RS50203B - Bliski infracrvenom fluorescentni kontrastni agens i tehničko polje pronalaska koje snima fluorescenciju - Google Patents

Bliski infracrvenom fluorescentni kontrastni agens i tehničko polje pronalaska koje snima fluorescenciju

Info

Publication number
RS50203B
RS50203B YU19801A YU19801A RS50203B RS 50203 B RS50203 B RS 50203B YU 19801 A YU19801 A YU 19801A YU 19801 A YU19801 A YU 19801A RS 50203 B RS50203 B RS 50203B
Authority
RS
Serbia
Prior art keywords
group
sulfoalkyl
contrast agent
fluorescence imaging
carbon atoms
Prior art date
Application number
YU19801A
Other languages
English (en)
Inventor
Naoto Miwa
Michihito Inagaki
Hiroaki Eguchi
Yoshio Inagaki
Toru Harada
Masafumi Okumura
Original Assignee
Bayer Schering Pharma Ag.,
Fuji Photo Film Co.Ltd.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag.,, Fuji Photo Film Co.Ltd., filed Critical Bayer Schering Pharma Ag.,
Publication of YU19801A publication Critical patent/YU19801A/sh
Publication of RS50203B publication Critical patent/RS50203B/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C09B23/0016—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being a halogen atom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C09B23/0025—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being bound through an oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C09B23/0033—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being bound through a sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C09B23/0041—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being bound through a nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0066—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/06—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups three >CH- groups, e.g. carbocyanines
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Transforming Light Signals Into Electric Signals (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Eye Examination Apparatus (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Natrijum so jedinjenja formule [III-1], naznačena time, što u molekulu ima tri ili više grupa sulfonske kiseline u kojoj su L1-L7 isti ili različiti i svaki je supstituisani ili nesupstituisani metin i L4 je metin supstituisan sa alkilom koji ima 1 do 4 ugljenikovih atoma, R19 i R20 su niži alkil koji ima 1 do 5 ugljenikovih atoma i koji su supstituisani grupom sulfonske kiseline, R21-R28 su isti ili različiti i svaki je atom vodonika, grupa sulfonske kiseline, karboksilna grupa, hidroksilna grupa, alkil(sulfoalkil)amino grupa, bis(sulfoalkil)amino grupa, sulfoalkoksi grupa, (sulfoalkil)sulfonil grupa ili (sulfoalkil)aminosulfonil grupa, i X' i Y' su isti ili različiti i svaki je grupa formule u kojoj su R17 i R18 nesupstituisani niži alkil koji ima 1 do 5 ugljenikovih atoma. Prijava sadrži još 5 patentnih zahteva.
YU19801A 1998-09-18 1999-09-16 Bliski infracrvenom fluorescentni kontrastni agens i tehničko polje pronalaska koje snima fluorescenciju RS50203B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10283301A JP2000095758A (ja) 1998-09-18 1998-09-18 近赤外蛍光造影剤および蛍光造影方法

Publications (2)

Publication Number Publication Date
YU19801A YU19801A (sh) 2005-06-10
RS50203B true RS50203B (sr) 2009-07-15

Family

ID=17663691

Family Applications (1)

Application Number Title Priority Date Filing Date
YU19801A RS50203B (sr) 1998-09-18 1999-09-16 Bliski infracrvenom fluorescentni kontrastni agens i tehničko polje pronalaska koje snima fluorescenciju

Country Status (30)

Country Link
US (1) US7488468B1 (sr)
EP (1) EP1113822B1 (sr)
JP (2) JP2000095758A (sr)
KR (2) KR100531708B1 (sr)
CN (2) CN1515552A (sr)
AT (1) ATE248608T1 (sr)
AU (1) AU763991B2 (sr)
BG (3) BG65172B1 (sr)
BR (1) BR9913849A (sr)
CA (1) CA2344315A1 (sr)
DE (1) DE69911034T2 (sr)
DK (1) DK1113822T3 (sr)
EA (2) EA004249B1 (sr)
EE (1) EE200100162A (sr)
ES (1) ES2207338T3 (sr)
HK (1) HK1042855B (sr)
HU (1) HUP0103503A3 (sr)
ID (1) ID29455A (sr)
IL (2) IL141656A0 (sr)
MX (1) MXPA01002194A (sr)
NO (2) NO322559B1 (sr)
NZ (1) NZ510019A (sr)
PL (1) PL193411B1 (sr)
PT (1) PT1113822E (sr)
RS (1) RS50203B (sr)
SK (1) SK3742001A3 (sr)
TR (1) TR200100746T2 (sr)
UA (2) UA67800C2 (sr)
WO (1) WO2000016810A1 (sr)
YU (1) YU97502A (sr)

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EA200201216A1 (ru) 2003-06-26
UA67800C2 (uk) 2004-07-15
NO20025819D0 (no) 2002-12-04
TR200100746T2 (tr) 2001-07-23
ES2207338T3 (es) 2004-05-16
WO2000016810A1 (en) 2000-03-30
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PL346709A1 (en) 2002-02-25
ATE248608T1 (de) 2003-09-15
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YU97502A (sh) 2006-01-16
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