CN1201016C - 用于监测dna聚合酶链反应的仪器 - Google Patents

用于监测dna聚合酶链反应的仪器 Download PDF

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Publication number
CN1201016C
CN1201016C CNB998061999A CN99806199A CN1201016C CN 1201016 C CN1201016 C CN 1201016C CN B998061999 A CNB998061999 A CN B998061999A CN 99806199 A CN99806199 A CN 99806199A CN 1201016 C CN1201016 C CN 1201016C
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emission
data
dye
excitation
detector
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Chinese (zh)
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CN1309766A (zh
Inventor
M·R·干比尼
J·G·阿特伍德
E·F·杨
E·J·拉卡托斯
A·L·塞罗内
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Applied Biosystems Inc
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Pe Co Ny
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    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
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    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
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    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2545/00—Reactions characterised by their quantitative nature
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    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
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    • G—PHYSICS
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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
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    • G—PHYSICS
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    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
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    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
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  • Chemical & Material Sciences (AREA)
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  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Mathematical Physics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Optics & Photonics (AREA)
  • Theoretical Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Clinical Laboratory Science (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
CNB998061999A 1998-05-16 1999-05-17 用于监测dna聚合酶链反应的仪器 Expired - Lifetime CN1201016C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8576598P 1998-05-16 1998-05-16
US60/085,765 1998-05-16
US9278498P 1998-07-14 1998-07-14
US60/092,784 1998-07-14

Related Child Applications (1)

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CN2005100548515A Division CN1664562A (zh) 1998-05-16 1999-05-17 用于监测dna聚合酶链反应的仪器

Publications (2)

Publication Number Publication Date
CN1309766A CN1309766A (zh) 2001-08-22
CN1201016C true CN1201016C (zh) 2005-05-11

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CNB998061999A Expired - Lifetime CN1201016C (zh) 1998-05-16 1999-05-17 用于监测dna聚合酶链反应的仪器
CN2005100548515A Pending CN1664562A (zh) 1998-05-16 1999-05-17 用于监测dna聚合酶链反应的仪器

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US (1) US9671342B2 (enExample)
EP (4) EP1978351B1 (enExample)
JP (7) JP2003524754A (enExample)
CN (2) CN1201016C (enExample)
AT (2) ATE425448T1 (enExample)
AU (1) AU759974B2 (enExample)
CA (1) CA2328609A1 (enExample)
DE (2) DE69939259D1 (enExample)
WO (1) WO1999060381A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107044886A (zh) * 2017-01-20 2017-08-15 武汉呵尔医疗科技发展有限公司 一种多波段光谱成像光源、成像方法及显微镜

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7560273B2 (en) * 2002-07-23 2009-07-14 Applied Biosystems, Llc Slip cover for heated platen assembly
US6818437B1 (en) 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
EP1978351B1 (en) 1998-05-16 2011-11-30 Life Technologies Corporation Instrument for monitoring polymerase chain reaction of dna
US7498164B2 (en) 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
US7410793B2 (en) 1999-05-17 2008-08-12 Applera Corporation Optical instrument including excitation source
US20050279949A1 (en) 1999-05-17 2005-12-22 Applera Corporation Temperature control for light-emitting diode stabilization
US7423750B2 (en) 2001-11-29 2008-09-09 Applera Corporation Configurations, systems, and methods for optical scanning with at least one first relative angular motion and at least one second angular motion or at least one linear motion
US7387891B2 (en) 1999-05-17 2008-06-17 Applera Corporation Optical instrument including excitation source
EP1617207A3 (en) * 1999-07-21 2006-05-31 Applera Corporation Luminescence detection workstation
EP1221038A4 (en) * 1999-07-21 2004-09-08 Applera Corp Luminescence detection workstation
CA2408939C (en) * 2000-05-09 2011-11-08 Xy, Inc. High purity x-chromosome bearing and y-chromosome bearing populations of spermatozoa
US6563581B1 (en) 2000-07-14 2003-05-13 Applera Corporation Scanning system and method for scanning a plurality of samples
JP3741051B2 (ja) * 2001-05-10 2006-02-01 横河電機株式会社 バイオチップ読取装置
US6594010B2 (en) * 2001-07-06 2003-07-15 Praxair Technology, Inc. Emission spectrometer having a charge coupled device detector
US6867005B2 (en) * 2001-10-24 2005-03-15 Beckman Coulter, Inc. Method and apparatus for increasing the dynamic range and accuracy of binding assays
US7635588B2 (en) 2001-11-29 2009-12-22 Applied Biosystems, Llc Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength
DE10201463B4 (de) 2002-01-16 2005-07-21 Clondiag Chip Technologies Gmbh Reaktionsgefäß zur Durchführung von Array-Verfahren
DE10204531A1 (de) * 2002-02-01 2003-08-21 Inst Chemo Biosensorik Deckelelement
US6982166B2 (en) 2002-05-16 2006-01-03 Applera Corporation Lens assembly for biological testing
US9157860B2 (en) 2002-05-16 2015-10-13 Applied Biosystems, Llc Achromatic lens array
AU2003243281A1 (en) 2002-05-17 2003-12-02 Applera Corporation Optical instrument includung excitation source
EP3312594B1 (en) 2002-05-17 2019-07-24 Life Technologies Corporation Apparatus for differentiating multiple fluorescence signals by excitation wavelength
KR100794699B1 (ko) * 2002-06-18 2008-01-14 (주)바이오니아 핵산증폭반응 산물의 실시간 모니터링 장치
US7083974B2 (en) 2002-07-12 2006-08-01 Applera Corporation Rotatable sample disk and method of loading a sample disk
US7452712B2 (en) 2002-07-30 2008-11-18 Applied Biosystems Inc. Sample block apparatus and method of maintaining a microcard on a sample block
US7148043B2 (en) * 2003-05-08 2006-12-12 Bio-Rad Laboratories, Inc. Systems and methods for fluorescence detection with a movable detection module
JP4996248B2 (ja) 2003-07-31 2012-08-08 ハンディーラブ インコーポレイテッド 粒子含有サンプルの処理
US7295316B2 (en) 2004-01-14 2007-11-13 Applera Corporation Fluorescent detector with automatic changing filters
JP2007518109A (ja) * 2004-01-14 2007-07-05 アプレラ コーポレイション 生物学的サンプルにおける蛍光検出のための装置および方法
ES2285578T3 (es) * 2005-01-18 2007-11-16 F. Hoffmann-La Roche Ag Visualizacion de señales de fluorescencia utilizando telecentricidad.
EP1681558B1 (en) * 2005-01-18 2007-11-14 Roche Diagnostics GmbH Imaging fluorescence signals using telecentric optics on the excitation and the imaging side
ATE357653T1 (de) * 2005-01-18 2007-04-15 Hoffmann La Roche Fluoreszenzabbildung mittels telezentrischer anregungs- und abbildungsoptiken
JP4724126B2 (ja) * 2005-01-24 2011-07-13 オリンパス株式会社 生化学検査装置および生化学検査方法
FI20055043A0 (fi) * 2005-01-31 2005-01-31 Wallac Oy Sovitelma mikrotiterkaivojen kuvausjärjestelmässä
US7446288B2 (en) 2005-05-06 2008-11-04 Applied Biosystems Inc. Device including inductively heatable fluid retainment region, and method
DE102005027407B3 (de) * 2005-06-13 2006-11-09 Eppendorf Ag Thermocycler
DE102005027555B3 (de) * 2005-06-14 2006-10-05 Eppendorf Ag Thermocycler
DE102005043834A1 (de) * 2005-09-13 2007-03-22 Eppendorf Ag Vorrichtung zur Durchführung von Real-Time PCR-Reaktionen
JP2007093249A (ja) * 2005-09-27 2007-04-12 Yokogawa Electric Corp 光量計測装置および光量計測方法
JP4696959B2 (ja) * 2006-02-22 2011-06-08 アイシン精機株式会社 光学検出装置
ES2692380T3 (es) 2006-03-24 2018-12-03 Handylab, Inc. Método para realizar PCR con un cartucho con varias pistas
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
JP2008082922A (ja) * 2006-09-28 2008-04-10 Sanyo Electric Co Ltd 撮影装置及び細胞観察装置
US8765076B2 (en) 2006-11-14 2014-07-01 Handylab, Inc. Microfluidic valve and method of making same
JP4842175B2 (ja) * 2007-03-07 2011-12-21 東京エレクトロン株式会社 温度測定装置及び温度測定方法
KR101089045B1 (ko) * 2007-06-28 2011-12-02 (주)바이오니아 핵산증폭반응 산물의 실시간 모니터링장치
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
EP2108699B1 (en) 2008-04-08 2014-06-25 F.Hoffmann-La Roche Ag Analytical processing and detection device
EP2288902B1 (de) * 2008-06-05 2013-05-22 Bohle AG Vorrichtung zur bestimmung der elementbelegung auf einer glasoberfläche mittels fluoreszenz
EP2148187A1 (de) 2008-07-25 2010-01-27 Roche Diagnostics GmbH Anregungs- und Abbildungsoptik für die Fluoreszenzdetektion
FR2938067B1 (fr) 2008-11-05 2010-12-31 Edixia Dispositif pour inspecter des soudures d'emballage.
WO2010110096A1 (ja) * 2009-03-26 2010-09-30 ユニバーサル・バイオ・リサーチ株式会社 反応光学測定装置およびその測定方法
CN102012357B (zh) * 2009-09-07 2012-12-12 复旦大学 可变光程的旁路浓度校准系统
WO2011031377A1 (en) 2009-09-09 2011-03-17 Helixis, Inc. Optical system for multiple reactions
WO2011086497A2 (en) * 2010-01-12 2011-07-21 Ahram Biosystems, Inc. Three-stage thermal convection apparatus and uses thereof
JP2011017721A (ja) * 2010-09-24 2011-01-27 Yokogawa Electric Corp 光量計測装置および光量計測方法
JP2010281842A (ja) * 2010-09-24 2010-12-16 Yokogawa Electric Corp 光量計測装置および光量計測方法
JP2012085605A (ja) * 2010-10-22 2012-05-10 Sony Corp 核酸増幅反応装置、核酸増幅反応装置に用いる基板、及び核酸増幅反応方法
CA3082652A1 (en) * 2011-04-15 2012-10-18 Becton, Dickinson And Company Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection
JP5842586B2 (ja) * 2011-12-14 2016-01-13 凸版印刷株式会社 真贋検証器及び真贋検証方法
JP5690359B2 (ja) 2012-03-30 2015-03-25 株式会社Ｓｃｒｅｅｎホールディングス 撮像装置および撮像方法
JP6057060B2 (ja) * 2012-08-29 2017-01-11 株式会社ニデック 眼底撮影装置
JP6449591B2 (ja) 2013-09-02 2019-01-09 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 生物学的液体の光測定装置
CN104729994B (zh) * 2013-12-20 2018-05-29 福州高意通讯有限公司 用于增强拉曼光谱仪信噪比的方法和装置
CN105092544A (zh) * 2014-05-12 2015-11-25 绍兴安尼特微电子科技有限公司 一种荧光定量pcr检测仪光学激发和检测系统
WO2016127107A2 (en) * 2015-02-06 2016-08-11 Life Technologies Corporation Systems and methods for biological analysis
ES2943159T3 (es) 2015-02-06 2023-06-09 Life Technologies Corp Instrumento óptico para análisis biológico
JP6622975B2 (ja) * 2015-03-13 2019-12-18 浜松ホトニクス株式会社 計測装置及び計測方法
KR101838640B1 (ko) * 2015-06-17 2018-03-14 (주)동국이노텍 마이크로플레이트 기반 세포 대사 측정 실험 장치
JP6747192B2 (ja) * 2016-09-07 2020-08-26 株式会社島津製作所 遺伝子増幅装置
WO2018065115A1 (en) * 2016-10-07 2018-04-12 Boehringer Ingelheim Vetmedica Gmbh Method for controlling an analysis device and analysis system
CN107746806B (zh) * 2017-11-20 2024-02-20 鲲鹏基因（北京）科技有限责任公司 一种实时荧光定量pcr仪
CN108181239B (zh) * 2018-02-07 2023-09-12 张哲夫 一种多通道荧光定量pcr仪的光学系统
IT201800004132A1 (it) * 2018-03-30 2019-09-30 St Microelectronics Srl Unita' di rilevamento di segnali fluorescenti, apparecchio di analisi di molecole che comprende tale unita' e metodo di rilevamento ed analisi dei segnali fluorescenti
KR102133633B1 (ko) * 2018-04-17 2020-07-13 (주)로고스바이오시스템스 핵산증폭반응산물을 실시간으로 검출하는 장치
US20210317515A1 (en) * 2018-07-10 2021-10-14 Gen-Probe Incorporated Methods and systems for detecting and quantifying nucleic acids
TWI726446B (zh) * 2019-08-11 2021-05-01 新加坡商克雷多生物醫學私人有限公司 分析系統及其分析方法
CN113376127B (zh) * 2020-02-25 2025-03-28 上海迈景纳米科技有限公司 一种适于生物分子多重检测的成像系统
WO2021169822A1 (zh) * 2020-02-25 2021-09-02 上海交通大学 一种适于生物分子多重检测的成像系统
US11480565B2 (en) 2020-06-12 2022-10-25 Bio-Rad Laboratories, Inc. Automated immunoassay
KR102409740B1 (ko) 2020-11-05 2022-06-20 (주)그린광학 텔레센트릭 광학계를 포함하는 형광 측정 장치
CN113481095A (zh) * 2021-07-12 2021-10-08 桂林电子科技大学 基于双芯光纤活体单细胞转动精准主动光操控方法及装置
EP4396338A1 (en) 2021-09-01 2024-07-10 Ludwig-Maximilians-Universität München Activatable dna polymerase

Family Cites Families (193)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2408646A1 (de) * 1974-02-22 1975-08-28 Max Planck Gesellschaft Reaktionskinetisches messgeraet
JPS53135660A (en) 1977-04-30 1978-11-27 Olympus Optical Co Ltd Fluorescent photometric microscope using laser light
SU938936A1 (ru) * 1978-11-01 1982-06-30 Институт биологической физики АН СССР Устройство дл поиска измененных клеток в цитологическом препарате
US4200801A (en) 1979-03-28 1980-04-29 The United States Of America As Represented By The United States Department Of Energy Portable spotter for fluorescent contaminants on surfaces
US4487477A (en) 1981-03-06 1984-12-11 The Perkin-Elmer Corporation Optical beam splitter
US4412543A (en) 1981-04-09 1983-11-01 Xanar, Inc. Apparatus for determining the concentration of a fluorescent material in an eye
JPS57186169A (en) 1981-05-12 1982-11-16 Olympus Optical Co Ltd Detector for particle coagulation pattern
US4537861A (en) * 1983-02-03 1985-08-27 Elings Virgil B Apparatus and method for homogeneous immunoassay
US4626684A (en) 1983-07-13 1986-12-02 Landa Isaac J Rapid and automatic fluorescence immunoassay analyzer for multiple micro-samples
DE3329257A1 (de) 1983-08-12 1985-02-28 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Fluorometer
JPS60108457A (ja) 1983-11-16 1985-06-13 Japan Synthetic Rubber Co Ltd 透明耐衝撃性樹脂組成物
US4660971A (en) 1984-05-03 1987-04-28 Becton, Dickinson And Company Optical features of flow cytometry apparatus
FR2566543B1 (fr) 1984-06-20 1988-02-26 Commissariat Energie Atomique Dispositif optique a rendement de collection eleve et cytofluorimetre en faisant application
US4661913A (en) 1984-09-11 1987-04-28 Becton, Dickinson And Company Apparatus and method for the detection and classification of articles using flow cytometry techniques
DE3574617D1 (de) 1984-09-11 1990-01-11 Partec Ag Verfahren und vorrichtung zur sortierung von mikroskopischen partikeln.
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5656493A (en) 1985-03-28 1997-08-12 The Perkin-Elmer Corporation System for automated performance of the polymerase chain reaction
JPS6216911U (enExample) * 1985-07-16 1987-01-31
US4989977A (en) 1985-07-29 1991-02-05 Becton, Dickinson And Company Flow cytometry apparatus with improved light beam adjustment
JPH0818666B2 (ja) 1985-11-26 1996-02-28 大同工業株式会社 コイル搬送装置
US4786165A (en) 1986-07-10 1988-11-22 Toa Medical Electronics Co., Ltd. Flow cytometry and apparatus therefor
JPS63287177A (ja) * 1987-05-19 1988-11-24 Canon Inc 撮像装置
DE3717274A1 (de) 1987-05-22 1988-12-01 Sick Erwin Gmbh Optische fehlerinspektionsvorrichtung
JP2550106B2 (ja) 1987-10-30 1996-11-06 株式会社日立製作所 光分散検出型電気泳動装置
US4887721A (en) 1987-11-30 1989-12-19 The United States Of America As Represented By The United States Department Of Energy Laser particle sorter
US4972258A (en) * 1989-07-31 1990-11-20 E. I. Du Pont De Nemours And Company Scanning laser microscope system and methods of use
GB8830039D0 (en) 1988-12-22 1989-02-15 Renishaw Plc Raman microscope
US5241363A (en) 1989-07-10 1993-08-31 General Atomics Micropipette adaptor with temperature control for PCR amplification
US5030002A (en) 1989-08-11 1991-07-09 Becton, Dickinson And Company Method and apparatus for sorting particles with a moving catcher tube
US5018866A (en) 1989-09-12 1991-05-28 Packard Instrument Company Method and apparatus for performing high sensitivity fluorescence measurements
AU6400790A (en) * 1989-09-27 1991-04-28 Astroscan Limited Analysis of carbohydrates
US5091652A (en) 1990-01-12 1992-02-25 The Regents Of The University Of California Laser excited confocal microscope fluorescence scanner and method
US5073029A (en) 1990-02-16 1991-12-17 Eqm Research, Inc. Multisource device for photometric analysis and associated chromogens
EP0443700A3 (en) 1990-02-21 1991-10-16 Mitsubishi Jukogyo Kabushiki Kaisha Method for counting living cells of microbes and apparatus therefor
DE4013586C2 (de) 1990-04-27 1994-08-18 Suzuki Motor Co Vorrichtung zur Feststellung der immunologischen Agglutination
US5215883A (en) 1990-07-09 1993-06-01 The Research Foundation Electrophoretic mobility of fluorophore labeled particles in gels by fluorophore movement after photobleaching
GB9015793D0 (en) 1990-07-18 1990-09-05 Medical Res Council Confocal scanning optical microscope
US5127730A (en) 1990-08-10 1992-07-07 Regents Of The University Of Minnesota Multi-color laser scanning confocal imaging system
US5141609A (en) 1990-11-16 1992-08-25 The Trustees Of The Leland Stanford Junior University Method and device employing time-delayed integration for detecting sample components after separation
KR100236506B1 (ko) 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
DE4139211C2 (de) 1990-11-30 1994-03-24 Hitachi Ltd Elektrophoresegerät
US6352672B1 (en) 1991-01-28 2002-03-05 Cis Bio International Apparatus for measuring the luminescence emitted in a luminescent assay
FR2672128B1 (fr) * 1991-01-28 1995-08-18 Cis Bio Int Procede de mesure de la luminescence emise dans un dosage par luminescence.
DE4102767A1 (de) 1991-01-31 1992-08-06 Metallgesellschaft Ag Verfahren zur qualitativen analyse von kunststoffteilchen
US5817462A (en) 1995-02-21 1998-10-06 Applied Spectral Imaging Method for simultaneous detection of multiple fluorophores for in situ hybridization and multicolor chromosome painting and banding
JPH04271800A (ja) 1991-02-28 1992-09-28 Hitachi Ltd 電気泳動装置
US5529679A (en) 1992-02-28 1996-06-25 Hitachi, Ltd. DNA detector and DNA detection method
US5516409A (en) 1991-02-28 1996-05-14 Hitachi, Ltd. DNA detector and DNA detection method
US5243540A (en) 1991-04-03 1993-09-07 The United States Of America As Represented By The Secretary Of The Army Computer-driven amino acid indexer for peptide synthesis
CA2109943A1 (en) * 1991-06-13 1992-12-23 Herbert S. Chow Automated specimen analyzing apparatus and method
JP2785530B2 (ja) 1991-09-13 1998-08-13 株式会社日立製作所 電気泳動装置
US5371624A (en) * 1991-11-29 1994-12-06 Olympus Optical Co., Ltd. Reflected fluorescence microscope
US5173748A (en) 1991-12-05 1992-12-22 Eastman Kodak Company Scanning multichannel spectrometry using a charge-coupled device (CCD) in time-delay integration (TDI) mode
US5670113A (en) 1991-12-20 1997-09-23 Sibia Neurosciences, Inc. Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same
US5315375A (en) 1992-02-11 1994-05-24 Acrogen, Inc. Sensitive light detection system
US5635402A (en) * 1992-03-05 1997-06-03 Alfano; Robert R. Technique for determining whether a cell is malignant as opposed to non-malignant using extrinsic fluorescence spectroscopy
CA2133643A1 (en) * 1992-04-06 1993-10-14 Stanley R. Bouma Method and device for detection of nucleic acid or analyte using total internal reflectance
SE500702C2 (sv) 1992-04-07 1994-08-15 Staffan Birnbaum Sätt och anordning för optisk analys av prov separerade i tunna kapillärer
US5355215A (en) 1992-09-30 1994-10-11 Environmental Research Institute Of Michigan Method and apparatus for quantitative fluorescence measurements
WO1994016104A1 (en) * 1993-01-08 1994-07-21 Ctrc Research Foundation Color imaging system for use in molecular biology
US5547849A (en) 1993-02-17 1996-08-20 Biometric Imaging, Inc. Apparatus and method for volumetric capillary cytometry
US5383023A (en) 1993-03-01 1995-01-17 Walleczek; Jan Method and apparatus for performing dual-beam dual-wavelength fluorescence spectrophotometric evaluation of a biological specimen
DE69323060T2 (de) 1993-03-18 1999-06-10 Novartis Ag, Basel Optische Detektorvorrichtung für die chemische Analyse von kleinen fluiden Probenvolumina
US5730850A (en) 1993-04-23 1998-03-24 Hitachi, Ltd. Capillary array electrophoresis system
US5371016A (en) 1993-04-26 1994-12-06 Becton, Dickinson And Company Detecting biological activities in culture vials
US5512492A (en) 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
US5439578A (en) 1993-06-03 1995-08-08 The Governors Of The University Of Alberta Multiple capillary biochemical analyzer
CA2129787A1 (en) * 1993-08-27 1995-02-28 Russell G. Higuchi Monitoring multiple amplification reactions simultaneously and analyzing same
US5397709A (en) 1993-08-27 1995-03-14 Becton Dickinson And Company System for detecting bacterial growth in a plurality of culture vials
US5515169A (en) * 1993-10-13 1996-05-07 Labintelligence Inc. Spectral wavelength discrimination system and method for using
JPH07120393A (ja) 1993-10-13 1995-05-12 Nippon Tectron Co Ltd 蛍光検出法
US5377004A (en) 1993-10-15 1994-12-27 Kaiser Optical Systems Remote optical measurement probe
US5470710A (en) * 1993-10-22 1995-11-28 University Of Utah Automated hybridization/imaging device for fluorescent multiplex DNA sequencing
JPH07120392A (ja) 1993-10-28 1995-05-12 Shimadzu Corp 塩基配列決定装置
US6309601B1 (en) 1993-11-01 2001-10-30 Nanogen, Inc. Scanning optical detection system
JP3448090B2 (ja) * 1994-02-16 2003-09-16 浜松ホトニクス株式会社 エネルギー移動検出法およびその装置
EP0746778A1 (en) 1994-02-25 1996-12-11 Massachusetts Institute Of Technology Methods and apparatus for detecting and imaging particles
US5491343A (en) 1994-03-25 1996-02-13 Brooker; Gary High-speed multiple wavelength illumination source, apparatus containing the same, and applications thereof to methods of irradiating luminescent samples and of quantitative luminescence ratio microscopy
AU698953B2 (en) 1994-04-29 1998-11-12 Applied Biosystems, Llc System for real time detection of nucleic acid amplification products
US5972716A (en) 1994-04-29 1999-10-26 The Perkin-Elmer Corporation Fluorescence monitoring device with textured optical tube and method for reducing background fluorescence
US5766889A (en) * 1994-06-08 1998-06-16 The Perkin-Elmer Corporation Method for determining the characteristics of the concentration growth of target nucleic acid molecules in polymerase chain reaction sample
JP3425810B2 (ja) * 1994-07-27 2003-07-14 オリンパス光学工業株式会社 光学系切換装置
US5633752A (en) * 1994-07-27 1997-05-27 Olympus Optical Co., Ltd. Optical switching apparatus for a reflected fluorescence microscope
US6800452B1 (en) * 1994-08-08 2004-10-05 Science Applications International Corporation Automated methods for simultaneously performing a plurality of signal-based assays
EP0801738B1 (en) * 1994-09-02 2003-04-09 BD Biosciences, Systems and Reagents, Inc. Calibration method and apparatus for optical scanner
US5672881A (en) * 1994-09-14 1997-09-30 Glyko, Inc. Charge-coupled device imaging apparatus
AU3963595A (en) 1994-12-08 1996-06-26 Molecular Dynamics, Inc. Fluorescence imaging system employing a macro scanning objective
DE4444002A1 (de) * 1994-12-10 1996-06-13 Behringwerke Ag Immunoassays für Haptene und hierfür verwendbare Haptentracer-Antikörper-Komplexe sowie Verfahren zur Herstellung derselben
US6014213A (en) * 1994-12-12 2000-01-11 Visible Genetics Inc. High dynamic range apparatus for separation and detection of polynucleotide fragments
US5710628A (en) 1994-12-12 1998-01-20 Visible Genetics Inc. Automated electrophoresis and fluorescence detection apparatus and method
JPH07174701A (ja) 1994-12-28 1995-07-14 Shimadzu Corp 塩基配列決定装置
US5675155A (en) 1995-04-26 1997-10-07 Beckman Instruments, Inc. Multicapillary fluorescent detection system
US6017434A (en) 1995-05-09 2000-01-25 Curagen Corporation Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments
US6485625B1 (en) 1995-05-09 2002-11-26 Curagen Corporation Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments
US5582705A (en) 1995-05-19 1996-12-10 Iowa State University Research Foundation, Inc. Multiplexed capillary electrophoresis system
US5567947A (en) 1995-06-01 1996-10-22 Aerodyne Research, Inc. Spectral line discriminator for passive detection of fluorescence
DE19624421B4 (de) * 1995-06-30 2008-07-10 Carl Zeiss Ag Vorrichtung und Verfahren zur ortsaufgelösten Vermessung von Wellenfrontdeformationen
US6411835B1 (en) 1997-01-13 2002-06-25 Medispectra, Inc. Spectral volume microprobe arrays
JPH0972843A (ja) * 1995-09-06 1997-03-18 Nikon Corp ウェルプレート
US5833827A (en) 1995-09-29 1998-11-10 Hitachi, Ltd. Capillary array electrophoresis system
ATE362546T1 (de) * 1995-10-12 2007-06-15 Lansdorp Peter M Verfahren zum nachweis von mehrfachkopien einer wiederholungssequenz in einem nukleinsäuremolekül
US5784157A (en) 1995-11-21 1998-07-21 The Research Foundation Of State University Of New York Method and apparatus for identifying fluorophores
JP3152140B2 (ja) * 1995-12-18 2001-04-03 横河電機株式会社 共焦点用光スキャナ
US5926271A (en) 1995-12-20 1999-07-20 Zeta Technology Laser-induced fluorescence detector having a capillary detection cell and method for identifying trace compounds implemented by the same device
JPH11510707A (ja) * 1995-12-22 1999-09-21 バイオラッド・ラボラトリーズ・インコーポレーテッド マルチパラメーター蛍光ｉｎ ｓｉｔｕハイブリダイゼーションを実施するための方法および装置
US5792610A (en) * 1996-05-01 1998-08-11 Biorad Laboratories, Inc. Method for conducting multiparametric fluorescence in situ hybridization
US5759781A (en) 1995-12-22 1998-06-02 Yale University Multiparametric fluorescence in situ hybridization
US5863502A (en) 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
US5837196A (en) 1996-01-26 1998-11-17 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US5717602A (en) 1996-02-05 1998-02-10 Kenning; Gregory G. Automated electrophoresis and analysis system
JPH09230246A (ja) * 1996-02-22 1997-09-05 Olympus Optical Co Ltd 走査型光学顕微鏡
US6133986A (en) 1996-02-28 2000-10-17 Johnson; Kenneth C. Microlens scanner for microlithography and wide-field confocal microscopy
JPH09229862A (ja) * 1996-02-28 1997-09-05 Nikon Corp 蛍光測光装置
US5851488A (en) * 1996-02-29 1998-12-22 Biocircuits Corporation Apparatus for automatic electro-optical chemical assay determination
AT403745B (de) 1996-02-29 1998-05-25 Avl Verbrennungskraft Messtech Messanordnung mit einem für anregungs- und messstrahlung transparentem trägerelement
EP0890093A4 (en) 1996-03-19 2000-03-15 Univ Utah Res Found SYSTEM FOR DETERMINING THE CONCENTRATION OF ANALYT
DE69630011T2 (de) 1996-03-27 2004-04-01 Agilent Technologies Inc., A Delaware Corp., Palo Alto Verfahren zum Nachweis von Probensubstanzen und Fluoreszenzspektrometer nach diesem Verfahren
JPH09281078A (ja) 1996-04-09 1997-10-31 Hitachi Electron Eng Co Ltd Ｄｎａ塩基配列決定装置
US6319683B1 (en) * 1996-04-12 2001-11-20 Intergen Company Method and composition for controlling formaldehyde fixation by delayed quenching
JPH09292572A (ja) 1996-04-24 1997-11-11 Nikon Corp 落射型蛍光顕微鏡
US5900949A (en) * 1996-05-23 1999-05-04 Hewlett-Packard Company CCD imager for confocal scanning microscopy
ATE390491T1 (de) * 1996-06-04 2008-04-15 Univ Utah Res Found Behälter zum durchführen und beobachten biologischer prozesse
US5736333A (en) * 1996-06-04 1998-04-07 The Perkin-Elmer Corporation Passive internal references for the detection of nucleic acid amplification products
US5699157A (en) 1996-07-16 1997-12-16 Caliper Technologies Corp. Fourier detection of species migrating in a microchannel
CN100356163C (zh) * 1996-08-16 2007-12-19 Ge保健尼亚加拉公司 用于分析井板、凝胶和斑点的数字成像系统
DE19634873A1 (de) 1996-08-29 1998-03-12 Boehringer Mannheim Gmbh System zur Unterscheidung fluoreszierender Molekülgruppen durch zeitaufgelöste Fluoreszenzmessung
US5754291A (en) 1996-09-19 1998-05-19 Molecular Dynamics, Inc. Micro-imaging system
JPH1096862A (ja) 1996-09-20 1998-04-14 Bunshi Bio Photonics Kenkyusho:Kk 落射蛍光顕微鏡装置
US5872623A (en) 1996-09-26 1999-02-16 Sarnoff Corporation Massively parallel detection
AU4607197A (en) 1996-09-26 1998-04-17 Sarnoff Corporation Massively parallel detection
US5854684A (en) 1996-09-26 1998-12-29 Sarnoff Corporation Massively parallel detection
AU4920297A (en) * 1996-10-25 1998-05-15 Applied Imaging, Inc. Multifluor-fluorescence in situ hybridization (m-fish) imaging techniques using multiple multiband filters with image registration
DE19649605A1 (de) * 1996-11-29 1998-06-04 Deutsches Krebsforsch Fluoreszenzkorrelationsspektroskopiemodul für ein Mikroskop
DE19651667C2 (de) * 1996-12-12 2003-07-03 Rudolf Groskopf Vorrichtung zur dreidimensionalen Untersuchung eines Objektes
US5833826A (en) 1996-12-13 1998-11-10 The Perkin-Elmer Corporation Method and apparatus for reducing the distortion of a sample zone eluting from a capillary electrophoresis capillary
WO1998028075A1 (en) * 1996-12-20 1998-07-02 Imaging Research Inc. A micro-well plate for imaging of fluorescent, chemiluminescent, bioluminescent, and colorimetric assays
EP0990142A4 (en) 1996-12-31 2000-09-27 Genometrix Genomics Inc MULTIPLEXED MOLECULAR ANALYSIS METHOD AND DEVICE
US5790727A (en) 1997-02-05 1998-08-04 Brookhaven Science Associates Llc Laser illumination of multiple capillaries that form a waveguide
CA2410688C (en) * 1997-02-27 2004-10-26 Cellomics, Inc. A system for cell-based screening
US5958349A (en) 1997-02-28 1999-09-28 Cepheid Reaction vessel for heat-exchanging chemical processes
US6084667A (en) 1997-03-12 2000-07-04 Nz Applied Technologies System and method for molecular sample measurement
WO1998048262A1 (en) * 1997-04-23 1998-10-29 Packard Instrument Company, Inc. Measurement of fluorescence
US6406845B1 (en) * 1997-05-05 2002-06-18 Trustees Of Tuft College Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample
US6096272A (en) 1997-05-23 2000-08-01 Becton Dickinson & Company Automated microbiological testing apparatus and methods therefor
US6365024B1 (en) 1997-06-30 2002-04-02 Spectrumedix Corporation Motorized positioning apparatus having coaxial carrousels
US5943129A (en) 1997-08-07 1999-08-24 Cambridge Research & Instrumentation Inc. Fluorescence imaging system
US5834203A (en) 1997-08-25 1998-11-10 Applied Spectral Imaging Method for classification of pixels into groups according to their spectra using a plurality of wide band filters and hardwire therefore
WO2001004608A1 (en) 1999-07-07 2001-01-18 Ljl Biosystems, Inc. Light detection device
US5858653A (en) 1997-09-30 1999-01-12 Surmodics, Inc. Reagent and method for attaching target molecules to a surface
DE19748211A1 (de) * 1997-10-31 1999-05-06 Zeiss Carl Fa Optisches Array-System und Reader für Mikrotiterplatten
JP3148702B2 (ja) * 1997-11-07 2001-03-26 オリンパス光学工業株式会社 顕微鏡用落射照明装置
JP3012825B2 (ja) * 1997-11-18 2000-02-28 オリンパス光学工業株式会社 光学顕微鏡
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
JPH11218690A (ja) 1998-02-04 1999-08-10 Olympus Optical Co Ltd 落射蛍光照明光学系を備えた顕微鏡
US6929953B1 (en) 1998-03-07 2005-08-16 Robert A. Levine Apparatus for analyzing biologic fluids
US6198577B1 (en) 1998-03-10 2001-03-06 Glaxo Wellcome, Inc. Doubly telecentric lens and imaging system for multiwell plates
US6388788B1 (en) 1998-03-16 2002-05-14 Praelux, Inc. Method and apparatus for screening chemical compounds
ATE227338T1 (de) 1998-03-18 2002-11-15 Massachusetts Inst Technology Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane
US6501091B1 (en) 1998-04-01 2002-12-31 Massachusetts Institute Of Technology Quantum dot white and colored light emitting diodes
US6818437B1 (en) 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
US7498164B2 (en) 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
EP1978351B1 (en) 1998-05-16 2011-11-30 Life Technologies Corporation Instrument for monitoring polymerase chain reaction of dna
US6010756A (en) 1998-05-19 2000-01-04 Lockheed Martin Corporation Rugate filter and method of making same
AT410718B (de) 1998-10-28 2003-07-25 Schindler Hansgeorg Dr Vorrichtung zur visualisierung von molekülen
US6455861B1 (en) 1998-11-24 2002-09-24 Cambridge Research & Instrumentation, Inc. Fluorescence polarization assay system and method
US6464852B1 (en) 1998-12-03 2002-10-15 State University Of New York At Stony Brook Multicapillary bundle for electrophoresis and detection for DNA
US7115365B2 (en) 1998-12-07 2006-10-03 Olympus Optical Co., Ltd. Method of analyzing a target nucleic acid
US6110683A (en) 1999-01-08 2000-08-29 Commonwealth Biotechnologies, Inc. Automated DNA Sequencer loading dye which contains a lane tracking aid
US20010006416A1 (en) 1999-01-11 2001-07-05 Johnson Paul E. Ribbon flow cytometry apparatus and methods
US6229252B1 (en) 1999-01-21 2001-05-08 Asahi Glass Company, Limited Dye combinations for multiple bandpass filters for video displays
US6249341B1 (en) 1999-01-25 2001-06-19 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
US6355934B1 (en) 1999-02-26 2002-03-12 Packard Biochip Technologies Imaging system for an optical scanner
DE19914279C1 (de) 1999-03-25 2000-09-07 Jena Optronik Gmbh Anordnung zum optischen Auslesen der Information von einem matrixförmigen Substrat mit einer Vielzahl von Einzelproben
US7410793B2 (en) 1999-05-17 2008-08-12 Applera Corporation Optical instrument including excitation source
US20050279949A1 (en) 1999-05-17 2005-12-22 Applera Corporation Temperature control for light-emitting diode stabilization
US7387891B2 (en) 1999-05-17 2008-06-17 Applera Corporation Optical instrument including excitation source
US6717668B2 (en) 2000-03-07 2004-04-06 Chemimage Corporation Simultaneous imaging and spectroscopy apparatus
US6381025B1 (en) 1999-08-19 2002-04-30 Texas Tech University Interferometric detection system and method
US6788414B1 (en) 1999-09-09 2004-09-07 Iowa State University Research Foundation, Inc. Method of analyzing multiple sample simultaneously by detecting absorption and systems for use in such a method
EP2264439A3 (en) 1999-11-12 2011-01-19 E.I. Du Pont De Nemours And Company Fluorometer with low heat-generating light source
US6331438B1 (en) 1999-11-24 2001-12-18 Iowa State University Research Foundation, Inc. Optical sensors and multisensor arrays containing thin film electroluminescent devices
WO2001063262A1 (en) 2000-02-25 2001-08-30 Cambridge Research & Instrumentation Inc. Multiple label fluorescence polarization assay system and method
US6749735B1 (en) 2000-03-16 2004-06-15 David Le Febre Electromobility focusing controlled channel electrophoresis system
JP4994560B2 (ja) 2000-08-25 2012-08-08 アムニス コーポレイション 細胞などの小さな移動物体の速度測定
AU2001290879A1 (en) 2000-09-15 2002-03-26 California Institute Of Technology Microfabricated crossflow devices and methods
EP1237128B1 (en) 2001-03-01 2012-08-01 Sicpa Holding Sa Improved luminescence characteristics detector
US6529275B2 (en) 2001-06-22 2003-03-04 Biocal Technology, Inc. Optical detection in bio-separation device using a widened detection zone
US6856390B2 (en) 2001-07-25 2005-02-15 Applera Corporation Time-delay integration in electrophoretic detection systems
US7265833B2 (en) 2001-07-25 2007-09-04 Applera Corporation Electrophoretic system with multi-notch filter and laser excitation source
JP2007163397A (ja) 2005-12-16 2007-06-28 Jtekt Corp 着磁パルサリング
JP2009072843A (ja) 2007-09-19 2009-04-09 Jtekt Corp 研削盤及び研削盤における回転砥石の成形方法
JP4820835B2 (ja) 2008-03-19 2011-11-24 アイシン・エィ・ダブリュ株式会社 運転状態警告システム、運転状態警告方法及びプログラム
EP3929459A1 (en) 2011-09-12 2021-12-29 Fox Factory, Inc. Methods and apparatus for suspension set up

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107044886A (zh) * 2017-01-20 2017-08-15 武汉呵尔医疗科技发展有限公司 一种多波段光谱成像光源、成像方法及显微镜

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ATE425448T1 (de) 2009-03-15
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