MY133606A - Farnesyl transferase inhibitors - Google Patents

Farnesyl transferase inhibitors

Info

Publication number
MY133606A
MY133606A MYPI20006011A MYPI20006011A MY133606A MY 133606 A MY133606 A MY 133606A MY PI20006011 A MYPI20006011 A MY PI20006011A MY PI20006011 A MYPI20006011 A MY PI20006011A MY 133606 A MY133606 A MY 133606A
Authority
MY
Malaysia
Prior art keywords
transferase inhibitors
farnesyl transferase
compounds
relates
farnesylation
Prior art date
Application number
MYPI20006011A
Other languages
English (en)
Inventor
Stanley Matusiak Zbigniew
Michael Wardleworth James
Thomas Boyle Francis
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MY133606A publication Critical patent/MY133606A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MYPI20006011A 1999-12-22 2000-12-20 Farnesyl transferase inhibitors MY133606A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9930318.2A GB9930318D0 (en) 1999-12-22 1999-12-22 Novel compounds

Publications (1)

Publication Number Publication Date
MY133606A true MY133606A (en) 2007-11-30

Family

ID=10866834

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI20006011A MY133606A (en) 1999-12-22 2000-12-20 Farnesyl transferase inhibitors

Country Status (27)

Country Link
US (1) US7101897B2 (enExample)
EP (1) EP1255733B1 (enExample)
JP (1) JP3742593B2 (enExample)
KR (1) KR20020063251A (enExample)
CN (2) CN1229344C (enExample)
AR (1) AR029460A1 (enExample)
AT (1) ATE316074T1 (enExample)
AU (1) AU776003B2 (enExample)
BR (1) BR0016669A (enExample)
CA (1) CA2387579A1 (enExample)
CO (1) CO5360641A1 (enExample)
CZ (1) CZ20022125A3 (enExample)
DE (1) DE60025650D1 (enExample)
EE (1) EE200200206A (enExample)
GB (1) GB9930318D0 (enExample)
HU (1) HUP0204135A3 (enExample)
IL (1) IL149871A0 (enExample)
IS (1) IS6358A (enExample)
MX (1) MXPA02005981A (enExample)
MY (1) MY133606A (enExample)
NO (1) NO20022924L (enExample)
NZ (1) NZ518341A (enExample)
PL (1) PL355887A1 (enExample)
RU (1) RU2259997C2 (enExample)
SK (1) SK8642002A3 (enExample)
WO (1) WO2001046137A1 (enExample)
ZA (1) ZA200202694B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005117864A1 (en) * 2004-05-28 2005-12-15 Astrazeneca Ab Combination product comprising anastrozole and a dual prenyl transferase inhibitor
CN101072783A (zh) * 2004-10-08 2007-11-14 寿制药株式会社 膦酸衍生物以及与血液高磷酸相关的疾病的治疗药
US20110136867A1 (en) * 2006-02-02 2011-06-09 Justman Craig J Treatment of Synucleinopathies
WO2009151683A2 (en) 2008-03-12 2009-12-17 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
CA2743717A1 (en) 2008-11-13 2010-05-20 Link Medicine Corporation Azaquinolinone derivatives and uses thereof
JP2012520884A (ja) 2009-03-18 2012-09-10 ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニバーシティー フラビウイルス科ウイルス感染症を治療する方法および組成物
WO2011088126A2 (en) * 2010-01-13 2011-07-21 Eiger Biopharmaceuticals, Inc. Treatment of viral infection with prenyltransferase inhibitors

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CA1283906C (en) 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
JPS60233076A (ja) 1984-05-03 1985-11-19 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物およびその製造法
CA1281720C (en) 1984-11-08 1991-03-19 Makoto Sunagawa Carbapenem compounds and production thereof
KR880006244A (ko) 1986-11-24 1988-07-22 후지사와 도모 기찌 로 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법
GB8921635D0 (en) 1989-09-25 1989-11-08 Fujisawa Pharmaceutical Co 3-pyrrolidinylthio-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives
CA2036163C (en) 1990-02-14 2001-06-19 Makoto Sunagawa Novel beta-lactam compounds and their production
CA2036941A1 (en) 1990-02-23 1991-08-24 Isao Kawamoto Carbapenem derivatives having antibiotic activity, their preparation and their use
GB9107363D0 (en) 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
US6083917A (en) 1990-04-18 2000-07-04 Board Of Regents, The University Of Texas System Methods and compositions for the identification, characterization and inhibition of farnesyltransferase
US5185248A (en) 1990-05-08 1993-02-09 E. R. Squibb & Sons, Inc. Farnesyl-protein transferase assay for identifying compounds that block neoplastic transformation
JPH0578360A (ja) 1991-01-31 1993-03-30 Banyu Pharmaceut Co Ltd ２−［２−（スルフアモイルアルキル）ピロリジニルチオカルバペネム誘導体
GB9107342D0 (en) 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
GB9107341D0 (en) 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
JP2559949B2 (ja) 1991-06-04 1996-12-04 三共株式会社 １−メチルカルバペネム誘導体
JPH04368386A (ja) 1991-06-18 1992-12-21 Sankyo Co Ltd １−メチルカルバペネム−３−カルボン酸の製造法
US5360798A (en) 1991-07-04 1994-11-01 Shionogi Seiyaku Kabushiki Kaisha Aminooxypyrrolidinylthiocarbapenem compounds
EP0537007B1 (en) 1991-10-11 1995-08-09 E.R. SQUIBB & SONS, INC. Use of formesyl-protein transferase inhibitors for the manufacture of a medicament for blocking neoplastic transformation of cells induced by ras oncogenes
JPH05239058A (ja) 1991-12-17 1993-09-17 Fujisawa Pharmaceut Co Ltd ３−ピロリジニルチオ−１−アザビシクロ［３．２．０ヘプト−２−エン−２−カルボン酸化合物
GB9202298D0 (en) 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds
HU218676B (hu) 1992-03-11 2000-10-28 Sankyo Co. Ltd. Antimikrobiális karbapenemszármazékok, ilyen vegyületeket tartalmazó gyógyászati készítmények és eljárás ezek előállítására
GB9304156D0 (en) 1992-03-26 1993-04-21 Zeneca Ltd Antibiotic compounds
CA2091309A1 (en) 1992-03-26 1993-09-27 Frederic H. Jung Antibiotic compounds
AU3904493A (en) 1992-04-13 1993-11-18 Fujisawa Pharmaceutical Co., Ltd. Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents
CA2099818A1 (en) 1992-07-21 1994-01-22 Frederic H. Jung Antibiotic compounds
EP0581502B1 (en) 1992-07-21 1998-10-21 Zeneca Limited Antibiotic carbapenem compounds
EP0581501B1 (en) 1992-07-21 1998-09-09 Zeneca Limited Antibiotic carbapenem compounds
EP0590885B1 (en) 1992-09-28 2000-03-15 Zeneca Limited Antibiotic carbapenem compounds
CA2106330A1 (en) 1992-10-07 1994-04-08 Patrice J. Siret Antibiotic compounds
CA2118985A1 (en) 1993-04-02 1994-10-03 Dinesh V. Patel Heterocyclic inhibitors of farnesyl protein transferase
EP0703905A1 (en) 1993-06-18 1996-04-03 Merck & Co. Inc. Inhibitors of farnesyl-protein transferase
JP2534823B2 (ja) 1993-07-07 1996-09-18 日本電気株式会社 印刷装置
US5468733A (en) 1993-09-30 1995-11-21 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
EP0725650A4 (en) 1993-09-30 1999-02-03 Merck & Co Inc INHIBITORS OF FARNESYL PROTEIN TRANSFERASE
CA2155448A1 (en) 1994-08-11 1996-02-12 Katerina Leftheris Inhibitors of farnesyl protein transferase
US5571835A (en) 1994-09-29 1996-11-05 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1996030015A1 (en) 1995-03-29 1996-10-03 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
BR9609744A (pt) 1995-07-31 1999-03-02 Shionogi & Co Derivados de pirrolidina tendo atividade inibitória de fosfolipase a2
GB9515975D0 (en) 1995-08-04 1995-10-04 Zeneca Ltd Chemical compounds
RU2128165C1 (ru) * 1995-09-18 1999-03-27 Санкио Компани Лимитед Производные амидов и композиция, обладающая асат-ингибирующей активностью
JPH1050029A (ja) 1996-05-28 1998-02-20 Nobuyuki Higuchi 情報記憶装置
EP0923545A1 (en) * 1996-08-17 1999-06-23 Zeneca Limited 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors
JP2001509156A (ja) 1997-01-29 2001-07-10 ゼネカ・リミテッド ファルネシルプロテイントランスフェラーゼの阻害剤
PH11998001073B1 (en) 1997-05-07 2007-07-23 Univ Pittsburgh Inhibitors of protein isoprenyl transferases
EP1054865A1 (en) * 1998-02-10 2000-11-29 AstraZeneca UK Limited Farnesyl transferase inhibitors

Also Published As

Publication number Publication date
HUP0204135A2 (hu) 2003-03-28
NZ518341A (en) 2004-01-30
EP1255733B1 (en) 2006-01-18
ATE316074T1 (de) 2006-02-15
AR029460A1 (es) 2003-07-02
MXPA02005981A (es) 2005-07-01
CN1229344C (zh) 2005-11-30
AU776003B2 (en) 2004-08-19
JP2003518091A (ja) 2003-06-03
CA2387579A1 (en) 2001-06-28
SK8642002A3 (en) 2002-12-03
RU2002119405A (ru) 2004-01-10
HUP0204135A3 (en) 2005-03-29
EE200200206A (et) 2003-04-15
CN1680313A (zh) 2005-10-12
RU2259997C2 (ru) 2005-09-10
US7101897B2 (en) 2006-09-05
JP3742593B2 (ja) 2006-02-08
IS6358A (is) 2002-04-23
CO5360641A1 (es) 2004-01-30
EP1255733A1 (en) 2002-11-13
NO20022924D0 (no) 2002-06-18
PL355887A1 (en) 2004-05-31
US20030083348A1 (en) 2003-05-01
DE60025650D1 (de) 2006-04-06
CN1411442A (zh) 2003-04-16
KR20020063251A (ko) 2002-08-01
WO2001046137A1 (en) 2001-06-28
CZ20022125A3 (cs) 2002-09-11
BR0016669A (pt) 2002-10-08
NO20022924L (no) 2002-06-18
IL149871A0 (en) 2002-11-10
GB9930318D0 (en) 2000-02-09
ZA200202694B (en) 2003-12-31
AU2201301A (en) 2001-07-03

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