ATE357653T1 - Fluoreszenzabbildung mittels telezentrischer anregungs- und abbildungsoptiken - Google Patents
Fluoreszenzabbildung mittels telezentrischer anregungs- und abbildungsoptikenInfo
- Publication number
- ATE357653T1 ATE357653T1 AT05000862T AT05000862T ATE357653T1 AT E357653 T1 ATE357653 T1 AT E357653T1 AT 05000862 T AT05000862 T AT 05000862T AT 05000862 T AT05000862 T AT 05000862T AT E357653 T1 ATE357653 T1 AT E357653T1
- Authority
- AT
- Austria
- Prior art keywords
- imaging
- excitation
- sites
- present
- directed
- Prior art date
Links
- 230000005284 excitation Effects 0.000 title abstract 4
- 238000003384 imaging method Methods 0.000 title abstract 3
- 238000012632 fluorescent imaging Methods 0.000 title 1
- 238000000018 DNA microarray Methods 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 238000000799 fluorescence microscopy Methods 0.000 abstract 1
- 238000009396 hybridization Methods 0.000 abstract 1
- 238000003753 real-time PCR Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
- G01N2021/6478—Special lenses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N2035/00099—Characterised by type of test elements
- G01N2035/00158—Elements containing microarrays, i.e. "biochip"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
Landscapes
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Microscoopes, Condenser (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05000862A EP1681555B1 (de) | 2005-01-18 | 2005-01-18 | Fluoreszenzabbildung mittels telezentrischer Anregungs- und Abbildungsoptiken |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE357653T1 true ATE357653T1 (de) | 2007-04-15 |
Family
ID=34933340
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05000862T ATE357653T1 (de) | 2005-01-18 | 2005-01-18 | Fluoreszenzabbildung mittels telezentrischer anregungs- und abbildungsoptiken |
| AT06000787T ATE399991T1 (de) | 2005-01-18 | 2006-01-14 | Fluoreszenzabbildung mittels telezentrischer anregungs- und abbildungsoptiken |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06000787T ATE399991T1 (de) | 2005-01-18 | 2006-01-14 | Fluoreszenzabbildung mittels telezentrischer anregungs- und abbildungsoptiken |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7687260B2 (de) |
| EP (2) | EP1681555B1 (de) |
| JP (1) | JP4980622B2 (de) |
| CN (1) | CN100543512C (de) |
| AT (2) | ATE357653T1 (de) |
| CA (1) | CA2533079C (de) |
| DE (2) | DE602005000749T2 (de) |
| DK (2) | DK1681555T3 (de) |
| ES (2) | ES2284087T3 (de) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2285578T3 (es) * | 2005-01-18 | 2007-11-16 | F. Hoffmann-La Roche Ag | Visualizacion de señales de fluorescencia utilizando telecentricidad. |
| US7858382B2 (en) * | 2005-05-27 | 2010-12-28 | Vidar Systems Corporation | Sensing apparatus having rotating optical assembly |
| US7528374B2 (en) * | 2006-03-03 | 2009-05-05 | Vidar Systems Corporation | Sensing apparatus having optical assembly that collimates emitted light for detection |
| US11001881B2 (en) | 2006-08-24 | 2021-05-11 | California Institute Of Technology | Methods for detecting analytes |
| US11525156B2 (en) | 2006-07-28 | 2022-12-13 | California Institute Of Technology | Multiplex Q-PCR arrays |
| WO2008014485A2 (en) | 2006-07-28 | 2008-01-31 | California Institute Of Technology | Multiplex q-pcr arrays |
| US11560588B2 (en) | 2006-08-24 | 2023-01-24 | California Institute Of Technology | Multiplex Q-PCR arrays |
| KR101089045B1 (ko) * | 2007-06-28 | 2011-12-02 | (주)바이오니아 | 핵산증폭반응 산물의 실시간 모니터링장치 |
| EP2148187A1 (de) | 2008-07-25 | 2010-01-27 | Roche Diagnostics GmbH | Anregungs- und Abbildungsoptik für die Fluoreszenzdetektion |
| JP2010032400A (ja) * | 2008-07-30 | 2010-02-12 | Yokogawa Electric Corp | バイオチップ読取装置 |
| JP5339838B2 (ja) * | 2008-10-01 | 2013-11-13 | キヤノン株式会社 | 遺伝子検査装置 |
| WO2010065779A2 (en) * | 2008-12-03 | 2010-06-10 | Helixis, Inc. | Optical system for multiple reactions |
| KR20100072528A (ko) * | 2008-12-22 | 2010-07-01 | 한국전자통신연구원 | 바이오 칩 및 바이오 물질 검출 장치 |
| EP2393943A2 (de) | 2009-02-09 | 2011-12-14 | Forensic Science Service Ltd | Verbesserungen an oder im zusammenhang mit dem leistungsverhalten |
| GB201005704D0 (en) * | 2010-04-06 | 2010-05-19 | It Is Internat Ltd | Improvements in systems for chemical and/or biochemical reactions |
| CN102329725A (zh) * | 2010-06-16 | 2012-01-25 | 三星泰科威株式会社 | 光透射温度控制装置、生物诊断设备和方法 |
| DE102010035003B4 (de) | 2010-08-20 | 2015-08-06 | PicoQuant GmbH. Unternehmen für optoelektronische Forschung und Entwicklung | Räumlich und zeitlich hochauflösende Mikroskopie |
| EP2511693A1 (de) | 2011-04-13 | 2012-10-17 | F. Hoffmann-La Roche AG | Analysesystem mit einer spektral kontrollierten Lichtquelle |
| EP2525211B1 (de) | 2011-05-16 | 2018-01-03 | F. Hoffmann-La Roche AG | Instrument und verfahren zum detektieren von analyten |
| KR101776776B1 (ko) | 2011-05-31 | 2017-09-11 | 삼성전자주식회사 | 형광 검출 광학계 및 이를 포함하는 다채널 형광 검출 장치 |
| EP2760585A2 (de) * | 2011-09-30 | 2014-08-06 | Life Technologies Corporation | Systeme und verfahren für biologische analysen |
| GB2496315B (en) * | 2011-11-04 | 2014-04-09 | Dynex Technologies Inc | Multiplex optical assembly |
| EP2608088B1 (de) | 2011-12-20 | 2018-12-12 | F. Hoffmann-La Roche AG | Verbessertes Verfahren zur Analyse von Nukleinsäure |
| CN102719357B (zh) * | 2012-05-31 | 2014-07-09 | 博奥生物集团有限公司 | 一种实时监控微阵列芯片分析过程的杂交系统 |
| BR112015013166A2 (pt) | 2012-12-05 | 2017-07-11 | Genepoc Inc | dispositivo de interrogação óptica |
| CN103033493B (zh) * | 2012-12-10 | 2015-08-05 | 厦门大学 | 一种可调谐荧光定量pcr检测系统 |
| CN103091298A (zh) * | 2013-02-01 | 2013-05-08 | 厦门大学 | 一种实时荧光定量pcr检测系统 |
| US9146248B2 (en) | 2013-03-14 | 2015-09-29 | Intelligent Bio-Systems, Inc. | Apparatus and methods for purging flow cells in nucleic acid sequencing instruments |
| US9591268B2 (en) | 2013-03-15 | 2017-03-07 | Qiagen Waltham, Inc. | Flow cell alignment methods and systems |
| KR101414248B1 (ko) * | 2013-03-27 | 2014-07-01 | (주)로고스바이오시스템스 | 형광 이미징 장치 |
| JP6449591B2 (ja) * | 2013-09-02 | 2019-01-09 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 生物学的液体の光測定装置 |
| US9541750B2 (en) | 2014-06-23 | 2017-01-10 | Li-Cor, Inc. | Telecentric, wide-field fluorescence scanning systems and methods |
| JP6707557B2 (ja) * | 2015-03-18 | 2020-06-10 | オプト・エンジニアリング・ソチエタ・ア・レスポンサビリタ・リミタータＯｐｔｏ Ｅｎｇｉｎｅｅｒｉｎｇ Ｓ．Ｒ．Ｌ． | テレセントリックレンズ |
| ITUB20155808A1 (it) * | 2015-11-23 | 2017-05-23 | Istituto Naz Di Astrofisica | Apparato e metodo per l'ispezione non invasiva di corpi solidi mediante imaging muonico |
| EP3208604B1 (de) * | 2016-02-22 | 2019-07-10 | F. Hoffmann-La Roche AG | Optik zur analyse von mikrovertiefungen |
| WO2017155858A1 (en) | 2016-03-07 | 2017-09-14 | Insilixa, Inc. | Nucleic acid sequence identification using solid-phase cyclic single base extension |
| US10450603B2 (en) | 2016-09-12 | 2019-10-22 | Delta Electronics Int'l (Singapore) Pte Ltd | Fluorescence detection device |
| EP3312593A1 (de) | 2016-10-20 | 2018-04-25 | Hain Lifescience GmbH | Verfahren und vorrichtung zur optischen anregung einer mehrzahl von analyten in einem array von reaktionsgefässen und zur erfassung von fluoreszenzlicht aus dem analyten |
| SG10201609334WA (en) | 2016-11-08 | 2018-06-28 | Delta Electronics Intl Singapore Pte Ltd | Multi-Channel Fluorescence Detection Device |
| JP7225108B2 (ja) * | 2017-06-06 | 2023-02-20 | ザ ユナイテッド ステーツ オブ アメリカ、アズ リプリゼンテッド バイ ザ セクレタリー、ディパートメント オブ ヘルス アンド ヒューマン サービシーズ | 多焦点構造化照明顕微鏡システム及び方法 |
| CN110184175A (zh) * | 2018-02-22 | 2019-08-30 | 致茂电子(苏州)有限公司 | 自动化荧光检测系统 |
| SG10201801853WA (en) | 2018-03-02 | 2019-10-30 | Delta Electronics Int’L Singapore Pte Ltd | Portable multi-color fluorescence detection device |
| EP3937780A4 (de) | 2019-03-14 | 2022-12-07 | InSilixa, Inc. | Verfahren und systeme zur zeitgesteuerten fluoreszenzbasierten detektion |
| CN110763657B (zh) * | 2019-11-20 | 2022-05-13 | 江苏赛诺格兰医疗科技有限公司 | 用于反射材料反射率测试系统的光电数字转换系统 |
| TWI722785B (zh) | 2020-01-31 | 2021-03-21 | 台達電子工業股份有限公司 | 光學校正工具 |
| DE102020108432A1 (de) | 2020-03-25 | 2021-09-30 | Jenoptik Optical Systems Gmbh | Vorrichtung und Verfahren zur Lumineszenzanalyse mehrerer Proben |
| CN111551531B (zh) * | 2020-05-19 | 2023-04-18 | 北京金诺美科技股份有限公司 | 一种荧光激发系统及实时荧光定量pcr仪 |
| KR20220148982A (ko) * | 2021-04-29 | 2022-11-08 | 삼성디스플레이 주식회사 | 액적 측정 시스템 |
| CN114198720A (zh) * | 2021-12-07 | 2022-03-18 | 深圳市豪恩智能物联股份有限公司 | 一种具有太阳图案的天空灯 |
| CN116699154A (zh) * | 2022-02-25 | 2023-09-05 | 深圳市理邦精密仪器股份有限公司 | 分子诊断设备及用于分子诊断设备的检测卡检测座 |
| KR102873342B1 (ko) * | 2023-05-25 | 2025-10-22 | 한양대학교 산학협력단 | 초분광 이미지를 이용한 입자 분석 장치, 이를 포함하는 입자 분석 시스템 및 입자 분석 방법 |
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| US1991866A (en) * | 1933-08-31 | 1935-02-19 | Ben Kapner | Light projection lamp |
| DE3717274A1 (de) * | 1987-05-22 | 1988-12-01 | Sick Erwin Gmbh | Optische fehlerinspektionsvorrichtung |
| US5118801A (en) * | 1988-09-30 | 1992-06-02 | The Public Health Research Institute | Nucleic acid process containing improved molecular switch |
| US5538848A (en) * | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| ES2215230T3 (es) | 1996-06-04 | 2004-10-01 | University Of Utah Research Foundation | Sistema y metodo para llevar a cabo y supervisar reacciones de cadena de polimerasa. |
| DE69739357D1 (de) | 1996-06-04 | 2009-05-28 | Univ Utah Res Found | Überwachung der hybridisierung während pcr |
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| DE19748211A1 (de) | 1997-10-31 | 1999-05-06 | Zeiss Carl Fa | Optisches Array-System und Reader für Mikrotiterplatten |
| US6198577B1 (en) * | 1998-03-10 | 2001-03-06 | Glaxo Wellcome, Inc. | Doubly telecentric lens and imaging system for multiwell plates |
| US7498164B2 (en) * | 1998-05-16 | 2009-03-03 | Applied Biosystems, Llc | Instrument for monitoring nucleic acid sequence amplification reaction |
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| JP2000074837A (ja) * | 1998-08-31 | 2000-03-14 | Fuji Photo Film Co Ltd | 撮影装置 |
| FI982005L (fi) * | 1998-09-17 | 2000-03-18 | Wallac Oy | Näytteiden kuvantamislaite |
| GB9905954D0 (en) * | 1999-03-16 | 1999-05-05 | Cambridge Imaging Ltd | Sample imaging |
| DE19919092A1 (de) * | 1999-04-27 | 2000-11-02 | Zeiss Carl Jena Gmbh | Anordnung zur optischen Auswertung eines Gegenstandsarrays |
| US7387891B2 (en) * | 1999-05-17 | 2008-06-17 | Applera Corporation | Optical instrument including excitation source |
| US7410793B2 (en) * | 1999-05-17 | 2008-08-12 | Applera Corporation | Optical instrument including excitation source |
| DE20004826U1 (de) * | 2000-03-16 | 2000-06-15 | Schäfter + Kirchhoff, 22761 Hamburg | Vorrichtung zur optischen Prüfung einer Münze |
| US20020005493A1 (en) * | 2000-04-04 | 2002-01-17 | Reese Steven A. | Optical components for microarray analysis |
| JP2002014044A (ja) * | 2000-06-29 | 2002-01-18 | Nikon Corp | 蛍光測定装置 |
| KR100418549B1 (ko) * | 2000-07-31 | 2004-02-11 | 가부시끼가이샤 도시바 | 컬러음극선관 |
| CA2417986C (en) | 2000-08-11 | 2013-11-26 | University Of Utah Research Foundation | Single-labeled oligonucleotide probes |
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| JP4834242B2 (ja) * | 2001-05-30 | 2011-12-14 | オリンパス株式会社 | 蛍光読み取り装置 |
| DE10131687A1 (de) | 2001-06-29 | 2003-01-16 | Eppendorf Ag | Vorrichtung zur Durchführung von Nukleinsäure-Amplifikationsreaktionen bei gleichzeitiger Verfolgung der Bildung von Amplifikationsprodukten |
| JP3999479B2 (ja) | 2001-07-10 | 2007-10-31 | オリンパス株式会社 | 光学装置 |
| JP2003028797A (ja) | 2001-07-11 | 2003-01-29 | Hitachi Software Eng Co Ltd | 蛍光読み取り装置 |
| DE10155142C2 (de) | 2001-11-12 | 2003-09-04 | Friz Biochem Gmbh | Dunkelfeld-Abbildungsvorrichtung zur ortsaufgelösten Dunkelfeldabbildung einer flächigen Probe |
| DE10200499A1 (de) | 2002-01-03 | 2003-07-10 | Zeiss Carl Jena Gmbh | Verfahren und/oder Anordnung zur Identifikation von fluoreszierenden, lumineszierenden und/oder absorbierenden Substanzen auf und/oder in Probenträgern |
| DE10206004A1 (de) | 2002-02-14 | 2003-08-28 | Zeiss Carl Jena Gmbh | Vorrichtung zur konfokalen optischen Mikroanalyse |
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-
2005
- 2005-01-18 ES ES05000862T patent/ES2284087T3/es not_active Expired - Lifetime
- 2005-01-18 EP EP05000862A patent/EP1681555B1/de not_active Expired - Lifetime
- 2005-01-18 AT AT05000862T patent/ATE357653T1/de active
- 2005-01-18 DK DK05000862T patent/DK1681555T3/da active
- 2005-01-18 DE DE602005000749T patent/DE602005000749T2/de not_active Expired - Lifetime
-
2006
- 2006-01-14 ES ES06000787T patent/ES2309835T3/es active Active
- 2006-01-14 DE DE602006001593T patent/DE602006001593D1/de active Active
- 2006-01-14 DK DK06000787T patent/DK1681557T3/da active
- 2006-01-14 AT AT06000787T patent/ATE399991T1/de active
- 2006-01-14 EP EP06000787A patent/EP1681557B1/de active Active
- 2006-01-16 CA CA2533079A patent/CA2533079C/en active Active
- 2006-01-17 US US11/333,617 patent/US7687260B2/en active Active
- 2006-01-17 CN CNB2006100050519A patent/CN100543512C/zh active Active
- 2006-01-17 JP JP2006009256A patent/JP4980622B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| HK1091904A1 (zh) | 2007-01-26 |
| ATE399991T1 (de) | 2008-07-15 |
| DE602005000749T2 (de) | 2007-12-06 |
| DE602005000749D1 (de) | 2007-05-03 |
| ES2309835T3 (es) | 2008-12-16 |
| CA2533079A1 (en) | 2006-07-18 |
| US20060166355A1 (en) | 2006-07-27 |
| ES2284087T3 (es) | 2007-11-01 |
| US7687260B2 (en) | 2010-03-30 |
| JP4980622B2 (ja) | 2012-07-18 |
| DE602006001593D1 (de) | 2008-08-14 |
| CN100543512C (zh) | 2009-09-23 |
| CN1808204A (zh) | 2006-07-26 |
| EP1681555A1 (de) | 2006-07-19 |
| EP1681557B1 (de) | 2008-07-02 |
| CA2533079C (en) | 2011-03-22 |
| JP2006226998A (ja) | 2006-08-31 |
| EP1681557A1 (de) | 2006-07-19 |
| EP1681555B1 (de) | 2007-03-21 |
| DK1681557T3 (da) | 2008-10-27 |
| DK1681555T3 (da) | 2007-07-02 |
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