DE69732483D1 - Heterocyclische azahexan-derivate mit antiviraler wirkung - Google Patents

Heterocyclische azahexan-derivate mit antiviraler wirkung

Info

Publication number
DE69732483D1
DE69732483D1 DE69732483T DE69732483T DE69732483D1 DE 69732483 D1 DE69732483 D1 DE 69732483D1 DE 69732483 T DE69732483 T DE 69732483T DE 69732483 T DE69732483 T DE 69732483T DE 69732483 D1 DE69732483 D1 DE 69732483D1
Authority
DE
Germany
Prior art keywords
azahexan
heterocyclic
derivatives
antiviral effect
antiviral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69732483T
Other languages
English (en)
Other versions
DE69732483T2 (de
Inventor
Alexander Faessler
Guido Bold
Hans-Georg Capraro
Marc Lang
Chandra Khanna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27171723&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69732483(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Publication of DE69732483D1 publication Critical patent/DE69732483D1/de
Application granted granted Critical
Publication of DE69732483T2 publication Critical patent/DE69732483T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/02—Compounds containing any of the groups, e.g. carbazates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/02—Compounds containing any of the groups, e.g. carbazates
    • C07C281/04—Compounds containing any of the groups, e.g. carbazates the other nitrogen atom being further doubly-bound to a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69732483T 1996-04-22 1997-04-14 Heterocyclische Azahexanderivate mit antiviraler Wirkung Expired - Lifetime DE69732483T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CH101896 1996-04-22
CH101896 1996-04-22
CH2997 1997-01-08
CH2997 1997-01-08
CH22397 1997-01-31
CH22397 1997-01-31
PCT/EP1997/001860 WO1997040029A1 (en) 1996-04-22 1997-04-14 Antivirally active heterocyclic azahexane derivatives

Publications (2)

Publication Number Publication Date
DE69732483D1 true DE69732483D1 (de) 2005-03-17
DE69732483T2 DE69732483T2 (de) 2005-07-28

Family

ID=27171723

Family Applications (2)

Application Number Title Priority Date Filing Date
DE200512000003 Pending DE122005000003I1 (de) 1996-04-22 1997-04-14 Heterocyclische Azahexanderivate mit Antiviraler wirkung.
DE69732483T Expired - Lifetime DE69732483T2 (de) 1996-04-22 1997-04-14 Heterocyclische Azahexanderivate mit antiviraler Wirkung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE200512000003 Pending DE122005000003I1 (de) 1996-04-22 1997-04-14 Heterocyclische Azahexanderivate mit Antiviraler wirkung.

Country Status (28)

Country Link
EP (1) EP0900210B1 (de)
JP (1) JP3174347B2 (de)
CN (3) CN1082508C (de)
AR (1) AR006720A1 (de)
AT (1) ATE288903T1 (de)
AU (1) AU706183B2 (de)
BR (1) BR9701877A (de)
CA (3) CA2250840C (de)
CY (1) CY2596B2 (de)
CZ (1) CZ296135B6 (de)
DE (2) DE122005000003I1 (de)
DK (1) DK0900210T3 (de)
EA (1) EA001794B1 (de)
ES (1) ES2238720T3 (de)
FR (1) FR05C0030I2 (de)
HK (2) HK1018788A1 (de)
HU (1) HU224125B1 (de)
IL (1) IL126381A (de)
LU (1) LU91189I2 (de)
MY (1) MY114457A (de)
NL (1) NL300203I2 (de)
NO (2) NO313330B1 (de)
NZ (3) NZ332118A (de)
PT (1) PT900210E (de)
SI (1) SI0900210T1 (de)
SK (1) SK285048B6 (de)
TW (1) TW409125B (de)
WO (1) WO1997040029A1 (de)

Families Citing this family (39)

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US6087383A (en) * 1998-01-20 2000-07-11 Bristol-Myers Squibb Company Bisulfate salt of HIV protease inhibitor
EP1077977A1 (de) * 1998-05-15 2001-02-28 Abbott Laboratories Retrovirale protease inhibitoren
US6251906B1 (en) 1998-05-15 2001-06-26 Abbott Laboratories Retroviral protease inhibiting compounds
US6096894A (en) * 1998-07-29 2000-08-01 Sumika Fine Chemicals Co., Ltd. Production method of 2-(p-alkylphenyl)pyridine compound
DK0979820T3 (da) 1998-08-07 2003-06-02 Sumika Fine Chemicals Co Ltd 2-phenylpyridinderivater og fremgangsmåder til deres fremstilling
US6255349B1 (en) 1998-12-09 2001-07-03 American Home Products Corporation Alph-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group
US6335350B1 (en) 1998-12-09 2002-01-01 American Home Products Corporation Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses
US6197803B1 (en) 1998-12-09 2001-03-06 American Home Products Corporation Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group
US6207715B1 (en) 1998-12-09 2001-03-27 American Home Products Corporation Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a substituted phenylene-diamine group
JP4222671B2 (ja) * 1999-02-15 2009-02-12 住友化学株式会社 ヒドラジン誘導体の製造方法
IT1313664B1 (it) * 1999-10-12 2002-09-09 Norpharma S P A Processo per la preparazione di un composto aril-piridinico.
US6365745B1 (en) 2000-07-14 2002-04-02 Sumika Fine Chemicals Co., Ltd. Method for producing hydrazine derivative
JP4278316B2 (ja) * 2000-07-14 2009-06-10 住友化学株式会社 ヒドラジン誘導体の製造方法
WO2004037790A1 (en) 2002-10-02 2004-05-06 Euticals Prime European Therapeuticals Spa Process for the preparation of aryl-piridyl compounds
US7943593B2 (en) * 2002-12-06 2011-05-17 Vertex Pharmaceuticals Incorporated Compositions comprising inhibitors of IMPDH enzyme
ITMI20032338A1 (it) * 2003-11-28 2005-05-29 Dinamite Dipharma S P A In Forma A Bbreviata Diph Composti feniltetrazolici.
CN1980666B (zh) * 2004-05-04 2011-03-30 布里斯托尔-迈尔斯斯奎布公司 制备阿扎那韦硫酸氢盐的方法和新的形式
EA013520B1 (ru) 2005-02-10 2010-06-30 Медивир Аб Ингибиторы протеазы вич
CA2657936C (en) * 2006-07-21 2017-01-10 Gilead Sciences, Inc. Antiviral protease inhibitors
PL2003120T3 (pl) 2007-06-12 2010-04-30 Concert Pharmaceuticals Inc Pochodne azapeptydu jako inhibitory proteazy HIV
WO2009130534A1 (en) * 2008-04-24 2009-10-29 Oxyrane (Pty) Ltd. Process for synthesizing atazanavir
EP2272830A1 (de) * 2009-06-18 2011-01-12 Esteve Química, S.A. Herstellungsverfahren für ein antivirales heterozyklisches Azahexan-Derivat
EP2272831A1 (de) 2009-06-26 2011-01-12 Prime European Therapeuticals S.p.A. Verfahren zur Herstellung von Arylpyridinylverbindungen
WO2011037467A1 (en) 2009-09-28 2011-03-31 Stichting Katholieke Universiteit Atazanavir for treating inflammatory diseases
WO2011080562A1 (en) 2009-12-29 2011-07-07 Hetero Research Foundation Novel aza-peptides containing 2,2-disubstituted cyclobutyl and/or substituted alkoxy benzyl derivatives as antivirals
US20130005780A1 (en) * 2010-03-01 2013-01-03 Lupin Limited Controlled release pharmaceutical compositions of tapentadol
WO2012041488A1 (en) 2010-09-28 2012-04-05 Ratiopharm Gmbh Dry processing of atazanavir
WO2013014633A1 (en) * 2011-07-27 2013-01-31 Ranbaxy Laboratories Limited Process for preparation of atazanavir or its bisulfate salt
JP2015536940A (ja) 2012-10-29 2015-12-24 シプラ・リミテッド 抗ウイルス性ホスホネート類似体及びその製造方法
CN104250224A (zh) * 2013-06-28 2014-12-31 上海威智医药科技有限公司 阿扎那韦富马酸盐及其制备和应用
CN104163787A (zh) * 2014-08-08 2014-11-26 山东威智医药工业有限公司 阿扎那韦及其硫酸盐的制备方法
CN107459496B (zh) * 2016-06-03 2022-07-19 华东理工大学 噻唑类衍生物在治疗病毒感染中的应用
JOP20180009A1 (ar) 2017-02-06 2019-01-30 Gilead Sciences Inc مركبات مثبط فيروس hiv
CN107245052A (zh) * 2017-06-21 2017-10-13 连云港杰瑞药业有限公司 一种阿扎那韦制备方法
TWI829205B (zh) * 2018-07-30 2024-01-11 美商基利科學股份有限公司 抗hiv化合物
CN109251165B (zh) * 2018-10-02 2022-09-23 国药集团川抗制药有限公司 阿扎那韦达二4-氨基苯磺酸盐及其制备方法
CN109574916A (zh) * 2018-12-29 2019-04-05 常州吉恩药业有限公司 阿扎那韦中间体2-[4-(2-吡啶基)苄基]-肼羧酸叔丁酯的工业化生产方法
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
CN113603634B (zh) * 2021-08-06 2023-03-21 江苏八巨药业有限公司 一种阿扎那韦中间体的制备方法

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Publication number Priority date Publication date Assignee Title
IE20010533A1 (en) * 1990-11-20 2003-03-05 Abbott Lab Intermediates for preparing retroviral protease inhibiting compounds
DE59207226D1 (de) * 1991-07-03 1996-10-31 Ciba Geigy Ag Pharmakologisch wirksame Hydrazinderivate und Verfahren zu deren Herstellung
DE59303870D1 (de) * 1992-12-23 1996-10-24 Ciba Geigy Ag Antiretrovirale hydrazinderivate
DK1302468T3 (da) * 1992-12-29 2009-03-02 Abbott Lab Fremgangsmåder og mellemprodukter til fremstilling af forbindelser, der inhiberer retroviral protease
US5461067A (en) * 1993-02-25 1995-10-24 Abbott Laboratories Retroviral protease inhibiting compounds

Also Published As

Publication number Publication date
CA2250840A1 (en) 1997-10-30
AU706183B2 (en) 1999-06-10
PT900210E (pt) 2005-06-30
IL126381A0 (en) 1999-05-09
CY2596B2 (en) 2010-03-03
FR05C0030I1 (de) 2005-08-12
JP3174347B2 (ja) 2001-06-11
TW409125B (en) 2000-10-21
EA199800899A1 (ru) 1999-10-28
CA2510945A1 (en) 1997-10-30
DE122005000003I1 (de) 2005-05-25
CA2568104C (en) 2009-08-04
NO313330B1 (no) 2002-09-16
HK1018788A1 (en) 2000-01-07
NZ509046A (en) 2002-05-31
AR006720A1 (es) 1999-09-08
LU91189I2 (fr) 2005-10-03
CN1319587A (zh) 2001-10-31
CZ296135B6 (cs) 2006-01-11
ATE288903T1 (de) 2005-02-15
FR05C0030I2 (fr) 2007-04-27
CA2250840C (en) 2006-07-04
DE69732483T2 (de) 2005-07-28
ES2238720T3 (es) 2005-09-01
CN1216539A (zh) 1999-05-12
CA2510945C (en) 2007-01-16
EP0900210B1 (de) 2005-02-09
EA001794B1 (ru) 2001-08-27
NZ509045A (en) 2002-09-27
WO1997040029A1 (en) 1997-10-30
HUP9901612A3 (en) 2000-06-28
CN1193010C (zh) 2005-03-16
CN1082508C (zh) 2002-04-10
CZ337398A3 (cs) 1999-01-13
HK1075043A1 (en) 2005-12-02
CA2568104A1 (en) 1997-10-30
MY114457A (en) 2002-10-31
IL126381A (en) 2001-08-26
HUP9901612A2 (hu) 1999-08-30
DK0900210T3 (da) 2005-05-02
HU224125B1 (hu) 2005-05-30
SI0900210T1 (de) 2005-08-31
SK145298A3 (en) 1999-06-11
NZ332118A (en) 2001-02-23
JPH11511177A (ja) 1999-09-28
NO984900L (no) 1998-12-21
EP0900210A1 (de) 1999-03-10
NL300203I1 (nl) 2005-10-03
AU2385997A (en) 1997-11-12
SK285048B6 (sk) 2006-05-04
CN1616453A (zh) 2005-05-18
BR9701877A (pt) 1998-09-29
NO984900D0 (no) 1998-10-21
NO2005010I1 (no) 2005-05-02
LU91189I9 (de) 2018-12-27
NL300203I2 (nl) 2005-11-01
CN1310905C (zh) 2007-04-18

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Legal Events

Date Code Title Description
R422 Decision on request for term extension (children's medicines) now final

Free format text: PRODUCT NAME: ATAZANAVIR UND/ODER EIN PHARMAZEUTISCH ANNEHMBARES SALZ HIERVON, INSBESONDERE ATAZANAV EU/1/03/267/001 BIS 007 20040302 IRSULFAT - REYATAZ ; NAT. REGISTRATION NO/DATE: EU/1/03/267/001-007 20040302; FIRST REGISTRATION: EU

Spc suppl protection certif: 122005000003

Filing date: 20050201

Expiry date: 20170415

Extension date: 20190904