CN1551781B - 单剂量猪肺炎支原体疫苗 - Google Patents
单剂量猪肺炎支原体疫苗 Download PDFInfo
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- CN1551781B CN1551781B CN028133447A CN02813344A CN1551781B CN 1551781 B CN1551781 B CN 1551781B CN 028133447 A CN028133447 A CN 028133447A CN 02813344 A CN02813344 A CN 02813344A CN 1551781 B CN1551781 B CN 1551781B
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- Prior art keywords
- mycoplasma hyopneumoniae
- vaccine
- pig
- protein
- mycoplasma
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Landscapes
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Abstract
Description
Claims (3)
Priority Applications (1)
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CN201210389058.0A CN102872456B (zh) | 2001-07-02 | 2002-06-07 | 单剂量猪肺炎支原体疫苗 |
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US30263601P | 2001-07-02 | 2001-07-02 | |
US60/302,636 | 2001-07-02 | ||
PCT/IB2002/002121 WO2003003941A2 (en) | 2001-07-02 | 2002-06-07 | One dose vaccination with mycoplasma hyopneumoniae |
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CN200810186079.6A Division CN101524532B (zh) | 2001-07-02 | 2002-06-07 | 单剂量猪肺炎支原体疫苗 |
CN201210389058.0A Division CN102872456B (zh) | 2001-07-02 | 2002-06-07 | 单剂量猪肺炎支原体疫苗 |
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CN1551781A CN1551781A (zh) | 2004-12-01 |
CN1551781B true CN1551781B (zh) | 2013-01-02 |
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CN201210389058.0A Expired - Lifetime CN102872456B (zh) | 2001-07-02 | 2002-06-07 | 单剂量猪肺炎支原体疫苗 |
CN200810186079.6A Expired - Lifetime CN101524532B (zh) | 2001-07-02 | 2002-06-07 | 单剂量猪肺炎支原体疫苗 |
CN028133447A Expired - Lifetime CN1551781B (zh) | 2001-07-02 | 2002-06-07 | 单剂量猪肺炎支原体疫苗 |
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CN201210389058.0A Expired - Lifetime CN102872456B (zh) | 2001-07-02 | 2002-06-07 | 单剂量猪肺炎支原体疫苗 |
CN200810186079.6A Expired - Lifetime CN101524532B (zh) | 2001-07-02 | 2002-06-07 | 单剂量猪肺炎支原体疫苗 |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY129765A (en) * | 2000-12-19 | 2007-04-30 | Wyeth Corp | Improved mycoplasma hyopneumoniae bacterin vaccine |
WO2006056841A1 (en) * | 2004-11-24 | 2006-06-01 | Pharmacia & Upjohn Company Llc | Multiple-strain mycoplasma hyopneumoniae vaccines |
UA95602C2 (ru) | 2004-12-30 | 2011-08-25 | Берингер Ингельхейм Ветмедика, Инк. | Иммуногенная композиция цвс2 и способы приготовления такой композиции |
US7833707B2 (en) | 2004-12-30 | 2010-11-16 | Boehringer Ingelheim Vetmedica, Inc. | Methods of overexpression and recovery of porcine circovirus type 2 ORF2 |
US7700285B1 (en) | 2005-12-29 | 2010-04-20 | Boehringer Ingelheim Vetmedica, Inc. | PCV2 immunogenic compositions and methods of producing such compositions |
US8834891B2 (en) | 2005-03-14 | 2014-09-16 | Boehringer Ingelheim Vetmedica, Inc. | Immunogenic compositions comprising Lawsonia intracellularis |
KR101436794B1 (ko) * | 2005-12-29 | 2014-09-04 | 베링거잉겔하임베트메디카인코퍼레이티드 | 다가 pcv2 면역원성 조성물 및 이러한 조성물의 제조방법 |
ES2572736T3 (es) | 2005-12-29 | 2016-06-02 | Boehringer Ingelheim Vetmedica, Inc. | Uso de una composición inmunógena para atenuar síntomas clínicos en cerdos |
BRPI0708522A2 (pt) * | 2006-03-03 | 2011-05-31 | Merial Ltd | vacina de mycoplasma hyopneumoniae |
EP2099927A4 (en) * | 2006-11-22 | 2010-05-05 | Boehringer Ingelheim Vetmed | METHODS FOR REDUCING FLAMBEES OF DISEASES ASSOCIATED WITH PORCINIC CIRCOVIRUS |
US20100129397A1 (en) | 2006-12-11 | 2010-05-27 | Boehringer Ingelheim Vetmedica, Inc. | Effective method of treatment of porcine circovirus and lawsonia intracellularis infections |
DK2094872T4 (da) | 2006-12-15 | 2020-05-18 | Boehringer Ingelheim Animal Health Usa Inc | Behandling af anti-PCV2-antistofseropositive svin med PCV2-antigen |
EP1941903A1 (en) | 2007-01-03 | 2008-07-09 | Boehringer Ingelheim Vetmedica Gmbh | Prophylaxis and treatment of PRDC |
EP1958644A1 (en) | 2007-02-13 | 2008-08-20 | Boehringer Ingelheim Vetmedica Gmbh | Prevention and treatment of sub-clinical pcvd |
US7829274B2 (en) | 2007-09-04 | 2010-11-09 | Boehringer Ingelheim Vetmedica, Inc. | Reduction of concomitant infections in pigs by the use of PCV2 antigen |
EP2217271B1 (en) * | 2007-11-06 | 2016-05-04 | Zoetis Services LLC | Mycoplasma hyopneumoniae avirulent -adjuvanted live vaccine |
AU2008347235A1 (en) * | 2007-12-31 | 2009-07-16 | Boehringer Ingelheim Vetmedica, Inc. | PCV2 ORF2 virus like particle with foreign amino acid insertion |
CN101236206B (zh) * | 2008-01-17 | 2014-10-15 | 中国兽医药品监察所 | 一种猪肺炎支原体重组抗原elisa检测试剂盒 |
US20090317423A1 (en) * | 2008-01-23 | 2009-12-24 | Boehringer Ingelheim Vetmedica, Inc. | Pcv2 mycoplasma hyopneumoniae immunogenic compositions and methods of producing such compositions |
US8444989B1 (en) * | 2008-04-18 | 2013-05-21 | Boehringer Ingelheim Vetmedica Gmbh | One dose vaccination against mycoplasma infections of pigs |
ES2569907T3 (es) | 2008-06-27 | 2016-05-13 | Zoetis Services Llc | Composiciones adyuvantes novedosas |
CN102448488B (zh) | 2009-06-04 | 2014-10-15 | 独立行政法人产业技术综合研究所 | 支原体感染症用疫苗 |
AR078253A1 (es) | 2009-09-02 | 2011-10-26 | Boehringer Ingelheim Vetmed | Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad |
CA2793959C (en) | 2010-03-25 | 2019-06-04 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
PL2569007T3 (pl) | 2010-05-11 | 2016-04-29 | Intervet Int Bv | Szczepionka przeciwko Mycoplasma Hyopneumoniae, odpowiednia do podawania w obecności przeciwciał pochodzących od matki |
EP3235506B1 (en) * | 2010-07-26 | 2023-12-06 | Qu Biologics Inc. | Immunogenic anti-inflammatory compositions |
US8546149B2 (en) | 2010-08-27 | 2013-10-01 | Intervet Inc. | Potency test for vaccine formulations |
JP5650327B2 (ja) * | 2010-08-27 | 2015-01-07 | インターベット インターナショナル ベー. フェー. | ワクチン製剤についての効力試験 |
HUE037408T2 (hu) | 2011-06-10 | 2018-08-28 | Univ Oregon Health & Science | CMV glikoproteinek és rekombináns vektorok |
UA115053C2 (uk) * | 2012-03-07 | 2017-09-11 | Сева Санте Анімаль | Композиція, що містить антиген і ліпополісахарид у формі масло-в-воді, та спосіб її використання (варіанти) |
UA114504C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs |
UA114503C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv та mycoplasma hyopneumoniae |
US9120859B2 (en) | 2012-04-04 | 2015-09-01 | Zoetis Services Llc | Mycoplasma hyopneumoniae vaccine |
WO2014105671A1 (en) | 2012-12-28 | 2014-07-03 | Boehringer Ingelheim Vetmedica Gmbh | Immunogenic composition comprising mycoplasma antigens |
WO2014105672A1 (en) | 2012-12-28 | 2014-07-03 | Boehringer Ingelheim Vetmedica Gmbh | Method of making a mycoplasma vaccine |
ES2812552T3 (es) * | 2013-02-05 | 2021-03-17 | Agricultural Tech Res Inst | Vacuna subunitaria contra Mycoplasma spp. |
CN104338125A (zh) * | 2013-07-29 | 2015-02-11 | 普莱柯生物工程股份有限公司 | 一种猪肺炎支原体抗原在预防和治疗猪呼吸道疾病综合征方面的应用 |
CA2924526A1 (en) | 2013-09-19 | 2015-03-26 | Paul Joseph Dominowski | Water-in-oil emulsions comprising immunostimulatory oligonucleotides |
JP6778104B2 (ja) | 2013-10-02 | 2020-10-28 | ベーリンガー・インゲルハイム・アニマル・ヘルス・ユーエスエー・インコーポレイテッドBoehringer Ingelheim Animal Health Usa Inc. | Pcv2 orf2タンパク質変種および前記を含むウイルス様粒子 |
JP6434017B2 (ja) | 2013-11-21 | 2018-12-05 | アグリカルチュラル テクノロジー リサーチ インスティテュート | マイコプラズマ属菌種の感染を予防する組成物 |
CN105012948B (zh) * | 2014-04-18 | 2019-07-30 | 普莱柯生物工程股份有限公司 | 一种疫苗组合物及其应用 |
CN104248753B (zh) * | 2014-05-15 | 2017-07-28 | 普莱柯生物工程股份有限公司 | 一种疫苗组合物及其应用 |
BR102014014727B1 (pt) * | 2014-06-16 | 2018-04-03 | Ouro Fino Saúde Animal Ltda | COMPLEXO DE POLIPROTEÍNAS IMUNOGÊNICAS DE M. hyopneumoniae, GENE SINTÉTICO CODIFICANTE DO COMPLEXO DE POLIPROTEÍNAS IMUNOGÊNICAS DE M. hyopneumoniae, COMPOSIÇÃO ANTIGÊNICA, PROCESSO DE OBTENÇÃO DE UM COMPLEXO DE POLIPROTEÍNAS IMUNOGÊNICAS DE M. hyopneumoniae |
US9814769B2 (en) | 2014-09-30 | 2017-11-14 | Qatar University | Vaccines against pathogenic Escherichia coli and methods of using the same |
PL3244920T3 (pl) | 2015-01-16 | 2023-09-25 | Zoetis Services Llc | Szczepionka przeciw pryszczycy |
KR20160099223A (ko) * | 2015-02-12 | 2016-08-22 | 강원대학교산학협력단 | 마이코플라스마 하이오뉴모니애 박테린 백신 및 이의 제조방법 |
KR101846478B1 (ko) * | 2016-08-12 | 2018-04-06 | 주식회사 이노백 | 재조합 단백질을 포함하는 돼지 마이코플라즈마 감염 예방용 백신 조성물 |
RU2668799C1 (ru) * | 2017-09-08 | 2018-10-02 | Эгрикалчурал Текнолоджи Рисерч Инститьют | Субъединичная вакцина против mycoplasma spp. |
CN108101969A (zh) * | 2017-11-13 | 2018-06-01 | 南京大爻网络科技有限公司 | 一种与猪支原体肺炎相关的抗原及其应用 |
RU2695679C1 (ru) * | 2018-09-11 | 2019-07-25 | Эгрикалчурал Текнолоджи Рисерч Инститьют | Субъединичная вакцина против mycoplasma spp. |
RU2759427C2 (ru) * | 2019-07-08 | 2021-11-12 | Эгрикалчурал Текнолоджи Рисерч Инститьют | Субъединичная вакцина против mycoplasma spp |
CN117305192A (zh) * | 2023-12-01 | 2023-12-29 | 北京瑞阳瑞泰生物科技有限公司 | 一种猪肺炎支原体rt02株、疫苗组合物及其应用 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0283840A3 (en) * | 1987-03-26 | 1989-08-09 | Ml Technology Ventures, L.P. | Mycoplasma hyopneumoniae antigen and uses therefor |
US5252328A (en) | 1987-03-26 | 1993-10-12 | Martin Marietta Energy Systems, Inc. | Mycoplasma hyopneumoniae antigen and uses therefor |
DE3881993T2 (de) | 1987-09-18 | 1993-09-30 | Akzo Nv | Mycoplasma-Impfstoff. |
JPH05506984A (ja) | 1990-04-02 | 1993-10-14 | サイナーゲン,インコーポレーテッド | 動物におけるマイコプラズマ感染に対する診断と治療に有用なポリペプチド |
US6113916A (en) * | 1990-05-29 | 2000-09-05 | American Cyanamid Company | Method of enhancing cell mediated immune responses |
AU657907B2 (en) | 1990-05-29 | 1995-03-30 | Wyeth Holdings Corporation | Mycoplasma hyopneumoniae vaccine |
US5565205A (en) * | 1990-08-16 | 1996-10-15 | Solvay Animal Health, Inc. | Inactivated Mycoplasma hypopneumoniae bacterin and method of use thereof |
EP0475185A1 (en) | 1990-08-27 | 1992-03-18 | Nippon Flour Mills Co., Ltd. | DNA's encoding surface antigen of mycoplasma hyopneumoniae, DNA fragments for primer, recombinant antigenic peptides and diagnostic method of mycoplasmal pneumoniae of swine using same |
US5338543A (en) * | 1992-02-27 | 1994-08-16 | Ambico, Inc. | Thimerosal inactivated mycoplasma hyopneumoniae vaccine |
ATE273022T1 (de) * | 1992-09-28 | 2004-08-15 | Wyeth Corp | Verfahren zur verstärkung zellularer immunantworten |
US5530874A (en) | 1993-02-02 | 1996-06-25 | 3Com Corporation | Network adapter with an indication signal mask and an interrupt signal mask |
WO1995009870A1 (en) | 1993-10-07 | 1995-04-13 | Iowa State University Research Foundation, Inc. | Characterization of mycoplasma hyopneumoniae adhesins |
BR9507717A (pt) | 1994-05-10 | 1997-09-23 | American Home Prod | Vacina brsv viva modificada aperfeiçoada |
US5788962A (en) | 1995-01-17 | 1998-08-04 | The Curators Of The University Of Missouri | DNA sequences coding for mycoplasma hyopneumoniae surface antigens, corresponding proteins and use in vaccines and diagnostic procedures |
AUPN178995A0 (en) | 1995-03-16 | 1995-04-13 | University Of Melbourne, The | Antigen composition |
ID21338A (id) | 1996-09-30 | 1999-05-27 | Embrex Inc | Metoda untuk menghasilkan kekebalan aktif dengan vaksin gabungan |
EP0846468B1 (en) | 1996-12-05 | 2004-06-09 | Akzo Nobel N.V. | Non-virulent mycoplasma synoviae and vaccine thereof |
KR20010032493A (ko) | 1997-11-26 | 2001-04-25 | 아이오와 스테이트 유니버시티 리서치 파운데이션, 인코퍼레이티드 | 재조합 미코플라스마 히오뉴모니아(Mycoplasmahyopneumoniae) 백신 |
AU6128900A (en) * | 1999-09-29 | 2001-04-05 | Pfizer Products Inc. | Nucleic acids and proteins of the mycoplasma hyopneumoniae mph3 gene and uses thereof |
US6585981B1 (en) * | 2000-07-27 | 2003-07-01 | Regents Of The University Of Minnesota | Temperature-sensitive live vaccine for Mycoplasma hyopneumoniae |
UA114504C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs |
-
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Non-Patent Citations (2)
Title |
---|
张道永等.猪支原体肺炎免疫试验.西南农业学报13 增刊.2000,13(增刊),第119页. |
张道永等.猪支原体肺炎免疫试验.西南农业学报13 增刊.2000,13(增刊),第119页. * |
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