ATE316074T1 - Farnesyltransferase inhibitoren - Google Patents

Farnesyltransferase inhibitoren

Info

Publication number
ATE316074T1
ATE316074T1 AT00985605T AT00985605T ATE316074T1 AT E316074 T1 ATE316074 T1 AT E316074T1 AT 00985605 T AT00985605 T AT 00985605T AT 00985605 T AT00985605 T AT 00985605T AT E316074 T1 ATE316074 T1 AT E316074T1
Authority
AT
Austria
Prior art keywords
transferase inhibitors
farnesyl transferase
farnesyl
inhibitors
transferase
Prior art date
Application number
AT00985605T
Other languages
English (en)
Inventor
Francis Thomas Boyle
James Michael Wardleworth
Zbigniew Matusiak
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Application granted granted Critical
Publication of ATE316074T1 publication Critical patent/ATE316074T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT00985605T 1999-12-22 2000-12-18 Farnesyltransferase inhibitoren ATE316074T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9930318.2A GB9930318D0 (en) 1999-12-22 1999-12-22 Novel compounds

Publications (1)

Publication Number Publication Date
ATE316074T1 true ATE316074T1 (de) 2006-02-15

Family

ID=10866834

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00985605T ATE316074T1 (de) 1999-12-22 2000-12-18 Farnesyltransferase inhibitoren

Country Status (27)

Country Link
US (1) US7101897B2 (de)
EP (1) EP1255733B1 (de)
JP (1) JP3742593B2 (de)
KR (1) KR20020063251A (de)
CN (2) CN1229344C (de)
AR (1) AR029460A1 (de)
AT (1) ATE316074T1 (de)
AU (1) AU776003B2 (de)
BR (1) BR0016669A (de)
CA (1) CA2387579A1 (de)
CO (1) CO5360641A1 (de)
CZ (1) CZ20022125A3 (de)
DE (1) DE60025650D1 (de)
EE (1) EE200200206A (de)
GB (1) GB9930318D0 (de)
HU (1) HUP0204135A3 (de)
IL (1) IL149871A0 (de)
IS (1) IS6358A (de)
MX (1) MXPA02005981A (de)
MY (1) MY133606A (de)
NO (1) NO20022924L (de)
NZ (1) NZ518341A (de)
PL (1) PL355887A1 (de)
RU (1) RU2259997C2 (de)
SK (1) SK8642002A3 (de)
WO (1) WO2001046137A1 (de)
ZA (1) ZA200202694B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005117864A1 (en) * 2004-05-28 2005-12-15 Astrazeneca Ab Combination product comprising anastrozole and a dual prenyl transferase inhibitor
US7691898B2 (en) * 2004-10-08 2010-04-06 Kotobuki Pharmaceutical Co., Ltd. Phosphonic acid derivatives and the treating agents of diseases related hyperphosphatemia
US20110136867A1 (en) * 2006-02-02 2011-06-09 Justman Craig J Treatment of Synucleinopathies
US8232402B2 (en) 2008-03-12 2012-07-31 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
BRPI0920927A2 (pt) 2008-11-13 2019-09-24 Link Medicine Corp derivados de azaquinolinona e usos dos mesmos
EP2408449A4 (de) 2009-03-18 2012-08-08 Univ Leland Stanford Junior Verfahren und zusammensetzungen zur behandlung von flaviviridae-virusinfektionen
WO2011088126A2 (en) * 2010-01-13 2011-07-21 Eiger Biopharmaceuticals, Inc. Treatment of viral infection with prenyltransferase inhibitors

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1283906C (en) 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
JPS60233076A (ja) 1984-05-03 1985-11-19 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物およびその製造法
DE3579888D1 (de) 1984-11-08 1990-10-31 Sumitomo Pharma Carbapenemverbindungen und deren herstellung.
KR880006244A (ko) 1986-11-24 1988-07-22 후지사와 도모 기찌 로 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법
GB8921635D0 (en) 1989-09-25 1989-11-08 Fujisawa Pharmaceutical Co 3-pyrrolidinylthio-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives
CA2036163C (en) 1990-02-14 2001-06-19 Makoto Sunagawa Novel beta-lactam compounds and their production
IE910606A1 (en) 1990-02-23 1991-08-28 Sankyo Co Carbapenem derivatives having antibiotic activity, their¹preparation and their use
GB9107363D0 (en) 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
US6083917A (en) 1990-04-18 2000-07-04 Board Of Regents, The University Of Texas System Methods and compositions for the identification, characterization and inhibition of farnesyltransferase
US5185248A (en) * 1990-05-08 1993-02-09 E. R. Squibb & Sons, Inc. Farnesyl-protein transferase assay for identifying compounds that block neoplastic transformation
JPH0578360A (ja) 1991-01-31 1993-03-30 Banyu Pharmaceut Co Ltd ２−［２−（スルフアモイルアルキル）ピロリジニルチオカルバペネム誘導体
GB9107341D0 (en) 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
GB9107342D0 (en) 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
JP2559949B2 (ja) 1991-06-04 1996-12-04 三共株式会社 １−メチルカルバペネム誘導体
JPH04368386A (ja) 1991-06-18 1992-12-21 Sankyo Co Ltd １−メチルカルバペネム−３−カルボン酸の製造法
US5360798A (en) 1991-07-04 1994-11-01 Shionogi Seiyaku Kabushiki Kaisha Aminooxypyrrolidinylthiocarbapenem compounds
DE69204007T2 (de) 1991-10-11 1996-03-21 Squibb & Sons Inc Verwendung von Farnesyl-Protein Transferaseinhibitoren zur Herstellung eines Arzneimittels zur Blockierung von durch Ras-Oncogenen hervorgerufenen neoplastischen Transformationen von Zellen.
JPH05239058A (ja) 1991-12-17 1993-09-17 Fujisawa Pharmaceut Co Ltd ３−ピロリジニルチオ−１−アザビシクロ［３．２．０ヘプト−２−エン−２−カルボン酸化合物
GB9202298D0 (en) * 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds
HU218676B (hu) 1992-03-11 2000-10-28 Sankyo Co. Ltd. Antimikrobiális karbapenemszármazékok, ilyen vegyületeket tartalmazó gyógyászati készítmények és eljárás ezek előállítására
CA2091309A1 (en) 1992-03-26 1993-09-27 Frederic H. Jung Antibiotic compounds
GB9304156D0 (en) 1992-03-26 1993-04-21 Zeneca Ltd Antibiotic compounds
JP3367104B2 (ja) 1992-04-13 2003-01-14 藤沢薬品工業株式会社 抗菌剤としての置換された３−ピロリジニルチオ−カルバペネム化合物
EP0581501B1 (de) 1992-07-21 1998-09-09 Zeneca Limited Antibiotische Carbapenemverbindungen
CA2099818A1 (en) 1992-07-21 1994-01-22 Frederic H. Jung Antibiotic compounds
EP0581502B1 (de) 1992-07-21 1998-10-21 Zeneca Limited Antibiotische carbapenemverbindungen
EP0590885B1 (de) 1992-09-28 2000-03-15 Zeneca Limited Antibiotische Carbapenemverbindungen
CA2106330A1 (en) 1992-10-07 1994-04-08 Patrice J. Siret Antibiotic compounds
CA2118985A1 (en) 1993-04-02 1994-10-03 Dinesh V. Patel Heterocyclic inhibitors of farnesyl protein transferase
AU675145B2 (en) 1993-06-18 1997-01-23 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
JP2534823B2 (ja) 1993-07-07 1996-09-18 日本電気株式会社 印刷装置
CA2172125A1 (en) 1993-09-30 1995-04-06 S. Jane Desolms Inhibitors of farnesyl-protein transferase
US5468733A (en) 1993-09-30 1995-11-21 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CA2155448A1 (en) 1994-08-11 1996-02-12 Katerina Leftheris Inhibitors of farnesyl protein transferase
US5571835A (en) 1994-09-29 1996-11-05 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
EP0817630A4 (de) 1995-03-29 1999-01-27 Merck & Co Inc Inhibitoren der farnesyl-protein transferase
JP3923079B2 (ja) 1995-07-31 2007-05-30 塩野義製薬株式会社 ホスホリパーゼａ２阻害活性を有するピロリジン誘導体
GB9515975D0 (en) * 1995-08-04 1995-10-04 Zeneca Ltd Chemical compounds
JPH1050029A (ja) 1996-05-28 1998-02-20 Nobuyuki Higuchi 情報記憶装置
US6946468B1 (en) * 1996-08-17 2005-09-20 Zeneca Limited 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors
WO1998032741A1 (en) * 1997-01-29 1998-07-30 Zeneca Limited Inhibitors of farnesyl protein transferase
ES2387211T3 (es) 1997-05-07 2012-09-18 University Of Pittsburgh Inhibidores de proteínas isoprenil transferass
WO1999041235A1 (en) * 1998-02-10 1999-08-19 Astrazeneca Uk Limited Farnesyl transferase inhibitors

Also Published As

Publication number Publication date
HUP0204135A2 (hu) 2003-03-28
SK8642002A3 (en) 2002-12-03
ZA200202694B (en) 2003-12-31
AR029460A1 (es) 2003-07-02
DE60025650D1 (de) 2006-04-06
US7101897B2 (en) 2006-09-05
CO5360641A1 (es) 2004-01-30
NZ518341A (en) 2004-01-30
BR0016669A (pt) 2002-10-08
CA2387579A1 (en) 2001-06-28
IS6358A (is) 2002-04-23
HUP0204135A3 (en) 2005-03-29
RU2259997C2 (ru) 2005-09-10
CN1680313A (zh) 2005-10-12
CZ20022125A3 (cs) 2002-09-11
AU776003B2 (en) 2004-08-19
WO2001046137A1 (en) 2001-06-28
RU2002119405A (ru) 2004-01-10
CN1411442A (zh) 2003-04-16
NO20022924D0 (no) 2002-06-18
CN1229344C (zh) 2005-11-30
GB9930318D0 (en) 2000-02-09
MXPA02005981A (es) 2005-07-01
MY133606A (en) 2007-11-30
IL149871A0 (en) 2002-11-10
EP1255733A1 (de) 2002-11-13
KR20020063251A (ko) 2002-08-01
JP3742593B2 (ja) 2006-02-08
EP1255733B1 (de) 2006-01-18
NO20022924L (no) 2002-06-18
EE200200206A (et) 2003-04-15
AU2201301A (en) 2001-07-03
US20030083348A1 (en) 2003-05-01
PL355887A1 (en) 2004-05-31
JP2003518091A (ja) 2003-06-03

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties