929,295 2004-08-30

Publications (1)

Publication Number Publication Date
CN1874769A true CN1874769A (zh) 2006-12-06

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ID=34218110

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800326551A Pending CN1874769A (zh) 2003-09-03 2004-09-01 Mek的杂环抑制剂及其使用方法

Country Status (18)

Country Link
US (5) US7144907B2 (enExample)
EP (1) EP1673339B1 (enExample)
JP (1) JP4131741B2 (enExample)
KR (1) KR20060070558A (enExample)
CN (1) CN1874769A (enExample)
AR (1) AR046081A1 (enExample)
AU (1) AU2004270699B2 (enExample)
BR (1) BRPI0414111A (enExample)
CA (1) CA2537321A1 (enExample)
IL (4) IL173936A (enExample)
IS (1) IS8392A (enExample)
MX (1) MXPA06002466A (enExample)
NO (1) NO20061506L (enExample)
PT (1) PT1673339E (enExample)
RU (1) RU2006109599A (enExample)
TW (1) TW200526607A (enExample)
WO (1) WO2005023759A2 (enExample)
ZA (1) ZA200602581B (enExample)

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WO2011106298A1 (en) 2010-02-25 2011-09-01 Dana-Farber Cancer Institute, Inc. Braf mutations conferring resistance to braf inhibitors
WO2013169858A1 (en) 2012-05-08 2013-11-14 The Broad Institute, Inc. Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy
US11078540B2 (en) 2010-03-09 2021-08-03 Dana-Farber Cancer Institute, Inc. Methods of diagnosing and treating cancer in patients having or developing resistance to a first cancer therapy

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US9084781B2 (en) 2008-12-10 2015-07-21 Novartis Ag MEK mutations conferring resistance to MEK inhibitors
WO2011106298A1 (en) 2010-02-25 2011-09-01 Dana-Farber Cancer Institute, Inc. Braf mutations conferring resistance to braf inhibitors
US8637246B2 (en) 2010-02-25 2014-01-28 Dana-Farber Cancer Institute, Inc. BRAF mutations conferring resistance to BRAF inhibitors
US9279144B2 (en) 2010-02-25 2016-03-08 Dana-Farber Cancer Institute, Inc. Screening method for BRAF inhibitors
EP3028699A1 (en) 2010-02-25 2016-06-08 Dana-Farber Cancer Institute, Inc. Braf mutations conferring resistance to braf inhibitors
US11078540B2 (en) 2010-03-09 2021-08-03 Dana-Farber Cancer Institute, Inc. Methods of diagnosing and treating cancer in patients having or developing resistance to a first cancer therapy
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BRPI0414111A (pt) 2006-10-31
US7144907B2 (en) 2006-12-05
US7271178B2 (en) 2007-09-18
WO2005023759A3 (en) 2005-09-22
PT1673339E (pt) 2013-07-29
EP1673339B1 (en) 2013-07-03
US20060189808A1 (en) 2006-08-24
IL219669A0 (en) 2012-06-28
US20050054701A1 (en) 2005-03-10
IS8392A (is) 2006-03-31
AU2004270699B2 (en) 2011-11-10
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IL219670A0 (en) 2012-06-28
IL173936A (en) 2012-07-31
JP4131741B2 (ja) 2008-08-13
IL219670A (en) 2013-03-24
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US20060189668A1 (en) 2006-08-24
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ZA200602581B (en) 2007-06-27
WO2005023759A2 (en) 2005-03-17
US7511058B2 (en) 2009-03-31
US7230099B2 (en) 2007-06-12
AR046081A1 (es) 2005-11-23
US20050049419A1 (en) 2005-03-03
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TW200526607A (en) 2005-08-16
EP1673339A4 (en) 2009-04-29
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AU2004270699A1 (en) 2005-03-17
US20060189649A1 (en) 2006-08-24

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