CN1630718A - 改进的类异戊二烯生产 - Google Patents

改进的类异戊二烯生产 Download PDF

Info

Publication number
CN1630718A
CN1630718A CNA028113802A CN02811380A CN1630718A CN 1630718 A CN1630718 A CN 1630718A CN A028113802 A CNA028113802 A CN A028113802A CN 02811380 A CN02811380 A CN 02811380A CN 1630718 A CN1630718 A CN 1630718A
Authority
CN
China
Prior art keywords
seq
sequence
pbbr
polypeptide
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA028113802A
Other languages
English (en)
Chinese (zh)
Inventor
艾伦·贝里
沃纳·布雷策尔
马库斯·许布林
鲁阿尔·洛佩兹－尤利巴里
安妮·F·迈耶
亚历克西·耶利西夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Publication of CN1630718A publication Critical patent/CN1630718A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1229—Phosphotransferases with a phosphate group as acceptor (2.7.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01034—Hydroxymethylglutaryl-CoA reductase (NADPH) (1.1.1.34)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01036—Acetoacetyl-CoA reductase (1.1.1.36)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/03—Acyl groups converted into alkyl on transfer (2.3.3)
    • C12Y203/0301—Hydroxymethylglutaryl-CoA synthase (2.3.3.10)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01036—Mevalonate kinase (2.7.1.36)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/04—Phosphotransferases with a phosphate group as acceptor (2.7.4)
    • C12Y207/04002—Phosphomevalonate kinase (2.7.4.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01033—Diphosphomevalonate decarboxylase (4.1.1.33), i.e. mevalonate-pyrophosphate decarboxylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Peptides Or Proteins (AREA)
CNA028113802A 2001-06-06 2002-06-05 改进的类异戊二烯生产 Pending CN1630718A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29629901P 2001-06-06 2001-06-06
US60/296,299 2001-06-06

Publications (1)

Publication Number Publication Date
CN1630718A true CN1630718A (zh) 2005-06-22

Family

ID=23141440

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA028113802A Pending CN1630718A (zh) 2001-06-06 2002-06-05 改进的类异戊二烯生产

Country Status (11)

Country Link
US (2) US6989257B2 (cg-RX-API-DMAC10.html)
EP (1) EP1392824B1 (cg-RX-API-DMAC10.html)
JP (1) JP4280627B2 (cg-RX-API-DMAC10.html)
KR (1) KR100704072B1 (cg-RX-API-DMAC10.html)
CN (1) CN1630718A (cg-RX-API-DMAC10.html)
AT (1) ATE405638T1 (cg-RX-API-DMAC10.html)
AU (1) AU2002316966B2 (cg-RX-API-DMAC10.html)
CA (1) CA2449885A1 (cg-RX-API-DMAC10.html)
DE (1) DE60228439D1 (cg-RX-API-DMAC10.html)
ES (1) ES2311613T3 (cg-RX-API-DMAC10.html)
WO (1) WO2002099095A2 (cg-RX-API-DMAC10.html)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102492701A (zh) * 2007-06-21 2012-06-13 日立造船株式会社 编码杜仲的甲羟戊酸途径的酶的基因
CN101484584B (zh) * 2006-05-26 2013-03-27 阿米瑞斯公司 类异戊二烯的生产
US9200296B2 (en) 2006-05-26 2015-12-01 Amyris Inc. Production of isoprenoids
CN105339490A (zh) * 2012-12-20 2016-02-17 帝斯曼知识产权资产管理有限公司 乙酰转移酶及其用于产生类胡萝卜素的用途
CN105331518A (zh) * 2006-05-26 2016-02-17 阿迈瑞斯公司 制造生物有机化合物的设备
CN108285902A (zh) * 2017-11-03 2018-07-17 杭州爱蔻思生物科技有限公司 生产高价值天然产物的工程菌的构造方法
CN109666683A (zh) * 2019-02-27 2019-04-23 昆明理工大学 乙酰辅酶A乙酰转移酶基因RKAcaT2及其应用
CN109715796A (zh) * 2016-03-31 2019-05-03 Jxtg能源株式会社 类胡萝卜素的制造方法
CN109777815A (zh) * 2019-03-28 2019-05-21 昆明理工大学 HMG-CoA合成酶基因RKHMGCS及其应用
CN111304260A (zh) * 2012-06-01 2020-06-19 朗泽科技新西兰有限公司 重组代谢微生物及其用途
CN115003823A (zh) * 2019-12-26 2022-09-02 加利福尼亚大学董事会 用于生产大麻素和其他异戊二烯化化合物的生物合成平台
CN115605589A (zh) * 2020-05-15 2023-01-13 巴斯夫欧洲公司（De） 改进的用于生产类异戊二烯的方法
CN117965414A (zh) * 2024-04-01 2024-05-03 北京微构工场生物技术有限公司 一种重组盐单胞菌及其在生产异戊二烯中的应用

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030033626A1 (en) 2000-07-31 2003-02-13 Hahn Frederick M. Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
US20040121309A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
US20030027135A1 (en) 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
WO2004060278A2 (en) 2002-12-06 2004-07-22 Isis Pharmaceuticals, Inc. Methods for rapid identification of pathogens in humans and animals
US8073627B2 (en) 2001-06-26 2011-12-06 Ibis Biosciences, Inc. System for indentification of pathogens
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
US7192751B2 (en) 2001-12-06 2007-03-20 The Regents Of The University Of California Biosynthesis of amorpha-4,11-diene
US7172886B2 (en) 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
NZ561169A (en) * 2003-01-21 2008-06-30 Thallion Pharmaceuticals Inc Farnesyl dibenzodiazepinones, processes for their production and their use as pharmaceuticals
US8057993B2 (en) 2003-04-26 2011-11-15 Ibis Biosciences, Inc. Methods for identification of coronaviruses
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US8158354B2 (en) 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
ES2323175T3 (es) * 2003-06-12 2009-07-08 Dsm Ip Assets B.V. Mevalonato-quinasas resistentes a la retroalimentacion.
US20060154349A1 (en) * 2003-07-08 2006-07-13 Alan Berry Production of coenzyme q-10
US20120122102A1 (en) 2003-09-11 2012-05-17 Rangarajan Sampath Compositions for use in identification of bacteria
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
JP2007507234A (ja) * 2003-09-29 2007-03-29 ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 生合成経路遺伝子産物を同定するための方法
US8163895B2 (en) 2003-12-05 2012-04-24 Ibis Biosciences, Inc. Compositions for use in identification of orthopoxviruses
US7666592B2 (en) 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
EP1765418B1 (en) 2004-05-21 2011-12-14 The Regents of the University of California Method for enhancing production of isoprenoid compounds
JP4810533B2 (ja) 2004-05-24 2011-11-09 アイビス バイオサイエンシズ インコーポレイティッド ディジタルスレショルド化による選択的イオン濾過作用を用いた質量分光測定法
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
EP1778843B1 (en) 2004-08-19 2012-09-19 DSM IP Assets B.V. Production of isoprenoids
CN101080490B (zh) * 2004-12-14 2012-08-15 帝斯曼知识产权资产管理有限公司 改进的甲羟戊酸激酶
CA2597499A1 (en) 2005-02-11 2006-08-17 Dsm Ip Assets B.V. Recombinant microorganisms in fermentative production of vitamin c and a process thereof
US20060205040A1 (en) 2005-03-03 2006-09-14 Rangarajan Sampath Compositions for use in identification of adventitious viruses
US8084207B2 (en) 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
AU2006227165B2 (en) 2005-03-18 2011-11-10 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
JP2006280297A (ja) * 2005-04-01 2006-10-19 Tosoh Corp ゲラニルゲラニル２リン酸合成酵素及びその遺伝子等
US8026084B2 (en) 2005-07-21 2011-09-27 Ibis Biosciences, Inc. Methods for rapid identification and quantitation of nucleic acid variants
EP1934344B1 (en) 2005-09-08 2010-02-24 DSM IP Assets B.V. Novel gene sms 37
JP5023474B2 (ja) * 2005-10-28 2012-09-12 東ソー株式会社 カロテノイド合成微生物の作製方法およびカロテノイドの製造方法
EP2471919A1 (en) 2005-10-28 2012-07-04 Tosoh Corporation Method of preparing carotenoid synthesizing microorganism and method of producing carotenoids
JP2007151475A (ja) * 2005-12-06 2007-06-21 Tosoh Corp 新規微生物およびそれを用いたゼアキサンチンの製造方法
JP4887764B2 (ja) * 2005-12-06 2012-02-29 東ソー株式会社 新規微生物およびそれを用いたリコペンの製造法
DE102006001868B4 (de) * 2006-01-13 2012-03-01 Austriamicrosystems Ag Schaltungsanordnung und Verfahren zur Ansteuerung einer elektrischen Last und eine Energieversorgungseinrichtung
WO2007136847A2 (en) * 2006-05-19 2007-11-29 The Regents Of The University Of California Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels
AU2012202630B2 (en) * 2006-05-26 2014-01-16 Amyris, Inc. Production of isoprenoids
WO2008008256A2 (en) * 2006-07-07 2008-01-17 The Regents Of The University Of California Methods for enhancing production of isoprenoid compounds by host cells
WO2008143627A2 (en) 2006-09-14 2008-11-27 Ibis Biosciences, Inc. Targeted whole genome amplification method for identification of pathogens
WO2008042338A2 (en) 2006-09-28 2008-04-10 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
JP5680304B2 (ja) 2007-02-23 2015-03-04 アイビス バイオサイエンシズ インコーポレイティッド 迅速な法医学的ｄｎａ分析法
US7531980B2 (en) * 2007-03-02 2009-05-12 Honeywell International Inc. Aircraft cabin pressure controls: duty cycle offset to compensate for asymmetric motor loading in an open-loop motor control system
US9598724B2 (en) 2007-06-01 2017-03-21 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
WO2009005704A1 (en) * 2007-07-03 2009-01-08 The Regents Of The University Of California Methods of increasing isoprenoid or isoprenoid precursor production
EP3354740A1 (en) 2007-12-13 2018-08-01 Danisco US Inc. Compositions and methods for producing isoprene
ES2330602B1 (es) * 2008-03-19 2010-09-30 Vitatene, S.A Metodo de produccion de fitoeno y/o fitoflueno, o mezclas de carotenoides con alto contenido en los mismos.
WO2009132220A2 (en) * 2008-04-23 2009-10-29 Danisco Us Inc. Isoprene synthase variants for improved microbial production of isoprene
CN102083990B (zh) 2008-07-04 2016-05-04 财富科学家股份有限公司 通过3-羟基烷酸的酶促脱羧制备烯
US9556456B2 (en) * 2008-09-09 2017-01-31 Battelle Memorial Institute Production of bio-based materials using photobioreactors with binary cultures
EP2347254A2 (en) 2008-09-16 2011-07-27 Ibis Biosciences, Inc. Sample processing units, systems, and related methods
EP2344893B1 (en) 2008-09-16 2014-10-15 Ibis Biosciences, Inc. Microplate handling systems and methods
EP2349549B1 (en) 2008-09-16 2012-07-18 Ibis Biosciences, Inc. Mixing cartridges, mixing stations, and related kits, and system
EP2396803A4 (en) 2009-02-12 2016-10-26 Ibis Biosciences Inc IONIZATION PROBE ASSEMBLIES
US8518686B2 (en) 2009-04-23 2013-08-27 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
US8950604B2 (en) 2009-07-17 2015-02-10 Ibis Biosciences, Inc. Lift and mount apparatus
WO2011008972A1 (en) 2009-07-17 2011-01-20 Ibis Biosciences, Inc. Systems for bioagent identification
WO2011032213A1 (en) * 2009-09-15 2011-03-24 Wwcc Limited Nucleic acid molecule encoding triterpenoid synthase
US9890408B2 (en) 2009-10-15 2018-02-13 Ibis Biosciences, Inc. Multiple displacement amplification
EP2336310A1 (en) 2009-12-16 2011-06-22 Isobionics B.V. Valencene synthase
BR112012017346A8 (pt) 2009-12-22 2018-06-26 Global Bioenergies Sa método para a produção enzimática de isoprenol usando mevalonato como um substrato
CN105671108A (zh) 2010-06-02 2016-06-15 沃维公司 甜菊糖苷的重组生产
WO2012052427A1 (en) 2010-10-19 2012-04-26 Global Bioenergies Production of alkenes by combined enzymatic conversion of 3-hydroxyalkanoic acids
CA2816306A1 (en) 2010-10-27 2012-05-03 Danisco Us Inc. Isoprene synthase variants for improved production of isoprene
EP2742142B2 (en) 2011-08-08 2020-03-25 Evolva SA Recombinant production of steviol glycosides
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene
WO2014052054A1 (en) * 2012-09-25 2014-04-03 Albert Einstein College Of Medicine Of Yeshiva University Enzymatic platform for the synthesis of isoprenoid precursors and uses thereof
US20150315599A1 (en) * 2012-12-07 2015-11-05 Ginkgo Bioworks, Inc Methods and Systems for Methylotrophic Production of Organic Compounds
CA2899276C (en) 2013-02-06 2022-11-01 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
US10017804B2 (en) 2013-02-11 2018-07-10 Evolva Sa Efficient production of steviol glycosides in recombinant hosts
KR102178036B1 (ko) * 2013-03-15 2020-11-13 디에스엠 아이피 어셋츠 비.브이. 핵산 분해를 위한 호열성 뉴클레아제의 용도
JP6282813B2 (ja) 2013-07-16 2018-02-21 住友ゴム工業株式会社 ヒドロキシメチルグルタリルＣｏＡレダクターゼの発現をｂＺＩＰ型転写因子により調整する方法、ｂＺＩＰ型転写因子をコードする遺伝子が導入されたイソプレノイド産生植物、及び該イソプレノイド産生植物を用いたポリイソプレノイドの製造方法
WO2016008885A1 (en) * 2014-07-14 2016-01-21 Photanol B.V. Biosynthesis of sesquiterpenes in cyanobacteria
MX2017001859A (es) 2014-08-11 2017-04-11 Evolva Sa Produccion de glicosidos de esteviol en hospederos recombinantes.
JP2017528134A (ja) 2014-09-09 2017-09-28 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． 組み換え宿主におけるステビオールグリコシドの生産
BR112017016338A2 (en) 2015-01-30 2018-03-27 Evolva Sa production of steviol glycosides in recombinant hosts
CA3255837A1 (en) 2015-03-16 2025-10-30 Dsm Ip Assets B.V. Udp-glycosyltransferases
JP2018522569A (ja) 2015-08-07 2018-08-16 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． 組換え宿主内でのステビオールグリコシドの産生
US20180291401A1 (en) * 2015-08-17 2018-10-11 Invista North America S.A.R.L. Methods, hosts, and reagents related thereto for production of unsaturated pentahydrocarbons, derivatives and intermediates thereof
JP6940503B2 (ja) * 2015-08-28 2021-09-29 フィトヴェルト グリーンテクノロジーズ ゲーエムベーハー 発酵によるα−イオノン製造の方法
MY198001A (en) 2016-04-13 2023-07-25 Evolva SA Production of steviol glycoside in recombinant hosts
WO2017198682A1 (en) 2016-05-16 2017-11-23 Evolva Sa Production of steviol glycosides in recombinant hosts
US11396669B2 (en) 2016-11-07 2022-07-26 Evolva Sa Production of steviol glycosides in recombinant hosts
US11162115B2 (en) 2017-06-30 2021-11-02 Inv Nylon Chemicals Americas, Llc Methods, synthetic hosts and reagents for the biosynthesis of hydrocarbons
US11634733B2 (en) 2017-06-30 2023-04-25 Inv Nylon Chemicals Americas, Llc Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof
US11505809B2 (en) 2017-09-28 2022-11-22 Inv Nylon Chemicals Americas Llc Organisms and biosynthetic processes for hydrocarbon synthesis
WO2019113387A1 (en) 2017-12-07 2019-06-13 Zymergen Inc. Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation
JP2021506316A (ja) 2017-12-21 2021-02-22 ザイマージェン インコーポレイテッド ネペタラクトールオキシドレダクターゼ、ネペタラクトールシンターゼ、及びネペタラクトンを産生する能力がある微生物
JP6810096B2 (ja) * 2018-05-09 2021-01-06 Ｅｎｅｏｓ株式会社 カロテノイドの製造方法
CN109880745A (zh) * 2019-03-15 2019-06-14 江苏大学 一种利用腌制废水、晒盐卤水分段培养盐藻的方法
JP7901281B2 (ja) * 2022-03-30 2026-08-06 三菱ケミカル株式会社 ポリエーテルジオールの製造方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3891504A (en) 1970-07-31 1975-06-24 Hoffmann La Roche Process for the manufacture of zeaxanthin
US5015580A (en) 1987-07-29 1991-05-14 Agracetus Particle-mediated transformation of soybean plants and lines
US5328845A (en) 1992-03-27 1994-07-12 Universal Foods Corporation Fungal negative microorganism capable of producing high levels of beta-carotene
US5466599A (en) 1993-04-19 1995-11-14 Universal Foods Corporation Astaxanthin over-producing strains of phaffia rhodozyma
US5985623A (en) 1995-01-24 1999-11-16 Shin-Etsu Bio, Inc. DNA segments and methods for increasing polysaccharide production
DK0747483T3 (da) 1995-06-09 2004-06-28 Dsm Ip Assets Bv Fermentativ carotenoid-produktion
ATE242812T1 (de) 1996-12-02 2003-06-15 Hoffmann La Roche Verbesserte fermentative herstellung von carotenoide
US5935808A (en) 1997-07-29 1999-08-10 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Carotenoid-producing bacterial species and process for production of carotenoids using same
US6208893B1 (en) 1998-01-27 2001-03-27 Genetronics, Inc. Electroporation apparatus with connective electrode template
CA2630341C (en) * 1998-04-14 2011-07-26 Kyowa Hakko Kogyo Co., Ltd. Process for producing isoprenoid compounds by microorganisms
ATE490332T1 (de) * 1998-07-06 2010-12-15 Dcv Inc Verfahren zur vitaminherstellung
BR9911873A (pt) 1998-07-06 2001-03-27 Eastman Chem Co Processo para produzir fitol, um derivado de fiteno, isofitol, um derivado de isofiteno, ou uma mistura dos mesmos, composto de epoxifitila substituìdo, composto de fiteno substituìdo, processo para produzir o mesmo, processo para produzir alfa-tocoferol, e, processo para coverter geranilgeraniol a alfa-tocoferol
ES2156735B1 (es) 1999-06-09 2002-02-16 Antibioticos Sau Procedimiento de produccion de licopeno.
US6133785A (en) 1999-06-30 2000-10-17 Harris Corporation False carrier lock receiver and associated methods for detection

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101484584B (zh) * 2006-05-26 2013-03-27 阿米瑞斯公司 类异戊二烯的生产
US9200296B2 (en) 2006-05-26 2015-12-01 Amyris Inc. Production of isoprenoids
CN105331518A (zh) * 2006-05-26 2016-02-17 阿迈瑞斯公司 制造生物有机化合物的设备
US10106822B2 (en) 2006-05-26 2018-10-23 Amyris, Inc. Production of isoprenoids
CN102492701B (zh) * 2007-06-21 2013-11-06 日立造船株式会社 编码杜仲的甲羟戊酸途径的酶的基因
CN102492701A (zh) * 2007-06-21 2012-06-13 日立造船株式会社 编码杜仲的甲羟戊酸途径的酶的基因
CN111304260A (zh) * 2012-06-01 2020-06-19 朗泽科技新西兰有限公司 重组代谢微生物及其用途
US12286660B2 (en) 2012-06-01 2025-04-29 Lanzatech, Inc. Microbial fermentation for the production of terpenes
CN105339490A (zh) * 2012-12-20 2016-02-17 帝斯曼知识产权资产管理有限公司 乙酰转移酶及其用于产生类胡萝卜素的用途
CN109715796B (zh) * 2016-03-31 2021-04-09 Jxtg能源株式会社 类胡萝卜素的制造方法
CN109715796A (zh) * 2016-03-31 2019-05-03 Jxtg能源株式会社 类胡萝卜素的制造方法
CN108285902A (zh) * 2017-11-03 2018-07-17 杭州爱蔻思生物科技有限公司 生产高价值天然产物的工程菌的构造方法
CN109666683A (zh) * 2019-02-27 2019-04-23 昆明理工大学 乙酰辅酶A乙酰转移酶基因RKAcaT2及其应用
CN109666683B (zh) * 2019-02-27 2021-10-29 昆明理工大学 乙酰辅酶A乙酰转移酶基因RKAcaT2及其应用
CN109777815A (zh) * 2019-03-28 2019-05-21 昆明理工大学 HMG-CoA合成酶基因RKHMGCS及其应用
CN115003823A (zh) * 2019-12-26 2022-09-02 加利福尼亚大学董事会 用于生产大麻素和其他异戊二烯化化合物的生物合成平台
CN115605589A (zh) * 2020-05-15 2023-01-13 巴斯夫欧洲公司（De） 改进的用于生产类异戊二烯的方法
CN117965414A (zh) * 2024-04-01 2024-05-03 北京微构工场生物技术有限公司 一种重组盐单胞菌及其在生产异戊二烯中的应用
CN117965414B (zh) * 2024-04-01 2024-06-14 北京微构工场生物技术有限公司 一种重组盐单胞菌及其在生产异戊二烯中的应用

Also Published As

Publication number Publication date
JP4280627B2 (ja) 2009-06-17
ES2311613T3 (es) 2009-02-16
US6989257B2 (en) 2006-01-24
EP1392824A2 (en) 2004-03-03
EP1392824B1 (en) 2008-08-20
ATE405638T1 (de) 2008-09-15
KR20040010683A (ko) 2004-01-31
CA2449885A1 (en) 2002-12-12
US7232679B2 (en) 2007-06-19
US20030148416A1 (en) 2003-08-07
AU2002316966B2 (en) 2007-05-17
WO2002099095A3 (en) 2003-12-18
US20050266518A1 (en) 2005-12-01
DE60228439D1 (de) 2008-10-02
JP2004527265A (ja) 2004-09-09
WO2002099095A2 (en) 2002-12-12
KR100704072B1 (ko) 2007-04-05

Similar Documents

Publication Publication Date Title
KR100704072B1 (ko) 개선된 이소프레노이드 제조 방법
CN1262648C (zh) 改进的类异戊二烯的生产
EP3230459B1 (en) Recombinant microorganisms exhibiting increased flux through a fermentation pathway
US10000749B2 (en) Valencene synthase polypeptides, encoding nucleic acid molecules and uses thereof
CN1227362C (zh) 生产刺糖噻杀虫剂所用的生物合成基因
CN101044243A (zh) 类异戊二烯的生产方法
CN111849794B (zh) 一种酿酒酵母重组菌及其构建方法和应用
CN1556855A (zh) 3-羟基丙酸及其它有机化合物
CN1961072A (zh) 改良型腈水合酶
WO2006089898A1 (en) Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof
CN101080490A (zh) 改进的甲羟戊酸激酶
CN1993377A (zh) 丙氨酸2,3氨基变位酶
CN1717493A (zh) 大环内酯化合物的产生方法
CN1266101A (zh) 虾青素合成酶
CN1813065A (zh) 反馈抗性乙酰羟酸合成酶突变体
US20220348974A1 (en) Biotin synthases for efficient production of biotin
EP2141236A1 (en) Process for production of lipstatin and microorganisms therefore
JP2022116107A (ja) スクアレン消費酵素のスクリーニング方法及びスクアレン－ホペン環化酵素
CN109072216B (zh) 变异型四异戊烯基-β-姜黄烯环化酶及龙涎香醇的制备方法
CN1387566A (zh) 环状缩肽合成酶及其基因、以及环状缩肽的大规模生产系统
CN1498270A (zh) 基因已被破坏的酵母
CN1230544C (zh) 磷酸己酮糖异构酶和编码该酶的基因
CN1906291A (zh) 用扩增zwf基因制备L－氨基酸的方法
WO2014102180A1 (en) Propanol production by lactobacillus bacterial hosts
CN1377407A (zh) 生产被官能团修饰的次级代谢产物的转化体和新的生物合成基因

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Open date: 20050622