DK0868527T3 - Fremgangsmåde til mikrobiel fremstilling af aminosyrer ved hjælp af en öget aktivitet hos eksportcarriers - Google Patents
Fremgangsmåde til mikrobiel fremstilling af aminosyrer ved hjælp af en öget aktivitet hos eksportcarriersInfo
- Publication number
- DK0868527T3 DK0868527T3 DK96946220T DK96946220T DK0868527T3 DK 0868527 T3 DK0868527 T3 DK 0868527T3 DK 96946220 T DK96946220 T DK 96946220T DK 96946220 T DK96946220 T DK 96946220T DK 0868527 T3 DK0868527 T3 DK 0868527T3
- Authority
- DK
- Denmark
- Prior art keywords
- amino acids
- increased activity
- microbial production
- export
- carriers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19548222A DE19548222A1 (de) | 1995-12-22 | 1995-12-22 | Verfahren zur mikrobiellen Herstellung von Aminosäuren durch gesteigerte Aktivität von Exportcarriern |
| PCT/DE1996/002485 WO1997023597A2 (de) | 1995-12-22 | 1996-12-18 | Verfahren zur mikrobiellen herstellung von aminosäuren durch gesteigerte aktivität von exportcarriern |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0868527T3 true DK0868527T3 (da) | 2007-05-07 |
Family
ID=7781070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96946220T DK0868527T3 (da) | 1995-12-22 | 1996-12-18 | Fremgangsmåde til mikrobiel fremstilling af aminosyrer ved hjælp af en öget aktivitet hos eksportcarriers |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6858406B1 (https=) |
| EP (1) | EP0868527B1 (https=) |
| JP (1) | JP3942194B2 (https=) |
| KR (1) | KR100444621B1 (https=) |
| CN (1) | CN1283797C (https=) |
| AR (1) | AR048561A1 (https=) |
| AU (1) | AU724536B2 (https=) |
| BR (1) | BR9612666A (https=) |
| CA (1) | CA2241111C (https=) |
| DE (2) | DE19548222A1 (https=) |
| DK (1) | DK0868527T3 (https=) |
| ES (1) | ES2281088T3 (https=) |
| MX (1) | MX9805050A (https=) |
| RU (1) | RU2225883C2 (https=) |
| WO (1) | WO1997023597A2 (https=) |
| ZA (1) | ZA9610768B (https=) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19726083A1 (de) * | 1997-06-19 | 1998-12-24 | Consortium Elektrochem Ind | Mikroorganismen und Verfahren zur fermentativen Herstellung von L-Cystein, L-Cystin, N-Acetyl-Serin oder Thiazolidinderivaten |
| DE19931317A1 (de) * | 1999-07-07 | 2001-01-11 | Degussa | L-Lysin produzierende coryneforme Bakterien und Verfahren zur Herstellung von L-Lysin |
| RU2144564C1 (ru) | 1998-10-13 | 2000-01-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | ФРАГМЕНТ ДНК rhtB, КОДИРУЮЩИЙ СИНТЕЗ БЕЛКА RhtB, ПРИДАЮЩЕГО УСТОЙЧИВОСТЬ К L-ГОМОСЕРИНУ БАКТЕРИЯМ ESCHERICHIA COLI, И СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ |
| RU2148642C1 (ru) * | 1998-12-23 | 2000-05-10 | ЗАО "Научно-исследовательский институт АДЖИНОМОТО-Генетика" (ЗАО "АГРИ") | Фрагмент днк rhtc, кодирующий синтез белка rhtc, придающего повышенную устойчивость к l-треонину бактериям escherichia coli, и способ получения l-аминокислоты |
| RU2175351C2 (ru) | 1998-12-30 | 2001-10-27 | Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО "АГРИ") | Фрагмент днк из escherichia coli, определяющий повышенную продукцию l-аминокислот (варианты), и способ получения l-аминокислот |
| US6861246B2 (en) | 1999-07-07 | 2005-03-01 | Degussa Ag | L-lysine-producing corynebacteria and process for the preparation of lysine |
| US20020086371A1 (en) | 1999-07-07 | 2002-07-04 | Degussa-Huls Aktiengesellschaft | L-lysine-producing corynebacteria and process for the preparation of L-lysine |
| DE19931314A1 (de) * | 1999-07-07 | 2001-01-11 | Degussa | L-Lysin produzierende coryneforme Bakterien und Verfahren zur Herstellung von Lysin |
| US6797509B1 (en) | 1999-07-09 | 2004-09-28 | Degussa-Huls Ag | Nucleotide sequences which code for the tal gene |
| DE19951708A1 (de) | 1999-10-27 | 2001-05-03 | Degussa | Für den Export verzweigtkettiger Aminosäuren kodierende Nikleotidsequenzen, Verfahren zu deren Isolierung und ihre Verwendung |
| EP1320616A2 (en) * | 2000-09-02 | 2003-06-25 | Degussa AG | Sequences which code for the sige gene of corynebacterium glutamicum |
| US6913908B2 (en) | 2000-09-02 | 2005-07-05 | Degussa Ag | Methods of making L-amino acids in coryneform using the sigE gene |
| DE60210697T2 (de) | 2001-02-13 | 2007-04-05 | Ajinomoto Co., Inc. | Verfahren zur Produktion von L-Aminosäuren mittels Bakterien der Gattung Escherichia |
| DE60232120D1 (de) | 2001-06-12 | 2009-06-10 | Ajinomoto Kk | Verfahren zur Herstellung von L-Lysin oder L-Arginin unter Verwendung methanolassimilierender Bakterien |
| US7252978B2 (en) | 2001-07-25 | 2007-08-07 | Ajinomoto Co., Inc. | Method for producing L-arginine |
| DE10154179A1 (de) * | 2001-11-05 | 2003-05-08 | Basf Ag | Gene die für membeansynthese-und Membrantransport-Proteine codieren |
| RU2229513C2 (ru) | 2001-11-23 | 2004-05-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Способ получения l-аминокислот, штамм escherichia coli - продуцент l-аминокислоты (варианты) |
| MXPA04004874A (es) | 2001-11-23 | 2004-09-03 | Ajinomoto Kk | Procedimiento para producir l-aminoacido utilizando escherichia. |
| DE10210527A1 (de) | 2002-03-09 | 2003-09-18 | Degussa | Allele des aceA-Gens aus coryneformen Bakterien |
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| DE102004001674B4 (de) | 2003-01-29 | 2019-01-24 | Ajinomoto Co., Inc. | Verfahren zur Herstellung von L-Lysin unter Einsatz von Methanol verwertenden Bakterien |
| US7335496B2 (en) | 2003-06-05 | 2008-02-26 | Ajinomoto Co., Inc. | Method for producing target substance |
| JP4665537B2 (ja) * | 2004-01-30 | 2011-04-06 | 味の素株式会社 | Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法 |
| BRPI0506369B1 (pt) | 2004-01-30 | 2020-11-03 | Ajinomoto Co., Inc | microorganismo transgênico, e, método para produzir um l-aminoácido |
| JP4665558B2 (ja) * | 2004-03-04 | 2011-04-06 | 味の素株式会社 | Ｌ−グルタミン酸生産微生物及びｌ−グルタミン酸の製造法 |
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| DE102004034865A1 (de) | 2004-07-19 | 2006-02-16 | Siemens Ag | Sensor zur Messung der Position eines Stellgliedes |
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| BR112022003571A2 (pt) | 2019-09-03 | 2022-05-24 | Ningxia Eppen Biotech Co Ltd | Cepa bacteriana geneticamente modificada e métodos para construir uma cepa bacteriana geneticamente modificada e para produzir l-triptofano |
| KR102183209B1 (ko) | 2019-09-09 | 2020-11-26 | 씨제이제일제당 주식회사 | L-쓰레오닌 배출 단백질의 변이체 및 이를 이용한 l-쓰레오닌 생산 방법 |
| KR102251948B1 (ko) * | 2019-10-31 | 2021-05-17 | 대상 주식회사 | mdfA 유전자 불활성 및 yicL 유전자 도입에 의해 방향족 아미노산 생산능력이 향상된 균주 |
| CN115724925B (zh) * | 2020-01-19 | 2025-06-03 | 中国科学院天津工业生物技术研究所 | 谷氨酸转运变体蛋白及其应用 |
| KR102139806B1 (ko) * | 2020-02-13 | 2020-07-30 | 씨제이제일제당 (주) | 변이형 LysE를 포함하는 미생물, 및 이를 이용한 L-아미노산 생산 방법 |
| KR102647745B1 (ko) | 2020-05-27 | 2024-03-14 | 씨제이제일제당 주식회사 | 신규 l-타이로신 배출 단백질 변이체 및 이를 이용한 l-타이로신을 생산하는 방법 |
| KR102617168B1 (ko) * | 2020-12-09 | 2023-12-21 | 씨제이제일제당 (주) | 쉬와넬라 오네이덴시스 유래 단백질을 발현하는 미생물, 및 이를 이용한 l-아미노산 생산 방법 |
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| CN114763372B (zh) | 2021-01-13 | 2024-12-10 | 中国科学院天津工业生物技术研究所 | 具有l-脯氨酸外排功能的蛋白及其应用 |
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| KR102875556B1 (ko) * | 2021-10-26 | 2025-10-23 | 씨제이제일제당 주식회사 | LysE 변이체 및 이를 이용한 L-아르기닌 생산방법 |
| KR20230131654A (ko) | 2022-03-07 | 2023-09-14 | 씨제이제일제당 (주) | 변이형 l-쓰레오닌 배출 단백질 및 이를 이용한 l-쓰레오닌 생산 방법 |
| KR102801642B1 (ko) | 2022-03-07 | 2025-04-29 | 씨제이제일제당 주식회사 | 변이형 l-쓰레오닌 배출 단백질 및 이를 이용한 l-쓰레오닌 생산 방법 |
| CN119012914A (zh) | 2022-04-04 | 2024-11-22 | 味之素株式会社 | 防治寄生植物的方法 |
| KR102770475B1 (ko) * | 2022-06-02 | 2025-02-20 | 씨제이제일제당 주식회사 | L-오르니틴 생산능을 가지는 미생물 및 이를 이용한 l-오르니틴 생산방법 |
| KR102801078B1 (ko) * | 2022-06-23 | 2025-04-24 | 씨제이제일제당 (주) | L-히스티딘 배출 단백질 및 이를 이용한 l-히스티딘 생산 방법 |
| CN115806601B (zh) * | 2022-10-24 | 2024-12-20 | 天津科技大学 | 一种转录调控因子LysG突变体及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5618596A (en) * | 1979-07-23 | 1981-02-21 | Ajinomoto Co Inc | Production of l-lysine through fermentation process |
| JPS575693A (en) * | 1980-06-13 | 1982-01-12 | Ajinomoto Co Inc | Production of l-arginine through fermentation process |
| DE4400926C1 (de) * | 1994-01-14 | 1995-06-01 | Forschungszentrum Juelich Gmbh | Herstellung von L-Isoleucin mittels rekombinanter Mikroorganismen mit deregulierter Threonindehydratase |
-
1995
- 1995-12-22 DE DE19548222A patent/DE19548222A1/de not_active Withdrawn
-
1996
- 1996-12-18 WO PCT/DE1996/002485 patent/WO1997023597A2/de not_active Ceased
- 1996-12-18 CN CNB961800968A patent/CN1283797C/zh not_active Expired - Fee Related
- 1996-12-18 KR KR10-1998-0704822A patent/KR100444621B1/ko not_active Expired - Lifetime
- 1996-12-18 DK DK96946220T patent/DK0868527T3/da active
- 1996-12-18 ES ES96946220T patent/ES2281088T3/es not_active Expired - Lifetime
- 1996-12-18 BR BR9612666-3A patent/BR9612666A/pt not_active Application Discontinuation
- 1996-12-18 JP JP52322297A patent/JP3942194B2/ja not_active Expired - Fee Related
- 1996-12-18 AU AU19218/97A patent/AU724536B2/en not_active Ceased
- 1996-12-18 DE DE59611412T patent/DE59611412D1/de not_active Expired - Lifetime
- 1996-12-18 RU RU98113861/13A patent/RU2225883C2/ru not_active IP Right Cessation
- 1996-12-18 CA CA002241111A patent/CA2241111C/en not_active Expired - Fee Related
- 1996-12-18 EP EP96946220A patent/EP0868527B1/de not_active Expired - Lifetime
- 1996-12-20 AR ARP960105827A patent/AR048561A1/es active IP Right Grant
- 1996-12-20 ZA ZA9610768A patent/ZA9610768B/xx unknown
-
1998
- 1998-06-17 US US09/105,117 patent/US6858406B1/en not_active Expired - Fee Related
- 1998-06-22 MX MX9805050A patent/MX9805050A/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| MX9805050A (es) | 1998-10-31 |
| KR100444621B1 (ko) | 2004-11-16 |
| KR19990076708A (ko) | 1999-10-15 |
| WO1997023597A2 (de) | 1997-07-03 |
| JP2000507086A (ja) | 2000-06-13 |
| DE59611412D1 (de) | 2007-02-22 |
| WO1997023597A3 (de) | 1997-10-09 |
| CA2241111A1 (en) | 1997-07-03 |
| US6858406B1 (en) | 2005-02-22 |
| CN1209169A (zh) | 1999-02-24 |
| CN1283797C (zh) | 2006-11-08 |
| BR9612666A (pt) | 1999-10-05 |
| ES2281088T3 (es) | 2007-09-16 |
| JP3942194B2 (ja) | 2007-07-11 |
| DE19548222A1 (de) | 1997-06-26 |
| EP0868527B1 (de) | 2007-01-10 |
| RU2225883C2 (ru) | 2004-03-20 |
| EP0868527A2 (de) | 1998-10-07 |
| CA2241111C (en) | 2009-09-22 |
| AR048561A1 (es) | 2006-05-10 |
| AU1921897A (en) | 1997-07-17 |
| AU724536B2 (en) | 2000-09-21 |
| ZA9610768B (en) | 1998-07-31 |
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