KR100714735B1 - 퀴놀린카르복시알데히드 유도체의 제조방법 및 그 중간체 - Google Patents

퀴놀린카르복시알데히드 유도체의 제조방법 및 그 중간체 Download PDF

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Publication number
KR100714735B1
KR100714735B1 KR1020037010708A KR20037010708A KR100714735B1 KR 100714735 B1 KR100714735 B1 KR 100714735B1 KR 1020037010708 A KR1020037010708 A KR 1020037010708A KR 20037010708 A KR20037010708 A KR 20037010708A KR 100714735 B1 KR100714735 B1 KR 100714735B1
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KR
South Korea
Prior art keywords
cyclopropyl
quinoline
reaction
fluorophenyl
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020037010708A
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English (en)
Korean (ko)
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KR20030071892A (ko
Inventor
하라다가쯔마사
니시노시게요시
히로쯔겐지
시마히데따까
오까다나오꼬
하라다다까시
나까무라아끼라
오다히로유끼
Original Assignee
닛산 가가쿠 고교 가부시키 가이샤
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Application filed by 닛산 가가쿠 고교 가부시키 가이샤 filed Critical 닛산 가가쿠 고교 가부시키 가이샤
Publication of KR20030071892A publication Critical patent/KR20030071892A/ko
Application granted granted Critical
Publication of KR100714735B1 publication Critical patent/KR100714735B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Quinoline Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020037010708A 2001-02-14 2002-02-14 퀴놀린카르복시알데히드 유도체의 제조방법 및 그 중간체 Expired - Fee Related KR100714735B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001036357 2001-02-14
JPJP-P-2001-00036357 2001-02-14
PCT/JP2002/001261 WO2002064569A1 (en) 2001-02-14 2002-02-14 Process for producing quinoline carboxyaldehyde derivative and intermediate thereof

Publications (2)

Publication Number Publication Date
KR20030071892A KR20030071892A (ko) 2003-09-06
KR100714735B1 true KR100714735B1 (ko) 2007-05-07

Family

ID=18899637

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020037010708A Expired - Fee Related KR100714735B1 (ko) 2001-02-14 2002-02-14 퀴놀린카르복시알데히드 유도체의 제조방법 및 그 중간체

Country Status (25)

Country Link
US (1) US6841681B2 (enExample)
EP (1) EP1361215B1 (enExample)
JP (1) JP4321065B2 (enExample)
KR (1) KR100714735B1 (enExample)
CN (1) CN1237053C (enExample)
AT (1) ATE550325T1 (enExample)
AU (1) AU2002232190B2 (enExample)
CA (1) CA2437954C (enExample)
CY (1) CY1112599T1 (enExample)
CZ (1) CZ305024B6 (enExample)
DK (1) DK1361215T3 (enExample)
ES (1) ES2383667T3 (enExample)
HU (1) HU230371B1 (enExample)
IL (2) IL157342A0 (enExample)
MX (1) MXPA03007233A (enExample)
NO (1) NO326000B1 (enExample)
NZ (1) NZ527552A (enExample)
PT (1) PT1361215E (enExample)
RU (1) RU2264391C2 (enExample)
SI (1) SI1361215T1 (enExample)
SK (1) SK287721B6 (enExample)
TW (1) TWI309644B (enExample)
UA (1) UA75113C2 (enExample)
WO (1) WO2002064569A1 (enExample)
ZA (1) ZA200306225B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4590749B2 (ja) * 2001-02-14 2010-12-01 宇部興産株式会社 キノリンカルボキシアルデヒド誘導体の製法
CN102442997B (zh) * 2010-10-12 2015-04-08 上海医药工业研究院 一类喹啉衍生物、其制备方法、中间体及其应用
CN103204807B (zh) * 2013-04-08 2015-12-23 黄河三角洲京博化工研究院有限公司 一种2-环丙基-4-（4-氟-苯基）-3-喹啉甲醛的合成方法
CN103508949B (zh) * 2013-10-22 2015-12-09 黄河三角洲京博化工研究院有限公司 一种（e）-3-[2-环丙基-4-（4-氟-苯基）-3-喹啉基]丙烯醛的合成方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0304063A2 (en) 1987-08-20 1989-02-22 Nissan Chemical Industries Ltd. Quinoline type mevalonolactones
JPH0340632A (ja) * 1989-07-07 1991-02-21 Canon Inc ターミナルアダプタ装置
WO2000005213A1 (en) * 1998-07-23 2000-02-03 Nissan Chemical Industries, Ltd. Process for the preparation of quinoline derivative and intermediate therefor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2569746B2 (ja) * 1987-08-20 1997-01-08 日産化学工業株式会社 キノリン系メバロノラクトン類
DE4105551A1 (de) * 1991-02-22 1992-08-27 Bayer Ag 2-substituierte chinoline, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
JP3130342B2 (ja) * 1991-10-04 2001-01-31 日産化学工業株式会社 動脈硬化性血管内膜肥厚抑制薬

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0304063A2 (en) 1987-08-20 1989-02-22 Nissan Chemical Industries Ltd. Quinoline type mevalonolactones
JPH0340632A (ja) * 1989-07-07 1991-02-21 Canon Inc ターミナルアダプタ装置
WO2000005213A1 (en) * 1998-07-23 2000-02-03 Nissan Chemical Industries, Ltd. Process for the preparation of quinoline derivative and intermediate therefor

Also Published As

Publication number Publication date
EP1361215B1 (en) 2012-03-21
US20040077866A1 (en) 2004-04-22
SK287721B6 (en) 2011-07-06
DK1361215T3 (da) 2012-06-11
CY1112599T1 (el) 2016-02-10
EP1361215A1 (en) 2003-11-12
NO20033592D0 (no) 2003-08-13
US6841681B2 (en) 2005-01-11
SI1361215T1 (sl) 2012-05-31
JP4321065B2 (ja) 2009-08-26
CZ305024B6 (cs) 2015-04-01
NO326000B1 (no) 2008-09-01
WO2002064569A1 (en) 2002-08-22
RU2264391C2 (ru) 2005-11-20
IL157342A (en) 2009-08-03
ATE550325T1 (de) 2012-04-15
ZA200306225B (en) 2004-08-12
PT1361215E (pt) 2012-04-12
UA75113C2 (uk) 2006-03-15
MXPA03007233A (es) 2005-07-01
KR20030071892A (ko) 2003-09-06
EP1361215A4 (en) 2004-03-17
HUP0303846A3 (en) 2013-06-28
NO20033592L (no) 2003-10-06
HU230371B1 (hu) 2016-03-29
CN1237053C (zh) 2006-01-18
RU2003127743A (ru) 2005-03-20
CN1491215A (zh) 2004-04-21
HUP0303846A2 (hu) 2004-03-29
TWI309644B (enExample) 2009-05-11
CZ20032251A3 (cs) 2003-12-17
JPWO2002064569A1 (ja) 2004-06-10
CA2437954A1 (en) 2002-08-22
AU2002232190B2 (en) 2006-07-13
SK11132003A3 (sk) 2004-02-03
ES2383667T3 (es) 2012-06-25
IL157342A0 (en) 2004-02-19
NZ527552A (en) 2005-08-26
CA2437954C (en) 2009-07-28

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