CN1515552A - 近红外荧光造影剂和荧光成像 - Google Patents

近红外荧光造影剂和荧光成像 Download PDF

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Publication number
CN1515552A
CN1515552A CNA021548455A CN02154845A CN1515552A CN 1515552 A CN1515552 A CN 1515552A CN A021548455 A CNA021548455 A CN A021548455A CN 02154845 A CN02154845 A CN 02154845A CN 1515552 A CN1515552 A CN 1515552A
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CN
China
Prior art keywords
compound
molecular formula
salt
group
sulfonic acid
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Pending
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CNA021548455A
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English (en)
Chinese (zh)
Inventor
ֱ
三轮直人
ʷ
稻垣陆史
江口博明
奥村正文
稻垣由夫
原田徹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Fujifilm Corp
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Schering AG
Fujifilm Corp
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Publication of CN1515552A publication Critical patent/CN1515552A/zh
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032Methine dyes, e.g. cyanine dyes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C09B23/0016Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being a halogen atom
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C09B23/0025Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being bound through an oxygen atom
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C09B23/0033Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being bound through a sulfur atom
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C09B23/0041Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being bound through a nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0066Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/06Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups three >CH- groups, e.g. carbocyanines
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/80Fluorescent dyes, e.g. rhodamine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Transforming Light Signals Into Electric Signals (AREA)
  • Medicinal Preparation (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Eye Examination Apparatus (AREA)
CNA021548455A 1998-09-18 1999-09-16 近红外荧光造影剂和荧光成像 Pending CN1515552A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP283301/1998 1998-09-18
JP10283301A JP2000095758A (ja) 1998-09-18 1998-09-18 近赤外蛍光造影剤および蛍光造影方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNB998103969A Division CN1196497C (zh) 1998-09-18 1999-09-16 近红外荧光造影剂和荧光成像

Publications (1)

Publication Number Publication Date
CN1515552A true CN1515552A (zh) 2004-07-28

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CNA021548455A Pending CN1515552A (zh) 1998-09-18 1999-09-16 近红外荧光造影剂和荧光成像
CNB998103969A Expired - Fee Related CN1196497C (zh) 1998-09-18 1999-09-16 近红外荧光造影剂和荧光成像

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US (1) US7488468B1 (enExample)
EP (1) EP1113822B1 (enExample)
JP (2) JP2000095758A (enExample)
KR (2) KR100531708B1 (enExample)
CN (2) CN1515552A (enExample)
AT (1) ATE248608T1 (enExample)
AU (1) AU763991B2 (enExample)
BG (3) BG65172B1 (enExample)
BR (1) BR9913849A (enExample)
CA (1) CA2344315A1 (enExample)
DE (1) DE69911034T2 (enExample)
DK (1) DK1113822T3 (enExample)
EA (2) EA005070B1 (enExample)
EE (1) EE200100162A (enExample)
ES (1) ES2207338T3 (enExample)
HK (1) HK1042855B (enExample)
HU (1) HUP0103503A3 (enExample)
ID (1) ID29455A (enExample)
IL (2) IL141656A0 (enExample)
MX (1) MXPA01002194A (enExample)
NO (2) NO322559B1 (enExample)
NZ (1) NZ510019A (enExample)
PL (1) PL193411B1 (enExample)
PT (1) PT1113822E (enExample)
RS (1) RS50203B (enExample)
SK (1) SK3742001A3 (enExample)
TR (1) TR200100746T2 (enExample)
UA (2) UA67800C2 (enExample)
WO (1) WO2000016810A1 (enExample)
YU (1) YU97502A (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113717089A (zh) * 2021-09-22 2021-11-30 中国科学院精密测量科学与技术创新研究院 一种氟化Cy7化合物及其合成方法和应用

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6593148B1 (en) 1994-03-01 2003-07-15 Li-Cor, Inc. Cyanine dye compounds and labeling methods
US7547721B1 (en) 1998-09-18 2009-06-16 Bayer Schering Pharma Ag Near infrared fluorescent contrast agent and fluorescence imaging
JP2000095758A (ja) 1998-09-18 2000-04-04 Schering Ag 近赤外蛍光造影剤および蛍光造影方法
AU2097500A (en) * 1999-12-15 2001-06-25 Fuji Photo Film Co., Ltd. Near infrared fluorescent contrast agent and fluorescence imaging
US7790144B2 (en) * 2000-01-18 2010-09-07 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
US20080233050A1 (en) * 2000-01-18 2008-09-25 Mallinckrodt Inc. Diagnostic and therapeutic optical agents
WO2002024815A1 (en) * 2000-09-19 2002-03-28 Li-Cor, Inc. Cyanine dyes
US7597878B2 (en) * 2000-09-19 2009-10-06 Li-Cor, Inc. Optical fluorescent imaging
US6663847B1 (en) * 2000-10-13 2003-12-16 Mallinckrodt Inc. Dynamic organ function monitoring agents
US6669926B1 (en) * 2000-10-16 2003-12-30 Mallinckrodt, Inc. Hydrophilic light absorbing indole compounds for determination of physiological function in critically ill patients
US6716413B1 (en) * 2000-10-16 2004-04-06 Mallinckrodt, Inc. Indole compounds as tissue-specific exogenous optical agents
US6733744B1 (en) * 2000-10-16 2004-05-11 Mallinckrodt Inc. Indole compounds as minimally invasive physiological function monitoring agents
US6673334B1 (en) * 2000-10-16 2004-01-06 Mallinkcrodt, Inc. Light sensitive compounds for instant determination of organ function
US6656451B1 (en) * 2000-10-16 2003-12-02 Mallinckrodt, Inc. Indole compounds as novel dyes for organ function monitoring
US7556797B2 (en) 2000-10-16 2009-07-07 Mallinckrodt Inc. Minimally invasive physiological function monitoring agents
EP1341557A2 (en) 2000-10-27 2003-09-10 Beth Israel Deaconess Medical Center Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates
WO2004065491A1 (en) * 2003-01-24 2004-08-05 Schering Ag Hydrophilic, thiol-reactive cyanine dyes and conjugates thereof with biomolecules for fluorescence diagnosis
JP2005145921A (ja) * 2003-11-19 2005-06-09 Konica Minolta Medical & Graphic Inc 診断用蛍光造影剤及び蛍光造影診断方法
US7682602B2 (en) * 2003-12-19 2010-03-23 Konica Minolta Medical & Graphic, Inc. Near-infrared fluorescent contrast medium
JP2005220045A (ja) * 2004-02-04 2005-08-18 Konica Minolta Medical & Graphic Inc 蛍光造影剤
DE602005025911D1 (de) * 2004-11-22 2011-02-24 Ge Healthcare As Kontrastmittel für eine extrazelluläre matrix
EP1679082A1 (en) * 2005-01-07 2006-07-12 Schering AG Use of cyanine dyes for the diagnosis of proliferative diseases
US8227621B2 (en) 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
FR2889700B1 (fr) * 2005-08-11 2012-11-23 Synthinnove Lab Marqueurs, leur procede de fabrication et leurs applications
US8173819B2 (en) 2005-09-02 2012-05-08 Visen Medical, Inc. Nicotinic and picolinic acid derived near-infrared fluorophores
JP5106397B2 (ja) 2005-09-02 2012-12-26 ビセン メディカル, インコーポレイテッド 生体適合性n,n−二置換スルホンアミド含有蛍光色素標識
US7947256B2 (en) 2005-09-02 2011-05-24 Visen Medical, Inc. Biocompatible fluorescent imaging agents
US8838210B2 (en) 2006-06-29 2014-09-16 AccuView, Inc. Scanned laser vein contrast enhancer using a single laser
ITSV20060002A1 (it) 2006-01-19 2007-07-20 Ferrania Technologies Spa Colorante fluorescente di tipo cianinico
EP1815870A1 (en) * 2006-02-01 2007-08-08 DKFZ Deutsches Krebsforschungszentrum Cyanine dye compounds linked to metal chelator for bi-modal diagnostic imaging
JP4958461B2 (ja) * 2006-03-30 2012-06-20 富士フイルム株式会社 近赤外吸収色素含有硬化性組成物
US7745645B2 (en) * 2007-01-22 2010-06-29 Pierce Biotechnology, Inc. Sulfonamide derivatives of xanthene compounds
US8344158B2 (en) * 2007-08-15 2013-01-01 Washington University Fluorescent polymethine cyanine dyes
DE102007059752A1 (de) 2007-12-10 2009-06-18 Bayer Schering Pharma Aktiengesellschaft Funktionalisierte, feste Polymernanopartikel enthaltend Epothilone
US20090214436A1 (en) 2008-02-18 2009-08-27 Washington University Dichromic fluorescent compounds
JP5500875B2 (ja) * 2009-01-30 2014-05-21 キヤノン株式会社 新規化合物、該新規化合物を用いたプローブ及び該新規化合物もしくは該プローブを用いた蛍光イメージング用造影剤
EP2396318A4 (en) 2009-02-11 2013-06-05 Life Technologies Corp COLORANTS WITH HIGH STOKES DERIVATION
JP2011046663A (ja) 2009-08-28 2011-03-10 Fujifilm Corp 近赤外蛍光造影剤
JP2011046662A (ja) 2009-08-28 2011-03-10 Fujifilm Corp 近赤外蛍光造影剤
EP2470887B1 (en) 2009-08-28 2020-03-11 VisEn Medical, Inc. Systems for tomographic imaging in diffuse media using a hybrid inversion technique
CA2810822C (en) 2009-09-22 2018-03-06 Visen Medical, Inc. Systems and methods for virtual index-matching of diffusive media
US8273875B2 (en) 2009-11-16 2012-09-25 University Of Notre Dame Du Lac High performance luminescent compounds
JP5817073B2 (ja) * 2010-01-28 2015-11-18 国立大学法人三重大学 新規インドシアニン化合物を用いた診断用組成物及び分析方法
PL2530093T3 (pl) * 2010-01-28 2019-06-28 National University Corporation Mie University Związek indocyjaninowy, jego metoda syntezy, metoda jego oczyszczania, kompozycja diagnostyczna wykorzystująca związek indocyjaninowy oraz urządzenie do pomiaru biokinetyki in vivo i urządzenie do wizualizacji krążenia wykorzystujące kompozycję diagnostyczną
WO2012123916A2 (en) 2011-03-15 2012-09-20 Ramot At Tel-Aviv University Ltd. Activatable fluorogenic compounds and uses thereof as near infrared probes
EP2764406B1 (en) * 2011-10-07 2018-03-14 Cedars-Sinai Medical Center Compositions and methods for tumor imaging and targeting by a class of organic heptamethine cyanine dyes that possess dual nuclear and near-infrared properties
EP3553075B1 (en) 2012-01-23 2025-01-08 Washington University Goggle imaging systems and methods
EP2906106B1 (en) 2012-10-15 2023-06-14 VisEn Medical, Inc. Systems, methods, and apparatus for imaging of diffuse media featuring cross-modality weighting of fluorescent and bioluminescent sources
US10517483B2 (en) 2012-12-05 2019-12-31 Accuvein, Inc. System for detecting fluorescence and projecting a representative image
US20170232119A1 (en) 2013-03-15 2017-08-17 Purdue Research Foundation Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
JP6192799B2 (ja) 2013-03-15 2017-09-06 パーデュー・リサーチ・ファウンデーションPurdue Research Foundation 腫瘍の標的画像化に使用される化合物にコンジュゲートしているアミノ酸連結基の合成および組成物
EP2997353B1 (en) * 2013-05-15 2022-10-12 The Administrators of The Tulane Educational Fund Microscopy of a tissue sample using structured illumination
US11001562B2 (en) 2013-10-31 2021-05-11 Beth Israel Deaconess Medical Center Near-infrared fluorescent nerve contrast agents and methods of use thereof
EP4147724A1 (en) 2013-10-31 2023-03-15 Beth Israel Deaconess Medical Center Near-infrared fluorescent contrast bioimaging agents and methods of use thereof
CN106455979A (zh) 2013-12-31 2017-02-22 纪念斯隆-凯特琳癌症中心 用于荧光源实时多通道成像的系统、方法和设备
AR102743A1 (es) * 2014-11-26 2017-03-22 Li Cor Inc Medios de contraste ir para imágenes por fluorescencia
KR20170094268A (ko) 2014-12-15 2017-08-17 메모리얼 슬로안-케터링 캔서 센터 향상된 신경-결합 선택성을 갖는 고리형 펩티드, 상기 고리형 펩티드와 결합된 나노입자, 및 실시간 생체내 신경 조직 영상화를 위한 이들의 용도
US10251711B2 (en) 2015-01-07 2019-04-09 Michael Frank Gunter WOOD Optical probes for corridor surgery
KR20160086481A (ko) 2015-01-09 2016-07-20 차의과학대학교 산학협력단 신규 유기 화합물 및 이를 포함하는 근적외선 형광 조영제, 그리고 조영제의 나노입자화 방법
US10806804B2 (en) 2015-05-06 2020-10-20 Washington University Compounds having RD targeting motifs and methods of use thereof
RU2720976C2 (ru) * 2015-06-03 2020-05-15 Сюржимаб С.А.С. Флуоресцентные конъюгаты и их применение для диагностики опухоли
US10405753B2 (en) 2015-11-10 2019-09-10 Intuitive Surgical Operations, Inc. Pharmaceutical compositions of near IR closed chain, sulfo-cyanine dyes
CA3007062A1 (en) * 2015-12-01 2017-06-08 Dishman Pharmaceuticals And Chemicals Limited An improved process for the preparation of indocyanine green
KR20180093961A (ko) 2015-12-15 2018-08-22 메모리얼 슬로안-케터링 캔서 센터 조직 구별, 예를 들어, 수술 중 시각화를 위한 영상화 시스템 및 방법
FR3058148A1 (fr) 2016-10-31 2018-05-04 Compagnie Generale Des Etablissements Michelin Composition de caoutchouc comprenant une charge renforcante specifique
WO2018102372A1 (en) 2016-11-30 2018-06-07 Memorial Sloan Kettering Cancer Center Inhibitor-functionalized ultrasmall nanoparticles and methods thereof
US10758631B2 (en) 2017-04-11 2020-09-01 Li-Cor, Inc. Solid cyanine dyes
WO2018191261A1 (en) * 2017-04-11 2018-10-18 Li-Cor, Inc. Solid cyanine dyes
KR101980292B1 (ko) * 2017-08-03 2019-05-20 (주)바이오액츠 형광 화합물 및 이의 제조방법
US11549017B2 (en) * 2017-09-29 2023-01-10 Perkinelmer Health Sciences, Inc. NIR to SWIR fluorescent compounds for imaging and detection
CN111278663B (zh) 2017-10-30 2022-04-26 米其林集团总公司 设有由至少异戊二烯弹性体、增强树脂和金属盐制成的内层的轮胎
CN109959612A (zh) * 2017-12-14 2019-07-02 深圳先进技术研究院 一种光声探针在制备ntr光声检测试剂中的应用
EP3773153A4 (en) 2018-03-30 2021-11-17 Perkinelmer Health Sciences Inc. SYSTEMS AND PROCEDURES FOR THE 3D RECONSTRUCTION OF ANATOMICAL ORGANS AND INCLUSIONS USING SHORT WAVE INFRARED (SWIR) PROJECTION STOMOGRAPHY
IL287989B2 (en) * 2019-05-13 2025-07-01 Bracco Imaging Spa Modified cyanine dyes and their conjugates
KR102034113B1 (ko) * 2019-06-13 2019-10-18 나우비젼 주식회사 종양특이성을 증가시킨 신장배출형 형광 조영제 및 이를 이용한 영상화 방법
JP7512577B2 (ja) * 2019-09-24 2024-07-09 株式会社ニコン 撮影方法、眼科装置、およびプログラム
EP4072598A4 (en) 2019-12-13 2024-02-21 Washington University Near infrared fluorescent dyes, formulations and related methods
EP4015004A1 (en) 2020-12-18 2022-06-22 Phi Pharma SA Proteoglycan specific branched peptides
WO2022163807A1 (ja) * 2021-01-29 2022-08-04 国立大学法人北海道大学 光音響イメージング剤
WO2022258455A1 (en) 2021-06-07 2022-12-15 Surgvision Gmbh Stable liquid phantom for near-infrared fluorescence verification
KR102414554B1 (ko) * 2022-02-27 2022-06-30 (주)바이오액츠 생체물질을 검출하기 위한 형광 화합물 및 이의 제조방법
US20250082795A1 (en) 2023-09-12 2025-03-13 Curadel Surgical Innovations, Inc. Combinations of imaging agent conjugates and application thereof

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62123454A (ja) * 1985-08-08 1987-06-04 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
US4871656A (en) 1987-04-24 1989-10-03 Eastman Kodak Company Photographic silver halide elements containing infrared filter dyes
ATE206395T1 (de) 1990-05-15 2001-10-15 Hyperion Inc Fluoreszierende porphyrin- und fluoreszierende phthalocyanin-polyethylenglykol-, polyol- und saccharidderivate als fluoreszierende sonden
US5298379A (en) 1992-06-30 1994-03-29 Eastman Kodak Company Radiation sensitive element with absorber dye to enhance spectral sensitivity range
JP2955803B2 (ja) 1992-07-22 1999-10-04 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
EP0591820A1 (en) * 1992-10-05 1994-04-13 E.I. Du Pont De Nemours And Company Near-infrared absorbing dyes prepared from Stenhouse salts
JPH06145539A (ja) 1992-11-04 1994-05-24 Fuji Photo Film Co Ltd シアニン化合物
US5658751A (en) 1993-04-13 1997-08-19 Molecular Probes, Inc. Substituted unsymmetrical cyanine dyes with selected permeability
US5440042A (en) 1993-05-26 1995-08-08 E. I. Du Pont De Nemours And Company Thioheterocyclic near-infrared dyes
DE4426892A1 (de) * 1994-07-29 1996-02-15 Riedel De Haen Ag Verwendung von Indolenincyanindisulfonsäure-Derivaten
DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
US5968479A (en) 1995-01-30 1999-10-19 Daiichi Pure Chemicals Co., Ltd. Diagnostic marker
IT1276833B1 (it) * 1995-10-09 1997-11-03 Sorin Biomedica Cardio Spa Coloranti fluorescenti della famiglia della solfo benz e indocianina
DE19539409C2 (de) 1995-10-11 1999-02-18 Diagnostikforschung Inst Kontrastmittel für die Nahinfrarot-Diagnostik
US5723204A (en) 1995-12-26 1998-03-03 Xerox Corporation Two-sided electrical paper
WO1997040104A1 (en) 1996-04-19 1997-10-30 Amersham Pharmacia Biotech Uk Limited Squarate dyes and their use in fluorescent sequencing method
US5672332A (en) 1996-05-13 1997-09-30 Mallinckrodt Medical, Inc. Delta 1,2 bicyclo 4,4,0! functional dyes for contrast enhancement in optical imaging
US5709845A (en) 1996-05-13 1998-01-20 Rajagopalan; Raghavan Tricyclic functional dyes for contrast enhancement in optical imaging
US5672333A (en) 1996-05-13 1997-09-30 Mallinckrodt Medical, Inc. Delta1,6 bicyclo 4,4,0! functional dyes for contrast enhancement in optical imaging
DE19649971A1 (de) * 1996-11-19 1998-05-28 Diagnostikforschung Inst Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung)
DE19717904A1 (de) * 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
GB9710049D0 (en) 1997-05-19 1997-07-09 Nycomed Imaging As Method
US6083486A (en) 1998-05-14 2000-07-04 The General Hospital Corporation Intramolecularly-quenched near infrared fluorescent probes
JP2000095758A (ja) 1998-09-18 2000-04-04 Schering Ag 近赤外蛍光造影剤および蛍光造影方法
US6114350A (en) 1999-04-19 2000-09-05 Nen Life Science Products, Inc. Cyanine dyes and synthesis methods thereof
US6159657A (en) 1999-08-31 2000-12-12 Eastman Kodak Company Thermal imaging composition and member containing sulfonated ir dye and methods of imaging and printing
US6663847B1 (en) 2000-10-13 2003-12-16 Mallinckrodt Inc. Dynamic organ function monitoring agents
US6673334B1 (en) 2000-10-16 2004-01-06 Mallinkcrodt, Inc. Light sensitive compounds for instant determination of organ function

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113717089A (zh) * 2021-09-22 2021-11-30 中国科学院精密测量科学与技术创新研究院 一种氟化Cy7化合物及其合成方法和应用

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