CN1283797C - 通过提高外运载体的活性而进行微生物生产氨基酸的方法 - Google Patents

通过提高外运载体的活性而进行微生物生产氨基酸的方法 Download PDF

Info

Publication number
CN1283797C
CN1283797C CNB961800968A CN96180096A CN1283797C CN 1283797 C CN1283797 C CN 1283797C CN B961800968 A CNB961800968 A CN B961800968A CN 96180096 A CN96180096 A CN 96180096A CN 1283797 C CN1283797 C CN 1283797C
Authority
CN
China
Prior art keywords
gene
export
lysine
amino acid
lyse
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB961800968A
Other languages
English (en)
Chinese (zh)
Other versions
CN1209169A (zh
Inventor
M·维尔利克
L·艾格林
H·萨姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Forschungszentrum Juelich GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forschungszentrum Juelich GmbH filed Critical Forschungszentrum Juelich GmbH
Publication of CN1209169A publication Critical patent/CN1209169A/zh
Application granted granted Critical
Publication of CN1283797C publication Critical patent/CN1283797C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CNB961800968A 1995-12-22 1996-12-18 通过提高外运载体的活性而进行微生物生产氨基酸的方法 Expired - Fee Related CN1283797C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19548222A DE19548222A1 (de) 1995-12-22 1995-12-22 Verfahren zur mikrobiellen Herstellung von Aminosäuren durch gesteigerte Aktivität von Exportcarriern
DE19548222.0 1995-12-22

Publications (2)

Publication Number Publication Date
CN1209169A CN1209169A (zh) 1999-02-24
CN1283797C true CN1283797C (zh) 2006-11-08

Family

ID=7781070

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB961800968A Expired - Fee Related CN1283797C (zh) 1995-12-22 1996-12-18 通过提高外运载体的活性而进行微生物生产氨基酸的方法

Country Status (16)

Country Link
US (1) US6858406B1 (https=)
EP (1) EP0868527B1 (https=)
JP (1) JP3942194B2 (https=)
KR (1) KR100444621B1 (https=)
CN (1) CN1283797C (https=)
AR (1) AR048561A1 (https=)
AU (1) AU724536B2 (https=)
BR (1) BR9612666A (https=)
CA (1) CA2241111C (https=)
DE (2) DE19548222A1 (https=)
DK (1) DK0868527T3 (https=)
ES (1) ES2281088T3 (https=)
MX (1) MX9805050A (https=)
RU (1) RU2225883C2 (https=)
WO (1) WO1997023597A2 (https=)
ZA (1) ZA9610768B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022152125A1 (zh) 2021-01-13 2022-07-21 中国科学院天津工业生物技术研究所 具有l-脯氨酸外排功能的蛋白及其应用

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19726083A1 (de) * 1997-06-19 1998-12-24 Consortium Elektrochem Ind Mikroorganismen und Verfahren zur fermentativen Herstellung von L-Cystein, L-Cystin, N-Acetyl-Serin oder Thiazolidinderivaten
DE19931317A1 (de) * 1999-07-07 2001-01-11 Degussa L-Lysin produzierende coryneforme Bakterien und Verfahren zur Herstellung von L-Lysin
RU2144564C1 (ru) 1998-10-13 2000-01-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" ФРАГМЕНТ ДНК rhtB, КОДИРУЮЩИЙ СИНТЕЗ БЕЛКА RhtB, ПРИДАЮЩЕГО УСТОЙЧИВОСТЬ К L-ГОМОСЕРИНУ БАКТЕРИЯМ ESCHERICHIA COLI, И СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ
RU2148642C1 (ru) * 1998-12-23 2000-05-10 ЗАО "Научно-исследовательский институт АДЖИНОМОТО-Генетика" (ЗАО "АГРИ") Фрагмент днк rhtc, кодирующий синтез белка rhtc, придающего повышенную устойчивость к l-треонину бактериям escherichia coli, и способ получения l-аминокислоты
RU2175351C2 (ru) 1998-12-30 2001-10-27 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО "АГРИ") Фрагмент днк из escherichia coli, определяющий повышенную продукцию l-аминокислот (варианты), и способ получения l-аминокислот
US6861246B2 (en) 1999-07-07 2005-03-01 Degussa Ag L-lysine-producing corynebacteria and process for the preparation of lysine
US20020086371A1 (en) 1999-07-07 2002-07-04 Degussa-Huls Aktiengesellschaft L-lysine-producing corynebacteria and process for the preparation of L-lysine
DE19931314A1 (de) * 1999-07-07 2001-01-11 Degussa L-Lysin produzierende coryneforme Bakterien und Verfahren zur Herstellung von Lysin
US6797509B1 (en) 1999-07-09 2004-09-28 Degussa-Huls Ag Nucleotide sequences which code for the tal gene
DE19951708A1 (de) 1999-10-27 2001-05-03 Degussa Für den Export verzweigtkettiger Aminosäuren kodierende Nikleotidsequenzen, Verfahren zu deren Isolierung und ihre Verwendung
EP1320616A2 (en) * 2000-09-02 2003-06-25 Degussa AG Sequences which code for the sige gene of corynebacterium glutamicum
US6913908B2 (en) 2000-09-02 2005-07-05 Degussa Ag Methods of making L-amino acids in coryneform using the sigE gene
DE60210697T2 (de) 2001-02-13 2007-04-05 Ajinomoto Co., Inc. Verfahren zur Produktion von L-Aminosäuren mittels Bakterien der Gattung Escherichia
DE60232120D1 (de) 2001-06-12 2009-06-10 Ajinomoto Kk Verfahren zur Herstellung von L-Lysin oder L-Arginin unter Verwendung methanolassimilierender Bakterien
US7252978B2 (en) 2001-07-25 2007-08-07 Ajinomoto Co., Inc. Method for producing L-arginine
DE10154179A1 (de) * 2001-11-05 2003-05-08 Basf Ag Gene die für membeansynthese-und Membrantransport-Proteine codieren
RU2229513C2 (ru) 2001-11-23 2004-05-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Способ получения l-аминокислот, штамм escherichia coli - продуцент l-аминокислоты (варианты)
MXPA04004874A (es) 2001-11-23 2004-09-03 Ajinomoto Kk Procedimiento para producir l-aminoacido utilizando escherichia.
DE10210527A1 (de) 2002-03-09 2003-09-18 Degussa Allele des aceA-Gens aus coryneformen Bakterien
JP4120364B2 (ja) * 2002-11-20 2008-07-16 味の素株式会社 メタノール資化性菌を用いたｌ−リジンまたはｌ−アルギニンの製造法
JP2004166592A (ja) 2002-11-20 2004-06-17 Ajinomoto Co Inc メチロトローフを用いたｌ−アミノ酸の製造法
DE102004001674B4 (de) 2003-01-29 2019-01-24 Ajinomoto Co., Inc. Verfahren zur Herstellung von L-Lysin unter Einsatz von Methanol verwertenden Bakterien
US7335496B2 (en) 2003-06-05 2008-02-26 Ajinomoto Co., Inc. Method for producing target substance
JP4665537B2 (ja) * 2004-01-30 2011-04-06 味の素株式会社 Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
BRPI0506369B1 (pt) 2004-01-30 2020-11-03 Ajinomoto Co., Inc microorganismo transgênico, e, método para produzir um l-aminoácido
JP4665558B2 (ja) * 2004-03-04 2011-04-06 味の素株式会社 Ｌ−グルタミン酸生産微生物及びｌ−グルタミン酸の製造法
US7344874B2 (en) 2004-03-04 2008-03-18 Ajinomoto Co., Inc. L-glutamic acid-producing microorganism and a method for producing L-glutamic acid
DE102004034865A1 (de) 2004-07-19 2006-02-16 Siemens Ag Sensor zur Messung der Position eines Stellgliedes
BRPI0516261A (pt) 2004-10-07 2008-08-26 Ajinomoto Kk método para produzir uma substãncia básica por fermentação, e, caldo de fermentação ou produto de fermentação contendo uma substáncia básica
CA2590719A1 (en) 2004-12-06 2006-08-31 Sage Biosciences Inc. Method of growing bacteria to deliver bioactive compounds to the intestine of ruminants
US20070092951A1 (en) 2005-03-24 2007-04-26 Degussa Ag Alleles of the zwf gene from coryneform bacteria
DE102005013676A1 (de) 2005-03-24 2006-09-28 Degussa Ag Allele des zwf-Gens aus coryneformen Bakterien
DE102005023829A1 (de) 2005-05-24 2006-11-30 Degussa Ag Allele des opcA-Gens aus coryneformen Bakterien
EP1979486B1 (en) 2006-01-30 2013-04-17 Ajinomoto Co., Inc. L-amino acid producing bacterium and method of producing l-amino acid
JP2009089603A (ja) * 2006-02-02 2009-04-30 Ajinomoto Co Inc メタノール資化性細菌を用いたｌ−リジンの製造法
JP2009153382A (ja) 2006-03-30 2009-07-16 Ajinomoto Co Inc メタノール資化性細菌を用いたカルボン酸の製造法
DE102007005072A1 (de) 2007-02-01 2008-08-07 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von Cadaverin
JP5319521B2 (ja) 2007-04-06 2013-10-16 協和発酵バイオ株式会社 ジペプチドの製造法
CN101688176B (zh) 2007-04-17 2013-11-06 味之素株式会社 具有羧基的酸性物质的生产方法
DE102008001874A1 (de) 2008-05-20 2009-11-26 Evonik Degussa Gmbh Verfahren zur Herstellung von L-Aminosäuren
US8623619B2 (en) 2009-02-09 2014-01-07 Kyowa Hakko Bio Co., Ltd. Process for producing L-amino acid
CN102753682A (zh) 2009-12-17 2012-10-24 巴斯夫欧洲公司 用于生产尸胺的方法和重组微生物
DE102010003419B4 (de) 2010-03-30 2019-09-12 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von L-Ornithin
DE102010019059A1 (de) * 2010-05-03 2011-11-03 Forschungszentrum Jülich GmbH Sensoren zur intrazellulären Metabolit-Detektion
US9387279B2 (en) 2010-05-05 2016-07-12 The Governing Council Of The University Of Toronto Implantable-glucose responsive insulin delivery device
US9745608B2 (en) 2011-02-22 2017-08-29 Basf Se Processes and recombinant microorganisms for the production of cadaverine
JP6519476B2 (ja) 2013-10-23 2019-05-29 味の素株式会社 目的物質の製造法
CN103695454A (zh) * 2013-12-18 2014-04-02 山东寿光巨能金玉米开发有限公司 表达l-赖氨酸转运蛋白的重组质粒、工程菌及应用
WO2017085241A1 (en) * 2015-11-19 2017-05-26 Danmarks Tekniske Universitet A family of microbial lysine transporter polypeptides
BR112018011503A2 (pt) 2015-12-07 2018-12-04 Zymergen Inc promotores da corynebacterium glutamicum
US9988624B2 (en) 2015-12-07 2018-06-05 Zymergen Inc. Microbial strain improvement by a HTP genomic engineering platform
US11208649B2 (en) 2015-12-07 2021-12-28 Zymergen Inc. HTP genomic engineering platform
US10544390B2 (en) 2016-06-30 2020-01-28 Zymergen Inc. Methods for generating a bacterial hemoglobin library and uses thereof
EP3478845A4 (en) 2016-06-30 2019-07-31 Zymergen, Inc. METHOD OF GENERATING A GLUCOSE PERMEASE LIBRARY AND USES THEREOF
MY186296A (en) * 2016-08-31 2021-07-06 Cj Cheiljedang Corp Novel promoter and use thereof
JP7066977B2 (ja) 2017-04-03 2022-05-16 味の素株式会社 Ｌ－アミノ酸の製造法
KR20200026881A (ko) 2017-06-07 2020-03-11 지머젠 인코포레이티드 코리네박테리움 글루타미컴으로부터의 프로모터 및 보조 유전자 발현을 조절하는 데 이의 용도
EP3467099A1 (en) 2017-10-05 2019-04-10 Evonik Degussa GmbH Method for the fermentative production of l-amino acids
KR101968317B1 (ko) * 2018-02-23 2019-04-11 씨제이제일제당 주식회사 신규 l-트립토판 배출 단백질 및 이를 이용한 l-트립토판을 생산하는 방법
RU2019128538A (ru) 2018-09-26 2021-03-11 Эвоник Оперейшенс ГмбХ Способ ферментативного получения l-лизина
EP3861109A1 (en) 2018-10-05 2021-08-11 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
KR102205717B1 (ko) 2019-04-05 2021-01-22 씨제이제일제당 주식회사 신규 l-트립토판 배출 단백질 변이체 및 이를 이용한 l-트립토판을 생산하는 방법
BR112022003571A2 (pt) 2019-09-03 2022-05-24 Ningxia Eppen Biotech Co Ltd Cepa bacteriana geneticamente modificada e métodos para construir uma cepa bacteriana geneticamente modificada e para produzir l-triptofano
KR102183209B1 (ko) 2019-09-09 2020-11-26 씨제이제일제당 주식회사 L-쓰레오닌 배출 단백질의 변이체 및 이를 이용한 l-쓰레오닌 생산 방법
KR102251948B1 (ko) * 2019-10-31 2021-05-17 대상 주식회사 mdfA 유전자 불활성 및 yicL 유전자 도입에 의해 방향족 아미노산 생산능력이 향상된 균주
CN115724925B (zh) * 2020-01-19 2025-06-03 中国科学院天津工业生物技术研究所 谷氨酸转运变体蛋白及其应用
KR102139806B1 (ko) * 2020-02-13 2020-07-30 씨제이제일제당 (주) 변이형 LysE를 포함하는 미생물, 및 이를 이용한 L-아미노산 생산 방법
KR102647745B1 (ko) 2020-05-27 2024-03-14 씨제이제일제당 주식회사 신규 l-타이로신 배출 단백질 변이체 및 이를 이용한 l-타이로신을 생산하는 방법
KR102617168B1 (ko) * 2020-12-09 2023-12-21 씨제이제일제당 (주) 쉬와넬라 오네이덴시스 유래 단백질을 발현하는 미생물, 및 이를 이용한 l-아미노산 생산 방법
KR102616694B1 (ko) * 2020-12-09 2023-12-20 씨제이제일제당 (주) 쉬와넬라 아틀란티카 유래 단백질을 발현하는 미생물, 및 이를 이용한 l-아미노산 생산 방법
WO2022155554A1 (en) * 2021-01-17 2022-07-21 Genomatica, Inc. Methods and compositions for making amide compounds
CN115746110B (zh) * 2021-09-02 2024-10-18 中国科学院天津工业生物技术研究所 一种转录调控因子LysG的突变体及其应用
KR102875556B1 (ko) * 2021-10-26 2025-10-23 씨제이제일제당 주식회사 LysE 변이체 및 이를 이용한 L-아르기닌 생산방법
KR20230131654A (ko) 2022-03-07 2023-09-14 씨제이제일제당 (주) 변이형 l-쓰레오닌 배출 단백질 및 이를 이용한 l-쓰레오닌 생산 방법
KR102801642B1 (ko) 2022-03-07 2025-04-29 씨제이제일제당 주식회사 변이형 l-쓰레오닌 배출 단백질 및 이를 이용한 l-쓰레오닌 생산 방법
CN119012914A (zh) 2022-04-04 2024-11-22 味之素株式会社 防治寄生植物的方法
KR102770475B1 (ko) * 2022-06-02 2025-02-20 씨제이제일제당 주식회사 L-오르니틴 생산능을 가지는 미생물 및 이를 이용한 l-오르니틴 생산방법
KR102801078B1 (ko) * 2022-06-23 2025-04-24 씨제이제일제당 (주) L-히스티딘 배출 단백질 및 이를 이용한 l-히스티딘 생산 방법
CN115806601B (zh) * 2022-10-24 2024-12-20 天津科技大学 一种转录调控因子LysG突变体及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5618596A (en) * 1979-07-23 1981-02-21 Ajinomoto Co Inc Production of l-lysine through fermentation process
JPS575693A (en) * 1980-06-13 1982-01-12 Ajinomoto Co Inc Production of l-arginine through fermentation process
DE4400926C1 (de) * 1994-01-14 1995-06-01 Forschungszentrum Juelich Gmbh Herstellung von L-Isoleucin mittels rekombinanter Mikroorganismen mit deregulierter Threonindehydratase

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022152125A1 (zh) 2021-01-13 2022-07-21 中国科学院天津工业生物技术研究所 具有l-脯氨酸外排功能的蛋白及其应用

Also Published As

Publication number Publication date
MX9805050A (es) 1998-10-31
KR100444621B1 (ko) 2004-11-16
KR19990076708A (ko) 1999-10-15
WO1997023597A2 (de) 1997-07-03
JP2000507086A (ja) 2000-06-13
DE59611412D1 (de) 2007-02-22
WO1997023597A3 (de) 1997-10-09
CA2241111A1 (en) 1997-07-03
US6858406B1 (en) 2005-02-22
CN1209169A (zh) 1999-02-24
BR9612666A (pt) 1999-10-05
ES2281088T3 (es) 2007-09-16
JP3942194B2 (ja) 2007-07-11
DE19548222A1 (de) 1997-06-26
EP0868527B1 (de) 2007-01-10
RU2225883C2 (ru) 2004-03-20
EP0868527A2 (de) 1998-10-07
CA2241111C (en) 2009-09-22
DK0868527T3 (da) 2007-05-07
AR048561A1 (es) 2006-05-10
AU1921897A (en) 1997-07-17
AU724536B2 (en) 2000-09-21
ZA9610768B (en) 1998-07-31

Similar Documents

Publication Publication Date Title
CN1283797C (zh) 通过提高外运载体的活性而进行微生物生产氨基酸的方法
CN1246470C (zh) 使用含有弱化的aspA基因的肠细菌科菌株制备L－氨基酸的方法
CN100336901C (zh) 生产化合物ⅱ的棒状细菌
CN1304997A (zh) 编码poxB基因的新核苷酸序列
CN1288058A (zh) 编码pgi基因的新核苷酸序列
CN1768147A (zh) 利用肠杆菌科的菌株生产L－氨基酸的方法,该菌株过表达编码半乳糖质子同向转运蛋白的galP基因
CN1539015A (zh) 用遗传修饰的谷氨酸棒杆菌生产l-赖氨酸
CN1639341A (zh) 使用属于埃希氏菌属的细菌生产l－苏氨酸的方法
CN1346402A (zh) L－氨基酸生产菌以及用于生产l－氨基酸的方法
CN1430672A (zh) 发酵制备l－苏氨酸的方法
CN1298019A (zh) 编码基因sucC和sucD的新核苷酸序列
CN1146216A (zh) 来自棒状杆菌属细菌的新基因及其用途
CN1317050A (zh) 编码tal基因的核苷酸序列
CN1934265A (zh) 使用棒状细菌生产l－氨基酸的方法
CN1440458A (zh) 编码mdhA基因的新核苷酸序列
CN1993461A (zh) 使用肠杆菌科菌株生产l－氨基酸的方法
CN1353758A (zh) 经扩增zwf基因发酵制备L－氨基酸的方法
CN1319668A (zh) 编码dapC基因的核苷酸序列及生产L－赖氨酸的方法
CN1350586A (zh) 经扩增gnd基因发酵制备L－氨基酸的方法
CN1680564A (zh) 利用棒状杆菌生产l－氨基酸的方法
CN100347190C (zh) 编码rpsL基因的核苷酸序列
CN1350589A (zh) 经扩增tkt基因发酵制备L－氨基酸的方法
CN100351387C (zh) 使用含有弱化的yjgF ORF序列的肠杆菌科菌株发酵生产L－氨基酸的方法
CN1446259A (zh) 编码1ysR2基因的核苷酸序列
ZA200508232B (en) Nucleotide sequences of coryneform bacteria coding for proteins involved in L-serine metabilism and method for production L-serine

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: EVONIK DEGUSSA CO., LTD.

Free format text: FORMER OWNER: YULIQI RESEARCHCENTER CO., LTD.

Effective date: 20100115

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20100115

Address after: essen

Patentee after: Evonik Degussa GmbH

Address before: The Federal Republic of Germany to leach

Patentee before: Forschungszentrum Julich GmbH

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20061108

Termination date: 20141218

EXPY Termination of patent right or utility model