ATE357653T1 - Fluoreszenzabbildung mittels telezentrischer anregungs- und abbildungsoptiken - Google Patents

Fluoreszenzabbildung mittels telezentrischer anregungs- und abbildungsoptiken

Info

Publication number
ATE357653T1
ATE357653T1 AT05000862T AT05000862T ATE357653T1 AT E357653 T1 ATE357653 T1 AT E357653T1 AT 05000862 T AT05000862 T AT 05000862T AT 05000862 T AT05000862 T AT 05000862T AT E357653 T1 ATE357653 T1 AT E357653T1
Authority
AT
Austria
Prior art keywords
imaging
excitation
sites
present
directed
Prior art date
Application number
AT05000862T
Other languages
English (en)
Inventor
Martin Gutekunst
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE357653T1 publication Critical patent/ATE357653T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6452Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6456Spatial resolved fluorescence measurements; Imaging
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6456Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458Fluorescence microscopy
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N2021/6463Optics
    • G01N2021/6478Special lenses
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099Characterised by type of test elements
    • G01N2035/00158Elements containing microarrays, i.e. "biochip"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates

Landscapes

  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Microscoopes, Condenser (AREA)
AT05000862T 2005-01-18 2005-01-18 Fluoreszenzabbildung mittels telezentrischer anregungs- und abbildungsoptiken ATE357653T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05000862A EP1681555B1 (de) 2005-01-18 2005-01-18 Fluoreszenzabbildung mittels telezentrischer Anregungs- und Abbildungsoptiken

Publications (1)

Publication Number Publication Date
ATE357653T1 true ATE357653T1 (de) 2007-04-15

Family

ID=34933340

Family Applications (2)

Application Number Title Priority Date Filing Date
AT05000862T ATE357653T1 (de) 2005-01-18 2005-01-18 Fluoreszenzabbildung mittels telezentrischer anregungs- und abbildungsoptiken
AT06000787T ATE399991T1 (de) 2005-01-18 2006-01-14 Fluoreszenzabbildung mittels telezentrischer anregungs- und abbildungsoptiken

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT06000787T ATE399991T1 (de) 2005-01-18 2006-01-14 Fluoreszenzabbildung mittels telezentrischer anregungs- und abbildungsoptiken

Country Status (10)

Country Link
US (1) US7687260B2 (de)
EP (2) EP1681555B1 (de)
JP (1) JP4980622B2 (de)
CN (1) CN100543512C (de)
AT (2) ATE357653T1 (de)
CA (1) CA2533079C (de)
DE (2) DE602005000749T2 (de)
DK (2) DK1681555T3 (de)
ES (2) ES2284087T3 (de)
HK (1) HK1091904A1 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE359500T1 (de) * 2005-01-18 2007-05-15 Hoffmann La Roche Fluoreszenzabbildung mittels telezentrizität
US7858382B2 (en) * 2005-05-27 2010-12-28 Vidar Systems Corporation Sensing apparatus having rotating optical assembly
US7528374B2 (en) * 2006-03-03 2009-05-05 Vidar Systems Corporation Sensing apparatus having optical assembly that collimates emitted light for detection
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
KR101089045B1 (ko) * 2007-06-28 2011-12-02 (주)바이오니아 핵산증폭반응 산물의 실시간 모니터링장치
EP2148187A1 (de) * 2008-07-25 2010-01-27 Roche Diagnostics GmbH Anregungs- und Abbildungsoptik für die Fluoreszenzdetektion
JP2010032400A (ja) * 2008-07-30 2010-02-12 Yokogawa Electric Corp バイオチップ読取装置
JP5339838B2 (ja) * 2008-10-01 2013-11-13 キヤノン株式会社 遺伝子検査装置
US9068947B2 (en) * 2008-12-03 2015-06-30 Pcr Max Limited Optical system for multiple reactions
KR20100072528A (ko) * 2008-12-22 2010-07-01 한국전자통신연구원 바이오 칩 및 바이오 물질 검출 장치
EP2393596B1 (de) 2009-02-09 2016-09-28 Whitespace Enterprise Corporation Mikrofluidische vorrichtungen und verfahren zur bereitstellung einer archivierungsprobe
GB201005704D0 (en) * 2010-04-06 2010-05-19 It Is Internat Ltd Improvements in systems for chemical and/or biochemical reactions
CN102329725A (zh) * 2010-06-16 2012-01-25 三星泰科威株式会社 光透射温度控制装置、生物诊断设备和方法
DE102010035003B4 (de) * 2010-08-20 2015-08-06 PicoQuant GmbH. Unternehmen für optoelektronische Forschung und Entwicklung Räumlich und zeitlich hochauflösende Mikroskopie
EP2511693A1 (de) 2011-04-13 2012-10-17 F. Hoffmann-La Roche AG Analysesystem mit einer spektral kontrollierten Lichtquelle
EP2525211B1 (de) * 2011-05-16 2018-01-03 F. Hoffmann-La Roche AG Instrument und verfahren zum detektieren von analyten
KR101776776B1 (ko) 2011-05-31 2017-09-11 삼성전자주식회사 형광 검출 광학계 및 이를 포함하는 다채널 형광 검출 장치
CN104114282B (zh) 2011-09-30 2017-07-04 生命技术公司 用于生物分析的系统和方法
DE202012104237U1 (de) * 2011-11-04 2013-05-22 Dynex Technologies Inc. Multiplex-Optikanordnung
EP2608088B1 (de) 2011-12-20 2018-12-12 F. Hoffmann-La Roche AG Verbessertes Verfahren zur Analyse von Nukleinsäure
CN102719357B (zh) * 2012-05-31 2014-07-09 博奥生物集团有限公司 一种实时监控微阵列芯片分析过程的杂交系统
JP6501714B2 (ja) * 2012-12-05 2019-04-17 ジェネポック・インコーポレイテッドGenepoc Inc. 光学調査装置
CN103033493B (zh) * 2012-12-10 2015-08-05 厦门大学 一种可调谐荧光定量pcr检测系统
CN103091298A (zh) * 2013-02-01 2013-05-08 厦门大学 一种实时荧光定量pcr检测系统
US9146248B2 (en) 2013-03-14 2015-09-29 Intelligent Bio-Systems, Inc. Apparatus and methods for purging flow cells in nucleic acid sequencing instruments
US9591268B2 (en) 2013-03-15 2017-03-07 Qiagen Waltham, Inc. Flow cell alignment methods and systems
KR101414248B1 (ko) * 2013-03-27 2014-07-01 (주)로고스바이오시스템스 형광 이미징 장치
JP6449591B2 (ja) * 2013-09-02 2019-01-09 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 生物学的液体の光測定装置
US9541750B2 (en) 2014-06-23 2017-01-10 Li-Cor, Inc. Telecentric, wide-field fluorescence scanning systems and methods
JP6707557B2 (ja) * 2015-03-18 2020-06-10 オプト・エンジニアリング・ソチエタ・ア・レスポンサビリタ・リミタータOpto Engineering S.R.L. テレセントリックレンズ
ITUB20155808A1 (it) * 2015-11-23 2017-05-23 Istituto Naz Di Astrofisica Apparato e metodo per l'ispezione non invasiva di corpi solidi mediante imaging muonico
EP3208604B1 (de) * 2016-02-22 2019-07-10 F. Hoffmann-La Roche AG Optik zur analyse von mikrovertiefungen
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
CN107817227B (zh) 2016-09-12 2020-08-28 台达电子国际(新加坡)私人有限公司 荧光检测装置
EP3312593A1 (de) 2016-10-20 2018-04-25 Hain Lifescience GmbH Verfahren und vorrichtung zur optischen anregung einer mehrzahl von analyten in einem array von reaktionsgefässen und zur erfassung von fluoreszenzlicht aus dem analyten
SG10201609334WA (en) 2016-11-08 2018-06-28 Delta Electronics Intl Singapore Pte Ltd Multi-Channel Fluorescence Detection Device
CN110184175A (zh) * 2018-02-22 2019-08-30 致茂电子(苏州)有限公司 自动化荧光检测系统
SG10201801853WA (en) 2018-03-02 2019-10-30 Delta Electronics Int’L Singapore Pte Ltd Portable multi-color fluorescence detection device
EP3937780A4 (de) 2019-03-14 2022-12-07 InSilixa, Inc. Verfahren und systeme zur zeitgesteuerten fluoreszenzbasierten detektion
CN110763657B (zh) * 2019-11-20 2022-05-13 江苏赛诺格兰医疗科技有限公司 用于反射材料反射率测试系统的光电数字转换系统
TWI722785B (zh) 2020-01-31 2021-03-21 台達電子工業股份有限公司 光學校正工具
DE102020108432A1 (de) 2020-03-25 2021-09-30 Jenoptik Optical Systems Gmbh Vorrichtung und Verfahren zur Lumineszenzanalyse mehrerer Proben
CN111551531B (zh) * 2020-05-19 2023-04-18 北京金诺美科技股份有限公司 一种荧光激发系统及实时荧光定量pcr仪

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1991866A (en) * 1933-08-31 1935-02-19 Ben Kapner Light projection lamp
DE3717274A1 (de) * 1987-05-22 1988-12-01 Sick Erwin Gmbh Optische fehlerinspektionsvorrichtung
US5118801A (en) * 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
US5538848A (en) * 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
EP0906449B1 (de) 1996-06-04 2004-03-03 University Of Utah Research Foundation Vorrichtung und verfahren zur durchführung und überwachung von polymerase kettenreaktionen
ATE295427T1 (de) 1996-06-04 2005-05-15 Univ Utah Res Found Überwachung der hybridisierung während pcr
IL128539A (en) * 1996-08-16 2004-01-04 Imaging Res Inc Digital imaging system for tests in lions, gels and absorbers
DE19748211A1 (de) 1997-10-31 1999-05-06 Zeiss Carl Fa Optisches Array-System und Reader für Mikrotiterplatten
US6198577B1 (en) * 1998-03-10 2001-03-06 Glaxo Wellcome, Inc. Doubly telecentric lens and imaging system for multiwell plates
EP1978351B1 (de) * 1998-05-16 2011-11-30 Life Technologies Corporation Instrument zur Überwachung der Polymerase-Kettenreaktion von DNS
US6818437B1 (en) * 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
US7498164B2 (en) * 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
JP2000074837A (ja) * 1998-08-31 2000-03-14 Fuji Photo Film Co Ltd 撮影装置
FI982005A (fi) * 1998-09-17 2000-03-18 Wallac Oy Näytteiden kuvantamislaite
GB9905954D0 (en) * 1999-03-16 1999-05-05 Cambridge Imaging Ltd Sample imaging
DE19919092A1 (de) 1999-04-27 2000-11-02 Zeiss Carl Jena Gmbh Anordnung zur optischen Auswertung eines Gegenstandsarrays
US7387891B2 (en) * 1999-05-17 2008-06-17 Applera Corporation Optical instrument including excitation source
US7410793B2 (en) * 1999-05-17 2008-08-12 Applera Corporation Optical instrument including excitation source
DE20004826U1 (de) * 2000-03-16 2000-06-15 Schaefter & Kirchhoff Vorrichtung zur optischen Prüfung einer Münze
US20020005493A1 (en) * 2000-04-04 2002-01-17 Reese Steven A. Optical components for microarray analysis
JP2002014044A (ja) 2000-06-29 2002-01-18 Nikon Corp 蛍光測定装置
KR100418549B1 (ko) * 2000-07-31 2004-02-11 가부시끼가이샤 도시바 컬러음극선관
CA2417986C (en) 2000-08-11 2013-11-26 University Of Utah Research Foundation Single-labeled oligonucleotide probes
US6650411B2 (en) * 2001-04-26 2003-11-18 Affymetrix, Inc. System, method, and product for pixel clocking in scanning of biological materials
JP4834242B2 (ja) 2001-05-30 2011-12-14 オリンパス株式会社 蛍光読み取り装置
DE10131687A1 (de) 2001-06-29 2003-01-16 Eppendorf Ag Vorrichtung zur Durchführung von Nukleinsäure-Amplifikationsreaktionen bei gleichzeitiger Verfolgung der Bildung von Amplifikationsprodukten
JP3999479B2 (ja) 2001-07-10 2007-10-31 オリンパス株式会社 光学装置
JP2003028797A (ja) 2001-07-11 2003-01-29 Hitachi Software Eng Co Ltd 蛍光読み取り装置
DE10155142C2 (de) 2001-11-12 2003-09-04 Friz Biochem Gmbh Dunkelfeld-Abbildungsvorrichtung zur ortsaufgelösten Dunkelfeldabbildung einer flächigen Probe
DE10200499A1 (de) 2002-01-03 2003-07-10 Zeiss Carl Jena Gmbh Verfahren und/oder Anordnung zur Identifikation von fluoreszierenden, lumineszierenden und/oder absorbierenden Substanzen auf und/oder in Probenträgern
DE10206004A1 (de) 2002-02-14 2003-08-28 Zeiss Carl Jena Gmbh Vorrichtung zur konfokalen optischen Mikroanalyse
AU2003243281A1 (en) 2002-05-17 2003-12-02 Applera Corporation Optical instrument includung excitation source

Also Published As

Publication number Publication date
EP1681555B1 (de) 2007-03-21
DE602005000749D1 (de) 2007-05-03
DE602005000749T2 (de) 2007-12-06
EP1681557A1 (de) 2006-07-19
ATE399991T1 (de) 2008-07-15
US20060166355A1 (en) 2006-07-27
JP4980622B2 (ja) 2012-07-18
DE602006001593D1 (de) 2008-08-14
HK1091904A1 (en) 2007-01-26
CA2533079A1 (en) 2006-07-18
DK1681557T3 (da) 2008-10-27
ES2284087T3 (es) 2007-11-01
CN100543512C (zh) 2009-09-23
EP1681557B1 (de) 2008-07-02
EP1681555A1 (de) 2006-07-19
JP2006226998A (ja) 2006-08-31
DK1681555T3 (da) 2007-07-02
CA2533079C (en) 2011-03-22
US7687260B2 (en) 2010-03-30
ES2309835T3 (es) 2008-12-16
CN1808204A (zh) 2006-07-26

Similar Documents

Publication Publication Date Title
ATE357653T1 (de) Fluoreszenzabbildung mittels telezentrischer anregungs- und abbildungsoptiken
ATE378582T1 (de) Fluoreszenzabbildung mittels telezentrischer optiken auf anregungs- und abbildungsseite
WO2005099394A3 (en) Methods and devices for microarray image analysis
JP2010032513A5 (de)
ES2875831T3 (es) Sistema óptico para reacciones químicas y/o bioquímicas
ATE507473T1 (de) Multiplex-fluoreszenznachweisvorrichtung mit mehreren über ein faserbündel an einen gemeinsamen detektor gekoppelten optischen modulen
EP2278303A3 (de) Verfahren und Vorrichtung für die genetische Multiplex-Analyse
US11300513B2 (en) Device for reading an IVD assay
ATE472099T1 (de) Multiplex-fluoreszenzdetektionsvorrichtung mit entfernbaren optischen modulen
SE0600642L (sv) Fluorescensläsare
EA200701455A1 (ru) Система для обнаружения флуоресценции
TW200710381A (en) Heating element for a rotating multiplex fluorescence detection device
EP2315005A3 (de) Vorrichtung und Verfahren zur Erkennung von Fluoreszenzen in biologischen Proben
EP1830174A3 (de) Optisches Mehrkanal-Fluoreszenzmesssystem und Mehrkanal-Fluoreszenzprobenanalysator
ATE537438T1 (de) Vorrichtung und verfahren zur unterscheidung mehrerer fluoreszenzsignale anhand ihrer anregungswellenlänge
JP2007093250A (ja) バイオチップ読み取り装置およびバイオチップ読み取り方法
FI20031357A0 (fi) Monikäyttöinen laitteisto näytteiden optiseen mittaukseen
JP2005274355A (ja) 蛍光画像取得装置
ATE517332T1 (de) Vorrichtung und verfahren zur tiefenaufgelösten optischen erfassung einer probe
US20040051031A1 (en) Luminescence imager
ATE546727T1 (de) Vorrichtung zur optischen anregung unter verwendung einer anordnung mit mehreren wellenlängen
WO2010052173A3 (de) Elektronische lupe
TW200710382A (en) Multiplex fluorescence detection device having removable optical modules

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1681555

Country of ref document: EP