DK0941465T3 - Fremgangsmåde til at skelne og detektere partikler i en sonde ved identifikation af tidsopløste signalafsnit,optiske råsignaler fra en sonde på basis af detektion af enkeltfotoner - Google Patents
Fremgangsmåde til at skelne og detektere partikler i en sonde ved identifikation af tidsopløste signalafsnit,optiske råsignaler fra en sonde på basis af detektion af enkeltfotonerInfo
- Publication number
- DK0941465T3 DK0941465T3 DK97951990T DK97951990T DK0941465T3 DK 0941465 T3 DK0941465 T3 DK 0941465T3 DK 97951990 T DK97951990 T DK 97951990T DK 97951990 T DK97951990 T DK 97951990T DK 0941465 T3 DK0941465 T3 DK 0941465T3
- Authority
- DK
- Denmark
- Prior art keywords
- raw signals
- optical raw
- sample
- probe
- particles
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 7
- 230000003287 optical effect Effects 0.000 title abstract 6
- 238000001514 detection method Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000000523 sample Substances 0.000 title 2
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/02—Investigating particle size or size distribution
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/02—Investigating particle size or size distribution
- G01N15/0205—Investigating particle size or size distribution by optical means
- G01N15/0211—Investigating a scatter or diffraction pattern
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Sustainable Development (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19649048A DE19649048C1 (de) | 1996-11-27 | 1996-11-27 | Verfahren zur Unterscheidung oder Erfassung von Partikeln in einer Probe durch Identifizierung von Signalabschnitten zeitaufgelöster, optischer Rohsignale aus der Probe auf Basis von Einzelphotonendetektion |
PCT/EP1997/006622 WO1998023942A2 (de) | 1996-11-27 | 1997-11-27 | Verfahren zur unterscheidung oder erfassung von partikeln in einer probe durch identifizierung von signalabschnitten zeitaufgelöster, optischer rohsignale aus der probe auf der basis von einzelphotonendetektion |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0941465T3 true DK0941465T3 (da) | 2003-06-30 |
Family
ID=7812873
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97951990T DK0941465T3 (da) | 1996-11-27 | 1997-11-27 | Fremgangsmåde til at skelne og detektere partikler i en sonde ved identifikation af tidsopløste signalafsnit,optiske råsignaler fra en sonde på basis af detektion af enkeltfotoner |
Country Status (6)
Country | Link |
---|---|
US (1) | US6208815B1 (da) |
EP (1) | EP0941465B1 (da) |
AT (1) | ATE235048T1 (da) |
DE (2) | DE19649048C1 (da) |
DK (1) | DK0941465T3 (da) |
WO (1) | WO1998023942A2 (da) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0884583A1 (en) * | 1997-06-10 | 1998-12-16 | Evotec BioSystems GmbH | A method for characterizing samples in at least two dimensional space of specific physical properties |
US6965113B2 (en) * | 2000-02-10 | 2005-11-15 | Evotec Ag | Fluorescence intensity multiple distributions analysis: concurrent determination of diffusion times and molecular brightness |
WO2002009483A1 (en) * | 2000-07-26 | 2002-01-31 | The Regents Of The University Of California | Manipulation of live cells and inorganic objects with optical micro beam arrays |
DE10040988A1 (de) * | 2000-08-22 | 2002-03-21 | Evotec Biosystems Ag | Verfahren und Vorrichtung zum Messen chemischer und/oder biologischer Proben |
US20030007894A1 (en) | 2001-04-27 | 2003-01-09 | Genoptix | Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles |
US6936811B2 (en) * | 2000-11-13 | 2005-08-30 | Genoptix, Inc. | Method for separating micro-particles |
US20020123112A1 (en) * | 2000-11-13 | 2002-09-05 | Genoptix | Methods for increasing detection sensitivity in optical dielectric sorting systems |
US20020160470A1 (en) * | 2000-11-13 | 2002-10-31 | Genoptix | Methods and apparatus for generating and utilizing linear moving optical gradients |
US6744038B2 (en) | 2000-11-13 | 2004-06-01 | Genoptix, Inc. | Methods of separating particles using an optical gradient |
US6784420B2 (en) * | 2000-11-13 | 2004-08-31 | Genoptix, Inc. | Method of separating particles using an optical gradient |
US6833542B2 (en) * | 2000-11-13 | 2004-12-21 | Genoptix, Inc. | Method for sorting particles |
US6778724B2 (en) | 2000-11-28 | 2004-08-17 | The Regents Of The University Of California | Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices |
US20030194755A1 (en) * | 2001-04-27 | 2003-10-16 | Genoptix, Inc. | Early detection of apoptotic events and apoptosis using optophoretic analysis |
US20040009540A1 (en) * | 2001-04-27 | 2004-01-15 | Genoptix, Inc | Detection and evaluation of cancer cells using optophoretic analysis |
US20030211461A1 (en) * | 2002-05-01 | 2003-11-13 | Genoptix, Inc | Optophoretic detection of durgs exhibiting inhibitory effect on Bcr-Abl positive tumor cells |
US20040033539A1 (en) * | 2002-05-01 | 2004-02-19 | Genoptix, Inc | Method of using optical interrogation to determine a biological property of a cell or population of cells |
US20040053209A1 (en) * | 2002-09-12 | 2004-03-18 | Genoptix, Inc | Detection and evaluation of topoisomerase inhibitors using optophoretic analysis |
US20040067167A1 (en) * | 2002-10-08 | 2004-04-08 | Genoptix, Inc. | Methods and apparatus for optophoretic diagnosis of cells and particles |
US20040121474A1 (en) * | 2002-12-19 | 2004-06-24 | Genoptix, Inc | Detection and evaluation of chemically-mediated and ligand-mediated t-cell activation using optophoretic analysis |
US20040121307A1 (en) * | 2002-12-19 | 2004-06-24 | Genoptix, Inc | Early detection of cellular differentiation using optophoresis |
EP1671109A4 (en) * | 2003-06-20 | 2007-09-19 | Univ California | ANALYSIS BY FLUORESCENCE WITH MODULATED EXCITATION |
WO2005022147A1 (en) * | 2003-08-28 | 2005-03-10 | Celula, Inc. | Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network |
US7198900B2 (en) * | 2003-08-29 | 2007-04-03 | Applera Corporation | Multiplex detection compositions, methods, and kits |
US20050048498A1 (en) * | 2003-08-29 | 2005-03-03 | Applera Corporation | Compositions, methods, and kits for assembling probes |
US20050069895A1 (en) * | 2003-08-29 | 2005-03-31 | Applera Corporation | Compositions, methods, and kits for fabricating coded molecular tags |
EP1670943B1 (en) | 2003-09-30 | 2013-11-13 | Evotec International GmbH | Diagnostic and therapeutic use of a sulfotransferase for alzheimer's disease |
JP2005329850A (ja) * | 2004-05-20 | 2005-12-02 | Yamaha Marine Co Ltd | 船外機の水冷装置 |
US20080301821A1 (en) | 2004-08-11 | 2008-12-04 | Evotec Neurosciences Gmbh | Diagnostic and Therapeutic use of a Plasma Membrane Atpase |
US7572640B2 (en) * | 2004-09-28 | 2009-08-11 | Singulex, Inc. | Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties |
US20060078998A1 (en) * | 2004-09-28 | 2006-04-13 | Singulex, Inc. | System and methods for sample analysis |
US8685711B2 (en) * | 2004-09-28 | 2014-04-01 | Singulex, Inc. | Methods and compositions for highly sensitive detection of molecules |
US9040305B2 (en) * | 2004-09-28 | 2015-05-26 | Singulex, Inc. | Method of analysis for determining a specific protein in blood samples using fluorescence spectrometry |
US20090172827A1 (en) | 2005-05-27 | 2009-07-02 | Johannes Pohlner | Kcnn3 as diagnostic and therapeutic target for neurodegenerative diseases |
US8114620B2 (en) | 2005-05-30 | 2012-02-14 | Takeda Pharmaceutical Company Limited | Diagnostic and therapeutic target PRKX proteins for neurodegenerative diseases |
WO2006128902A1 (en) | 2005-06-01 | 2006-12-07 | Evotec Neurosciences Gmbh | Diagnostic and therapeutic target slc39a12 proteins for neurodegenerative diseases |
DE602006019582D1 (de) | 2005-06-16 | 2011-02-24 | Evotec Neurosciences Gmbh | Adarb2 proteine als diagnostische und therapeutische targets für neurodegenerative erkrankungen |
US7838250B1 (en) | 2006-04-04 | 2010-11-23 | Singulex, Inc. | Highly sensitive system and methods for analysis of troponin |
JP5308328B2 (ja) | 2006-04-04 | 2013-10-09 | シングレックス,インコーポレイテッド | トロポニンの分析のための高感度のシステムおよび方法 |
US7914734B2 (en) | 2007-12-19 | 2011-03-29 | Singulex, Inc. | Scanning analyzer for single molecule detection and methods of use |
CN102016552A (zh) * | 2008-03-05 | 2011-04-13 | 神谷来克斯公司 | 用于分子的高灵敏性检测的方法和组合物 |
GB2464183A (en) * | 2008-09-19 | 2010-04-14 | Singulex Inc | Sandwich assay |
JP5678045B2 (ja) | 2009-06-08 | 2015-02-25 | シンギュレックス・インコーポレイテッド | 高感度バイオマーカーパネル |
WO2011136857A2 (en) | 2010-01-06 | 2011-11-03 | Trustees Of Boston University | Correlation confocal microscope |
JP2013525820A (ja) | 2010-05-06 | 2013-06-20 | シングレクス、インコーポレイテッド | 関節リウマチの発症に関するリスクを診断し、病期分類し、予測し、治療レスポンダーを同定するための方法 |
US8284398B2 (en) | 2010-06-24 | 2012-10-09 | Met One Instruments, Inc. | Nephelometer with concentration-modulated sample flow |
DE102013213362A1 (de) * | 2013-07-08 | 2015-01-08 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Identifizierung und Quantifizierung von emittierenden Teilchen in Systemen |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4979824A (en) * | 1989-05-26 | 1990-12-25 | Board Of Trustees Of The Leland Stanford Junior University | High sensitivity fluorescent single particle and single molecule detection apparatus and method |
DE4301005A1 (de) * | 1993-01-18 | 1994-07-21 | Diagen Inst Molekularbio | Verfahren und Vorrichtung zur Bewertung der Fitness von Biopolymeren |
WO1994016313A2 (de) * | 1993-01-18 | 1994-07-21 | Evotec Biosystems Gmbh | Verfahren und vorrichtung zur bewertung der fitness von biopolymeren |
DE4438391C2 (de) * | 1994-10-27 | 1997-07-03 | Evotec Biosystems Gmbh | Vorrichtung zur Bestimmung stoffspezifischer Parameter eines oder weniger Moleküle mittels Korrelations-Spektroskopie |
FI101829B (fi) | 1995-03-07 | 1998-08-31 | Erkki Juhani Soini | Biospesifinen määritysmenetelmä |
-
1996
- 1996-11-27 DE DE19649048A patent/DE19649048C1/de not_active Expired - Lifetime
-
1997
- 1997-11-27 AT AT97951990T patent/ATE235048T1/de not_active IP Right Cessation
- 1997-11-27 EP EP97951990A patent/EP0941465B1/de not_active Expired - Lifetime
- 1997-11-27 WO PCT/EP1997/006622 patent/WO1998023942A2/de active IP Right Grant
- 1997-11-27 DE DE59709584T patent/DE59709584D1/de not_active Expired - Lifetime
- 1997-11-27 DK DK97951990T patent/DK0941465T3/da active
- 1997-11-27 US US09/308,631 patent/US6208815B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE19649048C1 (de) | 1998-04-09 |
DE59709584D1 (de) | 2003-04-24 |
ATE235048T1 (de) | 2003-04-15 |
EP0941465A2 (de) | 1999-09-15 |
WO1998023942A2 (de) | 1998-06-04 |
WO1998023942A3 (de) | 1998-08-06 |
US6208815B1 (en) | 2001-03-27 |
EP0941465B1 (de) | 2003-03-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0941465T3 (da) | Fremgangsmåde til at skelne og detektere partikler i en sonde ved identifikation af tidsopløste signalafsnit,optiske råsignaler fra en sonde på basis af detektion af enkeltfotoner | |
ATE387884T1 (de) | Vorrichtung zur klassifizierung von gewebe | |
DE69332976D1 (de) | Digitale analytische nachweisvorrichtung | |
WO1998023941A3 (de) | Verfahren und anordnung zum bestimmen vorgegebener eigenschaften von zielpartikeln eines probenmediums | |
DE69737513D1 (de) | Teilchenförmiges markierungsmittel verwendendes analytassay | |
US6421121B1 (en) | Method and apparatus for rapid particle identification utilizing scattered light histograms | |
CA2092985A1 (en) | Detection of bacteria in blood culture bottles by time-resolved light scattering and absorption measurement | |
DE69804612D1 (de) | Verfahren zur charakterisierung von proben unter verwendung statistischer zwischendaten | |
ATE530891T1 (de) | Miniaturisierter zellsortierer | |
EP0008874B1 (en) | Method and apparatus for discriminating red blood cells from platelets | |
US4686371A (en) | Apparatus for measuring fluorescence decay characteristics of materials | |
JP2003035670A (ja) | 視距離、降水量、降水の種類を決定する方法および視距離測定器と降水量測定器とを組み合わせた前記方法を実施するための装置 | |
ATE340361T1 (de) | Nachweissystem unter verwendung liposomen und signalmodifikation | |
ATE336714T1 (de) | Verbesserten lichtstreuungsauslöser verwendendes axialmusteranalyse- und sortiergerät für vielzellorganismen | |
Delahaye et al. | A dual-beam spectropluviometer concept | |
GB2338299A (en) | Improved Rayleigh backscatter control apparatus and method | |
RU2102719C1 (ru) | Устройство для дисперсного анализа размеров взвешенных частиц | |
WO2003100471A3 (en) | Distributed contaminant optical monitoring system | |
Dahl et al. | Fire Detector. | |
JP2765750B2 (ja) | 光ファイバ式分布形温度測定装置 | |
JPS6439635A (en) | Recording information reproducing device for optical card | |
TW360855B (en) | Coin device and the coin identification method thereof | |
FR2708118B1 (fr) | Dispositif d'analyse de supports d'informations pourvu de moyens de compensation de ses signaux de sortie. | |
DAHL | Fire Detector(Patent) | |
WO1994002841A1 (en) | Multiple source and detection frequencies in detecting atomic or molecular spectra and/or threshold phenomena associated with the same |