ATE542534T1 - Methode zur schmerzbekämpfung - Google Patents

Methode zur schmerzbekämpfung

Info

Publication number
ATE542534T1
ATE542534T1 AT04022073T AT04022073T ATE542534T1 AT E542534 T1 ATE542534 T1 AT E542534T1 AT 04022073 T AT04022073 T AT 04022073T AT 04022073 T AT04022073 T AT 04022073T AT E542534 T1 ATE542534 T1 AT E542534T1
Authority
AT
Austria
Prior art keywords
pain control
anolgs
saxitoxin
tetrodotoxin
derivatives
Prior art date
Application number
AT04022073T
Other languages
English (en)
Inventor
Qingbin Dong
Frank Haykong Shum
Original Assignee
Wex Medical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wex Medical Ltd filed Critical Wex Medical Ltd
Application granted granted Critical
Publication of ATE542534T1 publication Critical patent/ATE542534T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • A61P23/02Local anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electrotherapy Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Laser Surgery Devices (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT04022073T 2000-09-18 2001-09-11 Methode zur schmerzbekämpfung ATE542534T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNB001245171A CN1284536C (zh) 2000-09-18 2000-09-18 河豚毒素或蛤蚌毒素及其类似物在制备用于全身镇痛的镇痛药中的应用

Publications (1)

Publication Number Publication Date
ATE542534T1 true ATE542534T1 (de) 2012-02-15

Family

ID=4590472

Family Applications (2)

Application Number Title Priority Date Filing Date
AT01982091T ATE447959T1 (de) 2000-09-18 2001-09-11 Methode zur reduktion des schmerzempfindens
AT04022073T ATE542534T1 (de) 2000-09-18 2001-09-11 Methode zur schmerzbekämpfung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT01982091T ATE447959T1 (de) 2000-09-18 2001-09-11 Methode zur reduktion des schmerzempfindens

Country Status (26)

Country Link
US (1) US6407088B1 (de)
EP (3) EP1320369B1 (de)
JP (1) JP2004508404A (de)
KR (2) KR20070112864A (de)
CN (1) CN1284536C (de)
AT (2) ATE447959T1 (de)
AU (1) AU2002213785A1 (de)
BG (1) BG107690A (de)
BR (1) BR0113961A (de)
CA (1) CA2421562C (de)
DE (1) DE60140466D1 (de)
EA (1) EA004870B1 (de)
EE (1) EE200300106A (de)
ES (1) ES2435463T3 (de)
HR (1) HRP20030202A2 (de)
HU (1) HUP0302677A3 (de)
IL (1) IL154342A0 (de)
IS (1) IS6719A (de)
MX (1) MXPA03002389A (de)
NO (1) NO323960B1 (de)
PL (1) PL360616A1 (de)
SK (1) SK3732003A3 (de)
UA (1) UA76960C2 (de)
WO (1) WO2002022129A1 (de)
YU (1) YU17103A (de)
ZA (1) ZA200301852B (de)

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US7119062B1 (en) 2001-02-23 2006-10-10 Neucoll, Inc. Methods and compositions for improved articular surgery using collagen
CN1269482C (zh) * 2001-05-18 2006-08-16 威克斯医药有限公司 钠离子通道阻断剂和阿片类镇痛剂在制备用于对哺乳动物进行协同镇痛的药物中的应用
CN1203860C (zh) * 2001-06-22 2005-06-01 威克斯医药有限公司 钠离子通道阻断剂和阿司匹林在制备用于对哺乳动物进行协同镇痛的药物中的应用
KR20100135884A (ko) 2001-11-15 2010-12-27 마이크로 알제 코포레이션 3, 4-프로피온퍼하이드로퓨린을 포함하는 약학 조성물 및 상기 조성물을 이용한 신경 전달의 블로킹 방법
WO2004013637A1 (en) * 2002-08-01 2004-02-12 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 37 (gpr37)
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CN1568999A (zh) 2003-07-14 2005-01-26 南宁枫叶药业有限公司 稳定的医药用河豚毒素冷冻干燥制剂
JP2005154368A (ja) * 2003-11-27 2005-06-16 Teikoku Seiyaku Co Ltd ジソピラミド含有神経因性疼痛の鎮痛剤
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US20060034823A1 (en) * 2004-08-13 2006-02-16 Paul Reid Method of production and use of crotoxin as an analgesic
CN100363006C (zh) * 2004-08-20 2008-01-23 厦门朝阳生物工程有限公司 一种戒毒制剂及其制备方法
JP2008513407A (ja) * 2004-09-21 2008-05-01 ウェックス ファーマシューティカルズ インコーポレイテッド 中枢神経由来の神経障害性疼痛の治療用テトロドトキシンおよびその誘導体
KR20070092698A (ko) * 2004-09-22 2007-09-13 라보라토리오스 델 드라. 에스테브.에스.에이. 말초 신경적으로 유발된 신경병증성 통증을 치료하기 위한테트로도톡신 및 그것의 유도체
AR053811A1 (es) * 2005-02-11 2007-05-23 Esteve Labor Dr Utilizacion de un bloqueador del canal de sodio y sus analogos para el tratamiento de la dependencia de la nicotina
EP1690541A1 (de) * 2005-02-11 2006-08-16 Laboratorios Del Dr. Esteve, S.A. Verwendung eines Natriumkanalblockers und deren Analoga zur Behandlung von Nikotinabhängigkeit
EP1714655A1 (de) * 2005-04-22 2006-10-25 Laboratorios Del Dr. Esteve, S.A. Verwendung eines Natriumkanalblockers und deren Analoga zur Behandlung von Nikotinabhängigkeit
EP1702627A1 (de) * 2005-03-18 2006-09-20 Laboratorios Del Dr. Esteve, S.A. Analgetische Kombination aus Natriumkanalblocker und Opioid Antagonisten
EP1928452A4 (de) * 2005-08-25 2010-09-01 Wex Medical Ltd Verwendung von natriumkanalblockern zur behanldung von viszeralen schmerzen oder schmerzen durch krebsbehandlung
WO2007025213A2 (en) * 2005-08-25 2007-03-01 Wex Pharmaceuticals, Inc. Use of sodium channel blockers for the management of musculoskeletal pain
US20070148159A1 (en) * 2005-12-22 2007-06-28 Reid Paul F Use of crotoxin as an analgesic - CIP
GB0603008D0 (en) * 2006-02-14 2006-03-29 Portela & Ca Sa Method
EP1844781A1 (de) 2006-02-22 2007-10-17 Wex Pharmaceuticals Inc. Verwendung von Natriumkanalblockern für die Behandlung von vorzeitigen Wehen
EP2394646B1 (de) 2006-03-27 2018-07-25 Wex Medical Limited Verwendung von Natriumkanalblockern zur Behandlung von neuropathischen Schmerzen infolge von Chemotherapie
WO2007110220A1 (en) * 2006-03-27 2007-10-04 Wex Pharmaceuticals Inc. USE OF 4,9-ANHYDRO-TETRODOTOXIN FOR THE TREATMENT OF DISEASES RELATED TO THE VOLTAGE-GATED SODIUM CHANNEL α SUBUNIT NAV 1.6
EP1844783A1 (de) * 2006-03-27 2007-10-17 Wex Pharmaceuticals, Inc 4,9-Anhydro-Tetrodoxin zur Behandlung von Krankheiten die in Zusammenhang mit der Potential-abhängigen Natrium-Kanal Subeinheit Nav1.6 stehen
EP1844782A1 (de) * 2006-03-27 2007-10-17 Wex Pharmaceuticals, Inc 4,9-Anhydro-Tetrodoxin zur Behandlung von Krankheiten die in Zusammenhang mit der Potential-abhängigen Natrium-Kanal Subeinheit Nav1.6 stehen
CN100438873C (zh) * 2006-06-26 2008-12-03 黄致强 将河鲀毒素作为镇痛药的耐受抑制剂在制备复方镇痛制剂中的应用
EP1882692A1 (de) * 2006-07-28 2008-01-30 Wex Pharmaceuticals Inc. Dimethano-[1,3]dioxocino[6,5-D]Pyrimidine-Spiro-Derivate von Tetrodotoxin, Verfahren ihrer Herstellung und ihre Verwendung zur Behandlung von Schmerzen
WO2009008997A2 (en) * 2007-07-06 2009-01-15 Nuon Therapeutics, Inc. Treatment of neuropathic pain
CN101352422B (zh) * 2008-09-17 2011-04-20 厦门朝阳生物工程有限公司 河豚毒素冻干粉针制剂及其制备方法
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JP6313420B2 (ja) * 2013-03-15 2018-04-18 ザ チルドレンズ メディカル センター コーポレイション 持続する局所麻酔のためのネオサキシトキシン併用製剤
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CN1269482C (zh) * 2001-05-18 2006-08-16 威克斯医药有限公司 钠离子通道阻断剂和阿片类镇痛剂在制备用于对哺乳动物进行协同镇痛的药物中的应用

Also Published As

Publication number Publication date
NO323960B1 (no) 2007-07-23
KR20070112864A (ko) 2007-11-27
BR0113961A (pt) 2004-01-13
IS6719A (is) 2003-02-14
EP1320369A1 (de) 2003-06-25
CA2421562C (en) 2011-05-24
CA2421562A1 (en) 2002-03-21
EP1320369B1 (de) 2009-11-11
EE200300106A (et) 2005-04-15
ES2435463T3 (es) 2013-12-19
AU2002213785A1 (en) 2002-03-26
EP1563839A1 (de) 2005-08-17
NO20030915D0 (no) 2003-02-27
EP2298306B1 (de) 2013-09-11
HRP20030202A2 (en) 2005-02-28
ATE447959T1 (de) 2009-11-15
HUP0302677A2 (hu) 2003-11-28
EP1563839B1 (de) 2012-01-25
WO2002022129A1 (en) 2002-03-21
EA004870B1 (ru) 2004-08-26
DE60140466D1 (de) 2009-12-24
EA200300172A1 (ru) 2003-12-25
EP1320369A4 (de) 2003-07-02
EP2298306A1 (de) 2011-03-23
SK3732003A3 (sk) 2005-05-05
MXPA03002389A (es) 2004-03-12
JP2004508404A (ja) 2004-03-18
KR100891568B1 (ko) 2009-04-03
ZA200301852B (en) 2004-06-21
CN1356104A (zh) 2002-07-03
BG107690A (bg) 2004-01-30
PL360616A1 (en) 2004-09-20
UA76960C2 (en) 2006-10-16
HUP0302677A3 (en) 2005-01-28
YU17103A (sh) 2006-03-03
IL154342A0 (en) 2003-09-17
NO20030915L (no) 2003-04-25
CN1284536C (zh) 2006-11-15
KR20030034181A (ko) 2003-05-01
US6407088B1 (en) 2002-06-18

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