CN1509270A - 在6-位取代的吲哚满酮,其制法及其作为激酶抑制剂的用途 - Google Patents

在6-位取代的吲哚满酮,其制法及其作为激酶抑制剂的用途 Download PDF

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Publication number
CN1509270A
CN1509270A CNA028099184A CN02809918A CN1509270A CN 1509270 A CN1509270 A CN 1509270A CN A028099184 A CNA028099184 A CN A028099184A CN 02809918 A CN02809918 A CN 02809918A CN 1509270 A CN1509270 A CN 1509270A
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CN
China
Prior art keywords
alkyl
amino
phenyl
aminocarbonyl
carbonyl
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Pending
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CNA028099184A
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English (en)
Chinese (zh)
Inventor
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弗兰克·希尔伯格
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阿明·赫克尔
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索尔斯滕·莱曼-林茨
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杰拉尔德·J·罗思
乔尔格·克利
雅各布斯·范米尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
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Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Publication of CN1509270A publication Critical patent/CN1509270A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNA028099184A 2001-04-06 2002-03-30 在6-位取代的吲哚满酮,其制法及其作为激酶抑制剂的用途 Pending CN1509270A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10117204.4 2001-04-06
DE10117204A DE10117204A1 (de) 2001-04-06 2001-04-06 In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
CN1509270A true CN1509270A (zh) 2004-06-30

Family

ID=7680648

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA028099184A Pending CN1509270A (zh) 2001-04-06 2002-03-30 在6-位取代的吲哚满酮,其制法及其作为激酶抑制剂的用途

Country Status (23)

Country Link
US (1) US6858641B2 (enExample)
EP (1) EP1379501A1 (enExample)
JP (1) JP2004525173A (enExample)
KR (1) KR20030090712A (enExample)
CN (1) CN1509270A (enExample)
AR (1) AR035813A1 (enExample)
BG (1) BG108220A (enExample)
BR (1) BR0208900A (enExample)
CA (1) CA2442695A1 (enExample)
CZ (1) CZ20032975A3 (enExample)
DE (1) DE10117204A1 (enExample)
EA (1) EA200301005A1 (enExample)
EC (1) ECSP034776A (enExample)
EE (1) EE200300491A (enExample)
HU (1) HUP0303737A3 (enExample)
IL (1) IL158254A0 (enExample)
MX (1) MXPA03008896A (enExample)
NO (1) NO20034434D0 (enExample)
PE (1) PE20021058A1 (enExample)
PL (1) PL366458A1 (enExample)
SK (1) SK12412003A3 (enExample)
WO (1) WO2002081445A1 (enExample)
ZA (1) ZA200307306B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101883755B (zh) * 2007-12-03 2013-06-26 贝林格尔.英格海姆国际有限公司 二氢吲哚酮衍生物及其制备方法
CN109153666A (zh) * 2016-03-08 2019-01-04 莱斯彼维特有限公司 吲哚衍生物及其作为蛋白激酶抑制剂的用途
CN109302846A (zh) * 2015-12-24 2019-02-01 莱斯彼维特有限公司 吲哚啉酮化合物及其在纤维化疾病治疗中的用途

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10233500A1 (de) * 2002-07-24 2004-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel
US7148249B2 (en) * 2002-09-12 2006-12-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments
JP4879492B2 (ja) * 2002-11-27 2012-02-22 アラーガン、インコーポレイテッド 疾患の治療のためのキナーゼ阻害剤
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
PE20061155A1 (es) * 2004-12-24 2006-12-16 Boehringer Ingelheim Int Derivados de indolinona como agentes para el tratamiento o la prevencion de enfermedades fibroticas
US20060154939A1 (en) * 2004-12-24 2006-07-13 Boehringer Ingelheim International Gmbh Medicaments for the Treatment or Prevention of Fibrotic Diseases
WO2007057397A1 (en) * 2005-11-15 2007-05-24 Boehringer Ingelheim International Gmbh Treatment of cancer
KR20100090772A (ko) 2007-10-12 2010-08-17 인게니움 파르마코이티칼스 게엠베하 단백질 키나제 억제제
US20170065529A1 (en) 2015-09-09 2017-03-09 Boehringer Ingelheim International Gmbh Pharmaceutical dosage form for immediate release of an indolinone derivative
EP2303841A1 (en) * 2008-07-14 2011-04-06 Gilead Sciences, Inc. Oxindolyl inhibitor compounds
US8853420B2 (en) 2008-07-29 2014-10-07 Boehringer Ingelheim International Gmbh Compounds
EA201201274A1 (ru) 2010-03-10 2013-04-30 Инджениум Фармасьютиклз Гмбх Ингибиторы протеинкиназ
CN102267934B (zh) * 2010-06-02 2013-04-17 金凯美(大连)医药科技有限公司 一种6-甲氧羰基吲哚酮的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE308520T1 (de) * 1996-08-23 2005-11-15 Sugen Inc Kombinatorische bibliotheken von indolinone und verwandte produkte und verfahren zur behandlung von krankheiten
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US6043254A (en) * 1998-04-03 2000-03-28 Boehringer Ingelheim Pharma Kg Indolinones having kinase-inhibiting activity
US6169106B1 (en) * 1998-04-15 2001-01-02 Boehringer Ingelheim Pharma Kg Indolinones having kinase inhibitory activity
DE19816624A1 (de) 1998-04-15 1999-10-21 Boehringer Ingelheim Pharma Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
DE19824922A1 (de) 1998-06-04 1999-12-09 Boehringer Ingelheim Pharma Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
US6319918B1 (en) * 1998-06-04 2001-11-20 Boehringer Ingelheim Pharma Kg Substituted indolinones with kinase inhibitory activity
DE19924401A1 (de) 1999-05-27 2000-11-30 Boehringer Ingelheim Pharma Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
US6794395B1 (en) 1999-08-27 2004-09-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituted indolinones, their manufacture and their use as medicaments
DE19940829A1 (de) 1999-08-27 2001-03-01 Boehringer Ingelheim Pharma Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
UA75054C2 (uk) 1999-10-13 2006-03-15 Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу
DE10042696A1 (de) 2000-08-31 2002-03-14 Boehringer Ingelheim Pharma In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101883755B (zh) * 2007-12-03 2013-06-26 贝林格尔.英格海姆国际有限公司 二氢吲哚酮衍生物及其制备方法
CN109302846A (zh) * 2015-12-24 2019-02-01 莱斯彼维特有限公司 吲哚啉酮化合物及其在纤维化疾病治疗中的用途
CN109302846B (zh) * 2015-12-24 2021-05-11 莱斯彼维特有限公司 吲哚啉酮化合物及其在纤维化疾病治疗中的用途
CN109153666A (zh) * 2016-03-08 2019-01-04 莱斯彼维特有限公司 吲哚衍生物及其作为蛋白激酶抑制剂的用途
CN109153666B (zh) * 2016-03-08 2021-07-16 莱斯彼维特有限公司 吲哚衍生物及其作为蛋白激酶抑制剂的用途

Also Published As

Publication number Publication date
EP1379501A1 (de) 2004-01-14
PE20021058A1 (es) 2003-01-20
CZ20032975A3 (cs) 2004-02-18
MXPA03008896A (es) 2003-12-08
NO20034434L (no) 2003-10-03
JP2004525173A (ja) 2004-08-19
HUP0303737A3 (en) 2004-09-28
NO20034434D0 (no) 2003-10-03
EA200301005A1 (ru) 2004-04-29
PL366458A1 (en) 2005-02-07
SK12412003A3 (sk) 2004-04-06
EE200300491A (et) 2004-02-16
KR20030090712A (ko) 2003-11-28
CA2442695A1 (en) 2002-10-17
HUP0303737A2 (hu) 2004-03-01
ECSP034776A (es) 2003-12-01
BR0208900A (pt) 2004-04-20
AR035813A1 (es) 2004-07-14
DE10117204A1 (de) 2002-10-10
WO2002081445A1 (de) 2002-10-17
US6858641B2 (en) 2005-02-22
IL158254A0 (en) 2004-05-12
ZA200307306B (en) 2004-08-31
US20030092756A1 (en) 2003-05-15
BG108220A (bg) 2004-09-30

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