IL126381A - Heterocyclic azahexane derivatives and antiviral compositions containing them - Google Patents

Heterocyclic azahexane derivatives and antiviral compositions containing them

Info

Publication number
IL126381A
IL126381A IL12638197A IL12638197A IL126381A IL 126381 A IL126381 A IL 126381A IL 12638197 A IL12638197 A IL 12638197A IL 12638197 A IL12638197 A IL 12638197A IL 126381 A IL126381 A IL 126381A
Authority
IL
Israel
Prior art keywords
compositions containing
antiviral compositions
heterocyclic
azahexane derivatives
heterocyclic azahexane
Prior art date
Application number
IL12638197A
Other languages
English (en)
Other versions
IL126381A0 (en
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27171723&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL126381(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IL126381A0 publication Critical patent/IL126381A0/xx
Publication of IL126381A publication Critical patent/IL126381A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36Radicals substituted by singly-bound nitrogen atoms
    • C07D213/42Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/02Compounds containing any of the groups, e.g. carbazates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/02Compounds containing any of the groups, e.g. carbazates
    • C07C281/04Compounds containing any of the groups, e.g. carbazates the other nitrogen atom being further doubly-bound to a carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04Five-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28Radicals substituted by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL12638197A 1996-04-22 1997-04-14 Heterocyclic azahexane derivatives and antiviral compositions containing them IL126381A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH101896 1996-04-22
CH2997 1997-01-08
CH22397 1997-01-31
PCT/EP1997/001860 WO1997040029A1 (en) 1996-04-22 1997-04-14 Antivirally active heterocyclic azahexane derivatives

Publications (2)

Publication Number Publication Date
IL126381A0 IL126381A0 (en) 1999-05-09
IL126381A true IL126381A (en) 2001-08-26

Family

ID=27171723

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12638197A IL126381A (en) 1996-04-22 1997-04-14 Heterocyclic azahexane derivatives and antiviral compositions containing them

Country Status (28)

Country Link
EP (1) EP0900210B1 (de)
JP (1) JP3174347B2 (de)
CN (3) CN1082508C (de)
AR (1) AR006720A1 (de)
AT (1) ATE288903T1 (de)
AU (1) AU706183B2 (de)
BR (1) BR9701877A (de)
CA (3) CA2250840C (de)
CY (1) CY2596B2 (de)
CZ (1) CZ296135B6 (de)
DE (2) DE122005000003I1 (de)
DK (1) DK0900210T3 (de)
EA (1) EA001794B1 (de)
ES (1) ES2238720T3 (de)
FR (1) FR05C0030I2 (de)
HK (2) HK1018788A1 (de)
HU (1) HU224125B1 (de)
IL (1) IL126381A (de)
LU (1) LU91189I2 (de)
MY (1) MY114457A (de)
NL (1) NL300203I2 (de)
NO (2) NO313330B1 (de)
NZ (3) NZ332118A (de)
PT (1) PT900210E (de)
SI (1) SI0900210T1 (de)
SK (1) SK285048B6 (de)
TW (1) TW409125B (de)
WO (1) WO1997040029A1 (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6087383A (en) * 1998-01-20 2000-07-11 Bristol-Myers Squibb Company Bisulfate salt of HIV protease inhibitor
EP1077977A1 (de) * 1998-05-15 2001-02-28 Abbott Laboratories Retrovirale protease inhibitoren
US6251906B1 (en) 1998-05-15 2001-06-26 Abbott Laboratories Retroviral protease inhibiting compounds
US6096894A (en) * 1998-07-29 2000-08-01 Sumika Fine Chemicals Co., Ltd. Production method of 2-(p-alkylphenyl)pyridine compound
DK0979820T3 (da) 1998-08-07 2003-06-02 Sumika Fine Chemicals Co Ltd 2-phenylpyridinderivater og fremgangsmåder til deres fremstilling
US6255349B1 (en) 1998-12-09 2001-07-03 American Home Products Corporation Alph-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group
US6335350B1 (en) 1998-12-09 2002-01-01 American Home Products Corporation Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses
US6197803B1 (en) 1998-12-09 2001-03-06 American Home Products Corporation Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group
US6207715B1 (en) 1998-12-09 2001-03-27 American Home Products Corporation Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a substituted phenylene-diamine group
JP4222671B2 (ja) * 1999-02-15 2009-02-12 住友化学株式会社 ヒドラジン誘導体の製造方法
IT1313664B1 (it) * 1999-10-12 2002-09-09 Norpharma S P A Processo per la preparazione di un composto aril-piridinico.
US6365745B1 (en) 2000-07-14 2002-04-02 Sumika Fine Chemicals Co., Ltd. Method for producing hydrazine derivative
JP4278316B2 (ja) * 2000-07-14 2009-06-10 住友化学株式会社 ヒドラジン誘導体の製造方法
WO2004037790A1 (en) 2002-10-02 2004-05-06 Euticals Prime European Therapeuticals Spa Process for the preparation of aryl-piridyl compounds
US7943593B2 (en) * 2002-12-06 2011-05-17 Vertex Pharmaceuticals Incorporated Compositions comprising inhibitors of IMPDH enzyme
ITMI20032338A1 (it) * 2003-11-28 2005-05-29 Dinamite Dipharma S P A In Forma A Bbreviata Diph Composti feniltetrazolici.
CN1980666B (zh) * 2004-05-04 2011-03-30 布里斯托尔-迈尔斯斯奎布公司 制备阿扎那韦硫酸氢盐的方法和新的形式
EA013520B1 (ru) 2005-02-10 2010-06-30 Медивир Аб Ингибиторы протеазы вич
CA2657936C (en) * 2006-07-21 2017-01-10 Gilead Sciences, Inc. Antiviral protease inhibitors
PL2003120T3 (pl) 2007-06-12 2010-04-30 Concert Pharmaceuticals Inc Pochodne azapeptydu jako inhibitory proteazy HIV
WO2009130534A1 (en) * 2008-04-24 2009-10-29 Oxyrane (Pty) Ltd. Process for synthesizing atazanavir
EP2272830A1 (de) * 2009-06-18 2011-01-12 Esteve Química, S.A. Herstellungsverfahren für ein antivirales heterozyklisches Azahexan-Derivat
EP2272831A1 (de) 2009-06-26 2011-01-12 Prime European Therapeuticals S.p.A. Verfahren zur Herstellung von Arylpyridinylverbindungen
WO2011037467A1 (en) 2009-09-28 2011-03-31 Stichting Katholieke Universiteit Atazanavir for treating inflammatory diseases
WO2011080562A1 (en) 2009-12-29 2011-07-07 Hetero Research Foundation Novel aza-peptides containing 2,2-disubstituted cyclobutyl and/or substituted alkoxy benzyl derivatives as antivirals
US20130005780A1 (en) * 2010-03-01 2013-01-03 Lupin Limited Controlled release pharmaceutical compositions of tapentadol
WO2012041488A1 (en) 2010-09-28 2012-04-05 Ratiopharm Gmbh Dry processing of atazanavir
WO2013014633A1 (en) * 2011-07-27 2013-01-31 Ranbaxy Laboratories Limited Process for preparation of atazanavir or its bisulfate salt
JP2015536940A (ja) 2012-10-29 2015-12-24 シプラ・リミテッド 抗ウイルス性ホスホネート類似体及びその製造方法
CN104250224A (zh) * 2013-06-28 2014-12-31 上海威智医药科技有限公司 阿扎那韦富马酸盐及其制备和应用
CN104163787A (zh) * 2014-08-08 2014-11-26 山东威智医药工业有限公司 阿扎那韦及其硫酸盐的制备方法
CN107459496B (zh) * 2016-06-03 2022-07-19 华东理工大学 噻唑类衍生物在治疗病毒感染中的应用
JOP20180009A1 (ar) 2017-02-06 2019-01-30 Gilead Sciences Inc مركبات مثبط فيروس hiv
CN107245052A (zh) * 2017-06-21 2017-10-13 连云港杰瑞药业有限公司 一种阿扎那韦制备方法
TWI829205B (zh) * 2018-07-30 2024-01-11 美商基利科學股份有限公司 抗hiv化合物
CN109251165B (zh) * 2018-10-02 2022-09-23 国药集团川抗制药有限公司 阿扎那韦达二4-氨基苯磺酸盐及其制备方法
CN109574916A (zh) * 2018-12-29 2019-04-05 常州吉恩药业有限公司 阿扎那韦中间体2-[4-(2-吡啶基)苄基]-肼羧酸叔丁酯的工业化生产方法
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
CN113603634B (zh) * 2021-08-06 2023-03-21 江苏八巨药业有限公司 一种阿扎那韦中间体的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE20010533A1 (en) * 1990-11-20 2003-03-05 Abbott Lab Intermediates for preparing retroviral protease inhibiting compounds
DE59207226D1 (de) * 1991-07-03 1996-10-31 Ciba Geigy Ag Pharmakologisch wirksame Hydrazinderivate und Verfahren zu deren Herstellung
DE59303870D1 (de) * 1992-12-23 1996-10-24 Ciba Geigy Ag Antiretrovirale hydrazinderivate
DK1302468T3 (da) * 1992-12-29 2009-03-02 Abbott Lab Fremgangsmåder og mellemprodukter til fremstilling af forbindelser, der inhiberer retroviral protease
US5461067A (en) * 1993-02-25 1995-10-24 Abbott Laboratories Retroviral protease inhibiting compounds

Also Published As

Publication number Publication date
CA2250840A1 (en) 1997-10-30
AU706183B2 (en) 1999-06-10
PT900210E (pt) 2005-06-30
IL126381A0 (en) 1999-05-09
CY2596B2 (en) 2010-03-03
FR05C0030I1 (de) 2005-08-12
JP3174347B2 (ja) 2001-06-11
TW409125B (en) 2000-10-21
EA199800899A1 (ru) 1999-10-28
DE69732483D1 (de) 2005-03-17
CA2510945A1 (en) 1997-10-30
DE122005000003I1 (de) 2005-05-25
CA2568104C (en) 2009-08-04
NO313330B1 (no) 2002-09-16
HK1018788A1 (en) 2000-01-07
NZ509046A (en) 2002-05-31
AR006720A1 (es) 1999-09-08
LU91189I2 (fr) 2005-10-03
CN1319587A (zh) 2001-10-31
CZ296135B6 (cs) 2006-01-11
ATE288903T1 (de) 2005-02-15
FR05C0030I2 (fr) 2007-04-27
CA2250840C (en) 2006-07-04
DE69732483T2 (de) 2005-07-28
ES2238720T3 (es) 2005-09-01
CN1216539A (zh) 1999-05-12
CA2510945C (en) 2007-01-16
EP0900210B1 (de) 2005-02-09
EA001794B1 (ru) 2001-08-27
NZ509045A (en) 2002-09-27
WO1997040029A1 (en) 1997-10-30
HUP9901612A3 (en) 2000-06-28
CN1193010C (zh) 2005-03-16
CN1082508C (zh) 2002-04-10
CZ337398A3 (cs) 1999-01-13
HK1075043A1 (en) 2005-12-02
CA2568104A1 (en) 1997-10-30
MY114457A (en) 2002-10-31
HUP9901612A2 (hu) 1999-08-30
DK0900210T3 (da) 2005-05-02
HU224125B1 (hu) 2005-05-30
SI0900210T1 (de) 2005-08-31
SK145298A3 (en) 1999-06-11
NZ332118A (en) 2001-02-23
JPH11511177A (ja) 1999-09-28
NO984900L (no) 1998-12-21
EP0900210A1 (de) 1999-03-10
NL300203I1 (nl) 2005-10-03
AU2385997A (en) 1997-11-12
SK285048B6 (sk) 2006-05-04
CN1616453A (zh) 2005-05-18
BR9701877A (pt) 1998-09-29
NO984900D0 (no) 1998-10-21
NO2005010I1 (no) 2005-05-02
LU91189I9 (de) 2018-12-27
NL300203I2 (nl) 2005-11-01
CN1310905C (zh) 2007-04-18

Similar Documents

Publication Publication Date Title
IL126381A (en) Heterocyclic azahexane derivatives and antiviral compositions containing them
IL112249A0 (en) Heterocyclic pyrimidine derivatives and pharmaceutical compositions containing them
HUP0001154A3 (en) 3-piperidyl-4-oxoquinazoline derivatives and medicincal compositions containing the same
HUP0101172A3 (en) Ortho-anthranilamide derivatives and their use as anti-coagulants
IL123887A0 (en) Dithiolan derivatives their use and pharmaceutical compositions containing the same
IL123162A (en) Pyridazin-3-one derivatives and herbicidal compositions comprising them
HUP9900424A2 (hu) Tiazolil-benzfurán-származékok és a vegyületeket tartalmazó gyógyászati készítmények
GB9309716D0 (en) Heterocyclic derivatives
HUP0100085A3 (en) Biphenylamidine derivatives and pharmaceutical compositions containing them
GB9408473D0 (en) Heterocyclic derivatives
IL120669A0 (en) Benzylamine derivatives and pharmaceutical compositions containing them
GB9311562D0 (en) Heterocyclic derivatives
IL121691A0 (en) N-benzylazolium derivatives their preparation and compositions containing them
HUP0000275A3 (en) Phenanethridinium derivatives and pharmaceutical compositions containing them
IL113542A0 (en) Substituted hydroxybenzyl-heteroaryl derivatives compositions containing them and their use
HUP9901968A3 (en) 2-thioxotetrahydropyrimidin-4-one derivatives and pharmaceutical compositions containing them
GB9405533D0 (en) Heterocyclic derivatives
HUP0003765A3 (en) Crambescidin derivatives and pharmaceutical compositions containing them
HUP9903539A3 (en) Substituted amidinobenzene derivatives and pharmaceutical compositions containing them
GB9623283D0 (en) Heterocyclic derivatives
IL118268A0 (en) Pyrrolinone derivatives and herbicidal compositions containing the same
ZA941917B (en) Nucleoside derivatives and anti-herpes composition
GB9424259D0 (en) Nitrogen heterocyclic derivatives
HUP0003827A2 (en) Cyanoamidine derivatives and pharmaceutical compositions containing them
GB9602145D0 (en) Heterocyclic derivatives

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
EXTP Application for extension order is pending
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired