AR029460A1 - COMPUESTO DERIVADO DE PIRROLIDINA, COMPOSICIoN FARMACEUTICA QUE LO COMPRENDE Y COMPUESTO INTERMEDIARIO - Google Patents

COMPUESTO DERIVADO DE PIRROLIDINA, COMPOSICIoN FARMACEUTICA QUE LO COMPRENDE Y COMPUESTO INTERMEDIARIO

Info

Publication number
AR029460A1
AR029460A1 ARP000106845A ARP000106845A AR029460A1 AR 029460 A1 AR029460 A1 AR 029460A1 AR P000106845 A ARP000106845 A AR P000106845A AR P000106845 A ARP000106845 A AR P000106845A AR 029460 A1 AR029460 A1 AR 029460A1
Authority
AR
Argentina
Prior art keywords
compound
pirrolidine
pharmaceutical composition
intermediary
derived
Prior art date
Application number
ARP000106845A
Other languages
English (en)
Inventor
Francis Boyle
Michael Wardelworth
Zbigniew Matusiak
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR029460A1 publication Critical patent/AR029460A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compuestos derivado de pirrolidina la formula (1) donde R1 y R2 se seleccionan independientemente de H o una porcion prodroga; R3 es hidrogeno o halogeno; R4 es hidrogeno o halogeno; Y es S, S(O) o S(O)2; o una sal del mismo. L es ûCH=CH- o -CH2-Z, donde Z es NH o O; Las composiciones farmacéuticas que comprenden dichos compuestos y un compuesto intermediario también se describen. Estos compuestos inhiben la farnesilacion de productos genéticos, como por ejemplo el gen ras, a través de la inhibicion de la enzima farnesil-protein transferasa (FPTasa)
ARP000106845A 1999-12-22 2000-12-21 COMPUESTO DERIVADO DE PIRROLIDINA, COMPOSICIoN FARMACEUTICA QUE LO COMPRENDE Y COMPUESTO INTERMEDIARIO AR029460A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9930318.2A GB9930318D0 (en) 1999-12-22 1999-12-22 Novel compounds

Publications (1)

Publication Number Publication Date
AR029460A1 true AR029460A1 (es) 2003-07-02

Family

ID=10866834

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000106845A AR029460A1 (es) 1999-12-22 2000-12-21 COMPUESTO DERIVADO DE PIRROLIDINA, COMPOSICIoN FARMACEUTICA QUE LO COMPRENDE Y COMPUESTO INTERMEDIARIO

Country Status (27)

Country Link
US (1) US7101897B2 (es)
EP (1) EP1255733B1 (es)
JP (1) JP3742593B2 (es)
KR (1) KR20020063251A (es)
CN (2) CN1680313A (es)
AR (1) AR029460A1 (es)
AT (1) ATE316074T1 (es)
AU (1) AU776003B2 (es)
BR (1) BR0016669A (es)
CA (1) CA2387579A1 (es)
CO (1) CO5360641A1 (es)
CZ (1) CZ20022125A3 (es)
DE (1) DE60025650D1 (es)
EE (1) EE200200206A (es)
GB (1) GB9930318D0 (es)
HU (1) HUP0204135A3 (es)
IL (1) IL149871A0 (es)
IS (1) IS6358A (es)
MX (1) MXPA02005981A (es)
MY (1) MY133606A (es)
NO (1) NO20022924D0 (es)
NZ (1) NZ518341A (es)
PL (1) PL355887A1 (es)
RU (1) RU2259997C2 (es)
SK (1) SK8642002A3 (es)
WO (1) WO2001046137A1 (es)
ZA (1) ZA200202694B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005117864A1 (en) * 2004-05-28 2005-12-15 Astrazeneca Ab Combination product comprising anastrozole and a dual prenyl transferase inhibitor
WO2006038719A1 (ja) * 2004-10-08 2006-04-13 Kotobuki Pharmaceutical Co., Ltd. ホスホン酸誘導体及び血中の高リン酸が関与する疾患の治療剤
WO2007092285A2 (en) * 2006-02-02 2007-08-16 Link Medicine Corporation Treatment of synucleinopathies
US8232402B2 (en) 2008-03-12 2012-07-31 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
CN102369202A (zh) 2008-11-13 2012-03-07 链接医药公司 氮杂喹啉酮衍生物及其应用
JP2012520884A (ja) 2009-03-18 2012-09-10 ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニバーシティー フラビウイルス科ウイルス感染症を治療する方法および組成物
WO2011088126A2 (en) * 2010-01-13 2011-07-21 Eiger Biopharmaceuticals, Inc. Treatment of viral infection with prenyltransferase inhibitors

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CA1283906C (en) 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
JPS60233076A (ja) 1984-05-03 1985-11-19 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物およびその製造法
DE3579888D1 (de) 1984-11-08 1990-10-31 Sumitomo Pharma Carbapenemverbindungen und deren herstellung.
KR880006244A (ko) 1986-11-24 1988-07-22 후지사와 도모 기찌 로 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법
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CA2036163C (en) 1990-02-14 2001-06-19 Makoto Sunagawa Novel beta-lactam compounds and their production
NZ237191A (en) 1990-02-23 1992-12-23 Sankyo Co 2-((substituted amide) substituted heterocyclylthio) carbpen-2-em derivatives and pharmaceutical compositions
GB9107363D0 (en) 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
US6083917A (en) 1990-04-18 2000-07-04 Board Of Regents, The University Of Texas System Methods and compositions for the identification, characterization and inhibition of farnesyltransferase
US5185248A (en) * 1990-05-08 1993-02-09 E. R. Squibb & Sons, Inc. Farnesyl-protein transferase assay for identifying compounds that block neoplastic transformation
JPH0578360A (ja) 1991-01-31 1993-03-30 Banyu Pharmaceut Co Ltd ２−［２−（スルフアモイルアルキル）ピロリジニルチオカルバペネム誘導体
GB9107342D0 (en) 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
GB9107341D0 (en) 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
FI101226B (fi) 1991-06-04 1998-05-15 Sankyo Co Menetelmä lääkeaineena käyttökelpoisten 2-£2-(karbonyyli)pyrrolidin-4- yylitio|-6-(1-hydroksietyyli)-1-metyylikarbapen-2-eemi-3-karboksyyliha ppojohdannaisten valmistamiseksi
JPH04368386A (ja) 1991-06-18 1992-12-21 Sankyo Co Ltd １−メチルカルバペネム−３−カルボン酸の製造法
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GB9515975D0 (en) * 1995-08-04 1995-10-04 Zeneca Ltd Chemical compounds
JPH1050029A (ja) 1996-05-28 1998-02-20 Nobuyuki Higuchi 情報記憶装置
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JP2002503650A (ja) 1998-02-10 2002-02-05 アストラゼネカ ユーケー リミテッド ファルネシルトランスフェラーゼ阻害剤

Also Published As

Publication number Publication date
CN1680313A (zh) 2005-10-12
JP3742593B2 (ja) 2006-02-08
DE60025650D1 (de) 2006-04-06
CN1229344C (zh) 2005-11-30
RU2259997C2 (ru) 2005-09-10
NO20022924L (no) 2002-06-18
NZ518341A (en) 2004-01-30
BR0016669A (pt) 2002-10-08
CN1411442A (zh) 2003-04-16
HUP0204135A3 (en) 2005-03-29
IL149871A0 (en) 2002-11-10
NO20022924D0 (no) 2002-06-18
JP2003518091A (ja) 2003-06-03
MY133606A (en) 2007-11-30
CA2387579A1 (en) 2001-06-28
EE200200206A (et) 2003-04-15
US7101897B2 (en) 2006-09-05
WO2001046137A1 (en) 2001-06-28
EP1255733B1 (en) 2006-01-18
GB9930318D0 (en) 2000-02-09
RU2002119405A (ru) 2004-01-10
PL355887A1 (en) 2004-05-31
ATE316074T1 (de) 2006-02-15
ZA200202694B (en) 2003-12-31
CZ20022125A3 (cs) 2002-09-11
AU776003B2 (en) 2004-08-19
EP1255733A1 (en) 2002-11-13
KR20020063251A (ko) 2002-08-01
AU2201301A (en) 2001-07-03
SK8642002A3 (en) 2002-12-03
HUP0204135A2 (hu) 2003-03-28
MXPA02005981A (es) 2005-07-01
CO5360641A1 (es) 2004-01-30
US20030083348A1 (en) 2003-05-01
IS6358A (is) 2002-04-23

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal