CN101563079B - 钠通道阻滞剂在制备治疗由于化疗而产生的神经病理性疼痛的药物中的用途 - Google Patents
钠通道阻滞剂在制备治疗由于化疗而产生的神经病理性疼痛的药物中的用途 Download PDFInfo
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Abstract
Description
异常性疼痛 | 降低的阈值 | 刺激和反应模式不同 |
痛觉过敏 | 增加的反应 | 刺激和反应率相同 |
疼痛性触觉过敏 | 升高的阈值;增加的反应 | 刺激和反应率可以相同或不同 |
河豚毒素 | 60mg |
0.5%稀乙酸 | 1ml |
乙酸-乙酸盐缓冲溶液(pH=3.5) | 50ml(5%总体积的制备药物溶液) |
添加无菌水至 | 1000ml |
河豚毒素 | 300mg |
0.5%稀乙酸 | 1ml |
乙酸-乙酸盐缓冲溶液(pH=3.5) | 50ml(5%总体积的制备药物溶液) |
添加无菌水至 | 1000ml |
河豚毒素 | 600mg |
0.5%稀乙酸 | 1ml |
乙酸-乙酸盐缓冲溶液(pH=3.5) | 50ml(5%总体积的制备药物溶液) |
添加无菌水至 | 1000ml |
河豚毒素 | 1800mg |
0.5%稀乙酸 | 1ml |
乙酸-乙酸盐缓冲溶液(pH=3.5) | 50ml(5%总体积的制备药物溶液) |
添加无菌水至 | 1000ml |
河豚毒素 | 500mg |
0.5%稀乙酸 | 1ml |
乙酸-乙酸盐缓冲溶液(pH=3.5) | 50ml(5%总体积的制备药物溶液) |
添加无菌水至 | 1000ml |
河豚毒素 | 1000mg |
0.5%稀乙酸 | 1ml |
乙酸-乙酸盐缓冲溶液(pH=3.5) | 50ml(5%总体积的制备药物溶液) |
添加无菌水至 | 1000ml |
河豚毒素 | 2000mg |
0.5%稀乙酸 | 1ml |
乙酸-乙酸盐缓冲溶液(pH=3.5) | 50ml(5%总体积的制备药物溶液) |
添加无菌水至 | 1000ml |
河豚毒素 | 3000mg |
0.5%稀乙酸 | 1ml |
乙酸-乙酸盐缓冲溶液(pH=3.5) | 50ml(5%总体积的制备药物溶液) |
添加无菌水至 | 1000ml |
Claims (25)
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EP06025476.0 | 2006-12-08 | ||
PCT/EP2007/002662 WO2007110221A1 (en) | 2006-03-27 | 2007-03-26 | Use of sodium channel blockers for the treatment of neuropathic pain developing as a consequence of chemotherapy |
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CN101563079B true CN101563079B (zh) | 2012-12-05 |
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CN2012103955320A Pending CN103271920A (zh) | 2006-03-27 | 2007-03-26 | 钠通道阻滞剂治疗由于化疗而产生的神经病理性疼痛的用途 |
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EP (2) | EP2012774A1 (zh) |
CN (2) | CN101563079B (zh) |
CA (1) | CA2647235C (zh) |
ES (1) | ES2691411T3 (zh) |
WO (1) | WO2007110221A1 (zh) |
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2007
- 2007-03-26 US US12/294,843 patent/US9018222B2/en active Active
- 2007-03-26 CN CN2007800113883A patent/CN101563079B/zh active Active
- 2007-03-26 CN CN2012103955320A patent/CN103271920A/zh active Pending
- 2007-03-26 CA CA2647235A patent/CA2647235C/en active Active
- 2007-03-26 ES ES11180427.4T patent/ES2691411T3/es active Active
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ES2691411T3 (es) | 2018-11-27 |
CN101563079A (zh) | 2009-10-21 |
US10624896B2 (en) | 2020-04-21 |
EP2394646A1 (en) | 2011-12-14 |
US20170000797A1 (en) | 2017-01-05 |
US9018222B2 (en) | 2015-04-28 |
CA2647235C (en) | 2019-03-12 |
EP2012774A1 (en) | 2009-01-14 |
WO2007110221A1 (en) | 2007-10-04 |
US20190160074A1 (en) | 2019-05-30 |
US20100215771A1 (en) | 2010-08-26 |
US20210252004A1 (en) | 2021-08-19 |
US10149852B2 (en) | 2018-12-11 |
US20150283140A1 (en) | 2015-10-08 |
CA2647235A1 (en) | 2007-10-04 |
EP2394646B1 (en) | 2018-07-25 |
CN103271920A (zh) | 2013-09-04 |
US11419873B2 (en) | 2022-08-23 |
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