ATE398769T1 - Vorrichtung und verfahren zum fluoreszenznachweis in biologischen proben - Google Patents

Vorrichtung und verfahren zum fluoreszenznachweis in biologischen proben

Info

Publication number
ATE398769T1
ATE398769T1 AT05705833T AT05705833T ATE398769T1 AT E398769 T1 ATE398769 T1 AT E398769T1 AT 05705833 T AT05705833 T AT 05705833T AT 05705833 T AT05705833 T AT 05705833T AT E398769 T1 ATE398769 T1 AT E398769T1
Authority
AT
Austria
Prior art keywords
excitation
emission
biological samples
samples
detecting fluorescence
Prior art date
Application number
AT05705833T
Other languages
English (en)
Inventor
Steven Boege
Mark Oldham
Liana Ilkova
Original Assignee
Applera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34740144&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE398769(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Applera Corp filed Critical Applera Corp
Application granted granted Critical
Publication of ATE398769T1 publication Critical patent/ATE398769T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6471—Special filters, filter wheel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6473—In-line geometry
    • G01N2021/6476—Front end, i.e. backscatter, geometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6478—Special lenses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/02—Mechanical
    • G01N2201/024—Modular construction
    • G01N2201/0245—Modular construction with insertable-removable part

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
AT05705833T 2004-01-14 2005-01-14 Vorrichtung und verfahren zum fluoreszenznachweis in biologischen proben ATE398769T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/758,667 US7295316B2 (en) 2004-01-14 2004-01-14 Fluorescent detector with automatic changing filters
US10/929,320 US7289217B2 (en) 2004-01-14 2004-08-30 Fluorescent detector with automatic changing filters

Publications (1)

Publication Number Publication Date
ATE398769T1 true ATE398769T1 (de) 2008-07-15

Family

ID=34740144

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05705833T ATE398769T1 (de) 2004-01-14 2005-01-14 Vorrichtung und verfahren zum fluoreszenznachweis in biologischen proben

Country Status (4)

Country Link
US (2) US7295316B2 (de)
EP (3) EP2315005B1 (de)
JP (1) JP2011022166A (de)
AT (1) ATE398769T1 (de)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1221038A4 (de) * 1999-07-21 2004-09-08 Applera Corp Arbeitsplatz zum nachweis von lumineszenz
DE102004015488B4 (de) * 2004-03-26 2008-01-31 Lavision Biotec Gmbh Verfahren zum Auslesen durch streifenweises Abtasten von flächigen Objekten mit Substanzen, die Fluoreszenzstrahlung abgeben
EP1681556B1 (de) * 2005-01-18 2007-04-11 Roche Diagnostics GmbH Fluoreszenzabbildung mittels Telezentrizität
US7430048B2 (en) 2005-02-16 2008-09-30 Applied Biosystems Inc. Axial illumination for capillary electrophoresis
US7507575B2 (en) * 2005-04-01 2009-03-24 3M Innovative Properties Company Multiplex fluorescence detection device having removable optical modules
US7709249B2 (en) * 2005-04-01 2010-05-04 3M Innovative Properties Company Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector
US7527763B2 (en) * 2005-07-05 2009-05-05 3M Innovative Properties Company Valve control system for a rotating multiplex fluorescence detection device
US20070009382A1 (en) * 2005-07-05 2007-01-11 William Bedingham Heating element for a rotating multiplex fluorescence detection device
US7630849B2 (en) * 2005-09-01 2009-12-08 Applied Biosystems, Llc Method of automated calibration and diagnosis of laboratory instruments
JP2009524832A (ja) 2006-01-24 2009-07-02 ライフ テクノロジーズ コーポレーション 検体を定量するためのデバイスおよび方法
CA2640441C (en) * 2006-02-15 2015-11-24 Ahmed Bouzid Fluorescence filtering system and method for molecular imaging
US20090080194A1 (en) * 2006-02-15 2009-03-26 Li-Cor, Inc. Fluorescence filtering system and method for molecular imaging
US20090206278A1 (en) * 2006-05-08 2009-08-20 Leatech, Llc Photo-optical-electronic gas, pressure and temperature sensor
DE102006036171B4 (de) * 2006-07-28 2008-10-09 Analytik Jena Ag Anordnung und Verfahren zur mehrkanaligen Fluoreszenzmessung in PCR-Proben
RU2009116936A (ru) * 2006-10-05 2010-11-10 Конинклейке Филипс Электроникс Н.В. (Nl) Способы и системы детектирования при фронтальном облучении
US7700928B2 (en) * 2007-01-25 2010-04-20 Etaluma, Inc. Apparatus and method for interleaving detection of fluorescence and luminescence
CA2722484A1 (en) * 2008-04-24 2009-10-29 Peter D. Ludowise Analysis of nucleic acid amplification curves using wavelet transformation
US20100124766A1 (en) 2008-11-14 2010-05-20 Life Technologies Corporation Apparatus and Method for Segmented Thermal Cycler
KR101165720B1 (ko) * 2008-11-18 2012-07-18 한국전자통신연구원 휴대용 광바이오 센서 측정 장치 및 그 측정 방법
US8448322B2 (en) * 2009-01-24 2013-05-28 Thomas Leen Method and system for replacing the water cooled laser in a microplate reader
WO2011026136A1 (en) * 2009-08-31 2011-03-03 Life Technologies Corporation Low-volume sequencing system and method of use
US8987685B2 (en) 2009-09-09 2015-03-24 Pcr Max Limited Optical system for multiple reactions
CN202281746U (zh) 2010-03-06 2012-06-20 伊鲁米那股份有限公司 检测来自样品光信号的测定设备及其光学组件和光学系统
CA2816014A1 (en) 2010-11-03 2012-05-10 Reametrix Inc. Method and device for fluorescent measurement of samples
WO2012082464A2 (en) 2010-12-14 2012-06-21 Life Technologies Corporation Systems and methods for run-time sequencing run quality monitoring
IT1403792B1 (it) * 2010-12-30 2013-10-31 St Microelectronics Srl Analizzatore per analisi biochimiche e metodo per la determinazione di concentrazioni di sostanze fluorescenti in una soluzione
KR101917402B1 (ko) 2011-02-04 2019-01-24 유니바사루 바이오 리사치 가부시키가이샤 자동 반응ㆍ광측정 장치 및 그 방법
US9134241B2 (en) 2011-04-11 2015-09-15 Li-Cor, Inc. Differential scan imaging systems and methods
US9737891B2 (en) 2011-06-01 2017-08-22 Streck, Inc. Rapid thermocycler system for rapid amplification of nucleic acids and related methods
US8421037B2 (en) * 2011-06-10 2013-04-16 Rockwell Automation Technologies, Inc. System and method for reduction of optical noise
US8480246B2 (en) 2011-06-10 2013-07-09 Rockwell Automation Technologies, Inc. System and method for reduction of optical noise
DE102011079942B4 (de) * 2011-07-27 2016-12-15 Leica Microsystems Cms Gmbh Mikroskopbeleuchtungsverfahren und Mikroskop
SG10201602113TA (en) * 2011-09-30 2016-04-28 Life Technologies Corp Systems And Methods For Biological Analysis
EP2761277B1 (de) 2011-09-30 2021-02-24 Life Technologies Corporation Optische systeme zur biologischen analyse
WO2013116760A1 (en) 2012-02-03 2013-08-08 The Trustees Of Columbia University In The City Of New York Optical analysis of emissions from stimulated liquids
WO2014039119A1 (en) * 2012-05-09 2014-03-13 Life Technologies Corporation Systems and method for fluorescence imaging
US9932632B2 (en) 2012-08-10 2018-04-03 Streck, Inc. Real-time optical system for polymerase chain reaction
CN102830224B (zh) * 2012-08-28 2014-09-24 天津市先石光学技术有限公司 用于均相发光免疫检测的光路切换机构
US10591416B2 (en) 2013-02-22 2020-03-17 Life Technologies Corporation Optical systems and methods for biological analysis
US8858886B1 (en) 2013-05-08 2014-10-14 Agilent Technologies, Inc. Scanning system with interchangeable optical cartridges for fluorescence measurements
EP3495803A1 (de) 2013-06-28 2019-06-12 Streck, Inc. Vorrichtungen für echtzeit-polymerasekettenreaktionen
DE102014108143A1 (de) * 2014-06-10 2015-12-10 Kist Europe-Korea Institute of Science and Technologie Europe Forschungsgesellschaft mbh An optical system for detecting fluorescent or luminescent signals of at least two samples
US9541750B2 (en) 2014-06-23 2017-01-10 Li-Cor, Inc. Telecentric, wide-field fluorescence scanning systems and methods
JP6416530B2 (ja) * 2014-07-24 2018-10-31 株式会社日立ハイテクノロジーズ 蛍光観察装置、および蛍光観察方法
DE102015011429B9 (de) * 2015-09-01 2020-01-09 Carl Zeiss Meditec Ag Optisches Filtersystem und Fluoreszenzbeobachtungssystem
KR101754108B1 (ko) 2015-10-02 2017-07-05 강태경 카메라 렌즈에 의한 비네팅을 측정하는 시스템
WO2017144619A1 (en) * 2016-02-26 2017-08-31 Single Technologies Ab Method and device for high throughput imaging
CN107817227B (zh) 2016-09-12 2020-08-28 台达电子国际（新加坡）私人有限公司 荧光检测装置
SG10201609334WA (en) 2016-11-08 2018-06-28 Delta Electronics Intl Singapore Pte Ltd Multi-Channel Fluorescence Detection Device
US11473081B2 (en) 2016-12-12 2022-10-18 xCella Biosciences, Inc. Methods and systems for screening using microcapillary arrays
CA3048904A1 (en) 2016-12-30 2018-07-05 xCella Biosciences, Inc. Multi-stage sample recovery system
US20180364150A1 (en) * 2017-06-14 2018-12-20 Cypress Semiconductor Corporation Optical monitoring of target characteristics
SG10201801853WA (en) 2018-03-02 2019-10-30 Delta Electronics Int’L Singapore Pte Ltd Portable multi-color fluorescence detection device
JP7098146B2 (ja) * 2018-07-05 2022-07-11 株式会社Iddk 顕微観察装置、蛍光検出器及び顕微観察方法
JP7022670B2 (ja) * 2018-09-10 2022-02-18 株式会社日立ハイテク スペクトル校正装置及びスペクトル校正方法
EP4371930B1 (de) 2018-12-06 2025-08-20 Xcella Biosciences, Inc. Laterale belastung von mikrokapillaranordnungen
WO2021010817A1 (en) 2019-07-12 2021-01-21 Sime Darby Plantation Intellectual Property Sdn. Bhd. Apparatus to measure ripeness of oil palm fruitlets via real-time chlorophyll content measurement
TWI722785B (zh) 2020-01-31 2021-03-21 台達電子工業股份有限公司 光學校正工具
CN112161927B (zh) * 2020-09-11 2024-12-24 广州万孚生物技术股份有限公司 体外诊断分析系统及光学检测装置
CN112326610A (zh) * 2020-10-28 2021-02-05 瑞莱生物科技江苏有限公司 一种定量荧光检测光学装置
TWI859369B (zh) * 2020-11-27 2024-10-21 緯創資通股份有限公司 檢測裝置與檢測方法
CN112782395B (zh) * 2020-12-30 2021-11-09 北京中科生仪科技有限公司 一种pcr检测仪及其方法
EP4420167A4 (de) * 2021-10-22 2025-05-07 Illumina Inc. Halbleiterlichtmessung
WO2025257247A1 (en) 2024-06-12 2025-12-18 Roche Diagnostics International Ag Automated pcr analyzer
WO2026030599A1 (en) * 2024-07-31 2026-02-05 Molecular Devices, Llc Fluoroscopy systems with rapid filter exchange

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH567733A5 (de) * 1973-04-02 1975-10-15 Leitz Ernst Gmbh
JP2749069B2 (ja) * 1988-04-26 1998-05-13 オリンパス光学工業株式会社 蛍光顕微鏡装置
US4972258A (en) 1989-07-31 1990-11-20 E. I. Du Pont De Nemours And Company Scanning laser microscope system and methods of use
JPH06507496A (ja) * 1991-06-13 1994-08-25 アボツト・ラボラトリーズ 位置決め及び細胞カウントのための光学像形成
US5528050A (en) * 1995-07-24 1996-06-18 Molecular Dynamics, Inc. Compact scan head with multiple scanning modalities
WO1998017992A2 (en) 1996-10-25 1998-04-30 Applied Imaging, Inc. Multifluor-fluorescence in situ hybridization (m-fish) imaging techniques using multiple multiband filters with image registration
JPH10206745A (ja) * 1997-01-22 1998-08-07 Olympus Optical Co Ltd 走査型光学顕微鏡
JP3697007B2 (ja) 1997-02-10 2005-09-21 浜松ホトニクス株式会社 マルチタイタープレート分析装置
US6534308B1 (en) 1997-03-27 2003-03-18 Oncosis, Llc Method and apparatus for selectively targeting specific cells within a mixed cell population
US6259807B1 (en) 1997-05-14 2001-07-10 Applied Imaging Corp. Identification of objects of interest using multiple illumination schemes and finding overlap of features in corresponding multiple images
JP3877380B2 (ja) * 1997-06-18 2007-02-07 オリンパス株式会社 光学顕微鏡
US5943129A (en) * 1997-08-07 1999-08-24 Cambridge Research & Instrumentation Inc. Fluorescence imaging system
US6043506A (en) * 1997-08-13 2000-03-28 Bio-Rad Laboratories, Inc. Multi parameter scanner
WO2000006989A2 (en) * 1998-07-27 2000-02-10 Ljl Biosystems, Inc. Apparatus and methods for identifying quenching effects in luminescence assays
JPH11218690A (ja) * 1998-02-04 1999-08-10 Olympus Optical Co Ltd 落射蛍光照明光学系を備えた顕微鏡
EP1978351B1 (de) 1998-05-16 2011-11-30 Life Technologies Corporation Instrument zur Überwachung der Polymerase-Kettenreaktion von DNS
US6818437B1 (en) 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
FI982005A7 (fi) 1998-09-17 2000-03-18 Wallac Oy Näytteiden kuvantamislaite
AT3085U1 (de) * 1998-10-23 1999-09-27 Tecan Austria Gmbh Messkopf
US7410793B2 (en) * 1999-05-17 2008-08-12 Applera Corporation Optical instrument including excitation source
AU5875900A (en) * 1999-06-18 2001-01-09 Genomic Solutions, Inc. An automated, ccd-based microarray imaging system
AU7131900A (en) * 1999-06-21 2001-01-09 Cellomics, Inc. A system for cell-based screening
EP1221038A4 (de) 1999-07-21 2004-09-08 Applera Corp Arbeitsplatz zum nachweis von lumineszenz
JP2001083090A (ja) 1999-09-10 2001-03-30 Fuji Photo Film Co Ltd マイクロタイタープレート用励起光源
US6645777B1 (en) * 1999-11-05 2003-11-11 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantation Tapered tubular optical waveguide probe for magnetic focusing immunosensors
AU1655901A (en) * 1999-11-12 2001-06-06 E.I. Du Pont De Nemours And Company Fluorometer with low heat-generating light source
US6333501B1 (en) * 2000-01-27 2001-12-25 Perkin-Elmer Corporation Methods, apparatus, and articles of manufacture for performing spectral calibration
TWI220926B (en) * 2000-03-24 2004-09-11 Ind Tech Res Inst Sieving apparatus for a bio-chip
JP2002014044A (ja) 2000-06-29 2002-01-18 Nikon Corp 蛍光測定装置
JP3576523B2 (ja) * 2000-12-26 2004-10-13 オリンパス株式会社 蛍光輝度測定方法及び装置
JP3999479B2 (ja) * 2001-07-10 2007-10-31 オリンパス株式会社 光学装置
US6744502B2 (en) 2001-09-28 2004-06-01 Pe Corporation (Ny) Shaped illumination geometry and intensity using a diffractive optical element
US20050227231A1 (en) * 2001-10-04 2005-10-13 Dimitri Tcherkassov Device for sequencing nucleic acid molecules
WO2003067230A1 (fr) * 2002-02-07 2003-08-14 Fuji Electric Holdings Co.,Ltd. Procede et dispositif de mesure d'une image fluorescente
US6982166B2 (en) * 2002-05-16 2006-01-03 Applera Corporation Lens assembly for biological testing
AU2003243268A1 (en) * 2002-05-17 2003-12-02 Applera Corporation Optical instrument including excitation source
DK1411345T3 (da) 2002-10-17 2007-01-02 Direvo Biotech Ag Multiparameter fluorimetrisk analyse parallelt med multifokalt arrangement
US7050224B2 (en) * 2003-11-07 2006-05-23 Olympus Corporation Fluorescence observing apparatus

Also Published As

Publication number Publication date
EP1873512A3 (de) 2008-12-03
US7289217B2 (en) 2007-10-30
EP1873512A2 (de) 2008-01-02
EP2315005B1 (de) 2016-01-13
EP2239558A2 (de) 2010-10-13
US20050151972A1 (en) 2005-07-14
US7295316B2 (en) 2007-11-13
EP2315005A2 (de) 2011-04-27
US20050190366A1 (en) 2005-09-01
EP2315005A3 (de) 2012-10-03
JP2011022166A (ja) 2011-02-03
EP2239558A3 (de) 2010-12-29

Similar Documents

Publication Publication Date Title
ATE398769T1 (de) Vorrichtung und verfahren zum fluoreszenznachweis in biologischen proben
BRPI0609544B8 (pt) dispositivo de detecção, sistema de detecção, e, método
WO2007118209A3 (en) Apparatus and method for rapid detection of analytes
ATE537438T1 (de) Vorrichtung und verfahren zur unterscheidung mehrerer fluoreszenzsignale anhand ihrer anregungswellenlänge
DE60235718D1 (de) Vorrichtung und verfahren zur untersuchung von analyten in flüssigsuspension oder lösung
ATE294383T1 (de) Vorrichtung und verfahren zum nachweis organischer moleküle in einer probensubstanz
US20140057805A1 (en) Dna-origami-based standard
BRPI0609769B8 (pt) dispositivo de detecção, sistema de detecção, e, método
WO2006055521A3 (en) Tirf single molecule analysis and method of sequencing nucleic acids
DK1681555T3 (da) Billeddannelse af fluorscenssignaler under anvendelse af telecentrisk excitation og billeddannende optikker
ATE390627T1 (de) Verfahren und vorrichtung zur oberflächenplasmonenmikroskopie
ATE460657T1 (de) Abtastvorrichtung und verfahren zum abtasten von mehreren proben
DK0941466T3 (da) Metode og anordning til bestemmelse af forudbestemte egenskaber af målpartikler i et prøvemedium
WO2002048693A1 (fr) Analyseur fluorometrique et analyse fluorometrique
EP1584917A3 (de) Verfahren und Vorrichtung zum Nachweis einer Substanz in einer biologischen Probe
EP1830174A3 (de) Optisches Mehrkanal-Fluoreszenzmesssystem und Mehrkanal-Fluoreszenzprobenanalysator
ATE297018T1 (de) ßHIGH-DENSITY-LIPOPROTEINß-TESTVORRICHTUNG UND VERFAHREN
ATE449319T1 (de) Verfahren und vorrichtung zur messung von wellenfronten
ATE333089T1 (de) Verfahren und vorrichtung zur multiparameter- akquisition von einzelphotonen zur simultanen erzeugung von zeit- und orts- sowie zeit- und wellenlängen-aufgelösten fluoreszenz-bildern
WO2006119277A3 (en) System and method for a pulsed light source used in fluorescence detection
DE60312091D1 (de) Verfahren, Vorrichtung und Reagenziensatz zum Zählen von Bakterien
EP1418238A4 (de) Vorrichtung und verfahren zur untersuchung von mikroben
WO2009014844A3 (en) Method and device for identifying an unknown biological substance
ATE384139T1 (de) Multi-test-analyse von echzeit- nukleinsäureamplifikationen
ATE393389T1 (de) Verfahren zur detektion von fluoreszenzlicht

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties