CN1237053C - 喹啉甲醛衍生物的制造方法及其中间体 - Google Patents
喹啉甲醛衍生物的制造方法及其中间体 Download PDFInfo
- Publication number
- CN1237053C CN1237053C CNB028048229A CN02804822A CN1237053C CN 1237053 C CN1237053 C CN 1237053C CN B028048229 A CNB028048229 A CN B028048229A CN 02804822 A CN02804822 A CN 02804822A CN 1237053 C CN1237053 C CN 1237053C
- Authority
- CN
- China
- Prior art keywords
- cyclopropyl
- quinoline
- reaction
- acid
- fluorophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Quinoline Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001036357 | 2001-02-14 | ||
| JP36357/01 | 2001-02-14 | ||
| JP36357/2001 | 2001-02-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1491215A CN1491215A (zh) | 2004-04-21 |
| CN1237053C true CN1237053C (zh) | 2006-01-18 |
Family
ID=18899637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB028048229A Expired - Fee Related CN1237053C (zh) | 2001-02-14 | 2002-02-14 | 喹啉甲醛衍生物的制造方法及其中间体 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6841681B2 (enExample) |
| EP (1) | EP1361215B1 (enExample) |
| JP (1) | JP4321065B2 (enExample) |
| KR (1) | KR100714735B1 (enExample) |
| CN (1) | CN1237053C (enExample) |
| AT (1) | ATE550325T1 (enExample) |
| AU (1) | AU2002232190B2 (enExample) |
| CA (1) | CA2437954C (enExample) |
| CY (1) | CY1112599T1 (enExample) |
| CZ (1) | CZ305024B6 (enExample) |
| DK (1) | DK1361215T3 (enExample) |
| ES (1) | ES2383667T3 (enExample) |
| HU (1) | HU230371B1 (enExample) |
| IL (2) | IL157342A0 (enExample) |
| MX (1) | MXPA03007233A (enExample) |
| NO (1) | NO326000B1 (enExample) |
| NZ (1) | NZ527552A (enExample) |
| PT (1) | PT1361215E (enExample) |
| RU (1) | RU2264391C2 (enExample) |
| SI (1) | SI1361215T1 (enExample) |
| SK (1) | SK287721B6 (enExample) |
| TW (1) | TWI309644B (enExample) |
| UA (1) | UA75113C2 (enExample) |
| WO (1) | WO2002064569A1 (enExample) |
| ZA (1) | ZA200306225B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4590749B2 (ja) * | 2001-02-14 | 2010-12-01 | 宇部興産株式会社 | キノリンカルボキシアルデヒド誘導体の製法 |
| CN102442997B (zh) * | 2010-10-12 | 2015-04-08 | 上海医药工业研究院 | 一类喹啉衍生物、其制备方法、中间体及其应用 |
| CN103204807B (zh) * | 2013-04-08 | 2015-12-23 | 黄河三角洲京博化工研究院有限公司 | 一种2-环丙基-4-（4-氟-苯基）-3-喹啉甲醛的合成方法 |
| CN103508949B (zh) * | 2013-10-22 | 2015-12-09 | 黄河三角洲京博化工研究院有限公司 | 一种（e）-3-[2-环丙基-4-（4-氟-苯基）-3-喹啉基]丙烯醛的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1336714C (en) | 1987-08-20 | 1995-08-15 | Yoshihiro Fujikawa | Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis |
| JP2569746B2 (ja) * | 1987-08-20 | 1997-01-08 | 日産化学工業株式会社 | キノリン系メバロノラクトン類 |
| JPH0340632A (ja) * | 1989-07-07 | 1991-02-21 | Canon Inc | ターミナルアダプタ装置 |
| DE4105551A1 (de) * | 1991-02-22 | 1992-08-27 | Bayer Ag | 2-substituierte chinoline, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
| JP3130342B2 (ja) * | 1991-10-04 | 2001-01-31 | 日産化学工業株式会社 | 動脈硬化性血管内膜肥厚抑制薬 |
| EP1099694B1 (en) | 1998-07-23 | 2005-08-17 | Nissan Chemical Industries, Ltd. | Process for the preparation of quinoline derivative and intermediate therefor |
-
2002
- 2002-02-08 TW TW091102496A patent/TWI309644B/zh not_active IP Right Cessation
- 2002-02-14 IL IL15734202A patent/IL157342A0/xx unknown
- 2002-02-14 WO PCT/JP2002/001261 patent/WO2002064569A1/ja not_active Ceased
- 2002-02-14 CA CA002437954A patent/CA2437954C/en not_active Expired - Fee Related
- 2002-02-14 EP EP02712360A patent/EP1361215B1/en not_active Expired - Lifetime
- 2002-02-14 MX MXPA03007233A patent/MXPA03007233A/es active IP Right Grant
- 2002-02-14 AU AU2002232190A patent/AU2002232190B2/en not_active Ceased
- 2002-02-14 SI SI200230978T patent/SI1361215T1/sl unknown
- 2002-02-14 HU HU0303846A patent/HU230371B1/hu not_active IP Right Cessation
- 2002-02-14 DK DK02712360.3T patent/DK1361215T3/da active
- 2002-02-14 NZ NZ527552A patent/NZ527552A/en not_active IP Right Cessation
- 2002-02-14 CN CNB028048229A patent/CN1237053C/zh not_active Expired - Fee Related
- 2002-02-14 KR KR1020037010708A patent/KR100714735B1/ko not_active Expired - Fee Related
- 2002-02-14 JP JP2002564502A patent/JP4321065B2/ja not_active Expired - Fee Related
- 2002-02-14 ES ES02712360T patent/ES2383667T3/es not_active Expired - Lifetime
- 2002-02-14 RU RU2003127743/04A patent/RU2264391C2/ru not_active IP Right Cessation
- 2002-02-14 CZ CZ2003-2251A patent/CZ305024B6/cs not_active IP Right Cessation
- 2002-02-14 US US10/468,062 patent/US6841681B2/en not_active Expired - Fee Related
- 2002-02-14 PT PT02712360T patent/PT1361215E/pt unknown
- 2002-02-14 UA UA2003087498A patent/UA75113C2/uk unknown
- 2002-02-14 SK SK1113-2003A patent/SK287721B6/sk not_active IP Right Cessation
- 2002-02-14 AT AT02712360T patent/ATE550325T1/de active
-
2003
- 2003-08-11 IL IL157342A patent/IL157342A/en not_active IP Right Cessation
- 2003-08-12 ZA ZA200306225A patent/ZA200306225B/en unknown
- 2003-08-13 NO NO20033592A patent/NO326000B1/no not_active IP Right Cessation
-
2012
- 2012-03-23 CY CY20121100304T patent/CY1112599T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20060118 Termination date: 20160214 |