CN1203089C - 新化合物 - Google Patents

新化合物 Download PDF

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Publication number
CN1203089C
CN1203089C CNB95196643XA CN95196643A CN1203089C CN 1203089 C CN1203089 C CN 1203089C CN B95196643X A CNB95196643X A CN B95196643XA CN 95196643 A CN95196643 A CN 95196643A CN 1203089 C CN1203089 C CN 1203089C
Authority
CN
China
Prior art keywords
phenyl
nmr
alkoxy
preparation
apci
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB95196643XA
Other languages
English (en)
Chinese (zh)
Other versions
CN1168675A (zh
Inventor
大木秀德
富岛昌纪
山田明
高杉寿
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26305774&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1203089(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB9420425A external-priority patent/GB9420425D0/en
Priority claimed from GBGB9508745.8A external-priority patent/GB9508745D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of CN1168675A publication Critical patent/CN1168675A/zh
Application granted granted Critical
Publication of CN1203089C publication Critical patent/CN1203089C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CNB95196643XA 1994-10-07 1995-09-29 新化合物 Expired - Lifetime CN1203089C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9420425A GB9420425D0 (en) 1994-10-07 1994-10-07 New compound
GB9420425.2 1994-10-07
GB9508745.8 1995-04-28
GBGB9508745.8A GB9508745D0 (en) 1995-04-28 1995-04-28 New compound

Publications (2)

Publication Number Publication Date
CN1168675A CN1168675A (zh) 1997-12-24
CN1203089C true CN1203089C (zh) 2005-05-25

Family

ID=26305774

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB95196643XA Expired - Lifetime CN1203089C (zh) 1994-10-07 1995-09-29 新化合物

Country Status (26)

Country Link
US (2) US6107458A (OSRAM)
EP (1) EP0788511B1 (OSRAM)
JP (2) JP2897427B2 (OSRAM)
KR (1) KR100353303B1 (OSRAM)
CN (1) CN1203089C (OSRAM)
AR (1) AR041770A1 (OSRAM)
AT (1) ATE229541T1 (OSRAM)
AU (1) AU696949B2 (OSRAM)
BR (2) BRPI9504791B8 (OSRAM)
CA (1) CA2202058C (OSRAM)
DE (2) DE69529172T2 (OSRAM)
DK (1) DK0788511T3 (OSRAM)
ES (1) ES2187575T3 (OSRAM)
FI (1) FI119988B (OSRAM)
FR (1) FR08C0028I2 (OSRAM)
HU (1) HU228151B1 (OSRAM)
IL (1) IL115484A (OSRAM)
LU (1) LU91452I2 (OSRAM)
MX (1) MX9702531A (OSRAM)
NL (1) NL300352I2 (OSRAM)
NO (2) NO328483B1 (OSRAM)
OA (1) OA10475A (OSRAM)
PT (1) PT788511E (OSRAM)
RU (1) RU2165423C2 (OSRAM)
TR (1) TR199501229A2 (OSRAM)
WO (1) WO1996011210A1 (OSRAM)

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US5696084A (en) * 1996-08-16 1997-12-09 Abbott Laboratories Amino-lipopetide antifungal agents
AUPO371596A0 (en) * 1996-11-19 1996-12-12 Fujisawa Pharmaceutical Co., Ltd. New compound
AUPO381496A0 (en) * 1996-11-25 1996-12-19 Fujisawa Pharmaceutical Co., Ltd. New compound
EP0994101A4 (en) * 1997-06-18 2002-05-02 Fujisawa Pharmaceutical Co NEW PREPARATION PROCESS
AU756792B2 (en) * 1998-02-09 2003-01-23 Fujisawa Pharmaceutical Co., Ltd. New compound
TR200003064T2 (tr) * 1998-02-09 2001-02-21 Fujisawa Pharmaceutical Co; Ltd. Yeni bileşik
US7084279B1 (en) * 1999-02-11 2006-08-01 Emisphere Technologies Inc. Oxadiazole compounds and compositions for delivering active agents
DE60024414T2 (de) * 1999-02-11 2006-06-14 Emisphere Tech Inc Oxadiazolverbindungen und -zusammensetzungen zur abgabe von wirkstoffen
AUPP999799A0 (en) * 1999-04-27 1999-05-20 Fujisawa Pharmaceutical Co., Ltd. New compound
AUPQ066399A0 (en) * 1999-05-31 1999-06-24 Fujisawa Pharmaceutical Co., Ltd. Antifungal combination use
TWI233805B (en) 1999-07-01 2005-06-11 Fujisawa Pharmaceutical Co Stabilized pharmaceutical composition in lyophilized form as antifungal agent
US7166572B1 (en) 1999-07-27 2007-01-23 Aventis Pharma Deutschland Gmbh Cyclohexapeptide compounds, processes for their production and their use as a pharmaceutical
AUPQ462399A0 (en) * 1999-12-13 2000-01-13 Fujisawa Pharmaceutical Co., Ltd. New use
TWI250992B (en) 2000-02-21 2006-03-11 Astellas Pharma Inc Polypeptide compounds for the prophylactic and/or therapeutic treatment of infectious diseases caused by pathogenic microorganisms
ES2191516B1 (es) * 2000-07-28 2005-01-01 Consejo Superior De Investigaciones Cientificas Antibioticos antifungicos de naturaleza peptidica inhibidores de la germinacion y el crecimiento de hongos fitopatogenos.
AUPQ938700A0 (en) * 2000-08-14 2000-09-07 Fujisawa Pharmaceutical Co., Ltd. Antifungal combination use
EP1356816B1 (en) 2001-01-29 2009-12-23 Shionogi & Co., Ltd. Medicinal preparation containing 5-methyl-1-phenyl-2-(1h)-pyridone as active ingredient
JP2005053782A (ja) * 2001-08-31 2005-03-03 Fujisawa Pharmaceut Co Ltd 環状リポペプチド化合物の新規結晶
CA2477088A1 (en) 2002-02-22 2003-10-02 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
WO2004014879A1 (en) * 2002-08-08 2004-02-19 Fujisawa Pharmaceutical Co., Ltd. New process
AU2003903205A0 (en) * 2003-06-23 2003-07-10 Fujisawa Pharmaceutical Co., Ltd. New compound
EP1654036B1 (en) * 2003-07-22 2007-12-26 Theravance, Inc. Use of an echinocandin antifungal agent in combination with a glycopeptide antibacterial agent
EP1663275A2 (en) * 2003-09-05 2006-06-07 Merck & Co., Inc. Stationary phases and a purification process using the stationary phases
ATE547404T1 (de) * 2003-09-22 2012-03-15 Msd Kk Piperidinderivate
US7476673B2 (en) * 2003-12-30 2009-01-13 Allergan, Inc. Disubstituted chalcone oximes as selective agonists of RARγ retinoid receptors
US20050261365A1 (en) * 2004-05-20 2005-11-24 The Scripps Research Institute Transthyretin stabilization
CA2580844A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase
US7919496B2 (en) 2004-09-20 2011-04-05 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes
WO2006034441A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
CN101084211A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为治疗剂的用途
JP4958785B2 (ja) 2004-09-20 2012-06-20 ゼノン・ファーマシューティカルズ・インコーポレイテッド 複素環誘導体およびステアロイル−ＣｏＡデサチュラーゼインヒビターとしてのそれらの使用
US7767677B2 (en) 2004-09-20 2010-08-03 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
AR051094A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
JP2008515992A (ja) * 2004-10-13 2008-05-15 ピーティーシー セラピューティクス，インコーポレーテッド 体細胞変異に起因する疾患の阻止／治療用医薬を製造するための規定化合物の使用
EP2540296A1 (en) 2005-06-03 2013-01-02 Xenon Pharmaceuticals Inc. Arminothiazole derivatives as human stearoyl-coa desaturase inhibitors
US7947707B2 (en) * 2005-10-07 2011-05-24 Kissei Pharmaceutical Co., Ltd. Nitrogenated heterocyclic compound and pharmaceutical composition comprising the same
CN101516387B (zh) * 2006-07-26 2014-06-04 桑多斯股份公司 卡泊芬净制剂
US8853392B2 (en) 2007-06-03 2014-10-07 Vanderbilt University Benzamide mGluR5 positive allosteric modulators and methods of making and using same
CN104054719B (zh) 2007-08-13 2016-09-28 孟山都技术有限责任公司 用于控制线虫的组合物和方法
TW200934507A (en) * 2007-10-29 2009-08-16 Astellas Pharma Inc Polypeptide compounds
US8034806B2 (en) 2007-11-02 2011-10-11 Vanderbilt University Bicyclic mGluR5 positive allosteric modulators and methods of making and using same
KR101273765B1 (ko) * 2008-06-24 2013-06-12 아이알엠 엘엘씨 Ｇ 단백질-커플링된 수용체를 조정하는 화합물 및 방법
US9394340B2 (en) 2009-03-24 2016-07-19 Cadila Healthcare Limited Purification process for lipopeptides
BR112013023531A2 (pt) * 2011-04-04 2016-12-06 Xellia Pharmaceuticals Aps processo de um único vaso para a fabricação de micafungina ou de um sal desta
HUE027806T2 (en) 2011-04-20 2016-11-28 Xellia Pharmaceuticals Aps A method for purifying micafungin
CN102775476B (zh) * 2011-05-12 2015-01-07 上海天伟生物制药有限公司 一种米卡芬净钠盐的制备方法
WO2012158844A1 (en) 2011-05-17 2012-11-22 Shionogi & Co., Ltd. Heterocyclic compounds
RU2014113624A (ru) * 2011-09-09 2015-10-20 Сандоз Аг Получение промежуточных продуктов для получения микафунгина
CN102659930B (zh) 2012-03-30 2014-04-23 上海天伟生物制药有限公司 一种高纯度环肽类物质的晶体及其制备方法和用途
CN102627689B (zh) * 2012-03-30 2014-08-06 上海天伟生物制药有限公司 一种环肽类化合物的水合物及其制备方法和用途
CN102627688B (zh) 2012-03-30 2014-12-31 上海天伟生物制药有限公司 一种高纯度环肽化合物及其制备方法和用途
EP3150621A4 (en) * 2014-05-29 2017-12-27 Shanghai Techwell Biopharmaceutical Co., Ltd Composition of cyclic peptide compound, preparation method for same, and uses thereof
CN104861044B (zh) * 2014-05-29 2019-03-01 上海天伟生物制药有限公司 一种环肽类化合物的溶剂合物及其制备方法和用途
WO2016056023A2 (en) * 2014-10-07 2016-04-14 Alaparthi Lakshmi Prasad Intermediates and processes to prepare micafungin
CA2937365C (en) 2016-03-29 2018-09-18 F. Hoffmann-La Roche Ag Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same
US12403173B2 (en) 2016-12-16 2025-09-02 Baxter International Inc. Micafungin compositions
EP3485873A1 (en) 2017-11-17 2019-05-22 Cadila Healthcare Limited Stable pharmaceutical injectable compositions of micafungin
CN108752430B (zh) * 2018-05-31 2022-02-18 杭州中美华东制药有限公司 米卡芬净钠新晶型及其制备方法
WO2020013116A1 (ja) * 2018-07-10 2020-01-16 京都薬品工業株式会社 Ｐｔｐ－１ｂ阻害剤およびその用途
CN110734408A (zh) * 2019-10-22 2020-01-31 重庆康乐制药有限公司 一种米卡芬净类衍生物侧链中间体的制备方法
CN115785226A (zh) * 2021-09-09 2023-03-14 上海天伟生物制药有限公司 一种棘白菌素药物杂质及其制备、纯化方法和应用

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IE990233A1 (en) * 1990-06-18 2000-11-15 Fujisawa Pharmaceutical Co New Polypeptide Compound and a Process for Preparation thereof
CZ288974B6 (cs) * 1992-03-19 2001-10-17 Eli Lilly And Company Acylový derivát echinocandinu, způsob jeho přípravy, farmaceutický prostředek s jeho obsahem a jeho pouľití

Also Published As

Publication number Publication date
MX9702531A (es) 1997-06-28
EP0788511A1 (en) 1997-08-13
NL300352I1 (nl) 2008-08-01
FI971397L (fi) 1997-05-27
IL115484A0 (en) 1996-01-19
FR08C0028I1 (OSRAM) 2008-08-15
US6107458A (en) 2000-08-22
HUT77736A (hu) 1998-07-28
NO328483B1 (no) 2010-03-01
DE122008000025I2 (de) 2011-02-17
AU3578095A (en) 1996-05-02
CN1168675A (zh) 1997-12-24
RU2165423C2 (ru) 2001-04-20
LU91452I2 (fr) 2008-08-04
HK1004136A1 (en) 1998-11-20
AU696949B2 (en) 1998-09-24
DE69529172T2 (de) 2003-04-17
NO2010016I1 (no) 2010-08-16
FI971397A0 (fi) 1997-04-04
JPH10507174A (ja) 1998-07-14
BRPI9504791B8 (pt) 2019-12-31
JP2897427B2 (ja) 1999-05-31
CA2202058A1 (en) 1996-04-18
NL300352I2 (nl) 2008-11-03
KR970707150A (ko) 1997-12-01
WO1996011210A1 (en) 1996-04-18
FI119988B (fi) 2009-05-29
NO971544D0 (no) 1997-04-04
DE122008000025I1 (de) 2008-08-21
CA2202058C (en) 2007-11-06
TR199501229A2 (tr) 1996-07-21
IL115484A (en) 2000-07-16
EP0788511B1 (en) 2002-12-11
JP3518665B2 (ja) 2004-04-12
OA10475A (en) 2002-04-08
DK0788511T3 (da) 2003-03-31
FR08C0028I2 (OSRAM) 2009-11-20
PT788511E (pt) 2003-04-30
NO971544L (no) 1997-06-04
NO2010016I2 (no) 2011-10-17
JPH10324695A (ja) 1998-12-08
DE69529172D1 (de) 2003-01-23
KR100353303B1 (ko) 2003-01-15
US6265536B1 (en) 2001-07-24
BR9504791A (pt) 1996-10-22
ATE229541T1 (de) 2002-12-15
BR9504791B1 (pt) 2010-10-05
HU228151B1 (en) 2012-12-28
ES2187575T3 (es) 2003-06-16
AR041770A1 (es) 2005-06-01

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Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee

Owner name: ASTELLAS PHARMA INC.

Free format text: FORMER NAME OR ADDRESS: FUJISAWA PHARMACEUTICAL CO., LTD.

CP03 Change of name, title or address

Address after: Tokyo, Japan

Patentee after: Yamanouchi Pharma Co., Ltd.

Address before: Osaka City, Osaka of Japan

Patentee before: Fujisawa Pharmaceutical Co., Ltd.

CX01 Expiry of patent term

Granted publication date: 20050525

EXPY Termination of patent right or utility model