JP3942194B2 - エキスポートキャリヤーの活性を増加してアミノ酸を微生物によって産生する方法 - Google Patents

エキスポートキャリヤーの活性を増加してアミノ酸を微生物によって産生する方法 Download PDF

Info

Publication number
JP3942194B2
JP3942194B2 JP52322297A JP52322297A JP3942194B2 JP 3942194 B2 JP3942194 B2 JP 3942194B2 JP 52322297 A JP52322297 A JP 52322297A JP 52322297 A JP52322297 A JP 52322297A JP 3942194 B2 JP3942194 B2 JP 3942194B2
Authority
JP
Japan
Prior art keywords
gene
export
lyse
lysine
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP52322297A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000507086A (ja
JP2000507086A5 (https=
Inventor
ヴルリーツ・マリナ
エッゲリング・ロタール
ザーム・ヘルマン
Original Assignee
フォルシュングスツェントルム・ユーリッヒ・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by フォルシュングスツェントルム・ユーリッヒ・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング filed Critical フォルシュングスツェントルム・ユーリッヒ・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング
Publication of JP2000507086A publication Critical patent/JP2000507086A/ja
Publication of JP2000507086A5 publication Critical patent/JP2000507086A5/ja
Application granted granted Critical
Publication of JP3942194B2 publication Critical patent/JP3942194B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/08Lysine; Diaminopimelic acid; Threonine; Valine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP52322297A 1995-12-22 1996-12-18 エキスポートキャリヤーの活性を増加してアミノ酸を微生物によって産生する方法 Expired - Fee Related JP3942194B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19548222A DE19548222A1 (de) 1995-12-22 1995-12-22 Verfahren zur mikrobiellen Herstellung von Aminosäuren durch gesteigerte Aktivität von Exportcarriern
DE19548222.0 1995-12-22
PCT/DE1996/002485 WO1997023597A2 (de) 1995-12-22 1996-12-18 Verfahren zur mikrobiellen herstellung von aminosäuren durch gesteigerte aktivität von exportcarriern

Publications (3)

Publication Number Publication Date
JP2000507086A JP2000507086A (ja) 2000-06-13
JP2000507086A5 JP2000507086A5 (https=) 2004-11-04
JP3942194B2 true JP3942194B2 (ja) 2007-07-11

Family

ID=7781070

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52322297A Expired - Fee Related JP3942194B2 (ja) 1995-12-22 1996-12-18 エキスポートキャリヤーの活性を増加してアミノ酸を微生物によって産生する方法

Country Status (16)

Country Link
US (1) US6858406B1 (https=)
EP (1) EP0868527B1 (https=)
JP (1) JP3942194B2 (https=)
KR (1) KR100444621B1 (https=)
CN (1) CN1283797C (https=)
AR (1) AR048561A1 (https=)
AU (1) AU724536B2 (https=)
BR (1) BR9612666A (https=)
CA (1) CA2241111C (https=)
DE (2) DE19548222A1 (https=)
DK (1) DK0868527T3 (https=)
ES (1) ES2281088T3 (https=)
MX (1) MX9805050A (https=)
RU (1) RU2225883C2 (https=)
WO (1) WO1997023597A2 (https=)
ZA (1) ZA9610768B (https=)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19726083A1 (de) * 1997-06-19 1998-12-24 Consortium Elektrochem Ind Mikroorganismen und Verfahren zur fermentativen Herstellung von L-Cystein, L-Cystin, N-Acetyl-Serin oder Thiazolidinderivaten
DE19931317A1 (de) * 1999-07-07 2001-01-11 Degussa L-Lysin produzierende coryneforme Bakterien und Verfahren zur Herstellung von L-Lysin
RU2144564C1 (ru) 1998-10-13 2000-01-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" ФРАГМЕНТ ДНК rhtB, КОДИРУЮЩИЙ СИНТЕЗ БЕЛКА RhtB, ПРИДАЮЩЕГО УСТОЙЧИВОСТЬ К L-ГОМОСЕРИНУ БАКТЕРИЯМ ESCHERICHIA COLI, И СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ
RU2148642C1 (ru) * 1998-12-23 2000-05-10 ЗАО "Научно-исследовательский институт АДЖИНОМОТО-Генетика" (ЗАО "АГРИ") Фрагмент днк rhtc, кодирующий синтез белка rhtc, придающего повышенную устойчивость к l-треонину бактериям escherichia coli, и способ получения l-аминокислоты
RU2175351C2 (ru) 1998-12-30 2001-10-27 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО "АГРИ") Фрагмент днк из escherichia coli, определяющий повышенную продукцию l-аминокислот (варианты), и способ получения l-аминокислот
US6861246B2 (en) 1999-07-07 2005-03-01 Degussa Ag L-lysine-producing corynebacteria and process for the preparation of lysine
DE19931314A1 (de) * 1999-07-07 2001-01-11 Degussa L-Lysin produzierende coryneforme Bakterien und Verfahren zur Herstellung von Lysin
US20020086371A1 (en) 1999-07-07 2002-07-04 Degussa-Huls Aktiengesellschaft L-lysine-producing corynebacteria and process for the preparation of L-lysine
US6797509B1 (en) 1999-07-09 2004-09-28 Degussa-Huls Ag Nucleotide sequences which code for the tal gene
DE19951708A1 (de) 1999-10-27 2001-05-03 Degussa Für den Export verzweigtkettiger Aminosäuren kodierende Nikleotidsequenzen, Verfahren zu deren Isolierung und ihre Verwendung
US6913908B2 (en) 2000-09-02 2005-07-05 Degussa Ag Methods of making L-amino acids in coryneform using the sigE gene
AU2001285843A1 (en) * 2000-09-02 2002-03-13 Degussa A.G. Sequences which code for the sige gene
EP1239041B1 (en) 2001-02-13 2006-04-19 Ajinomoto Co., Inc. Method for producing L-amino acid using bacteria belonging to the genus Escherichia
EP1266966B1 (en) 2001-06-12 2009-04-29 Ajinomoto Co., Inc. Method for producing L-lysine or L-arginine by using methanol assimilating bacterium
US7252978B2 (en) 2001-07-25 2007-08-07 Ajinomoto Co., Inc. Method for producing L-arginine
DE10154179A1 (de) * 2001-11-05 2003-05-08 Basf Ag Gene die für membeansynthese-und Membrantransport-Proteine codieren
CN1615359B (zh) 2001-11-23 2010-04-28 味之素株式会社 利用埃希杆菌属细菌生产l-氨基酸的方法
RU2229513C2 (ru) 2001-11-23 2004-05-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Способ получения l-аминокислот, штамм escherichia coli - продуцент l-аминокислоты (варианты)
DE10210527A1 (de) 2002-03-09 2003-09-18 Degussa Allele des aceA-Gens aus coryneformen Bakterien
JP2004166592A (ja) 2002-11-20 2004-06-17 Ajinomoto Co Inc メチロトローフを用いたl−アミノ酸の製造法
JP4120364B2 (ja) 2002-11-20 2008-07-16 味の素株式会社 メタノール資化性菌を用いたl−リジンまたはl−アルギニンの製造法
DE102004001674B4 (de) 2003-01-29 2019-01-24 Ajinomoto Co., Inc. Verfahren zur Herstellung von L-Lysin unter Einsatz von Methanol verwertenden Bakterien
ATE531803T1 (de) 2003-06-05 2011-11-15 Ajinomoto Kk Fermentierungsverfahren mittels veränderter bakterien mit einer erhöhten aufnahme von nebenprodukten
JP4665537B2 (ja) * 2004-01-30 2011-04-06 味の素株式会社 L−アミノ酸生産菌及びl−アミノ酸の製造法
KR100786987B1 (ko) 2004-01-30 2007-12-18 아지노모토 가부시키가이샤 L-아미노산 생산 미생물 및 l-아미노산 생산 방법
US7344874B2 (en) * 2004-03-04 2008-03-18 Ajinomoto Co., Inc. L-glutamic acid-producing microorganism and a method for producing L-glutamic acid
JP4665558B2 (ja) * 2004-03-04 2011-04-06 味の素株式会社 L−グルタミン酸生産微生物及びl−グルタミン酸の製造法
DE102004034865A1 (de) 2004-07-19 2006-02-16 Siemens Ag Sensor zur Messung der Position eines Stellgliedes
CN103088080B (zh) 2004-10-07 2016-02-17 味之素株式会社 生产碱性物质的方法
WO2006090212A2 (en) 2004-12-06 2006-08-31 Sage Biosciences Inc. Method of growing bacteria to deliver bioactive compounds to the intestine of ruminants
DE102005013676A1 (de) 2005-03-24 2006-09-28 Degussa Ag Allele des zwf-Gens aus coryneformen Bakterien
US20070092951A1 (en) 2005-03-24 2007-04-26 Degussa Ag Alleles of the zwf gene from coryneform bacteria
DE102005023829A1 (de) 2005-05-24 2006-11-30 Degussa Ag Allele des opcA-Gens aus coryneformen Bakterien
WO2007086618A1 (en) 2006-01-30 2007-08-02 Ajinomoto Co., Inc. L-amino acid producing bacterium and method of producing l-amino acid
JP2009089603A (ja) 2006-02-02 2009-04-30 Ajinomoto Co Inc メタノール資化性細菌を用いたl−リジンの製造法
JP2009153382A (ja) 2006-03-30 2009-07-16 Ajinomoto Co Inc メタノール資化性細菌を用いたカルボン酸の製造法
DE102007005072A1 (de) 2007-02-01 2008-08-07 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von Cadaverin
ES2526490T3 (es) 2007-04-06 2015-01-12 Kyowa Hakko Bio Co., Ltd. Método para producir un dipéptido
JP5218400B2 (ja) 2007-04-17 2013-06-26 味の素株式会社 カルボキシル基を有する酸性物質の製造法
DE102008001874A1 (de) 2008-05-20 2009-11-26 Evonik Degussa Gmbh Verfahren zur Herstellung von L-Aminosäuren
EP2395096B1 (en) 2009-02-09 2014-04-09 Kyowa Hakko Bio Co., Ltd. Process for producing L-amino acids
DE112010004851T5 (de) 2009-12-17 2012-09-20 Basf Se Verfahren und rekombinante Mikroorganismen für die Herstellung von Cadaverin
DE102010003419B4 (de) 2010-03-30 2019-09-12 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von L-Ornithin
DE102010019059A1 (de) * 2010-05-03 2011-11-03 Forschungszentrum Jülich GmbH Sensoren zur intrazellulären Metabolit-Detektion
US9387279B2 (en) 2010-05-05 2016-07-12 The Governing Council Of The University Of Toronto Implantable-glucose responsive insulin delivery device
CN103492553B (zh) 2011-02-22 2018-06-12 巴斯夫欧洲公司 用于生产尸胺的方法和重组微生物
WO2015060391A1 (ja) 2013-10-23 2015-04-30 味の素株式会社 目的物質の製造法
CN103695454A (zh) * 2013-12-18 2014-04-02 山东寿光巨能金玉米开发有限公司 表达l-赖氨酸转运蛋白的重组质粒、工程菌及应用
WO2017085241A1 (en) * 2015-11-19 2017-05-26 Danmarks Tekniske Universitet A family of microbial lysine transporter polypeptides
US9988624B2 (en) 2015-12-07 2018-06-05 Zymergen Inc. Microbial strain improvement by a HTP genomic engineering platform
US11208649B2 (en) 2015-12-07 2021-12-28 Zymergen Inc. HTP genomic engineering platform
JP6821598B2 (ja) 2015-12-07 2021-01-27 ザイマージェン インコーポレイテッド Corynebacterium glutamicum由来のプロモーター
JP2019519241A (ja) 2016-06-30 2019-07-11 ザイマージェン インコーポレイテッド グルコース透過酵素ライブラリーを生成するための方法およびその使用
EP3478833A4 (en) 2016-06-30 2019-10-02 Zymergen, Inc. METHOD FOR PRODUCING A BACTERIAL HEMOGLOBIN LIBRARY AND ITS USE
MY186296A (en) * 2016-08-31 2021-07-06 Cj Cheiljedang Corp Novel promoter and use thereof
JP7066977B2 (ja) 2017-04-03 2022-05-16 味の素株式会社 L-アミノ酸の製造法
CA3064777A1 (en) 2017-06-07 2018-12-13 Zach Serber Promoters from corynebacterium glutamicum and uses thereof in regulating ancillary gene expression
EP3467099A1 (en) 2017-10-05 2019-04-10 Evonik Degussa GmbH Method for the fermentative production of l-amino acids
KR101968317B1 (ko) 2018-02-23 2019-04-11 씨제이제일제당 주식회사 신규 l-트립토판 배출 단백질 및 이를 이용한 l-트립토판을 생산하는 방법
RU2019128538A (ru) 2018-09-26 2021-03-11 Эвоник Оперейшенс ГмбХ Способ ферментативного получения l-лизина
WO2020071538A1 (en) 2018-10-05 2020-04-09 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
KR102205717B1 (ko) 2019-04-05 2021-01-22 씨제이제일제당 주식회사 신규 l-트립토판 배출 단백질 변이체 및 이를 이용한 l-트립토판을 생산하는 방법
WO2021042460A1 (zh) 2019-09-03 2021-03-11 宁夏伊品生物科技股份有限公司 提高l-色氨酸生产效率的转运载体基因在大肠杆菌中的应用
KR102183209B1 (ko) 2019-09-09 2020-11-26 씨제이제일제당 주식회사 L-쓰레오닌 배출 단백질의 변이체 및 이를 이용한 l-쓰레오닌 생산 방법
KR102251948B1 (ko) * 2019-10-31 2021-05-17 대상 주식회사 mdfA 유전자 불활성 및 yicL 유전자 도입에 의해 방향족 아미노산 생산능력이 향상된 균주
CN115724925B (zh) * 2020-01-19 2025-06-03 中国科学院天津工业生物技术研究所 谷氨酸转运变体蛋白及其应用
KR102139806B1 (ko) * 2020-02-13 2020-07-30 씨제이제일제당 (주) 변이형 LysE를 포함하는 미생물, 및 이를 이용한 L-아미노산 생산 방법
KR102647745B1 (ko) 2020-05-27 2024-03-14 씨제이제일제당 주식회사 신규 l-타이로신 배출 단백질 변이체 및 이를 이용한 l-타이로신을 생산하는 방법
KR102617168B1 (ko) * 2020-12-09 2023-12-21 씨제이제일제당 (주) 쉬와넬라 오네이덴시스 유래 단백질을 발현하는 미생물, 및 이를 이용한 l-아미노산 생산 방법
KR102616694B1 (ko) * 2020-12-09 2023-12-20 씨제이제일제당 (주) 쉬와넬라 아틀란티카 유래 단백질을 발현하는 미생물, 및 이를 이용한 l-아미노산 생산 방법
CN114763372B (zh) 2021-01-13 2024-12-10 中国科学院天津工业生物技术研究所 具有l-脯氨酸外排功能的蛋白及其应用
JP2024503868A (ja) * 2021-01-17 2024-01-29 ジェノマティカ, インコーポレイテッド アミド化合物を生成する方法および組成物
CN115746110B (zh) * 2021-09-02 2024-10-18 中国科学院天津工业生物技术研究所 一种转录调控因子LysG的突变体及其应用
KR102875556B1 (ko) * 2021-10-26 2025-10-23 씨제이제일제당 주식회사 LysE 변이체 및 이를 이용한 L-아르기닌 생산방법
KR102801642B1 (ko) 2022-03-07 2025-04-29 씨제이제일제당 주식회사 변이형 l-쓰레오닌 배출 단백질 및 이를 이용한 l-쓰레오닌 생산 방법
KR20230131654A (ko) 2022-03-07 2023-09-14 씨제이제일제당 (주) 변이형 l-쓰레오닌 배출 단백질 및 이를 이용한 l-쓰레오닌 생산 방법
CN119012914A (zh) 2022-04-04 2024-11-22 味之素株式会社 防治寄生植物的方法
KR102770475B1 (ko) * 2022-06-02 2025-02-20 씨제이제일제당 주식회사 L-오르니틴 생산능을 가지는 미생물 및 이를 이용한 l-오르니틴 생산방법
KR102801078B1 (ko) * 2022-06-23 2025-04-24 씨제이제일제당 (주) L-히스티딘 배출 단백질 및 이를 이용한 l-히스티딘 생산 방법
CN115806601B (zh) * 2022-10-24 2024-12-20 天津科技大学 一种转录调控因子LysG突变体及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5618596A (en) * 1979-07-23 1981-02-21 Ajinomoto Co Inc Production of l-lysine through fermentation process
JPS575693A (en) * 1980-06-13 1982-01-12 Ajinomoto Co Inc Production of l-arginine through fermentation process
DE4400926C1 (de) * 1994-01-14 1995-06-01 Forschungszentrum Juelich Gmbh Herstellung von L-Isoleucin mittels rekombinanter Mikroorganismen mit deregulierter Threonindehydratase

Also Published As

Publication number Publication date
DE59611412D1 (de) 2007-02-22
CA2241111A1 (en) 1997-07-03
EP0868527A2 (de) 1998-10-07
ZA9610768B (en) 1998-07-31
DK0868527T3 (da) 2007-05-07
JP2000507086A (ja) 2000-06-13
CA2241111C (en) 2009-09-22
US6858406B1 (en) 2005-02-22
ES2281088T3 (es) 2007-09-16
MX9805050A (es) 1998-10-31
WO1997023597A3 (de) 1997-10-09
KR100444621B1 (ko) 2004-11-16
AR048561A1 (es) 2006-05-10
CN1283797C (zh) 2006-11-08
AU1921897A (en) 1997-07-17
WO1997023597A2 (de) 1997-07-03
EP0868527B1 (de) 2007-01-10
RU2225883C2 (ru) 2004-03-20
CN1209169A (zh) 1999-02-24
KR19990076708A (ko) 1999-10-15
DE19548222A1 (de) 1997-06-26
BR9612666A (pt) 1999-10-05
AU724536B2 (en) 2000-09-21

Similar Documents

Publication Publication Date Title
JP3942194B2 (ja) エキスポートキャリヤーの活性を増加してアミノ酸を微生物によって産生する方法
JP4638048B2 (ja) L−バリンを微生物により製造する方法
KR102260001B1 (ko) 글리신 절단 시스템을 사용하는 코리네박테리아에서의 l-아미노산의 생산 방법
KR100526316B1 (ko) 아스파테이트 및 글루타메이트계열 아미노산의 미생물적제조방법과 이 방법에 사용되는 작용제
Kruse et al. Influence of threonine exporters on threonine production in Escherichia coli
Eikmanns et al. Molecular aspects of lysine, threonine, and isoleucine biosynthesis in Corynebacterium glutamicum
JP2002508921A (ja) アスパラギン酸−及び(又は)グルタミン酸系アミノ酸の微生物による産生方法及びこの方法で使用可能な剤
JP2001161386A (ja) poxB−遺伝子をコードする新規ヌクレオチド配列
CA2310870A1 (en) L-lysine-producing corynebacteria and process for the preparation of l-lysine
KR20000029006A (ko) L-호모세린에 대한 내성을 세균 에스케리키아 콜라이에제공하는 단백질을 암호화하는 dna, 및 l-아미노산을제조하는 방법
HUP9904448A2 (hu) Eljárás D-pantoténsav fermentációs előállítására coryneform baktériumokkal
KR100782867B1 (ko) L-리신을 생산하는 코리네박테리아 및 리신을 제조하는방법
KR20160145827A (ko) 호알칼리성 박테리아를 사용하는 l-아미노산 생산 방법
KR20010070044A (ko) thrE 유전자를 암호화하는 뉴클레오티드 서열 및코리네형 박테리아를 사용하는 L-트레오닌의 효소적 생산방법
PL218071B1 (pl) Produkująca L-treoninę bakteria z gatunku Escherichia coli, która jest oporna na kwas α-amino-β-hydroksywalerianowy, wykorzystujący ją sposób wytwarzania L-treoniny lub zawierających ją dodatków do żywności oraz szczep Escherichia coli
MXPA02008416A (es) Proceso para la preparacion fermentativa de l-treonina.
MXPA00012091A (es) Nuevas secuencias nucleotidas codificantes al gen zwa2.
PL205611B1 (pl) Wyizolowany gen zwf z Corynebacterium glutamicum, rekombinowana bakteria coryneform wytwarzająca L-lizynę lub L-treoninę oraz sposób wytwarzania L-lizyny lub L-treoniny przez fermentację bakterii
CN116004501A (zh) Nadp-铁氧还蛋白还原酶突变体及其在生产谷氨酸中的应用
Chen et al. The cloning and nucleotide sequence of a Corynebacterium glutamicum 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase gene
KR20040099299A (ko) 아미노산 생성 박테리아 및 l-아미노산의 제조 방법
JP2001008693A (ja) 複製可能なdna、アミノ酸配列、コリネ型微生物、シャトルベクター及びl−アミノ酸の製造方法
CN100368545C (zh) 编码lysR3基因的核苷酸序列
JP2003525046A (ja) L−セリンの生合成に関与する蛋白質をコードするヌクレオチド配列、l−セリンを微生物学的に製造するための改善された方法、ならびにこのために適切な遺伝子的に改変した微生物
CN110819663A (zh) 使用改良的肠杆菌科菌株制备l氨基酸的方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20031201

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20031201

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20060718

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20061018

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20061204

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070105

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20070313

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20070403

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20100413

Year of fee payment: 3

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20100413

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110413

Year of fee payment: 4

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110413

Year of fee payment: 4

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120413

Year of fee payment: 5

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130413

Year of fee payment: 6

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20140413

Year of fee payment: 7

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees