DK0941466T3 - Metode og anordning til bestemmelse af forudbestemte egenskaber af målpartikler i et prøvemedium - Google Patents

Metode og anordning til bestemmelse af forudbestemte egenskaber af målpartikler i et prøvemedium

Info

Publication number
DK0941466T3
DK0941466T3 DK97952809T DK97952809T DK0941466T3 DK 0941466 T3 DK0941466 T3 DK 0941466T3 DK 97952809 T DK97952809 T DK 97952809T DK 97952809 T DK97952809 T DK 97952809T DK 0941466 T3 DK0941466 T3 DK 0941466T3
Authority
DK
Denmark
Prior art keywords
pct
correlation functions
time
parameters
sec
Prior art date
Application number
DK97952809T
Other languages
English (en)
Inventor
Claus Seidel
Leif Brand
Rolf Guenther
Original Assignee
Max Planck Gesellschaft
Evotec Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19649048A external-priority patent/DE19649048C1/de
Priority claimed from DE19702914A external-priority patent/DE19702914C2/de
Application filed by Max Planck Gesellschaft, Evotec Ag filed Critical Max Planck Gesellschaft
Application granted granted Critical
Publication of DK0941466T3 publication Critical patent/DK0941466T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means, e.g. by light scattering, diffraction, holography or imaging
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means, e.g. by light scattering, diffraction, holography or imaging
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G01N2015/0222—Investigating a scatter or diffraction pattern from dynamic light scattering, e.g. photon correlation spectroscopy

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Sampling And Sample Adjustment (AREA)
DK97952809T 1996-11-27 1997-11-26 Metode og anordning til bestemmelse af forudbestemte egenskaber af målpartikler i et prøvemedium DK0941466T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19649048A DE19649048C1 (de) 1996-11-27 1996-11-27 Verfahren zur Unterscheidung oder Erfassung von Partikeln in einer Probe durch Identifizierung von Signalabschnitten zeitaufgelöster, optischer Rohsignale aus der Probe auf Basis von Einzelphotonendetektion
DE19702914A DE19702914C2 (de) 1997-01-28 1997-01-28 Verfahren und Anordnung zum Bestimmen vorgegebener Eigenschaften von Zielpartikeln eines Probenmediums
PCT/EP1997/006601 WO1998023941A2 (de) 1996-11-27 1997-11-26 Verfahren und anordnung zum bestimmen vorgegebener eigenschaften von zielpartikeln eines probenmediums

Publications (1)

Publication Number Publication Date
DK0941466T3 true DK0941466T3 (da) 2004-03-01

Family

ID=26031638

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97952809T DK0941466T3 (da) 1996-11-27 1997-11-26 Metode og anordning til bestemmelse af forudbestemte egenskaber af målpartikler i et prøvemedium

Country Status (7)

Country Link
US (1) US6137584A (da)
EP (1) EP0941466B1 (da)
JP (1) JP3830167B2 (da)
AT (1) ATE252729T1 (da)
DE (1) DE59710903D1 (da)
DK (1) DK0941466T3 (da)
WO (1) WO1998023941A2 (da)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58102538A (ja) * 1981-12-14 1983-06-18 Fujitsu Ltd 半導体装置の製造方法
US6469311B1 (en) 1997-07-16 2002-10-22 Molecular Devices Corporation Detection device for light transmitted from a sensed volume
US7745142B2 (en) 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
WO2000050877A1 (en) 1999-02-23 2000-08-31 Ljl Biosystems, Inc. Frequency-domain light detection device
US6825921B1 (en) 1999-11-10 2004-11-30 Molecular Devices Corporation Multi-mode light detection system
WO2000006990A2 (en) 1998-07-27 2000-02-10 Ljl Biosystems, Inc. Apparatus and methods for time-resolved spectroscopic measurements
US6576476B1 (en) 1998-09-02 2003-06-10 Ljl Biosystems, Inc. Chemiluminescence detection method and device
US6326605B1 (en) 1998-02-20 2001-12-04 Ljl Biosystems, Inc. Broad range light detection system
WO2000006991A2 (en) 1998-07-27 2000-02-10 Ljl Biosystems, Inc. Apparatus and methods for spectroscopic measurements
GB9813613D0 (en) * 1998-06-25 1998-08-26 Univ Manchester Pulse response assessment
US6528801B1 (en) * 1998-11-04 2003-03-04 The Research Foundation Of State University Of New York Method and apparatus for detecting radiation
US6615531B1 (en) * 2002-03-04 2003-09-09 Larry Holmberg Range finder
US6376843B1 (en) 1999-06-23 2002-04-23 Evotec Oai Ag Method of characterizing fluorescent molecules or other particles using generating functions
EP1063502A1 (en) * 1999-06-23 2000-12-27 Evotec BioSystems AG A method of characterizing fluorescent molecules or other particles using generating functions
DK1175602T3 (da) * 1999-04-29 2003-05-26 Evotec Ag Fremgangsmåde til karakterisering af fluorescente molekyler eller andre partikler, der anvender frembringerfunktioner
US6690463B2 (en) * 2000-02-10 2004-02-10 Evotec Biosystems Ag Fluorescence intensity and lifetime distribution analysis
US6965113B2 (en) 2000-02-10 2005-11-15 Evotec Ag Fluorescence intensity multiple distributions analysis: concurrent determination of diffusion times and molecular brightness
DE60135148D1 (de) * 2000-12-21 2008-09-11 Evotec Ag Verfahren zum chrakterisieren von proben von sekundärlicht emittierenden partikeln
FR2827959B1 (fr) * 2001-07-26 2004-03-19 Centre Nat Rech Scient Dispositif et procede de mesure d'un echantillon par spectroscopie par correlation
DE10144435B4 (de) * 2001-09-06 2005-03-24 EuroPhoton GmbH Gesellschaft für optische Sensorik Verfahren zur Charakterisierung der Eigenschaften von fluoreszierenden Proben, insbesondere lebenden Zellen und Geweben, in multi-well, in in-vitro Fluoreszenz-Assays, in DNA-Chips, Vorrichtungen zur Durchführung des Verfahrens und deren Verwendung
GB2382648B (en) 2001-12-11 2003-11-12 Amersham Pharm Biotech Uk Ltd System and method for time correlated multi-photon counting measurements
WO2004011903A2 (en) * 2002-07-25 2004-02-05 The Regents Of The University Of California Monitoring molecular interactions using photon arrival-time interval distribution analysis
US6934030B2 (en) * 2002-12-18 2005-08-23 The Research Foundation Of State University Of New York Method and apparatus for detecting radiation
WO2004081548A1 (en) * 2003-03-10 2004-09-23 Tiax Llc System and method for bioaerosol discrimination by time-resolved fluorescence
US7060992B1 (en) 2003-03-10 2006-06-13 Tiax Llc System and method for bioaerosol discrimination by time-resolved fluorescence
US7456954B2 (en) * 2003-06-20 2008-11-25 The Regents Of The University Of California Modulated excitation fluorescence analysis
US20050069895A1 (en) * 2003-08-29 2005-03-31 Applera Corporation Compositions, methods, and kits for fabricating coded molecular tags
US20050048498A1 (en) * 2003-08-29 2005-03-03 Applera Corporation Compositions, methods, and kits for assembling probes
US7198900B2 (en) * 2003-08-29 2007-04-03 Applera Corporation Multiplex detection compositions, methods, and kits
CN100339698C (zh) * 2004-11-18 2007-09-26 上海交通大学 激光荧光关联谱单分子分析仪
DE102005020202A1 (de) 2005-04-28 2006-11-09 Picoquant Gmbh Hochauflösende optische Mikroskopie
FR2896877A1 (fr) * 2006-01-31 2007-08-03 Commissariat Energie Atomique Appareil et procede de caracterisation d'un systeme de comptage de particules elementaires
DE102007052551B4 (de) * 2007-10-30 2019-06-19 Carl Zeiss Microscopy Gmbh Verfahren zur Durchführung einer Rasterbildkorrelationsspektroskopiemessung sowie Steuereinheit, Laser-Scanning-Mikroskop und Computerprogramm
DE102008004549B4 (de) 2008-01-15 2013-04-18 PicoQuant GmbH. Unternehmen für optoelektronische Forschung und Entwicklung Vorrichtung und Verfahren zur simultanen zeitaufgelösten Einzelphotonenregistrierung aus einer Mehrzahl von Detektionskanälen
DE102011055330A1 (de) 2011-11-14 2013-05-16 Leica Microsystems Cms Gmbh Verfahren zum Messen der Lebensdauer eines angeregten Zustandes in einer Probe
DE102011055945A1 (de) * 2011-12-01 2013-06-06 Leica Microsystems Cms Gmbh Verfahren und Vorrichtung zum Untersuchen einer Probe
DE102014220547B4 (de) * 2014-01-24 2020-09-10 Becker & Hickl Gmbh Verfahren und Vorrichtung zur Ermittlung von Intensitätswerten bei der zeitkorrelierten Messung optischer Signale
CN108152265B (zh) * 2017-12-26 2023-12-19 同方威视技术股份有限公司 拉曼光谱检测设备及其检测安全性的监控方法
JP6856559B2 (ja) * 2018-01-23 2021-04-07 浜松ホトニクス株式会社 光測定装置及び光測定方法
JP6856558B2 (ja) * 2018-01-23 2021-04-07 浜松ホトニクス株式会社 光測定装置及び光測定方法
EP3953756A1 (en) * 2019-04-09 2022-02-16 Carl Zeiss Microscopy GmbH Light microscope with reconfigurable sensor array
CN114364970A (zh) * 2019-08-05 2022-04-15 金展科技有限公司 用于钻石认证的系统和工艺
CN112255635A (zh) * 2020-09-03 2021-01-22 奥诚信息科技(上海)有限公司 一种距离测量方法、系统及设备
CN112162310B (zh) * 2020-09-18 2023-01-03 上海联影医疗科技股份有限公司 光子计数探测器去极化的方法、系统和计算机设备
CN116235040A (zh) 2020-09-18 2023-06-06 莱卡微系统Cms有限责任公司 压缩来自时间相关单光子计数的时间标记数据的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68924749T2 (de) * 1988-09-15 1996-07-04 Univ Arkansas Kennzeichnung von Teilchen durch modulierte dynamische Lichtstreuung.

Also Published As

Publication number Publication date
EP0941466A2 (de) 1999-09-15
US6137584A (en) 2000-10-24
WO1998023941A2 (de) 1998-06-04
JP2001509255A (ja) 2001-07-10
ATE252729T1 (de) 2003-11-15
JP3830167B2 (ja) 2006-10-04
EP0941466B1 (de) 2003-10-22
DE59710903D1 (de) 2003-11-27
WO1998023941A3 (de) 1998-07-30

Similar Documents

Publication Publication Date Title
DK0941466T3 (da) Metode og anordning til bestemmelse af forudbestemte egenskaber af målpartikler i et prøvemedium
EP1873512A3 (en) Apparatus and method for fluorescent detection in biological samples
ATE416674T1 (de) Nachweis von verunreinigungen mittels selbstständiger einheiten die zielmaterialbindende farbstoffe gebrauchen
EP0420944A1 (en) Optical inspection of food products
DK0898701T3 (da) Fremgangsmåde til at bestemme modenheden og kvaliteten af frø og apparat til at sortere frø
DK1095270T3 (da) Screeninganordning og fremgangsmåde til screening af en immunpröve-test
RU2003100531A (ru) Композиции, содержащие краситель на основе производного мочевины, для выявления аналита, и способы их использования
DK0941465T3 (da) Fremgangsmåde til at skelne og detektere partikler i en sonde ved identifikation af tidsopløste signalafsnit,optiske råsignaler fra en sonde på basis af detektion af enkeltfotoner
ATE78586T1 (de) Verfahren zur messung von strahlungsschwankungen und anwendung desselben zum nachweis eines analyten.
ATE355387T1 (de) Verfahren, vorrichtung und reagenziensatz zum zählen von bakterien
ATE333089T1 (de) Verfahren und vorrichtung zur multiparameter- akquisition von einzelphotonen zur simultanen erzeugung von zeit- und orts- sowie zeit- und wellenlängen-aufgelösten fluoreszenz-bildern
Cao et al. Expanding the potential of standard flow cytometry by extracting fluorescence lifetimes from cytometric pulse shifts
US6759247B2 (en) Method and apparatus for detecting radiation
WO2005040759A3 (en) Apparatus and methods for detecting target analyte
NO20003709L (no) Fremgangsmate for detektering av en analytt, og omsluttingsmiddel og kit for anvendelse deri
ATE384139T1 (de) Multi-test-analyse von echzeit- nukleinsäureamplifikationen
DK1173748T3 (da) Fremgangsmåde og indretning til detektering af variationer af optiske egenskaber af en prøve i en analyseproces
de Andrade et al. Multicommuted flow analysis procedure for total polyphenols determination in wines employing chemiluminescence detection
AU757897B2 (en) Response assessment
SU1403784A1 (ru) Способ идентификации люминесцирующих минералов
Geerts Experimental realization and optimalization of a fluorescence correlation spectroscopy apparatus
SU996960A1 (ru) Способ измерени напр женности нестационарного магнитного пол в полосковых лини х
Deka et al. Time-resolved fluorescence decay measurements for flowing particles
Bisson et al. Confirmatory measurement channels for LIF-based bioaerosol instrumentation
ES2129001B1 (es) Metodo para la deteccion y visualizacion de una secuencia especifica de dna.