EE200200206A - Farnesüüli transferaasiinhibiitorid - Google Patents
Farnesüüli transferaasiinhibiitoridInfo
- Publication number
- EE200200206A EE200200206A EEP200200206A EEP200200206A EE200200206A EE 200200206 A EE200200206 A EE 200200206A EE P200200206 A EEP200200206 A EE P200200206A EE P200200206 A EEP200200206 A EE P200200206A EE 200200206 A EE200200206 A EE 200200206A
- Authority
- EE
- Estonia
- Prior art keywords
- transferase inhibitors
- farnesyl transferase
- farnesyl
- inhibitors
- transferase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9930318.2A GB9930318D0 (en) | 1999-12-22 | 1999-12-22 | Novel compounds |
PCT/GB2000/004856 WO2001046137A1 (en) | 1999-12-22 | 2000-12-18 | Farnesyl transferase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
EE200200206A true EE200200206A (et) | 2003-04-15 |
Family
ID=10866834
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EEP200200206A EE200200206A (et) | 1999-12-22 | 2000-12-18 | Farnesüüli transferaasiinhibiitorid |
Country Status (27)
Country | Link |
---|---|
US (1) | US7101897B2 (et) |
EP (1) | EP1255733B1 (et) |
JP (1) | JP3742593B2 (et) |
KR (1) | KR20020063251A (et) |
CN (2) | CN1229344C (et) |
AR (1) | AR029460A1 (et) |
AT (1) | ATE316074T1 (et) |
AU (1) | AU776003B2 (et) |
BR (1) | BR0016669A (et) |
CA (1) | CA2387579A1 (et) |
CO (1) | CO5360641A1 (et) |
CZ (1) | CZ20022125A3 (et) |
DE (1) | DE60025650D1 (et) |
EE (1) | EE200200206A (et) |
GB (1) | GB9930318D0 (et) |
HU (1) | HUP0204135A3 (et) |
IL (1) | IL149871A0 (et) |
IS (1) | IS6358A (et) |
MX (1) | MXPA02005981A (et) |
MY (1) | MY133606A (et) |
NO (1) | NO20022924D0 (et) |
NZ (1) | NZ518341A (et) |
PL (1) | PL355887A1 (et) |
RU (1) | RU2259997C2 (et) |
SK (1) | SK8642002A3 (et) |
WO (1) | WO2001046137A1 (et) |
ZA (1) | ZA200202694B (et) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005117864A1 (en) * | 2004-05-28 | 2005-12-15 | Astrazeneca Ab | Combination product comprising anastrozole and a dual prenyl transferase inhibitor |
JP4880473B2 (ja) * | 2004-10-08 | 2012-02-22 | 壽製薬株式会社 | ホスホン酸誘導体及び血中の高リン酸が関与する疾患の治療剤 |
US20110136867A1 (en) * | 2006-02-02 | 2011-06-09 | Justman Craig J | Treatment of Synucleinopathies |
WO2009151683A2 (en) | 2008-03-12 | 2009-12-17 | Link Medicine Corporation | Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications |
CN102369202A (zh) | 2008-11-13 | 2012-03-07 | 链接医药公司 | 氮杂喹啉酮衍生物及其应用 |
CN102448458B (zh) | 2009-03-18 | 2015-07-22 | 小利兰·斯坦福大学理事会 | 治疗黄病毒科病毒感染的方法和组合物 |
WO2011088126A2 (en) * | 2010-01-13 | 2011-07-21 | Eiger Biopharmaceuticals, Inc. | Treatment of viral infection with prenyltransferase inhibitors |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1283906C (en) | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF |
JPS60233076A (ja) | 1984-05-03 | 1985-11-19 | Sumitomo Chem Co Ltd | 新規なβ−ラクタム化合物およびその製造法 |
CA1281720C (en) | 1984-11-08 | 1991-03-19 | Makoto Sunagawa | Carbapenem compounds and production thereof |
KR880006244A (ko) | 1986-11-24 | 1988-07-22 | 후지사와 도모 기찌 로 | 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법 |
GB8921635D0 (en) | 1989-09-25 | 1989-11-08 | Fujisawa Pharmaceutical Co | 3-pyrrolidinylthio-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives |
CA2036163C (en) | 1990-02-14 | 2001-06-19 | Makoto Sunagawa | Novel beta-lactam compounds and their production |
CA2036941A1 (en) | 1990-02-23 | 1991-08-24 | Isao Kawamoto | Carbapenem derivatives having antibiotic activity, their preparation and their use |
GB9107363D0 (en) | 1991-04-08 | 1991-05-22 | Ici Plc | Antibiotic compounds |
US6083917A (en) | 1990-04-18 | 2000-07-04 | Board Of Regents, The University Of Texas System | Methods and compositions for the identification, characterization and inhibition of farnesyltransferase |
US5185248A (en) * | 1990-05-08 | 1993-02-09 | E. R. Squibb & Sons, Inc. | Farnesyl-protein transferase assay for identifying compounds that block neoplastic transformation |
JPH0578360A (ja) | 1991-01-31 | 1993-03-30 | Banyu Pharmaceut Co Ltd | 2−[2−(スルフアモイルアルキル)ピロリジニルチオカルバペネム誘導体 |
GB9107341D0 (en) | 1991-04-08 | 1991-05-22 | Ici Plc | Antibiotic compounds |
GB9107342D0 (en) | 1991-04-08 | 1991-05-22 | Ici Plc | Antibiotic compounds |
AU651887B2 (en) | 1991-06-04 | 1994-08-04 | Sankyo Company Limited | 1-methylcarbapenem derivatives, their preparation and their use as antibiotics |
JPH04368386A (ja) | 1991-06-18 | 1992-12-21 | Sankyo Co Ltd | 1−メチルカルバペネム−3−カルボン酸の製造法 |
US5360798A (en) | 1991-07-04 | 1994-11-01 | Shionogi Seiyaku Kabushiki Kaisha | Aminooxypyrrolidinylthiocarbapenem compounds |
EP0537007B1 (en) | 1991-10-11 | 1995-08-09 | E.R. SQUIBB & SONS, INC. | Use of formesyl-protein transferase inhibitors for the manufacture of a medicament for blocking neoplastic transformation of cells induced by ras oncogenes |
JPH05239058A (ja) | 1991-12-17 | 1993-09-17 | Fujisawa Pharmaceut Co Ltd | 3−ピロリジニルチオ−1−アザビシクロ[3.2.0ヘプト−2−エン−2−カルボン酸化合物 |
GB9202298D0 (en) * | 1992-02-04 | 1992-03-18 | Ici Plc | Antibiotic compounds |
HU218676B (hu) | 1992-03-11 | 2000-10-28 | Sankyo Co. Ltd. | Antimikrobiális karbapenemszármazékok, ilyen vegyületeket tartalmazó gyógyászati készítmények és eljárás ezek előállítására |
CA2091309A1 (en) | 1992-03-26 | 1993-09-27 | Frederic H. Jung | Antibiotic compounds |
GB9304156D0 (en) | 1992-03-26 | 1993-04-21 | Zeneca Ltd | Antibiotic compounds |
WO1993021186A1 (en) | 1992-04-13 | 1993-10-28 | Fujisawa Pharmaceutical Co., Ltd. | Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents |
EP0581502B1 (en) | 1992-07-21 | 1998-10-21 | Zeneca Limited | Antibiotic carbapenem compounds |
CA2099818A1 (en) | 1992-07-21 | 1994-01-22 | Frederic H. Jung | Antibiotic compounds |
EP0581501B1 (en) | 1992-07-21 | 1998-09-09 | Zeneca Limited | Antibiotic carbapenem compounds |
EP0590885B1 (en) | 1992-09-28 | 2000-03-15 | Zeneca Limited | Antibiotic carbapenem compounds |
CA2106330A1 (en) | 1992-10-07 | 1994-04-08 | Patrice J. Siret | Antibiotic compounds |
CA2118985A1 (en) | 1993-04-02 | 1994-10-03 | Dinesh V. Patel | Heterocyclic inhibitors of farnesyl protein transferase |
AU675145B2 (en) | 1993-06-18 | 1997-01-23 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
JP2534823B2 (ja) | 1993-07-07 | 1996-09-18 | 日本電気株式会社 | 印刷装置 |
CA2172125A1 (en) | 1993-09-30 | 1995-04-06 | S. Jane Desolms | Inhibitors of farnesyl-protein transferase |
US5468733A (en) | 1993-09-30 | 1995-11-21 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
CA2155448A1 (en) | 1994-08-11 | 1996-02-12 | Katerina Leftheris | Inhibitors of farnesyl protein transferase |
US5571835A (en) | 1994-09-29 | 1996-11-05 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
AU706008B2 (en) | 1995-03-29 | 1999-06-03 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
AU707537B2 (en) | 1995-07-31 | 1999-07-15 | Anthera Pharmaceuticals, Inc. | Pyrrolidine derivatives having phospholipase a2 inhibitory activity |
GB9515975D0 (en) | 1995-08-04 | 1995-10-04 | Zeneca Ltd | Chemical compounds |
JPH1050029A (ja) | 1996-05-28 | 1998-02-20 | Nobuyuki Higuchi | 情報記憶装置 |
WO1998007692A1 (en) * | 1996-08-17 | 1998-02-26 | Zeneca Limited | 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors |
AU5772698A (en) * | 1997-01-29 | 1998-08-18 | Zeneca Limited | Inhibitors of farnesyl protein transferase |
ATE546139T1 (de) | 1997-05-07 | 2012-03-15 | Univ Pittsburgh | Isoprentransferase proteine inhibitoren |
JP2002503650A (ja) | 1998-02-10 | 2002-02-05 | アストラゼネカ ユーケー リミテッド | ファルネシルトランスフェラーゼ阻害剤 |
-
1999
- 1999-12-22 GB GBGB9930318.2A patent/GB9930318D0/en not_active Ceased
-
2000
- 2000-12-18 AT AT00985605T patent/ATE316074T1/de not_active IP Right Cessation
- 2000-12-18 WO PCT/GB2000/004856 patent/WO2001046137A1/en active IP Right Grant
- 2000-12-18 PL PL00355887A patent/PL355887A1/xx not_active Application Discontinuation
- 2000-12-18 US US10/110,690 patent/US7101897B2/en not_active Expired - Fee Related
- 2000-12-18 CZ CZ20022125A patent/CZ20022125A3/cs unknown
- 2000-12-18 BR BR0016669-3A patent/BR0016669A/pt not_active IP Right Cessation
- 2000-12-18 DE DE60025650T patent/DE60025650D1/de not_active Expired - Lifetime
- 2000-12-18 IL IL14987100A patent/IL149871A0/xx unknown
- 2000-12-18 JP JP2001547048A patent/JP3742593B2/ja not_active Expired - Fee Related
- 2000-12-18 CN CNB008174202A patent/CN1229344C/zh not_active Expired - Fee Related
- 2000-12-18 KR KR1020027008034A patent/KR20020063251A/ko not_active Application Discontinuation
- 2000-12-18 MX MXPA02005981A patent/MXPA02005981A/es unknown
- 2000-12-18 RU RU2002119405/04A patent/RU2259997C2/ru not_active IP Right Cessation
- 2000-12-18 CA CA002387579A patent/CA2387579A1/en not_active Abandoned
- 2000-12-18 SK SK864-2002A patent/SK8642002A3/sk unknown
- 2000-12-18 EE EEP200200206A patent/EE200200206A/et unknown
- 2000-12-18 NZ NZ518341A patent/NZ518341A/xx unknown
- 2000-12-18 CN CNA2005100563322A patent/CN1680313A/zh active Pending
- 2000-12-18 HU HU0204135A patent/HUP0204135A3/hu unknown
- 2000-12-18 EP EP00985605A patent/EP1255733B1/en not_active Expired - Lifetime
- 2000-12-18 AU AU22013/01A patent/AU776003B2/en not_active Ceased
- 2000-12-20 MY MYPI20006011A patent/MY133606A/en unknown
- 2000-12-21 AR ARP000106845A patent/AR029460A1/es not_active Application Discontinuation
- 2000-12-22 CO CO00097282A patent/CO5360641A1/es not_active Application Discontinuation
-
2002
- 2002-04-05 ZA ZA200202694A patent/ZA200202694B/en unknown
- 2002-04-23 IS IS6358A patent/IS6358A/is unknown
- 2002-06-18 NO NO20022924A patent/NO20022924D0/no unknown
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