CN1284536C - 河豚毒素或蛤蚌毒素及其类似物在制备用于全身镇痛的镇痛药中的应用 - Google Patents
河豚毒素或蛤蚌毒素及其类似物在制备用于全身镇痛的镇痛药中的应用 Download PDFInfo
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- CN1284536C CN1284536C CNB001245171A CN00124517A CN1284536C CN 1284536 C CN1284536 C CN 1284536C CN B001245171 A CNB001245171 A CN B001245171A CN 00124517 A CN00124517 A CN 00124517A CN 1284536 C CN1284536 C CN 1284536C
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Priority Applications (30)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001245171A CN1284536C (zh) | 2000-09-18 | 2000-09-18 | 河豚毒素或蛤蚌毒素及其类似物在制备用于全身镇痛的镇痛药中的应用 |
| US09/695,053 US6407088B1 (en) | 2000-09-18 | 2000-10-25 | Method of analgesia |
| EEP200300106A EE200300106A (et) | 2000-09-18 | 2001-09-11 | Farmatseutiline kompositsioon kui süsteemne analgeetikum |
| IL15434201A IL154342A0 (en) | 2000-09-18 | 2001-09-11 | A method of analgesia |
| AU2002213785A AU2002213785A1 (en) | 2000-09-18 | 2001-09-11 | A method of analgesia |
| KR1020037003723A KR100891568B1 (ko) | 2000-09-18 | 2001-09-11 | 나트륨 채널 차단 화합물인 테트로도톡신의 무통 제공 방법 |
| EP04022073A EP1563839B1 (en) | 2000-09-18 | 2001-09-11 | A method of analgesia |
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| KR1020077023825A KR20070112864A (ko) | 2000-09-18 | 2001-09-11 | 나트륨 채널 차단 화합물인 테트로도톡신의 약학적 조성물 |
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| CN1356104A CN1356104A (zh) | 2002-07-03 |
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| US7119062B1 (en) | 2001-02-23 | 2006-10-10 | Neucoll, Inc. | Methods and compositions for improved articular surgery using collagen |
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| CN1203860C (zh) * | 2001-06-22 | 2005-06-01 | 威克斯医药有限公司 | 钠离子通道阻断剂和阿司匹林在制备用于对哺乳动物进行协同镇痛的药物中的应用 |
| US20030100574A1 (en) | 2001-11-15 | 2003-05-29 | Wilson Nestor Antonio Lagos | Use and application of a pharmaceutical composition containing a mixture of natural-origin heterocyclical guanidine, for cosmetology, wound healing, focal dystonia and muscular spasm-related clinical pathologies |
| WO2004013637A1 (en) * | 2002-08-01 | 2004-02-12 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 37 (gpr37) |
| EP1589959A2 (en) * | 2003-01-30 | 2005-11-02 | Dynogen Pharmaceuticals Inc. | Methods of treating lower urinary tract disorders using sodium channel modulators |
| CN1568999A (zh) | 2003-07-14 | 2005-01-26 | 南宁枫叶药业有限公司 | 稳定的医药用河豚毒素冷冻干燥制剂 |
| JP2005154368A (ja) * | 2003-11-27 | 2005-06-16 | Teikoku Seiyaku Co Ltd | ジソピラミド含有神経因性疼痛の鎮痛剤 |
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| US20060034823A1 (en) * | 2004-08-13 | 2006-02-16 | Paul Reid | Method of production and use of crotoxin as an analgesic |
| CN100363006C (zh) * | 2004-08-20 | 2008-01-23 | 厦门朝阳生物工程有限公司 | 一种戒毒制剂及其制备方法 |
| CA2581128A1 (en) * | 2004-09-21 | 2006-03-30 | Laboratorios Del Dr. Esteve, S.A. | Tetrodotoxin and its derivatives for the treatment of central-nervously derived neuropathic pain |
| CA2581083A1 (en) * | 2004-09-22 | 2006-03-30 | Helmut Henrich Buschmann | Tetrodotoxin and its derivatives for the treatment of peripheral-nervously derived neuropathic pain |
| EP1690541A1 (en) * | 2005-02-11 | 2006-08-16 | Laboratorios Del Dr. Esteve, S.A. | Use of a sodium channel blocker and their analogues for the treatment of nicotine dependency |
| PE20061036A1 (es) * | 2005-02-11 | 2006-11-24 | Esteve Labor Dr | Bloqueadores del canal de sodio, tetrodotoxina o saxitoxina, como agentes para el tratamiento de la dependencia de nicotina |
| EP1714655A1 (en) * | 2005-04-22 | 2006-10-25 | Laboratorios Del Dr. Esteve, S.A. | Use of sodium channel blockers and their analogues for the treatment of nicotine dependency |
| EP1702627A1 (en) * | 2005-03-18 | 2006-09-20 | Laboratorios Del Dr. Esteve, S.A. | Analgesic combination of sodium channel blockers with opioid antagonists |
| WO2007025212A2 (en) * | 2005-08-25 | 2007-03-01 | Wex Pharmaceuticals, Inc. | Use of sodium channel blockers for the treatment of visceral pain or pain caused by cancer treatment |
| CA2619668A1 (en) * | 2005-08-25 | 2007-03-01 | Edge Renfeng Wang | Use of sodium channel blockers for the management of musculoskeletal pain |
| US20070148159A1 (en) * | 2005-12-22 | 2007-06-28 | Reid Paul F | Use of crotoxin as an analgesic - CIP |
| GB0603008D0 (en) * | 2006-02-14 | 2006-03-29 | Portela & Ca Sa | Method |
| EP1844781A1 (en) | 2006-02-22 | 2007-10-17 | Wex Pharmaceuticals Inc. | Use of sodium channel blockers for the treatment of preterm labor |
| CN101563079B (zh) | 2006-03-27 | 2012-12-05 | 威克斯药业有限公司 | 钠通道阻滞剂在制备治疗由于化疗而产生的神经病理性疼痛的药物中的用途 |
| EP1844783A1 (en) * | 2006-03-27 | 2007-10-17 | Wex Pharmaceuticals, Inc | Use of 4,9-anhydro-tetrodotoxin for the treatment of diseases related to the voltage-gated sodium channel - subunit Nav1.6 |
| WO2007110220A1 (en) * | 2006-03-27 | 2007-10-04 | Wex Pharmaceuticals Inc. | USE OF 4,9-ANHYDRO-TETRODOTOXIN FOR THE TREATMENT OF DISEASES RELATED TO THE VOLTAGE-GATED SODIUM CHANNEL α SUBUNIT NAV 1.6 |
| EP1844782A1 (en) * | 2006-03-27 | 2007-10-17 | Wex Pharmaceuticals, Inc | Use of 4,9-anhydro-tetrodotoxin for the treatment of diseases related to the voltage-gated sodium channel subunit Nav1.6 |
| CN100438873C (zh) * | 2006-06-26 | 2008-12-03 | 黄致强 | 将河鲀毒素作为镇痛药的耐受抑制剂在制备复方镇痛制剂中的应用 |
| EP1882692A1 (en) * | 2006-07-28 | 2008-01-30 | Wex Pharmaceuticals Inc. | Dimethano-[1,3]dioxocino[6,5-D]pyrimidine-spiro derivatives of tetrodotoxin, process for their synthesis and uses thereof in the treatment of pain |
| AU2008275752A1 (en) * | 2007-07-06 | 2009-01-15 | Nuon Therapeutics, Inc. | Treatment of neuropathic pain |
| CN101352422B (zh) * | 2008-09-17 | 2011-04-20 | 厦门朝阳生物工程有限公司 | 河豚毒素冻干粉针制剂及其制备方法 |
| US8952152B2 (en) | 2009-03-24 | 2015-02-10 | Proteus S.A. | Methods for purifying phycotoxins, pharmaceutical compositions containing purified phycotoxins, and methods of use thereof |
| US20120034296A1 (en) * | 2009-04-08 | 2012-02-09 | Massachusetts Institute Of Technology | Prolonged duration local anesthesia with minimal toxicity |
| EP2533785B1 (en) * | 2010-02-10 | 2014-04-23 | Phytotox Limited | Treatment of loss of sense of touch with saxitoxin derivatives |
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| WO2014159595A2 (en) | 2013-03-14 | 2014-10-02 | Regeneron Pharmaceuticals, Inc. | Human antibodies to nav1.7 |
| KR20210062693A (ko) | 2013-03-15 | 2021-05-31 | 더 칠드런스 메디칼 센터 코포레이션 | 지속성 국소 마취용 네오삭시톡신 조합 제형 |
| US8992927B1 (en) | 2014-07-15 | 2015-03-31 | Kymab Limited | Targeting human NAV1.7 variants for treatment of pain |
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| BR112018076260A2 (pt) | 2016-06-20 | 2019-03-26 | Kymab Limited | anticorpo ou fragmento do mesmo que se liga especificamente a hpd-l1, anticorpo biespecífico ou proteína de fusão, uso de um anticorpo ou fragmento, método, composição farmacêutica, método de modulação, método de inibição, método de tratamento, ácido nucleico, vetor, hospedeiro e imunocitocina |
| US11779604B2 (en) | 2016-11-03 | 2023-10-10 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses and methods |
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-
2000
- 2000-09-18 CN CNB001245171A patent/CN1284536C/zh not_active Expired - Lifetime
- 2000-10-25 US US09/695,053 patent/US6407088B1/en not_active Expired - Lifetime
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2001
- 2001-09-11 SK SK373-2003A patent/SK3732003A3/sk unknown
- 2001-09-11 CA CA2421562A patent/CA2421562C/en not_active Expired - Lifetime
- 2001-09-11 IL IL15434201A patent/IL154342A0/xx unknown
- 2001-09-11 KR KR1020077023825A patent/KR20070112864A/ko not_active Withdrawn
- 2001-09-11 DE DE60140466T patent/DE60140466D1/de not_active Expired - Lifetime
- 2001-09-11 JP JP2002526380A patent/JP2004508404A/ja not_active Abandoned
- 2001-09-11 EP EP01982091A patent/EP1320369B1/en not_active Expired - Lifetime
- 2001-09-11 AU AU2002213785A patent/AU2002213785A1/en not_active Abandoned
- 2001-09-11 YU YU17103A patent/YU17103A/sh unknown
- 2001-09-11 HR HR20030202A patent/HRP20030202A2/hr not_active Application Discontinuation
- 2001-09-11 AT AT01982091T patent/ATE447959T1/de not_active IP Right Cessation
- 2001-09-11 KR KR1020037003723A patent/KR100891568B1/ko not_active Expired - Lifetime
- 2001-09-11 EA EA200300172A patent/EA004870B1/ru unknown
- 2001-09-11 HU HU0302677A patent/HUP0302677A3/hu unknown
- 2001-09-11 BR BR0113961-4A patent/BR0113961A/pt not_active IP Right Cessation
- 2001-09-11 PL PL36061601A patent/PL360616A1/xx unknown
- 2001-09-11 MX MXPA03002389A patent/MXPA03002389A/es active IP Right Grant
- 2001-09-11 ES ES10180006T patent/ES2435463T3/es not_active Expired - Lifetime
- 2001-09-11 WO PCT/CN2001/001391 patent/WO2002022129A1/en not_active Ceased
- 2001-09-11 EP EP04022073A patent/EP1563839B1/en not_active Expired - Lifetime
- 2001-09-11 EP EP10180006.8A patent/EP2298306B1/en not_active Expired - Lifetime
- 2001-09-11 AT AT04022073T patent/ATE542534T1/de active
- 2001-09-11 EE EEP200300106A patent/EE200300106A/xx unknown
- 2001-11-09 UA UA2003032528A patent/UA76960C2/uk unknown
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- 2003-02-27 NO NO20030915A patent/NO323960B1/no unknown
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