CN1229344C - 法尼基转移酶抑制剂 - Google Patents

法尼基转移酶抑制剂 Download PDF

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Publication number
CN1229344C
CN1229344C CNB008174202A CN00817420A CN1229344C CN 1229344 C CN1229344 C CN 1229344C CN B008174202 A CNB008174202 A CN B008174202A CN 00817420 A CN00817420 A CN 00817420A CN 1229344 C CN1229344 C CN 1229344C
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CN
China
Prior art keywords
compound
formula
salt
group
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB008174202A
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English (en)
Chinese (zh)
Other versions
CN1411442A (zh
Inventor
F·T·博伊尔
J·M·瓦德勒沃斯
Z·马图斯尔克
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AstraZeneca AB
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AstraZeneca AB
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Filing date
Publication date
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Publication of CN1411442A publication Critical patent/CN1411442A/zh
Application granted granted Critical
Publication of CN1229344C publication Critical patent/CN1229344C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNB008174202A 1999-12-22 2000-12-18 法尼基转移酶抑制剂 Expired - Fee Related CN1229344C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9930318.2A GB9930318D0 (en) 1999-12-22 1999-12-22 Novel compounds
GB9930318.2 1999-12-22

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2005100563322A Division CN1680313A (zh) 1999-12-22 2000-12-18 法尼基转移酶抑制剂

Publications (2)

Publication Number Publication Date
CN1411442A CN1411442A (zh) 2003-04-16
CN1229344C true CN1229344C (zh) 2005-11-30

Family

ID=10866834

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB008174202A Expired - Fee Related CN1229344C (zh) 1999-12-22 2000-12-18 法尼基转移酶抑制剂
CNA2005100563322A Pending CN1680313A (zh) 1999-12-22 2000-12-18 法尼基转移酶抑制剂

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA2005100563322A Pending CN1680313A (zh) 1999-12-22 2000-12-18 法尼基转移酶抑制剂

Country Status (27)

Country Link
US (1) US7101897B2 (enExample)
EP (1) EP1255733B1 (enExample)
JP (1) JP3742593B2 (enExample)
KR (1) KR20020063251A (enExample)
CN (2) CN1229344C (enExample)
AR (1) AR029460A1 (enExample)
AT (1) ATE316074T1 (enExample)
AU (1) AU776003B2 (enExample)
BR (1) BR0016669A (enExample)
CA (1) CA2387579A1 (enExample)
CO (1) CO5360641A1 (enExample)
CZ (1) CZ20022125A3 (enExample)
DE (1) DE60025650D1 (enExample)
EE (1) EE200200206A (enExample)
GB (1) GB9930318D0 (enExample)
HU (1) HUP0204135A3 (enExample)
IL (1) IL149871A0 (enExample)
IS (1) IS6358A (enExample)
MX (1) MXPA02005981A (enExample)
MY (1) MY133606A (enExample)
NO (1) NO20022924L (enExample)
NZ (1) NZ518341A (enExample)
PL (1) PL355887A1 (enExample)
RU (1) RU2259997C2 (enExample)
SK (1) SK8642002A3 (enExample)
WO (1) WO2001046137A1 (enExample)
ZA (1) ZA200202694B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005117864A1 (en) * 2004-05-28 2005-12-15 Astrazeneca Ab Combination product comprising anastrozole and a dual prenyl transferase inhibitor
WO2006038719A1 (ja) * 2004-10-08 2006-04-13 Kotobuki Pharmaceutical Co., Ltd. ホスホン酸誘導体及び血中の高リン酸が関与する疾患の治療剤
US20110136867A1 (en) * 2006-02-02 2011-06-09 Justman Craig J Treatment of Synucleinopathies
WO2009151683A2 (en) 2008-03-12 2009-12-17 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
WO2010057006A1 (en) 2008-11-13 2010-05-20 Link Medicine Corporation Azaquinolinone derivatives and uses thereof
US8975247B2 (en) 2009-03-18 2015-03-10 The Board Of Trustees Of The Leland Stanford Junion University Methods and compositions of treating a flaviviridae family viral infection
WO2011088126A2 (en) * 2010-01-13 2011-07-21 Eiger Biopharmaceuticals, Inc. Treatment of viral infection with prenyltransferase inhibitors

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SU422723A1 (ru) * 1972-03-29 1974-04-05 Б. В. Салов, Т. А. Губенкова , И. В. Быховска Способ получения 5-нитро-2-аминобензойнойкислоты
CA1283906C (en) 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
JPS60233076A (ja) 1984-05-03 1985-11-19 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物およびその製造法
EP0182213B1 (en) 1984-11-08 1990-09-26 Sumitomo Pharmaceuticals Company, Limited Carbapenem compounds and production thereof
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CA2036163C (en) 1990-02-14 2001-06-19 Makoto Sunagawa Novel beta-lactam compounds and their production
FI96863C (fi) 1990-02-23 1996-09-10 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten /2-(1-homopiperatsiinikarbonyyli)pyrrolidin-4-yylitio/-6-(1-hydroksietyyli)-1-karbapen-2-eemi-3-karboksylaattisuolojen valmistamiseksi
GB9107363D0 (en) 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
US6083917A (en) 1990-04-18 2000-07-04 Board Of Regents, The University Of Texas System Methods and compositions for the identification, characterization and inhibition of farnesyltransferase
US5185248A (en) 1990-05-08 1993-02-09 E. R. Squibb & Sons, Inc. Farnesyl-protein transferase assay for identifying compounds that block neoplastic transformation
JPH0578360A (ja) 1991-01-31 1993-03-30 Banyu Pharmaceut Co Ltd ２−［２−（スルフアモイルアルキル）ピロリジニルチオカルバペネム誘導体
GB9107341D0 (en) 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
GB9107342D0 (en) 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
AU651887B2 (en) 1991-06-04 1994-08-04 Sankyo Company Limited 1-methylcarbapenem derivatives, their preparation and their use as antibiotics
JPH04368386A (ja) 1991-06-18 1992-12-21 Sankyo Co Ltd １−メチルカルバペネム−３−カルボン酸の製造法
US5360798A (en) 1991-07-04 1994-11-01 Shionogi Seiyaku Kabushiki Kaisha Aminooxypyrrolidinylthiocarbapenem compounds
DE69204007T2 (de) 1991-10-11 1996-03-21 Squibb & Sons Inc Verwendung von Farnesyl-Protein Transferaseinhibitoren zur Herstellung eines Arzneimittels zur Blockierung von durch Ras-Oncogenen hervorgerufenen neoplastischen Transformationen von Zellen.
JPH05239058A (ja) 1991-12-17 1993-09-17 Fujisawa Pharmaceut Co Ltd ３−ピロリジニルチオ−１−アザビシクロ［３．２．０ヘプト−２−エン−２−カルボン酸化合物
GB9202298D0 (en) 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds
CZ290002B6 (cs) 1992-03-11 2002-05-15 Sankyo Company Limited Antimikrobiální karbapenemové deriváty, způsob výroby a farmaceutický prostředek
GB9304156D0 (en) 1992-03-26 1993-04-21 Zeneca Ltd Antibiotic compounds
CA2091309A1 (en) 1992-03-26 1993-09-27 Frederic H. Jung Antibiotic compounds
JP3367104B2 (ja) 1992-04-13 2003-01-14 藤沢薬品工業株式会社 抗菌剤としての置換された３−ピロリジニルチオ−カルバペネム化合物
EP0581501B1 (en) 1992-07-21 1998-09-09 Zeneca Limited Antibiotic carbapenem compounds
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CA2099818A1 (en) 1992-07-21 1994-01-22 Frederic H. Jung Antibiotic compounds
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CA2165176A1 (en) 1993-06-18 1995-01-05 Samuel L. Graham Inhibitors of farnesyl-protein transferase
JP2534823B2 (ja) 1993-07-07 1996-09-18 日本電気株式会社 印刷装置
US5468733A (en) 1993-09-30 1995-11-21 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
EP0725650A4 (en) 1993-09-30 1999-02-03 Merck & Co Inc INHIBITORS OF FARNESYL PROTEIN TRANSFERASE
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US5571835A (en) 1994-09-29 1996-11-05 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
EP0817630A4 (en) 1995-03-29 1999-01-27 Merck & Co Inc INHIBITORS OF FARNESYL PROTEIN TRANSFERASE
BR9609744A (pt) 1995-07-31 1999-03-02 Shionogi & Co Derivados de pirrolidina tendo atividade inibitória de fosfolipase a2
GB9515975D0 (en) 1995-08-04 1995-10-04 Zeneca Ltd Chemical compounds
NO307879B1 (no) * 1995-09-18 2000-06-13 Sankyo Co Nye ureaderivater med ACAT-inhiberende aktivitet og farmasøytisk preparat inneholdende disse
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WO1998007692A1 (en) * 1996-08-17 1998-02-26 Zeneca Limited 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors
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WO1999041235A1 (en) * 1998-02-10 1999-08-19 Astrazeneca Uk Limited Farnesyl transferase inhibitors

Also Published As

Publication number Publication date
NO20022924D0 (no) 2002-06-18
AU776003B2 (en) 2004-08-19
GB9930318D0 (en) 2000-02-09
DE60025650D1 (de) 2006-04-06
AU2201301A (en) 2001-07-03
NO20022924L (no) 2002-06-18
EP1255733B1 (en) 2006-01-18
BR0016669A (pt) 2002-10-08
IL149871A0 (en) 2002-11-10
JP3742593B2 (ja) 2006-02-08
IS6358A (is) 2002-04-23
CN1680313A (zh) 2005-10-12
EP1255733A1 (en) 2002-11-13
EE200200206A (et) 2003-04-15
CO5360641A1 (es) 2004-01-30
AR029460A1 (es) 2003-07-02
ATE316074T1 (de) 2006-02-15
CN1411442A (zh) 2003-04-16
KR20020063251A (ko) 2002-08-01
SK8642002A3 (en) 2002-12-03
MY133606A (en) 2007-11-30
JP2003518091A (ja) 2003-06-03
WO2001046137A1 (en) 2001-06-28
ZA200202694B (en) 2003-12-31
US7101897B2 (en) 2006-09-05
RU2259997C2 (ru) 2005-09-10
CZ20022125A3 (cs) 2002-09-11
PL355887A1 (en) 2004-05-31
RU2002119405A (ru) 2004-01-10
US20030083348A1 (en) 2003-05-01
HUP0204135A2 (hu) 2003-03-28
CA2387579A1 (en) 2001-06-28
MXPA02005981A (es) 2005-07-01
HUP0204135A3 (en) 2005-03-29
NZ518341A (en) 2004-01-30

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