ATE447959T1 - Methode zur reduktion des schmerzempfindens - Google Patents
Methode zur reduktion des schmerzempfindensInfo
- Publication number
- ATE447959T1 ATE447959T1 AT01982091T AT01982091T ATE447959T1 AT E447959 T1 ATE447959 T1 AT E447959T1 AT 01982091 T AT01982091 T AT 01982091T AT 01982091 T AT01982091 T AT 01982091T AT E447959 T1 ATE447959 T1 AT E447959T1
- Authority
- AT
- Austria
- Prior art keywords
- pain
- sensation
- reducing
- anolgs
- saxitoxin
- Prior art date
Links
- 230000008058 pain sensation Effects 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 108010052164 Sodium Channels Proteins 0.000 abstract 1
- 102000018674 Sodium Channels Human genes 0.000 abstract 1
- 230000036592 analgesia Effects 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000036407 pain Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- RPQXVSUAYFXFJA-HGRQIUPRSA-N saxitoxin Chemical compound NC(=O)OC[C@@H]1N=C(N)N2CCC(O)(O)[C@@]22N=C(N)N[C@@H]12 RPQXVSUAYFXFJA-HGRQIUPRSA-N 0.000 abstract 1
- RPQXVSUAYFXFJA-UHFFFAOYSA-N saxitoxin hydrate Natural products NC(=O)OCC1N=C(N)N2CCC(O)(O)C22NC(N)=NC12 RPQXVSUAYFXFJA-UHFFFAOYSA-N 0.000 abstract 1
- 238000007910 systemic administration Methods 0.000 abstract 1
- CFMYXEVWODSLAX-QOZOJKKESA-N tetrodotoxin Chemical compound O([C@@]([C@H]1O)(O)O[C@H]2[C@@]3(O)CO)[C@H]3[C@@H](O)[C@]11[C@H]2[C@@H](O)N=C(N)N1 CFMYXEVWODSLAX-QOZOJKKESA-N 0.000 abstract 1
- 229950010357 tetrodotoxin Drugs 0.000 abstract 1
- CFMYXEVWODSLAX-UHFFFAOYSA-N tetrodotoxin Natural products C12C(O)NC(=N)NC2(C2O)C(O)C3C(CO)(O)C1OC2(O)O3 CFMYXEVWODSLAX-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Anesthesiology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Electrotherapy Devices (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Laser Surgery Devices (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001245171A CN1284536C (zh) | 2000-09-18 | 2000-09-18 | 河豚毒素或蛤蚌毒素及其类似物在制备用于全身镇痛的镇痛药中的应用 |
| PCT/CN2001/001391 WO2002022129A1 (en) | 2000-09-18 | 2001-09-11 | A method of analgesia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE447959T1 true ATE447959T1 (de) | 2009-11-15 |
Family
ID=4590472
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01982091T ATE447959T1 (de) | 2000-09-18 | 2001-09-11 | Methode zur reduktion des schmerzempfindens |
| AT04022073T ATE542534T1 (de) | 2000-09-18 | 2001-09-11 | Methode zur schmerzbekämpfung |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04022073T ATE542534T1 (de) | 2000-09-18 | 2001-09-11 | Methode zur schmerzbekämpfung |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6407088B1 (de) |
| EP (3) | EP1320369B1 (de) |
| JP (1) | JP2004508404A (de) |
| KR (2) | KR100891568B1 (de) |
| CN (1) | CN1284536C (de) |
| AT (2) | ATE447959T1 (de) |
| AU (1) | AU2002213785A1 (de) |
| BG (1) | BG107690A (de) |
| BR (1) | BR0113961A (de) |
| CA (1) | CA2421562C (de) |
| DE (1) | DE60140466D1 (de) |
| EA (1) | EA004870B1 (de) |
| EE (1) | EE200300106A (de) |
| ES (1) | ES2435463T3 (de) |
| HR (1) | HRP20030202A2 (de) |
| HU (1) | HUP0302677A3 (de) |
| IL (1) | IL154342A0 (de) |
| IS (1) | IS6719A (de) |
| MX (1) | MXPA03002389A (de) |
| NO (1) | NO323960B1 (de) |
| PL (1) | PL360616A1 (de) |
| SK (1) | SK3732003A3 (de) |
| UA (1) | UA76960C2 (de) |
| WO (1) | WO2002022129A1 (de) |
| YU (1) | YU17103A (de) |
| ZA (1) | ZA200301852B (de) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ500590A (en) | 1997-04-22 | 2001-11-30 | Cocensys Inc | Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereof |
| CN1236773C (zh) * | 2000-11-22 | 2006-01-18 | 南宁枫叶药业有限公司 | 用于镇痛、麻醉或治疗药物依赖性的制剂 |
| US7119062B1 (en) | 2001-02-23 | 2006-10-10 | Neucoll, Inc. | Methods and compositions for improved articular surgery using collagen |
| CN1269482C (zh) * | 2001-05-18 | 2006-08-16 | 威克斯医药有限公司 | 钠离子通道阻断剂和阿片类镇痛剂在制备用于对哺乳动物进行协同镇痛的药物中的应用 |
| CN1203860C (zh) * | 2001-06-22 | 2005-06-01 | 威克斯医药有限公司 | 钠离子通道阻断剂和阿司匹林在制备用于对哺乳动物进行协同镇痛的药物中的应用 |
| BR0214126A (pt) | 2001-11-15 | 2004-10-13 | Micro Algae Corp | Composiçáo farmacêutica para interferir na transmissão neuronal, preparação para o rejuvenescimento facial, e, métodos para interferir na transmissão neuronal, e na contração muscular |
| AU2003250128A1 (en) * | 2002-08-01 | 2004-02-23 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 37 (gpr37) |
| AU2004207010A1 (en) * | 2003-01-30 | 2004-08-12 | Dynogen Pharmaceuticals, Inc. | Methods of treating lower urinary tract disorders using sodium channel modulators |
| CN1568999A (zh) | 2003-07-14 | 2005-01-26 | 南宁枫叶药业有限公司 | 稳定的医药用河豚毒素冷冻干燥制剂 |
| JP2005154368A (ja) * | 2003-11-27 | 2005-06-16 | Teikoku Seiyaku Co Ltd | ジソピラミド含有神経因性疼痛の鎮痛剤 |
| CA2606530C (en) * | 2004-05-07 | 2014-01-07 | Phytotox Limited | Phycotoxins and uses thereof |
| MXPA06012960A (es) * | 2004-05-07 | 2007-06-12 | Phytotox Ltd | Administracion transdermal de ficotoxinas. |
| US20050282836A1 (en) * | 2004-06-22 | 2005-12-22 | Weiyang Lin | Solid orally ingestible formulations of tetrodotoxin |
| US20060034823A1 (en) * | 2004-08-13 | 2006-02-16 | Paul Reid | Method of production and use of crotoxin as an analgesic |
| CN100363006C (zh) * | 2004-08-20 | 2008-01-23 | 厦门朝阳生物工程有限公司 | 一种戒毒制剂及其制备方法 |
| CN101039674A (zh) * | 2004-09-21 | 2007-09-19 | 埃斯蒂文博士实验室股份有限公司 | 河豚毒素及其衍生物用于治疗中枢神经源性神经痛 |
| AU2005287580A1 (en) * | 2004-09-22 | 2006-03-30 | Wex Medical Limited | Tetrodotoxin and its derivatives for the treatment of peripheral-nervously derived neuropathic pain |
| WO2006084765A1 (en) * | 2005-02-11 | 2006-08-17 | Wex Pharmaceuticals, Inc. | Use of sodium channel blockers and their analogues for the treatment of nicotine dependency |
| EP1690541A1 (de) * | 2005-02-11 | 2006-08-16 | Laboratorios Del Dr. Esteve, S.A. | Verwendung eines Natriumkanalblockers und deren Analoga zur Behandlung von Nikotinabhängigkeit |
| EP1714655A1 (de) * | 2005-04-22 | 2006-10-25 | Laboratorios Del Dr. Esteve, S.A. | Verwendung eines Natriumkanalblockers und deren Analoga zur Behandlung von Nikotinabhängigkeit |
| EP1702627A1 (de) * | 2005-03-18 | 2006-09-20 | Laboratorios Del Dr. Esteve, S.A. | Analgetische Kombination aus Natriumkanalblocker und Opioid Antagonisten |
| EP1931349A4 (de) * | 2005-08-25 | 2009-08-05 | Wex Pharmaceuticals Inc | Verwendung von natriumkanalblockern zur behanldung von muskel- und skelettschmerzen |
| EP1928452A4 (de) * | 2005-08-25 | 2010-09-01 | Wex Medical Ltd | Verwendung von natriumkanalblockern zur behanldung von viszeralen schmerzen oder schmerzen durch krebsbehandlung |
| US20070148159A1 (en) * | 2005-12-22 | 2007-06-28 | Reid Paul F | Use of crotoxin as an analgesic - CIP |
| GB0603008D0 (en) * | 2006-02-14 | 2006-03-29 | Portela & Ca Sa | Method |
| EP1844781A1 (de) | 2006-02-22 | 2007-10-17 | Wex Pharmaceuticals Inc. | Verwendung von Natriumkanalblockern für die Behandlung von vorzeitigen Wehen |
| EP1844783A1 (de) * | 2006-03-27 | 2007-10-17 | Wex Pharmaceuticals, Inc | 4,9-Anhydro-Tetrodoxin zur Behandlung von Krankheiten die in Zusammenhang mit der Potential-abhängigen Natrium-Kanal Subeinheit Nav1.6 stehen |
| EP2394646B1 (de) | 2006-03-27 | 2018-07-25 | Wex Medical Limited | Verwendung von Natriumkanalblockern zur Behandlung von neuropathischen Schmerzen infolge von Chemotherapie |
| WO2007110220A1 (en) * | 2006-03-27 | 2007-10-04 | Wex Pharmaceuticals Inc. | USE OF 4,9-ANHYDRO-TETRODOTOXIN FOR THE TREATMENT OF DISEASES RELATED TO THE VOLTAGE-GATED SODIUM CHANNEL α SUBUNIT NAV 1.6 |
| EP1844782A1 (de) * | 2006-03-27 | 2007-10-17 | Wex Pharmaceuticals, Inc | 4,9-Anhydro-Tetrodoxin zur Behandlung von Krankheiten die in Zusammenhang mit der Potential-abhängigen Natrium-Kanal Subeinheit Nav1.6 stehen |
| CN100438873C (zh) * | 2006-06-26 | 2008-12-03 | 黄致强 | 将河鲀毒素作为镇痛药的耐受抑制剂在制备复方镇痛制剂中的应用 |
| EP1882692A1 (de) * | 2006-07-28 | 2008-01-30 | Wex Pharmaceuticals Inc. | Dimethano-[1,3]dioxocino[6,5-D]Pyrimidine-Spiro-Derivate von Tetrodotoxin, Verfahren ihrer Herstellung und ihre Verwendung zur Behandlung von Schmerzen |
| KR20100047860A (ko) * | 2007-07-06 | 2010-05-10 | 누온 테라피우틱스, 아이엔씨. | 신경병증 통증의 치료 |
| CN101352422B (zh) * | 2008-09-17 | 2011-04-20 | 厦门朝阳生物工程有限公司 | 河豚毒素冻干粉针制剂及其制备方法 |
| US8952152B2 (en) | 2009-03-24 | 2015-02-10 | Proteus S.A. | Methods for purifying phycotoxins, pharmaceutical compositions containing purified phycotoxins, and methods of use thereof |
| WO2010117996A1 (en) * | 2009-04-08 | 2010-10-14 | Children's Medical Center Corporation | Prolonged duration local anesthesia with minimal toxicity |
| WO2011098539A1 (en) | 2010-02-10 | 2011-08-18 | Phytotox Limited | Treatment of loss of sense of touch with saxitoxin derivatives |
| US20120310140A1 (en) | 2010-12-01 | 2012-12-06 | Spinal Modulation, Inc. | Directed delivery of agents to neural anatomy |
| KR20150127618A (ko) | 2013-03-14 | 2015-11-17 | 리제너론 파아마슈티컬스, 인크. | Nav1.7에 대한 사람 항체 |
| EP2968225B1 (de) | 2013-03-15 | 2019-02-20 | The Children's Medical Center Corporation | Neosaxitoxinkombinationsformulierungen für verlängerte lokalanästhesie |
| US8992927B1 (en) | 2014-07-15 | 2015-03-31 | Kymab Limited | Targeting human NAV1.7 variants for treatment of pain |
| US8986694B1 (en) | 2014-07-15 | 2015-03-24 | Kymab Limited | Targeting human nav1.7 variants for treatment of pain |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| TWI640536B (zh) | 2016-06-20 | 2018-11-11 | 克馬伯有限公司 | 抗體 |
| US11779604B2 (en) | 2016-11-03 | 2023-10-10 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses and methods |
| CN107198689A (zh) * | 2017-07-11 | 2017-09-26 | 东新皓特（北京）生化科技有限公司 | 用于治疗疼痛病症的河豚毒素药物组合物及外用药 |
| AU2022261799A1 (en) | 2021-04-23 | 2023-10-26 | Wex Pharmaceuticals Inc. | Tetrodotoxin liquid formulations |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4029793A (en) | 1973-06-12 | 1977-06-14 | Astra Pharmaceutical Products, Inc. | Synergistic local anesthetic compositions |
| US4022899A (en) | 1973-06-12 | 1977-05-10 | Astra Pharmaceutical Products, Inc. | Synergistic local anesthetic compositions |
| WO1995024903A1 (en) * | 1994-03-17 | 1995-09-21 | Nanning Maple Leaf Pharmaceutical Co., Ltd. | The use of amino hydrogenated quinazoline compounds and derivatives thereof for abstaining from drug dependence |
| CN1072486C (zh) * | 1996-09-24 | 2001-10-10 | 王维国 | 用于戒毒、镇痛的药剂及其制法 |
| US6030974A (en) * | 1997-04-02 | 2000-02-29 | The Regents Of The University Of California | Method of anesthesia |
| AU7389098A (en) * | 1997-05-16 | 1998-12-08 | Brigham And Women's Hospital | Local anesthetic formulations |
| CN1236773C (zh) * | 2000-11-22 | 2006-01-18 | 南宁枫叶药业有限公司 | 用于镇痛、麻醉或治疗药物依赖性的制剂 |
| CN1269482C (zh) * | 2001-05-18 | 2006-08-16 | 威克斯医药有限公司 | 钠离子通道阻断剂和阿片类镇痛剂在制备用于对哺乳动物进行协同镇痛的药物中的应用 |
-
2000
- 2000-09-18 CN CNB001245171A patent/CN1284536C/zh not_active Expired - Lifetime
- 2000-10-25 US US09/695,053 patent/US6407088B1/en not_active Expired - Lifetime
-
2001
- 2001-09-11 ES ES10180006T patent/ES2435463T3/es not_active Expired - Lifetime
- 2001-09-11 DE DE60140466T patent/DE60140466D1/de not_active Expired - Lifetime
- 2001-09-11 WO PCT/CN2001/001391 patent/WO2002022129A1/en not_active Ceased
- 2001-09-11 JP JP2002526380A patent/JP2004508404A/ja not_active Abandoned
- 2001-09-11 MX MXPA03002389A patent/MXPA03002389A/es active IP Right Grant
- 2001-09-11 YU YU17103A patent/YU17103A/sh unknown
- 2001-09-11 SK SK373-2003A patent/SK3732003A3/sk unknown
- 2001-09-11 AT AT01982091T patent/ATE447959T1/de not_active IP Right Cessation
- 2001-09-11 PL PL36061601A patent/PL360616A1/xx unknown
- 2001-09-11 HR HR20030202A patent/HRP20030202A2/hr not_active Application Discontinuation
- 2001-09-11 EE EEP200300106A patent/EE200300106A/xx unknown
- 2001-09-11 BR BR0113961-4A patent/BR0113961A/pt not_active IP Right Cessation
- 2001-09-11 EP EP01982091A patent/EP1320369B1/de not_active Expired - Lifetime
- 2001-09-11 EP EP04022073A patent/EP1563839B1/de not_active Expired - Lifetime
- 2001-09-11 EP EP10180006.8A patent/EP2298306B1/de not_active Expired - Lifetime
- 2001-09-11 AT AT04022073T patent/ATE542534T1/de active
- 2001-09-11 CA CA2421562A patent/CA2421562C/en not_active Expired - Lifetime
- 2001-09-11 KR KR1020037003723A patent/KR100891568B1/ko not_active Expired - Lifetime
- 2001-09-11 HU HU0302677A patent/HUP0302677A3/hu unknown
- 2001-09-11 AU AU2002213785A patent/AU2002213785A1/en not_active Abandoned
- 2001-09-11 EA EA200300172A patent/EA004870B1/ru unknown
- 2001-09-11 IL IL15434201A patent/IL154342A0/xx unknown
- 2001-09-11 KR KR1020077023825A patent/KR20070112864A/ko not_active Withdrawn
- 2001-11-09 UA UA2003032528A patent/UA76960C2/uk unknown
-
2003
- 2003-02-14 IS IS6719A patent/IS6719A/is unknown
- 2003-02-27 NO NO20030915A patent/NO323960B1/no unknown
- 2003-03-06 ZA ZA200301852A patent/ZA200301852B/en unknown
- 2003-03-31 BG BG107690A patent/BG107690A/bg unknown
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