JP3742593B2 - ファルネシルトランスフェラーゼ阻害剤 - Google Patents

ファルネシルトランスフェラーゼ阻害剤 Download PDF

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Publication number
JP3742593B2
JP3742593B2 JP2001547048A JP2001547048A JP3742593B2 JP 3742593 B2 JP3742593 B2 JP 3742593B2 JP 2001547048 A JP2001547048 A JP 2001547048A JP 2001547048 A JP2001547048 A JP 2001547048A JP 3742593 B2 JP3742593 B2 JP 3742593B2
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JP
Japan
Prior art keywords
compound
formula
group
amino
groups
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2001547048A
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English (en)
Japanese (ja)
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JP2003518091A (ja
JP2003518091A5 (enExample
Inventor
ボイル，フランシス・トーマス
ウォードレウォース，ジェイムス・マイケル
マツシアク，ズビグニエウ
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AstraZeneca AB
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AstraZeneca AB
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Publication of JP2003518091A publication Critical patent/JP2003518091A/ja
Publication of JP2003518091A5 publication Critical patent/JP2003518091A5/ja
Application granted granted Critical
Publication of JP3742593B2 publication Critical patent/JP3742593B2/ja
Anticipated expiration legal-status Critical
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2001547048A 1999-12-22 2000-12-18 ファルネシルトランスフェラーゼ阻害剤 Expired - Fee Related JP3742593B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9930318.2A GB9930318D0 (en) 1999-12-22 1999-12-22 Novel compounds
GB9930318.2 1999-12-22
PCT/GB2000/004856 WO2001046137A1 (en) 1999-12-22 2000-12-18 Farnesyl transferase inhibitors

Publications (3)

Publication Number Publication Date
JP2003518091A JP2003518091A (ja) 2003-06-03
JP2003518091A5 JP2003518091A5 (enExample) 2005-12-22
JP3742593B2 true JP3742593B2 (ja) 2006-02-08

Family

ID=10866834

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001547048A Expired - Fee Related JP3742593B2 (ja) 1999-12-22 2000-12-18 ファルネシルトランスフェラーゼ阻害剤

Country Status (27)

Country Link
US (1) US7101897B2 (enExample)
EP (1) EP1255733B1 (enExample)
JP (1) JP3742593B2 (enExample)
KR (1) KR20020063251A (enExample)
CN (2) CN1229344C (enExample)
AR (1) AR029460A1 (enExample)
AT (1) ATE316074T1 (enExample)
AU (1) AU776003B2 (enExample)
BR (1) BR0016669A (enExample)
CA (1) CA2387579A1 (enExample)
CO (1) CO5360641A1 (enExample)
CZ (1) CZ20022125A3 (enExample)
DE (1) DE60025650D1 (enExample)
EE (1) EE200200206A (enExample)
GB (1) GB9930318D0 (enExample)
HU (1) HUP0204135A3 (enExample)
IL (1) IL149871A0 (enExample)
IS (1) IS6358A (enExample)
MX (1) MXPA02005981A (enExample)
MY (1) MY133606A (enExample)
NO (1) NO20022924L (enExample)
NZ (1) NZ518341A (enExample)
PL (1) PL355887A1 (enExample)
RU (1) RU2259997C2 (enExample)
SK (1) SK8642002A3 (enExample)
WO (1) WO2001046137A1 (enExample)
ZA (1) ZA200202694B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005117864A1 (en) * 2004-05-28 2005-12-15 Astrazeneca Ab Combination product comprising anastrozole and a dual prenyl transferase inhibitor
WO2006038719A1 (ja) * 2004-10-08 2006-04-13 Kotobuki Pharmaceutical Co., Ltd. ホスホン酸誘導体及び血中の高リン酸が関与する疾患の治療剤
US20110136867A1 (en) * 2006-02-02 2011-06-09 Justman Craig J Treatment of Synucleinopathies
WO2009151683A2 (en) 2008-03-12 2009-12-17 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
WO2010057006A1 (en) 2008-11-13 2010-05-20 Link Medicine Corporation Azaquinolinone derivatives and uses thereof
US8975247B2 (en) 2009-03-18 2015-03-10 The Board Of Trustees Of The Leland Stanford Junion University Methods and compositions of treating a flaviviridae family viral infection
WO2011088126A2 (en) * 2010-01-13 2011-07-21 Eiger Biopharmaceuticals, Inc. Treatment of viral infection with prenyltransferase inhibitors

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SU422723A1 (ru) * 1972-03-29 1974-04-05 Б. В. Салов, Т. А. Губенкова , И. В. Быховска Способ получения 5-нитро-2-аминобензойнойкислоты
CA1283906C (en) 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
JPS60233076A (ja) 1984-05-03 1985-11-19 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物およびその製造法
EP0182213B1 (en) 1984-11-08 1990-09-26 Sumitomo Pharmaceuticals Company, Limited Carbapenem compounds and production thereof
KR880006244A (ko) 1986-11-24 1988-07-22 후지사와 도모 기찌 로 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법
GB8921635D0 (en) 1989-09-25 1989-11-08 Fujisawa Pharmaceutical Co 3-pyrrolidinylthio-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives
CA2036163C (en) 1990-02-14 2001-06-19 Makoto Sunagawa Novel beta-lactam compounds and their production
FI96863C (fi) 1990-02-23 1996-09-10 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten /2-(1-homopiperatsiinikarbonyyli)pyrrolidin-4-yylitio/-6-(1-hydroksietyyli)-1-karbapen-2-eemi-3-karboksylaattisuolojen valmistamiseksi
GB9107363D0 (en) 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
US6083917A (en) 1990-04-18 2000-07-04 Board Of Regents, The University Of Texas System Methods and compositions for the identification, characterization and inhibition of farnesyltransferase
US5185248A (en) 1990-05-08 1993-02-09 E. R. Squibb & Sons, Inc. Farnesyl-protein transferase assay for identifying compounds that block neoplastic transformation
JPH0578360A (ja) 1991-01-31 1993-03-30 Banyu Pharmaceut Co Ltd ２−［２−（スルフアモイルアルキル）ピロリジニルチオカルバペネム誘導体
GB9107341D0 (en) 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
GB9107342D0 (en) 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
AU651887B2 (en) 1991-06-04 1994-08-04 Sankyo Company Limited 1-methylcarbapenem derivatives, their preparation and their use as antibiotics
JPH04368386A (ja) 1991-06-18 1992-12-21 Sankyo Co Ltd １−メチルカルバペネム−３−カルボン酸の製造法
US5360798A (en) 1991-07-04 1994-11-01 Shionogi Seiyaku Kabushiki Kaisha Aminooxypyrrolidinylthiocarbapenem compounds
DE69204007T2 (de) 1991-10-11 1996-03-21 Squibb & Sons Inc Verwendung von Farnesyl-Protein Transferaseinhibitoren zur Herstellung eines Arzneimittels zur Blockierung von durch Ras-Oncogenen hervorgerufenen neoplastischen Transformationen von Zellen.
JPH05239058A (ja) 1991-12-17 1993-09-17 Fujisawa Pharmaceut Co Ltd ３−ピロリジニルチオ−１−アザビシクロ［３．２．０ヘプト−２−エン−２−カルボン酸化合物
GB9202298D0 (en) 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds
CZ290002B6 (cs) 1992-03-11 2002-05-15 Sankyo Company Limited Antimikrobiální karbapenemové deriváty, způsob výroby a farmaceutický prostředek
GB9304156D0 (en) 1992-03-26 1993-04-21 Zeneca Ltd Antibiotic compounds
CA2091309A1 (en) 1992-03-26 1993-09-27 Frederic H. Jung Antibiotic compounds
JP3367104B2 (ja) 1992-04-13 2003-01-14 藤沢薬品工業株式会社 抗菌剤としての置換された３−ピロリジニルチオ−カルバペネム化合物
EP0581501B1 (en) 1992-07-21 1998-09-09 Zeneca Limited Antibiotic carbapenem compounds
EP0581502B1 (en) 1992-07-21 1998-10-21 Zeneca Limited Antibiotic carbapenem compounds
CA2099818A1 (en) 1992-07-21 1994-01-22 Frederic H. Jung Antibiotic compounds
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CA2106330A1 (en) 1992-10-07 1994-04-08 Patrice J. Siret Antibiotic compounds
CA2118985A1 (en) 1993-04-02 1994-10-03 Dinesh V. Patel Heterocyclic inhibitors of farnesyl protein transferase
CA2165176A1 (en) 1993-06-18 1995-01-05 Samuel L. Graham Inhibitors of farnesyl-protein transferase
JP2534823B2 (ja) 1993-07-07 1996-09-18 日本電気株式会社 印刷装置
US5468733A (en) 1993-09-30 1995-11-21 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
EP0725650A4 (en) 1993-09-30 1999-02-03 Merck & Co Inc INHIBITORS OF FARNESYL PROTEIN TRANSFERASE
CA2155448A1 (en) 1994-08-11 1996-02-12 Katerina Leftheris Inhibitors of farnesyl protein transferase
US5571835A (en) 1994-09-29 1996-11-05 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
EP0817630A4 (en) 1995-03-29 1999-01-27 Merck & Co Inc INHIBITORS OF FARNESYL PROTEIN TRANSFERASE
BR9609744A (pt) 1995-07-31 1999-03-02 Shionogi & Co Derivados de pirrolidina tendo atividade inibitória de fosfolipase a2
GB9515975D0 (en) 1995-08-04 1995-10-04 Zeneca Ltd Chemical compounds
NO307879B1 (no) * 1995-09-18 2000-06-13 Sankyo Co Nye ureaderivater med ACAT-inhiberende aktivitet og farmasøytisk preparat inneholdende disse
JPH1050029A (ja) 1996-05-28 1998-02-20 Nobuyuki Higuchi 情報記憶装置
WO1998007692A1 (en) * 1996-08-17 1998-02-26 Zeneca Limited 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors
US6414145B1 (en) 1997-01-29 2002-07-02 Zeneca Limited Imidazolyl compounds as inhibitors of farnesyl-protein tranferase
AR015649A1 (es) 1997-05-07 2001-05-16 Univ Pittsburgh Inhibidores de isoprenil-transferasas proteicas, composiciones que los comprenden y el uso de los mismos para la fabricacion de un medicamento
WO1999041235A1 (en) * 1998-02-10 1999-08-19 Astrazeneca Uk Limited Farnesyl transferase inhibitors

Also Published As

Publication number Publication date
NO20022924D0 (no) 2002-06-18
AU776003B2 (en) 2004-08-19
GB9930318D0 (en) 2000-02-09
DE60025650D1 (de) 2006-04-06
AU2201301A (en) 2001-07-03
NO20022924L (no) 2002-06-18
EP1255733B1 (en) 2006-01-18
BR0016669A (pt) 2002-10-08
IL149871A0 (en) 2002-11-10
IS6358A (is) 2002-04-23
CN1680313A (zh) 2005-10-12
EP1255733A1 (en) 2002-11-13
EE200200206A (et) 2003-04-15
CO5360641A1 (es) 2004-01-30
AR029460A1 (es) 2003-07-02
ATE316074T1 (de) 2006-02-15
CN1411442A (zh) 2003-04-16
KR20020063251A (ko) 2002-08-01
SK8642002A3 (en) 2002-12-03
MY133606A (en) 2007-11-30
JP2003518091A (ja) 2003-06-03
WO2001046137A1 (en) 2001-06-28
ZA200202694B (en) 2003-12-31
US7101897B2 (en) 2006-09-05
RU2259997C2 (ru) 2005-09-10
CZ20022125A3 (cs) 2002-09-11
PL355887A1 (en) 2004-05-31
RU2002119405A (ru) 2004-01-10
CN1229344C (zh) 2005-11-30
US20030083348A1 (en) 2003-05-01
HUP0204135A2 (hu) 2003-03-28
CA2387579A1 (en) 2001-06-28
MXPA02005981A (es) 2005-07-01
HUP0204135A3 (en) 2005-03-29
NZ518341A (en) 2004-01-30

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