CN1310905C - 具有抗病毒活性的杂环氮杂己烷衍生物 - Google Patents

具有抗病毒活性的杂环氮杂己烷衍生物 Download PDF

Info

Publication number
CN1310905C
CN1310905C CNB2004100791875A CN200410079187A CN1310905C CN 1310905 C CN1310905 C CN 1310905C CN B2004100791875 A CNB2004100791875 A CN B2004100791875A CN 200410079187 A CN200410079187 A CN 200410079187A CN 1310905 C CN1310905 C CN 1310905C
Authority
CN
China
Prior art keywords
phenyl
acid
amino
compound
methoxycarbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB2004100791875A
Other languages
English (en)
Chinese (zh)
Other versions
CN1616453A (zh
Inventor
A·法斯勒
G·伯德
H-G·卡普拉罗
M·朗
S·C·克哈纳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27171723&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1310905(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN1616453A publication Critical patent/CN1616453A/zh
Application granted granted Critical
Publication of CN1310905C publication Critical patent/CN1310905C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/02—Compounds containing any of the groups, e.g. carbazates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/02—Compounds containing any of the groups, e.g. carbazates
    • C07C281/04—Compounds containing any of the groups, e.g. carbazates the other nitrogen atom being further doubly-bound to a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
CNB2004100791875A 1996-04-22 1997-04-14 具有抗病毒活性的杂环氮杂己烷衍生物 Expired - Lifetime CN1310905C (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
CH101896 1996-04-22
CH1018/1996 1996-04-22
CH29/1997 1997-01-08
CH2997 1997-01-08
CH223/1997 1997-01-31
CH1018/96 1997-01-31
CH223/97 1997-01-31
CH22397 1997-01-31
CH29/97 1997-01-31

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNB011034947A Division CN1193010C (zh) 1996-04-22 2001-02-16 具有抗病毒活性的杂环氮杂己烷衍生物

Publications (2)

Publication Number Publication Date
CN1616453A CN1616453A (zh) 2005-05-18
CN1310905C true CN1310905C (zh) 2007-04-18

Family

ID=27171723

Family Applications (3)

Application Number Title Priority Date Filing Date
CNB2004100791875A Expired - Lifetime CN1310905C (zh) 1996-04-22 1997-04-14 具有抗病毒活性的杂环氮杂己烷衍生物
CN97194025A Expired - Lifetime CN1082508C (zh) 1996-04-22 1997-04-14 具有抗病毒活性的杂环氮杂己烷衍生物
CNB011034947A Expired - Lifetime CN1193010C (zh) 1996-04-22 2001-02-16 具有抗病毒活性的杂环氮杂己烷衍生物

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN97194025A Expired - Lifetime CN1082508C (zh) 1996-04-22 1997-04-14 具有抗病毒活性的杂环氮杂己烷衍生物
CNB011034947A Expired - Lifetime CN1193010C (zh) 1996-04-22 2001-02-16 具有抗病毒活性的杂环氮杂己烷衍生物

Country Status (27)

Country Link
EP (1) EP0900210B1 (https=)
JP (1) JP3174347B2 (https=)
CN (3) CN1310905C (https=)
AR (1) AR006720A1 (https=)
AT (1) ATE288903T1 (https=)
AU (1) AU706183B2 (https=)
BR (1) BR9701877A (https=)
CA (3) CA2250840C (https=)
CY (1) CY2596B2 (https=)
CZ (1) CZ296135B6 (https=)
DE (2) DE69732483T2 (https=)
DK (1) DK0900210T3 (https=)
EA (1) EA001794B1 (https=)
ES (1) ES2238720T3 (https=)
FR (1) FR05C0030I2 (https=)
HU (1) HU224125B1 (https=)
IL (1) IL126381A (https=)
LU (1) LU91189I2 (https=)
MY (1) MY114457A (https=)
NL (1) NL300203I2 (https=)
NO (2) NO313330B1 (https=)
NZ (3) NZ509045A (https=)
PT (1) PT900210E (https=)
SI (1) SI0900210T1 (https=)
SK (1) SK285048B6 (https=)
TW (1) TW409125B (https=)
WO (1) WO1997040029A1 (https=)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6087383A (en) * 1998-01-20 2000-07-11 Bristol-Myers Squibb Company Bisulfate salt of HIV protease inhibitor
WO1999059994A1 (en) * 1998-05-15 1999-11-25 Abbott Laboratories Retroviral protease inhibiting compounds
US6251906B1 (en) 1998-05-15 2001-06-26 Abbott Laboratories Retroviral protease inhibiting compounds
EP0976736A1 (en) * 1998-07-29 2000-02-02 SUMIKA FINE CHEMICALS Co., Ltd. Production method of 2-(p-alkylphenyl)pyridine compound
EP0979820B1 (en) * 1998-08-07 2003-05-07 SUMIKA FINE CHEMICALS Co., Ltd. 2-Phenylpyridine derivatives and production method thereof
US6255349B1 (en) 1998-12-09 2001-07-03 American Home Products Corporation Alph-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group
US6335350B1 (en) 1998-12-09 2002-01-01 American Home Products Corporation Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses
US6207715B1 (en) 1998-12-09 2001-03-27 American Home Products Corporation Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a substituted phenylene-diamine group
US6197803B1 (en) 1998-12-09 2001-03-06 American Home Products Corporation Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group
JP4222671B2 (ja) * 1999-02-15 2009-02-12 住友化学株式会社 ヒドラジン誘導体の製造方法
IT1313664B1 (it) * 1999-10-12 2002-09-09 Norpharma S P A Processo per la preparazione di un composto aril-piridinico.
US6365745B1 (en) 2000-07-14 2002-04-02 Sumika Fine Chemicals Co., Ltd. Method for producing hydrazine derivative
JP4278316B2 (ja) * 2000-07-14 2009-06-10 住友化学株式会社 ヒドラジン誘導体の製造方法
WO2004037790A1 (en) 2002-10-02 2004-05-06 Euticals Prime European Therapeuticals Spa Process for the preparation of aryl-piridyl compounds
US7943593B2 (en) * 2002-12-06 2011-05-17 Vertex Pharmaceuticals Incorporated Compositions comprising inhibitors of IMPDH enzyme
ITMI20032338A1 (it) * 2003-11-28 2005-05-29 Dinamite Dipharma S P A In Forma A Bbreviata Diph Composti feniltetrazolici.
CN1980666B (zh) * 2004-05-04 2011-03-30 布里斯托尔-迈尔斯斯奎布公司 制备阿扎那韦硫酸氢盐的方法和新的形式
CA2594395A1 (en) 2005-02-10 2006-08-17 Medivir Ab Hiv protease inhibitors
PT2069303E (pt) 2006-07-21 2016-06-08 Gilead Sciences Inc Inibidores de protease antiviral
EP2116532B1 (en) * 2007-06-12 2011-12-07 Concert Pharmaceuticals, Inc. Azapeptide derivatives as HIV protease inhibitors
WO2009130534A1 (en) * 2008-04-24 2009-10-29 Oxyrane (Pty) Ltd. Process for synthesizing atazanavir
EP2272830A1 (en) * 2009-06-18 2011-01-12 Esteve Química, S.A. Preparation process of an antivirally heterocyclic azahexane derivative
EP2272831A1 (en) 2009-06-26 2011-01-12 Prime European Therapeuticals S.p.A. Process for the preparation of arylpyridinyl compounds
WO2011037467A1 (en) 2009-09-28 2011-03-31 Stichting Katholieke Universiteit Atazanavir for treating inflammatory diseases
WO2011080562A1 (en) 2009-12-29 2011-07-07 Hetero Research Foundation Novel aza-peptides containing 2,2-disubstituted cyclobutyl and/or substituted alkoxy benzyl derivatives as antivirals
WO2011107843A2 (en) * 2010-03-01 2011-09-09 Lupin Limited Process for the preparation of atazanavir sulfate substantially free of diastereomers
EA201390464A1 (ru) 2010-09-28 2013-08-30 Рациофарм Гмбх Способ сухой обработки атазанавира
US20140343290A1 (en) * 2011-07-27 2014-11-20 Rakesh Kumar Singh Process for the preparation of atazanavir or its bisulfate salt
EP2912047B1 (en) 2012-10-29 2016-08-24 Cipla Limited Antiviral phosphonate analogues and process for preparation thereof
CN104250224A (zh) * 2013-06-28 2014-12-31 上海威智医药科技有限公司 阿扎那韦富马酸盐及其制备和应用
CN104163787A (zh) * 2014-08-08 2014-11-26 山东威智医药工业有限公司 阿扎那韦及其硫酸盐的制备方法
CN107459496B (zh) * 2016-06-03 2022-07-19 华东理工大学 噻唑类衍生物在治疗病毒感染中的应用
AR110922A1 (es) 2017-02-06 2019-05-15 Gilead Sciences Inc Compuestos inhibidores del vih
CN107245052A (zh) * 2017-06-21 2017-10-13 连云港杰瑞药业有限公司 一种阿扎那韦制备方法
TWI829205B (zh) * 2018-07-30 2024-01-11 美商基利科學股份有限公司 抗hiv化合物
CN109251165B (zh) * 2018-10-02 2022-09-23 国药集团川抗制药有限公司 阿扎那韦达二4-氨基苯磺酸盐及其制备方法
CN109574916A (zh) * 2018-12-29 2019-04-05 常州吉恩药业有限公司 阿扎那韦中间体2-[4-(2-吡啶基)苄基]-肼羧酸叔丁酯的工业化生产方法
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
CN113603634B (zh) * 2021-08-06 2023-03-21 江苏八巨药业有限公司 一种阿扎那韦中间体的制备方法
CN116987024B (zh) * 2023-08-01 2026-02-13 浙江荣耀生物科技股份有限公司 一种阿扎那韦中间体的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994014436A1 (en) * 1992-12-29 1994-07-07 Abbott Laboratories Retroviral protease inhibiting compounds
WO1994019332A1 (en) * 1993-02-25 1994-09-01 Abbott Laboratories Retroviral protease inhibiting compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE20010533A1 (en) * 1990-11-20 2003-03-05 Abbott Lab Intermediates for preparing retroviral protease inhibiting compounds
DE59207226D1 (de) * 1991-07-03 1996-10-31 Ciba Geigy Ag Pharmakologisch wirksame Hydrazinderivate und Verfahren zu deren Herstellung
DE59303870D1 (de) * 1992-12-23 1996-10-24 Ciba Geigy Ag Antiretrovirale hydrazinderivate
DE69710731T2 (de) 1996-07-17 2002-10-24 Novartis Ag, Basel Anilinopeptid-derivate

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994014436A1 (en) * 1992-12-29 1994-07-07 Abbott Laboratories Retroviral protease inhibiting compounds
WO1994019332A1 (en) * 1993-02-25 1994-09-01 Abbott Laboratories Retroviral protease inhibiting compounds

Also Published As

Publication number Publication date
CZ296135B6 (cs) 2006-01-11
ATE288903T1 (de) 2005-02-15
HK1075043A1 (en) 2005-12-02
CA2510945C (en) 2007-01-16
BR9701877A (pt) 1998-09-29
DE69732483T2 (de) 2005-07-28
CA2250840A1 (en) 1997-10-30
NO984900D0 (no) 1998-10-21
EA199800899A1 (ru) 1999-10-28
CA2510945A1 (en) 1997-10-30
DE122005000003I1 (de) 2005-05-25
AR006720A1 (es) 1999-09-08
CA2568104A1 (en) 1997-10-30
HUP9901612A2 (hu) 1999-08-30
WO1997040029A1 (en) 1997-10-30
CN1082508C (zh) 2002-04-10
CY2596B2 (en) 2010-03-03
NO313330B1 (no) 2002-09-16
CN1193010C (zh) 2005-03-16
LU91189I2 (fr) 2005-10-03
NL300203I1 (nl) 2005-10-03
NO984900L (no) 1998-12-21
TW409125B (en) 2000-10-21
ES2238720T3 (es) 2005-09-01
AU2385997A (en) 1997-11-12
HU224125B1 (hu) 2005-05-30
NZ332118A (en) 2001-02-23
HK1018788A1 (en) 2000-01-07
PT900210E (pt) 2005-06-30
SK145298A3 (en) 1999-06-11
JPH11511177A (ja) 1999-09-28
FR05C0030I2 (fr) 2007-04-27
NZ509046A (en) 2002-05-31
AU706183B2 (en) 1999-06-10
FR05C0030I1 (https=) 2005-08-12
HUP9901612A3 (en) 2000-06-28
LU91189I9 (https=) 2018-12-27
IL126381A0 (en) 1999-05-09
CZ337398A3 (cs) 1999-01-13
NL300203I2 (nl) 2005-11-01
CN1216539A (zh) 1999-05-12
CA2250840C (en) 2006-07-04
DE69732483D1 (de) 2005-03-17
CN1616453A (zh) 2005-05-18
CN1319587A (zh) 2001-10-31
SI0900210T1 (https=) 2005-08-31
MY114457A (en) 2002-10-31
IL126381A (en) 2001-08-26
EA001794B1 (ru) 2001-08-27
NO2005010I1 (no) 2005-05-02
NZ509045A (en) 2002-09-27
EP0900210A1 (en) 1999-03-10
DK0900210T3 (da) 2005-05-02
EP0900210B1 (en) 2005-02-09
CA2568104C (en) 2009-08-04
SK285048B6 (sk) 2006-05-04
JP3174347B2 (ja) 2001-06-11

Similar Documents

Publication Publication Date Title
CN1310905C (zh) 具有抗病毒活性的杂环氮杂己烷衍生物
CN1039321C (zh) 新的β－氨基－α羟基羧酸的制备方法
CN1341593A (zh) 蛋白酶抑制剂
CN1149210C (zh) 凝血酶抑制剂
CN1171870C (zh) 半胱氨酸蛋白酶抑制剂
CN1266118C (zh) 新的δ－氨基－γ－羟基－ω－芳基－链烷酰胺类化合物
CN1225471C (zh) 具有生长激素释放特性的化合物
CN1027271C (zh) 正斯塔提尼及正环斯塔提尼多肽的制备方法
CN1132756A (zh) 抗病毒的天冬氨酸蛋白酶底物等排物的醚
CN1054598C (zh) 具有药理活性的肼类衍生物及其制备方法
CN1030411A (zh) 新颖氨基酸衍生物，其制备方法及含其的药物组合物
CN1208405A (zh) 逆病毒蛋白酶抑制化合物
CN1974596A (zh) 丙型肝炎病毒抑制剂
CN100344632C (zh) 稠合的呋喃化合物
CN1501942A (zh) 作为c型肝炎病毒ns3-丝氨酸蛋白酶抑制剂的二芳基肽
CN1175953A (zh) 作为凝血酶抑制剂的新的二肽脒类
CN1253559A (zh) 芳族磺酰基α－羟基异羟肟酸化合物
CN1078968A (zh) 2-哌嗪酮化合物及它们的制备和使用
CN1215055C (zh) 芳基磺酰氨基取代的异羟肟酸衍生物
CN1136556A (zh) 芳香族取代的w-氨基链烷酸酰胺和链烷酸二酰胺
CN1261276A (zh) 蛋白酶抑制剂
CN1214040C (zh) 具有噻唑基－丙氨酸残基的新型肽类衍生物
CN1195343A (zh) 哌啶衍生物及其用途
HK1046289A1 (zh) 凝血酶抑制剂的前体药物
CN1145075A (zh) 内皮素受体拮抗剂

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1075043

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee

Owner name: NOVARTIS CO., LTD.

Free format text: FORMER NAME: NOVARTIS AG

CP01 Change in the name or title of a patent holder

Address after: Basel

Patentee after: Novartis Ag

Address before: Basel

Patentee before: Novartis AG

CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20070418