SK8642002A3 - Farnesyl transferase inhibitors, process for their preparation and pharmaceutical compositions containing them - Google Patents

Farnesyl transferase inhibitors, process for their preparation and pharmaceutical compositions containing them Download PDF

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Publication number
SK8642002A3
SK8642002A3 SK864-2002A SK8642002A SK8642002A3 SK 8642002 A3 SK8642002 A3 SK 8642002A3 SK 8642002 A SK8642002 A SK 8642002A SK 8642002 A3 SK8642002 A3 SK 8642002A3
Authority
SK
Slovakia
Prior art keywords
compound
formula
optionally substituted
ester
carbon atoms
Prior art date
Application number
SK864-2002A
Other languages
English (en)
Slovak (sk)
Inventor
Francis Thomas Boyle
James Michael Wardleworth
Zbigniew Matusiak
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of SK8642002A3 publication Critical patent/SK8642002A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SK864-2002A 1999-12-22 2000-12-18 Farnesyl transferase inhibitors, process for their preparation and pharmaceutical compositions containing them SK8642002A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9930318.2A GB9930318D0 (en) 1999-12-22 1999-12-22 Novel compounds
PCT/GB2000/004856 WO2001046137A1 (en) 1999-12-22 2000-12-18 Farnesyl transferase inhibitors

Publications (1)

Publication Number Publication Date
SK8642002A3 true SK8642002A3 (en) 2002-12-03

Family

ID=10866834

Family Applications (1)

Application Number Title Priority Date Filing Date
SK864-2002A SK8642002A3 (en) 1999-12-22 2000-12-18 Farnesyl transferase inhibitors, process for their preparation and pharmaceutical compositions containing them

Country Status (27)

Country Link
US (1) US7101897B2 (de)
EP (1) EP1255733B1 (de)
JP (1) JP3742593B2 (de)
KR (1) KR20020063251A (de)
CN (2) CN1229344C (de)
AR (1) AR029460A1 (de)
AT (1) ATE316074T1 (de)
AU (1) AU776003B2 (de)
BR (1) BR0016669A (de)
CA (1) CA2387579A1 (de)
CO (1) CO5360641A1 (de)
CZ (1) CZ20022125A3 (de)
DE (1) DE60025650D1 (de)
EE (1) EE200200206A (de)
GB (1) GB9930318D0 (de)
HU (1) HUP0204135A3 (de)
IL (1) IL149871A0 (de)
IS (1) IS6358A (de)
MX (1) MXPA02005981A (de)
MY (1) MY133606A (de)
NO (1) NO20022924L (de)
NZ (1) NZ518341A (de)
PL (1) PL355887A1 (de)
RU (1) RU2259997C2 (de)
SK (1) SK8642002A3 (de)
WO (1) WO2001046137A1 (de)
ZA (1) ZA200202694B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005117864A1 (en) * 2004-05-28 2005-12-15 Astrazeneca Ab Combination product comprising anastrozole and a dual prenyl transferase inhibitor
US7691898B2 (en) * 2004-10-08 2010-04-06 Kotobuki Pharmaceutical Co., Ltd. Phosphonic acid derivatives and the treating agents of diseases related hyperphosphatemia
US20110136867A1 (en) * 2006-02-02 2011-06-09 Justman Craig J Treatment of Synucleinopathies
WO2009151683A2 (en) 2008-03-12 2009-12-17 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
MX2011005096A (es) 2008-11-13 2011-11-18 Link Medicine Corp Derivados de azaquinolinona y usos de los mismos.
US8975247B2 (en) 2009-03-18 2015-03-10 The Board Of Trustees Of The Leland Stanford Junion University Methods and compositions of treating a flaviviridae family viral infection
WO2011088126A2 (en) * 2010-01-13 2011-07-21 Eiger Biopharmaceuticals, Inc. Treatment of viral infection with prenyltransferase inhibitors

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1283906C (en) 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
JPS60233076A (ja) 1984-05-03 1985-11-19 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物およびその製造法
CA1281720C (en) 1984-11-08 1991-03-19 Makoto Sunagawa Carbapenem compounds and production thereof
KR880006244A (ko) 1986-11-24 1988-07-22 후지사와 도모 기찌 로 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법
GB8921635D0 (en) 1989-09-25 1989-11-08 Fujisawa Pharmaceutical Co 3-pyrrolidinylthio-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives
CA2036163C (en) 1990-02-14 2001-06-19 Makoto Sunagawa Novel beta-lactam compounds and their production
FI96863C (fi) 1990-02-23 1996-09-10 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten /2-(1-homopiperatsiinikarbonyyli)pyrrolidin-4-yylitio/-6-(1-hydroksietyyli)-1-karbapen-2-eemi-3-karboksylaattisuolojen valmistamiseksi
GB9107363D0 (en) 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
US6083917A (en) 1990-04-18 2000-07-04 Board Of Regents, The University Of Texas System Methods and compositions for the identification, characterization and inhibition of farnesyltransferase
US5185248A (en) 1990-05-08 1993-02-09 E. R. Squibb & Sons, Inc. Farnesyl-protein transferase assay for identifying compounds that block neoplastic transformation
JPH0578360A (ja) 1991-01-31 1993-03-30 Banyu Pharmaceut Co Ltd ２−［２−（スルフアモイルアルキル）ピロリジニルチオカルバペネム誘導体
GB9107341D0 (en) 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
GB9107342D0 (en) 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
JP2559949B2 (ja) 1991-06-04 1996-12-04 三共株式会社 １−メチルカルバペネム誘導体
JPH04368386A (ja) 1991-06-18 1992-12-21 Sankyo Co Ltd １−メチルカルバペネム−３−カルボン酸の製造法
US5360798A (en) 1991-07-04 1994-11-01 Shionogi Seiyaku Kabushiki Kaisha Aminooxypyrrolidinylthiocarbapenem compounds
CA2080172A1 (en) 1991-10-11 1993-04-12 Scott A. Biller Method for blocking neoplastic transformation of cells induced by ras oncogenes
JPH05239058A (ja) 1991-12-17 1993-09-17 Fujisawa Pharmaceut Co Ltd ３−ピロリジニルチオ−１−アザビシクロ［３．２．０ヘプト−２−エン−２−カルボン酸化合物
GB9202298D0 (en) 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds
FI103046B1 (fi) 1992-03-11 1999-04-15 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten pyrrolidinyylitiokarbapeneemijohdannaisten valmistamiseksi
GB9304156D0 (en) 1992-03-26 1993-04-21 Zeneca Ltd Antibiotic compounds
CA2091309A1 (en) 1992-03-26 1993-09-27 Frederic H. Jung Antibiotic compounds
CA2117899A1 (en) 1992-04-13 1993-10-28 Masayoshi Murata Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents
EP0581501B1 (de) 1992-07-21 1998-09-09 Zeneca Limited Antibiotische Carbapenemverbindungen
EP0581502B1 (de) 1992-07-21 1998-10-21 Zeneca Limited Antibiotische carbapenemverbindungen
CA2099818A1 (en) 1992-07-21 1994-01-22 Frederic H. Jung Antibiotic compounds
EP0590885B1 (de) 1992-09-28 2000-03-15 Zeneca Limited Antibiotische Carbapenemverbindungen
CA2106330A1 (en) 1992-10-07 1994-04-08 Patrice J. Siret Antibiotic compounds
CA2118985A1 (en) 1993-04-02 1994-10-03 Dinesh V. Patel Heterocyclic inhibitors of farnesyl protein transferase
WO1995000497A1 (en) 1993-06-18 1995-01-05 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
JP2534823B2 (ja) 1993-07-07 1996-09-18 日本電気株式会社 印刷装置
US5468733A (en) 1993-09-30 1995-11-21 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5576293A (en) 1993-09-30 1996-11-19 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CA2155448A1 (en) 1994-08-11 1996-02-12 Katerina Leftheris Inhibitors of farnesyl protein transferase
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CA2216564A1 (en) 1995-03-29 1996-10-03 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CN1064682C (zh) 1995-07-31 2001-04-18 盐野义制药株式会社 具有磷脂酶a2抑制活性的吡咯烷衍生物
GB9515975D0 (en) 1995-08-04 1995-10-04 Zeneca Ltd Chemical compounds
JPH1050029A (ja) 1996-05-28 1998-02-20 Nobuyuki Higuchi 情報記憶装置
JP2001500118A (ja) 1996-08-17 2001-01-09 ゼネカ・リミテッド ファルネシルタンパク質トランスフェラーゼ阻害剤としての３―メルカプトピロリジン
US6414145B1 (en) 1997-01-29 2002-07-02 Zeneca Limited Imidazolyl compounds as inhibitors of farnesyl-protein tranferase
PH11998001072B1 (en) 1997-05-07 2006-11-21 Univ Pittsburgh Inhibitors of protein isoprenyl transferases
JP2002503650A (ja) 1998-02-10 2002-02-05 アストラゼネカ ユーケー リミテッド ファルネシルトランスフェラーゼ阻害剤

Also Published As

Publication number Publication date
WO2001046137A1 (en) 2001-06-28
US20030083348A1 (en) 2003-05-01
ATE316074T1 (de) 2006-02-15
IS6358A (is) 2002-04-23
RU2259997C2 (ru) 2005-09-10
MXPA02005981A (es) 2005-07-01
JP3742593B2 (ja) 2006-02-08
CN1680313A (zh) 2005-10-12
PL355887A1 (en) 2004-05-31
CN1411442A (zh) 2003-04-16
BR0016669A (pt) 2002-10-08
EP1255733A1 (de) 2002-11-13
NO20022924D0 (no) 2002-06-18
CO5360641A1 (es) 2004-01-30
AU2201301A (en) 2001-07-03
EP1255733B1 (de) 2006-01-18
CA2387579A1 (en) 2001-06-28
NZ518341A (en) 2004-01-30
RU2002119405A (ru) 2004-01-10
AR029460A1 (es) 2003-07-02
CZ20022125A3 (cs) 2002-09-11
NO20022924L (no) 2002-06-18
GB9930318D0 (en) 2000-02-09
DE60025650D1 (de) 2006-04-06
AU776003B2 (en) 2004-08-19
EE200200206A (et) 2003-04-15
KR20020063251A (ko) 2002-08-01
HUP0204135A3 (en) 2005-03-29
MY133606A (en) 2007-11-30
JP2003518091A (ja) 2003-06-03
CN1229344C (zh) 2005-11-30
US7101897B2 (en) 2006-09-05
ZA200202694B (en) 2003-12-31
HUP0204135A2 (hu) 2003-03-28
IL149871A0 (en) 2002-11-10

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